Galectins and microenvironmental niches during hematopoiesis.

abstract：PURPOSE OF REVIEW:The presence of the Philadelphia chromosome causing the fusion between BCR to ABL1 in B cell precursor acute lymphoblastic leukemias (ALLs) was associated with a particularly bad prognosis, which has been markedly improved with the addition of imatinib to chemotherapy. Recent genomic studies have lead...

journal_title：Current opinion in hematology

authors： Izraeli S

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Gfi-1, originally identified as a transcriptional repressor in lymphoid cells, is now recognized to have essential, independent functions in neutrophil maturation and hematopoietic stem cell biology. Here we review recent studies pertaining to Gfi-1 and its cell context specific functions in hematopoi...

journal_title：Current opinion in hematology

authors： Hock H,Orkin SH

更新日期：2006-01-01 00:00:00

abstract：:This article presents the most recent insights into the biology, prognostic significance, and therapeutic approaches to TEL/AML1-positive leukemia. The TEL/AML1 fusion gene, also known as ETV6 /CBFA2, is the most commonly occurring gene rearrangement in pediatric acute lymphoblastic leukemia (ALL). Considerable contro...

journal_title：Current opinion in hematology

authors： Loh ML,Rubnitz JE

更新日期：2002-07-01 00:00:00

abstract：:Following on the heels of multiple failed clinical trials of adjunctive therapeutic agents in sepsis, the positive outcome of a recent phase III study using activated protein C (APC) has led to a renewed optimism in targeted biotherapies for this syndrome. A growing body of data (both preclinical and clinical) suggest...

journal_title：Current opinion in hematology

authors： Key NS,Ely EW

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the current literature regarding retrievable inferior vena cava filters and to discuss the appropriate indications for their clinical use. RECENT FINDINGS:Permanent filters have been shown to be effective, but have a number of long-term complications such as filter thrombosis or migration....

journal_title：Current opinion in hematology

authors： Imberti D,Ageno W,Carpenedo M

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Core binding factor acute myeloid leukemia (CBF-AML) corresponds to two distinct subtypes of AML characterized by recurrent favorable chromosome translocations, namely t(8;21) and inv(16)/t(16;16). Given the relatively good outcome of patients with CBF-AML, when treated with intensive chemotherapy inc...

journal_title：Current opinion in hematology

authors： Dombret H,Preudhomme C,Boissel N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Vasculogenesis and hematopoiesis are essential for development. Recently, the ETS domain transcription factor Etv2 has been identified as an essential regulator of vasculogenesis and hematopoiesis. Here, we review the recent studies that have established the critical role of Etv2 in the specification ...

journal_title：Current opinion in hematology

authors： Lammerts van Bueren K,Black BL

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Microtransplantation (MST) has been successfully used to manage patients with hematological malignancies, especially older patients with acute myeloid leukemia (AML). Recent clinical applications and mechanistic studies of MST are reviewed. RECENT FINDINGS:MST improves complete remission rates which ...

journal_title：Current opinion in hematology

authors： Cai B,Guo M,Ai H

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on advances in the area of iron chelation therapy, including new indications and uses of currently available agents, and preliminary data on potential new agents in development. RECENT FINDINGS:Two new oral agents, deferasirox and deferiprone, have become available in t...

journal_title：Current opinion in hematology

authors： Sheth S

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is designed to help readers understand seasonal blood shortages and provide solutions through the use of technology that can increase the number of red blood cell units collected and the use of recruitment and marketing initiatives that appeal to the increasingly diverse donor base. RECEN...

journal_title：Current opinion in hematology

authors： Gilcher RO,McCombs S

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The polycomb group gene BMI1 fulfills essential roles in both normal and leukemic stem cells. The underlying molecular mechanisms are beginning to become unraveled and an overview of the current knowledge on BMI1 signaling in normal and leukemic stem cells will be presented here. RECENT FINDINGS:In a...

journal_title：Current opinion in hematology

authors： Schuringa JJ,Vellenga E

更新日期：2010-07-01 00:00:00

abstract：:Contrast venography remains the gold standard for the diagnosis of deep-vein thrombosis (DVT). However, an ongoing interest exists in developing safe diagnostic strategies that are less invasive, less expensive, widely and readily available, and more acceptable to patients than venography. For patients with symptoms s...

journal_title：Current opinion in hematology

authors： Birdwell B

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Infantile hemangioma is a common vascular tumor with a unique lifecycle: rapid growth in infancy, followed by a period of involution, leading to complete regression. This review summarizes recent studies of molecular mechanisms of hemangioma formation and places new findings and hypotheses in the cont...

journal_title：Current opinion in hematology

authors： Boye E,Olsen BR

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms...

journal_title：Current opinion in hematology

authors： Zhao L,Lu W

更新日期：2014-01-01 00:00:00

abstract：:Bone marrow transplantation protocols for inherited metabolic storage diseases are unique for each disorder treated. Differences depend also upon how old the patient was when onset occurred and rate of progression of disease. Treatment is directed to prevent or ameliorate the inexorable neurological deterioration that...

journal_title：Current opinion in hematology

authors： Krivit W,Aubourg P,Shapiro E,Peters C

更新日期：1999-11-01 00:00:00

abstract：:Matching for human leukocyte antigen (HLA) loci is the most crucial factor in the selection of bone marrow donors. The techniques utilized to assign HLA type have evolved significantly since the application of polymerase chain reaction-based methodologies. A significant challenge for DNA typing methodologies is to be ...

