Immune and idiopathic neutropenia.

abstract：PURPOSE OF REVIEW:Vasculogenesis and hematopoiesis are essential for development. Recently, the ETS domain transcription factor Etv2 has been identified as an essential regulator of vasculogenesis and hematopoiesis. Here, we review the recent studies that have established the critical role of Etv2 in the specification ...

journal_title：Current opinion in hematology

authors： Lammerts van Bueren K,Black BL

更新日期：2012-05-01 00:00:00

abstract：:Therapy with unconjugated monoclonal antibodies (mAbs) and radiolabeled mAbs has shown activity in patients with B-cell non-Hodgkin's lymphoma and leukemia. Drug-conjugated mAbs are active in relapsed leukemia. Using these new agents with and after chemotherapy induces a high rate of remission, but this needs to be co...

journal_title：Current opinion in hematology

authors： Maloney DG

更新日期：1999-07-01 00:00:00

abstract：:The reconstitution of T-cell populations is a critical component of immune recovery after allogeneic stem cell transplantation. Recent studies have used new techniques to focus on the interplay of thymopoiesis and peripheral expansion that defines T-cell repopulation. Peripheral expansion, driven by host cytokines and...

journal_title：Current opinion in hematology

authors： Hakim FT,Gress RE

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Since the first discovery of microRNAs (miRNAs) in 1993, the involvement of miRNAs in different aspects of vascular disease has emerged as an important research field. In this review, we summarize the fundamental roles of miRNAs in controlling endothelial cell functions and their implication with seve...

journal_title：Current opinion in hematology

authors： Fernández-Hernando C,Suárez Y

更新日期：2018-05-01 00:00:00

abstract：:This article presents the most recent insights into the biology, prognostic significance, and therapeutic approaches to TEL/AML1-positive leukemia. The TEL/AML1 fusion gene, also known as ETV6 /CBFA2, is the most commonly occurring gene rearrangement in pediatric acute lymphoblastic leukemia (ALL). Considerable contro...

journal_title：Current opinion in hematology

authors： Loh ML,Rubnitz JE

更新日期：2002-07-01 00:00:00

abstract：:Disorders of the erythrocyte membrane, such as hereditary spherocytosis, hereditary elliptocytosis, and hereditary pyropoikilocytosis, are characterized by heterogeneity in their clinical and laboratory manifestations. Recent work has shown that these disorders also exhibit marked genetic heterogeneity. Multiple genet...

journal_title：Current opinion in hematology

authors： Gallagher PG,Ferriera JD

更新日期：1997-03-01 00:00:00

abstract：:Although the mature enucleated erythrocyte is no longer active in nuclear processes such as pre-mRNA splicing, the function of many of its major structural proteins is dependent on alternative splicing choices made during the earlier stages of erythropoiesis. These splicing decisions fundamentally regulate many aspect...

journal_title：Current opinion in hematology

authors： Hou VC,Conboy JG

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Monitoring for residual leukemic burden is an integral part of ongoing evaluation in chronic myeloid leukemia. With high rates of complete cytogenetic response induced by imatinib and other tyrosine kinase inhibitors, exploring refinements in current methods of minimal residual disease monitoring ...

journal_title：Current opinion in hematology

authors： Sahay T,Schiffer CA

更新日期：2008-03-01 00:00:00

abstract：:Human immunodeficiency virus infection causes multilineage hematopoietic defects. Defects in the production and function of CD4+ helper cells have been the focus of the majority of HIV research, but anemia, neutropenia, and thrombocytopenia are significant clinical problems as well. Bone marrow suppression is the dose...

journal_title：Current opinion in hematology

authors： Miles S

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Re...

journal_title：Current opinion in hematology

authors： Harris ES,Weyrich AS,Zimmerman GA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate recent findings in the multifaceted pathophysiological mechanisms underlying thrombocytopenia in patients with chronic liver disease and to assess its therapeutic management. RECENT FINDINGS:Antiplatelet antibodies, despite being observed rather frequently in patients with chronic viral l...

journal_title：Current opinion in hematology

authors： Giannini EG,Savarino V

更新日期：2008-09-01 00:00:00

abstract：:The search for, and discovery of, a physiologic model in which the developmentally regulated switch from fetal to adult globin gene expression could be prevented has resulted in the development of a new class of therapeutic agents, consisting of simple fatty acids, such as butyric acid, for the treatment of the beta-h...

journal_title：Current opinion in hematology

authors： Faller DV,Perrine SP

更新日期：1995-03-01 00:00:00

abstract：:Hematopoietic stem cells are the cells primarily responsible for short term and long term hematological reconstitution when a graft is infused into a myeloablated host. The number and quality of hematopoietic stem cells within a graft are the major determinants of the time to and durability of hematological reconstitu...

journal_title：Current opinion in hematology

authors： Hoffman R

更新日期：1999-05-01 00:00:00

abstract：:Hematopoietic stem cells, defined as cells with extensive self-renewal and pluripotent differentiation potential, represent a minor population of adult bone marrow (< 1 in 10(4) to 10(5) nucleated marrow cells). Recent advances in cell surface phenotype analysis and separation technology have permitted enrichment of h...

