'Waterloo': when normal blood cells meet leukemia.

abstract：:Genetic defects of the blood platelet membrane glycoproteins, GPIIb-IIIa (alpha IIb/beta 3; CD41/CD61) and GPIb-V-IX (CD42) are the origin of several rare bleeding disorders, the best known of which are Glanzmann's thrombasthenia, Bernard-Soulier syndrome, and platelet-type von Willebrand's disease. In Glanzmann's thr...

journal_title：Current opinion in hematology

authors： Clemetson KJ,Clemetson JM

更新日期：1994-09-01 00:00:00

abstract：:Multiple myeloma is the second most common hematologic malignancy, with approximately 15,000 new cases each year in the United States. Our understanding of the pathophysiology underlying myeloma continues to expand, but the cause of this plasma cell dyscrasia remains unclear. Though controversy remains regarding a pos...

journal_title：Current opinion in hematology

authors： Sjak-Shie NN,Vescio RA,Berenson JR

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Monitoring for residual leukemic burden is an integral part of ongoing evaluation in chronic myeloid leukemia. With high rates of complete cytogenetic response induced by imatinib and other tyrosine kinase inhibitors, exploring refinements in current methods of minimal residual disease monitoring ...

journal_title：Current opinion in hematology

authors： Sahay T,Schiffer CA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:There are three kindlin family members in vertebrates, which have high-sequence homology and a common organization signature with a C-terminal 4.1, ezrin, radixin, moesin (FERM) domain bisected by a pleckstrin-homology domain. Although the cell and tissue distributions of the three kindlins differ, th...

journal_title：Current opinion in hematology

authors： Plow EF,Qin J,Byzova T

更新日期：2009-09-01 00:00:00

abstract：:Bone marrow transplantation protocols for inherited metabolic storage diseases are unique for each disorder treated. Differences depend also upon how old the patient was when onset occurred and rate of progression of disease. Treatment is directed to prevent or ameliorate the inexorable neurological deterioration that...

journal_title：Current opinion in hematology

authors： Krivit W,Aubourg P,Shapiro E,Peters C

更新日期：1999-11-01 00:00:00

abstract：:Each year, approximately one in 1000 individuals suffers from venous thromboembolism. The pathogenesis of the disease is multifactorial and a thrombotic event is the result of a combination of genetic and circumstantial risk factors. Until recently, genetic defects could only be identified in a minority of thrombosis ...

journal_title：Current opinion in hematology

authors： Zöller B,Dahlbäck B

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF. RECENT FINDINGS:Levels of circulating active VWF are increased in von Willebrand disease type 2B, HELLP syndrome, ma...

journal_title：Current opinion in hematology

authors： Groot E,de Groot PG,Fijnheer R,Lenting PJ

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The review describes recent advances in our understanding of mechanisms leading to development of neutralizing antibodies following factor VIII (FVIII) replacement therapy for hemophilia A. Novel interventions with translational potential to lessen the incidence of these deleterious immune responses a...

journal_title：Current opinion in hematology

authors： Pratt KP

更新日期：2012-09-01 00:00:00

abstract：:D-dimer, a breakdown product of cross-linked fibrin has been extensively evaluated as a diagnostic test for acute venous thromboembolism. Rapid, highly sensitive D-dimer assays are now available that are suitable for testing in the emergency setting. Preliminary studies suggest that when using a highly sensitive D-dim...

journal_title：Current opinion in hematology

authors： Anderson DR,Wells PS

更新日期：2000-09-01 00:00:00

abstract：:Despite the reliance on platelet transfusion support in patients receiving myeloablative therapy, controversies surround platelet transfusion practices. These include the appropriate platelet dose and the threshold at which prophylactic platelet transfusions will be most effective. These issues bear directly on patien...

journal_title：Current opinion in hematology

authors： Rinder HM,Arbini AA,Snyder EL

更新日期：1999-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence and current trends in the use of haematopoietic stem cell transplantation (HSCT) for autoimmune diseases. RECENT FINDINGS:Updates of published trials and data from the registries indicate a long-lasting, immunosuppression-free condition in about 50% of the patients who un...

journal_title：Current opinion in hematology

authors： Saccardi R,Di Gioia M,Bosi A

更新日期：2008-11-01 00:00:00

abstract：:Neutropenia is often attributed to immunologically mediated injury to mature neutrophils or their precursors. Clinically it is useful to classify immune mediated neutropenias as isoimmune, autoimmune (including some drug-associated neutropenias), and idiopathic (cases possibly with an immune mechanism). Isoimmune neut...

journal_title：Current opinion in hematology

authors： Dale DC

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss how mechanical cues and Rho signaling contribute to control of vascular development and hematopoiesis. RECENT FINDINGS:Rho guanine trinucleotide phosphatases are ubiquitious regulators of cytoskeletal structure and tension generation. Recent work shows that Rho-dependent mechanical interac...

journal_title：Current opinion in hematology

authors： Mammoto A,Mammoto T,Ingber DE

更新日期：2008-05-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection remains a major cause of morbidity and mortality in recipients of an allogeneic stem cell transplant (SCT). Due to the broad application of antiviral prophylaxis and preemptive therapy, a decrease in early-onset and a subsequent increase in late-onset CMV disease has been observed. New ...

journal_title：Current opinion in hematology

authors： Hebart H,Einsele H

更新日期：1998-11-01 00:00:00

abstract：:Over a decade has passed since the first cases of AIDS were reported in hemophiliacs and transfusion recipients. Studies published over the past year offer an increasingly clear understanding of the extent of the early transfusion-associated AIDS epidemic, and of the effectiveness of progressive donor screening measur...