journal_title：Current opinion in hematology

authors： Little AM,Marsh SG,Madrigal JA

更新日期：1998-11-01 00:00:00

abstract：:Fibrinogen abnormalities can be classified as congenital or acquired. Each class manifests quantitative or qualitative alterations; the latter are known as dysfibrinogenemias. In dysfibrinogenemias, structural defects cause alterations in the conversion of fibrinogen to fibrin. Approximately 300 abnormal fibrinogens h...

journal_title：Current opinion in hematology

authors： Martinez J

更新日期：1997-09-01 00:00:00

abstract：:The reconstitution of T-cell populations is a critical component of immune recovery after allogeneic stem cell transplantation. Recent studies have used new techniques to focus on the interplay of thymopoiesis and peripheral expansion that defines T-cell repopulation. Peripheral expansion, driven by host cytokines and...

journal_title：Current opinion in hematology

authors： Hakim FT,Gress RE

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Adoptive T-cell therapy has become one of the most exciting fields of cancer therapy in the past few years. In this article, we describe a method which combines adoptive T-cell therapy with antibody therapy by arming T cells from cord blood, normal patients, and cancer patients with bispecific antibod...

journal_title：Current opinion in hematology

authors： Bhutani D,Lum LG

更新日期：2015-11-01 00:00:00

abstract：:Hematopoietic stem cells are the cells primarily responsible for short term and long term hematological reconstitution when a graft is infused into a myeloablated host. The number and quality of hematopoietic stem cells within a graft are the major determinants of the time to and durability of hematological reconstitu...

journal_title：Current opinion in hematology

authors： Hoffman R

更新日期：1999-05-01 00:00:00

abstract：:Neutropenia is often attributed to immunologically mediated injury to mature neutrophils or their precursors. Clinically it is useful to classify immune mediated neutropenias as isoimmune, autoimmune (including some drug-associated neutropenias), and idiopathic (cases possibly with an immune mechanism). Isoimmune neut...

journal_title：Current opinion in hematology

authors： Dale DC

更新日期：1998-01-01 00:00:00

abstract：:Leukocytes use an array of antimicrobial peptides and proteins to help them destroy invading microorganisms. These endogenous antibiotic molecules are remarkable for their structural variety, rapid evolutionary divergence, intraspecies variation, and complex yet subtle interactions with their targets. This arsenal has...

journal_title：Current opinion in hematology

authors： Ganz T,Lehrer RI

更新日期：1997-01-01 00:00:00

abstract：:When a new product with huge clinical potential explodes on the scene, the hope is that the benefits far outweigh the risks in long-term administration. After 10 years of clinical use, granulocyte colony-stimulating factor (G-CSF) has lived up to that promise so far. In the context of severe chronic neutropenia, more ...

journal_title：Current opinion in hematology

authors： Freedman MH

更新日期：1997-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The identification of regulatory T cells (Tregs) as regulators of immunological self-tolerance has stimulated tremendous interest in the field. Over the past 12 months, new studies have added greatly to our understanding of the role of Tregs in autoimmune disease, details of which are presented here. ...

journal_title：Current opinion in hematology

authors： Vila J,Isaacs JD,Anderson AE

更新日期：2009-07-01 00:00:00

abstract：:Advances in platelet transfusion have contributed to improved outcomes in the treatment of patients with cancer and leukemia. However, the optimal strategies to avoid some of the side effects that could result from platelet transfusions remain under investigation. These side effects include the development of refracto...

journal_title：Current opinion in hematology

authors： Sarkodee-Adoo C,Schiffer CA

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron homeostasis and erythropoiesis regulate each other to ensure optimal delivery of oxygen and iron to cells and tissues. Defining the mechanisms of this crosstalk is important for understanding the pathogenesis of common conditions associated with disordered iron metabolism and erythropoiesis. REC...

journal_title：Current opinion in hematology

authors： Kim A,Nemeth E

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Re...

journal_title：Current opinion in hematology

authors： Harris ES,Weyrich AS,Zimmerman GA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to describe the physiopathological and therapeutic aspects of neutrophilic dermatosis, taking into account their most frequent associated conditions. RECENT FINDINGS:In autoinflammatory syndromes featuring neutrophilic dermatosis, the role of interleukin-1 and tumor necr...

journal_title：Current opinion in hematology

authors： Maalouf D,Battistella M,Bouaziz JD

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In response to agonists produced at vascular lesions, platelets release a host of components from their three granules: dense core, alpha, and lysosome. This releasate activates other platelets, promotes wound repair, and initiates inflammatory responses. Although widely accepted, the specific mechani...

journal_title：Current opinion in hematology

authors： Ren Q,Ye S,Whiteheart SW

更新日期：2008-09-01 00:00:00

abstract：:The ability to move is one of the most basic and critical functions of the neutrophil. The neutrophil changes its shape from round to highly polar and glides along the surface, pausing every 45 to 60 seconds to reestablish its direction. Iterations of this sequence of small-scale motion, or shape change, sum to form t...

journal_title：Current opinion in hematology

authors： Coates TD

更新日期：1996-01-01 00:00:00