journal_title：Current opinion in hematology

authors： Moore MA,Shapiro F

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial cells dysfunctions are crucial determinants of several human diseases. We review here the most recent reports on endothelial cell defects in cerebral cavernous malformations (CCMs), particularly focusing on adherens junctions. CCM is a vascular disease that affects specifically the venous ...

journal_title：Current opinion in hematology

authors： Lampugnani MG,Malinverno M,Dejana E,Rudini N

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From the moment of HSC embryonic specification from hemogenic endothelium, endothelial cells (ECs) act as a critical cellular-hub that regulates a ...

journal_title：Current opinion in hematology

authors： Ramalingam P,Poulos MG,Butler JM

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:While the risks of transfusion-transmitted human immunodeficiency virus, hepatitis C virus, and human T-cell leukemia virus I/II continue to decrease, additional threats to transfusion safety are posed by emerging "new" infectious diseases. RECENT FINDINGS:Following the introduction of nucleic acid t...

journal_title：Current opinion in hematology

authors： Pomper GJ,Wu Y,Snyder EL

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The review describes recent advances in our understanding of mechanisms leading to development of neutralizing antibodies following factor VIII (FVIII) replacement therapy for hemophilia A. Novel interventions with translational potential to lessen the incidence of these deleterious immune responses a...

journal_title：Current opinion in hematology

authors： Pratt KP

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Development of a technique prospectively to isolate hematopoietic stem cells (HSCs) to near homogeneity has enabled clonal analysis and thus converted our understanding of HSCs from conceptual and qualitative to realistic and quantitative. Recent studies have revealed that despite their high prolifera...

journal_title：Current opinion in hematology

authors： Yamazaki S,Nakauchi H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:A major goal in repopulating hematopoietic stem cell (HSC) gene therapies is achieving high-efficacy gene transfer, while maintaining robust HSC engraftment and differentiation in vivo. Recent studies have documented that rapamycin treatment of HSC during lentiviral vector transduction enhances gene t...

journal_title：Current opinion in hematology

authors： Wang CX,Torbett BE

更新日期：2015-07-01 00:00:00

abstract：:Gene transfer has allowed a number of biologic issues in the therapy of hematologic malignancy to be addressed. In autologous bone marrow transplantation, gene marking studies have shown that infused marrow contributes to relapse in acute myeloid leukemia, neuroblastoma, and chronic myeloid leukemia. In addition, doub...

journal_title：Current opinion in hematology

authors： Heslop HE,Roskrow M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 von Willebrand disease (VWD) is the most common form of VWD, but has remained [corrected] the least well understood. Recent work is changing this situation. This review summarizes recent analysis of the genetic basis of the disease. RECENT FINDINGS:Linkage analysis demonstrates that dominantly...

journal_title：Current opinion in hematology

authors： Goodeve A

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis and/or obstetrical morbidity in the presence of persistently positive antiphospholipid antibodies. Recent insights into the pathogenesis of APS have begun to elucidate pathophysiology and led to...

journal_title：Current opinion in hematology

authors： Chaturvedi S,McCrae KR

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:B-cell tumors originating from the transformation of germinal center B cells frequently harbor genetic mutations, leading to constitutive activation of the nuclear factor-κB (NF-κB) signaling pathway. The present review highlights recent insights into the roles of separate NF-κB transcription factors ...

journal_title：Current opinion in hematology

authors： Klein U,Heise N

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the application of minimal residual disease (MRD) testing in childhood acute lymphoblastic leukemia (ALL). RECENT FINDINGS:Polymerase chain reaction amplification of antigen receptor genes, one of the two main methods to study MRD in ALL, could be made more r...

journal_title：Current opinion in hematology

authors： Campana D

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite improvements in the achievement of complete remission and progress in the supportive care of adults with acute lymphoblastic leukemia during the last decade, the majority of patients have eventually relapsed with overall survival in adult acute lymphoblastic leukemia of only 30-40%. However, t...

journal_title：Current opinion in hematology

authors： Larson S,Stock W

更新日期：2008-07-01 00:00:00

abstract：:This overview concentrates on familial and congenital polycythemias in the context of other polycythemic disorders, with emphasis on those with established molecular lesions. Recent advances in the regulation of erythropoiesis, as they may relate to polycythemic states, are discussed as a background for those well-def...

journal_title：Current opinion in hematology

authors： Prchal JF,Prchal JT

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we focus on three specific concepts related to platelet transfusion in the neonatal and pediatric population: choice of transfusion threshold; use of ABO-mismatched platelets; transfusion of pathogen-reduced or inactivated platelets. RECENT FINDINGS:Recent trials support the use of lo...

journal_title：Current opinion in hematology

authors： Patel RM,Josephson C

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Mortality and morbidity associated with leukemia are largely due to frequently occurring cytopenias or the dysfunction of normal blood cells in patients. Our knowledge of how normal blood cells degenerate in response to leukemic cell infiltration has been quite limited. This review summarizes recent f...

journal_title：Current opinion in hematology

authors： Cheng H,Cheng T

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron homeostasis and erythropoiesis regulate each other to ensure optimal delivery of oxygen and iron to cells and tissues. Defining the mechanisms of this crosstalk is important for understanding the pathogenesis of common conditions associated with disordered iron metabolism and erythropoiesis. REC...

journal_title：Current opinion in hematology

authors： Kim A,Nemeth E

更新日期：2015-05-01 00:00:00