journal_title：Current opinion in hematology

authors： Busch MP

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The capacity of lithium to induce neutrophilia and increase circulating CD34(+) cells of marrow origin has long been known. Lithium has been the object of hematological investigations for many years, but no definitive use in hematology has yet emerged. RECENT FINDINGS:We review the evidence that lith...

journal_title：Current opinion in hematology

authors： Petrini M,Azzarà A

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence has accumulated to suggest that innate immune defense mechanisms might interact with proinflammatory pathways and exacerbate or perhaps even initiate development of arterial plaques. Unti...

journal_title：Current opinion in hematology

authors： Michelsen KS,Arditi M

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Core binding factor acute myeloid leukemia (CBF-AML) corresponds to two distinct subtypes of AML characterized by recurrent favorable chromosome translocations, namely t(8;21) and inv(16)/t(16;16). Given the relatively good outcome of patients with CBF-AML, when treated with intensive chemotherapy inc...

journal_title：Current opinion in hematology

authors： Dombret H,Preudhomme C,Boissel N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To outline the rationale, limitations, and execution of bloodless medical and surgical programs, highlighting characteristics that contribute to successful outcomes. RECENT FINDINGS:Clinical experiences with patients who refuse blood transfusions for religious reasons have provided valuable lessons a...

journal_title：Current opinion in hematology

authors： Shander A,Goodnough LT

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the crucial role of vascular endothelial growth factor (VEGF)A in vessel development, it has become apparent that the VEGF signaling pathway (VSP) plays an important role during adulthood in the maintenance of tissue homeostasis in normal physiological processes, as well as in pathologi...

journal_title：Current opinion in hematology

authors： Sung HK,Michael IP,Nagy A

更新日期：2010-05-01 00:00:00

abstract：:Gene transfer has allowed a number of biologic issues in the therapy of hematologic malignancy to be addressed. In autologous bone marrow transplantation, gene marking studies have shown that infused marrow contributes to relapse in acute myeloid leukemia, neuroblastoma, and chronic myeloid leukemia. In addition, doub...

journal_title：Current opinion in hematology

authors： Heslop HE,Roskrow M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Microtransplantation (MST) has been successfully used to manage patients with hematological malignancies, especially older patients with acute myeloid leukemia (AML). Recent clinical applications and mechanistic studies of MST are reviewed. RECENT FINDINGS:MST improves complete remission rates which ...

journal_title：Current opinion in hematology

authors： Cai B,Guo M,Ai H

更新日期：2018-11-01 00:00:00

abstract：:When a new product with huge clinical potential explodes on the scene, the hope is that the benefits far outweigh the risks in long-term administration. After 10 years of clinical use, granulocyte colony-stimulating factor (G-CSF) has lived up to that promise so far. In the context of severe chronic neutropenia, more ...

journal_title：Current opinion in hematology

authors： Freedman MH

更新日期：1997-05-01 00:00:00

abstract：:The idea that blood in naturally occurring transmissible spongiform encephalopathies is not infectious has imploded in the face of recent transmissions from the blood of naturally occurring scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans. Although donor exclusion criteria ensure that the number of ...

journal_title：Current opinion in hematology

authors： Brown P,Cervenakova L

更新日期：2004-09-01 00:00:00

abstract：:Considerable data now support the hypothesis that platelets actively regulate the propagation of coagulation by (1) expressing specific, high-affinity receptors for coagulation proteases, zymogens, and cofactors; (2) protecting the bound coagulation enzymes from inactivation/inhibition; (3) restricting coagulant activ...

journal_title：Current opinion in hematology

authors： Bouchard BA,Tracy PB

更新日期：2001-09-01 00:00:00

abstract：:Recent advances in our understanding of hypereosinophilia have related particularly to the definition of criteria for distinguishing between eosinophilic leukemia and the 'idiopathic' hypereosinophilic syndromes. In this article, leukemogenic mechanisms have been identified in a number of subtypes of eosinophilic leuk...

journal_title：Current opinion in hematology

authors： Bain BJ

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Gfi-1, originally identified as a transcriptional repressor in lymphoid cells, is now recognized to have essential, independent functions in neutrophil maturation and hematopoietic stem cell biology. Here we review recent studies pertaining to Gfi-1 and its cell context specific functions in hematopoi...

journal_title：Current opinion in hematology

authors： Hock H,Orkin SH

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Deficiency of antithrombin, protein C, and protein S increases the risk of a first venous thromboembolism (VTE) by at least 10-fold and is rare (i.e., <0.5% of population), whereas factor V Leiden and the prothrombin G20210A gene increase this risk by 2-5-fold and are common (2-5% of whites). Antiphos...

journal_title：Current opinion in hematology

authors： Kearon C

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Hemolytic anemias caused by premature destruction of red blood cells occur in many disorders including hemoglobinopathies, autoimmune conditions, during infection or following reaction to drugs or transfusions. Recent studies which will be reviewed here have uncovered several novel mechanisms by which...

journal_title：Current opinion in hematology

authors： Zhong H,Yazdanbakhsh K

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic idiopathic and severe congenital neutropenias are rare disorders for which recent discoveries have highlighted mechanisms and consequences. RECENT FINDINGS:An inflammatory bone marrow milieu has been shown to be a major contributor to the pathophysiology of chronic idiopathic neutropenia. Act...

journal_title：Current opinion in hematology

authors： Palmblad J,Papadaki HA

更新日期：2008-01-01 00:00:00