Regulation of alternative pre-mRNA splicing during erythroid differentiation.

abstract：:Over the past year, substantial progress was made toward understanding transcriptional control of red cell differentiation. Complementary DNAs encoding two novel erythroid-restricted transcription factors--globin locus control region regulatory factor NF-E2 and CACC-binding protein EKLF--were cloned and characterized....

journal_title：Current opinion in hematology

authors： Andrews NC,Orkin SH

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic cell transplantation offers potentially curative therapy for patients with myelodysplastic syndrome. The median patient age at diagnosis, however, is about 70 years, which has limited the application of conventional hematopoietic cell transplantation. In addition, the optimum timing of t...

journal_title：Current opinion in hematology

authors： Deeg HJ

更新日期：2006-03-01 00:00:00

abstract：:Multiple myeloma is the second most common hematologic malignancy, with approximately 15,000 new cases each year in the United States. Our understanding of the pathophysiology underlying myeloma continues to expand, but the cause of this plasma cell dyscrasia remains unclear. Though controversy remains regarding a pos...

journal_title：Current opinion in hematology

authors： Sjak-Shie NN,Vescio RA,Berenson JR

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Adoptive T-cell therapy has become one of the most exciting fields of cancer therapy in the past few years. In this article, we describe a method which combines adoptive T-cell therapy with antibody therapy by arming T cells from cord blood, normal patients, and cancer patients with bispecific antibod...

journal_title：Current opinion in hematology

authors： Bhutani D,Lum LG

更新日期：2015-11-01 00:00:00

abstract：:Modern molecular technology helped identify more than 10 protein tyrosine kinases related to myeloid malignancies, which allowed the development of small molecule inhibitors targeting deregulated protein tyrosine kinase activity. Protein tyrosine kinase deregulation can occur as a consequence of fusion gene formation ...

journal_title：Current opinion in hematology

authors： Anastasiadou E,Schwaller J

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this article, we summarize the recent advances in treating primary immune deficiency (PID) disorders by stem cell transplantation (SCT); we have focused on articles published in the past 2 years since the last major review of SCT for PID. RECENT FINDINGS:Analyses of the outcomes of SCT for PID by ...

journal_title：Current opinion in hematology

authors： Worth AJ,Booth C,Veys P

更新日期：2013-11-01 00:00:00

abstract：:Each year, approximately one in 1000 individuals suffers from venous thromboembolism. The pathogenesis of the disease is multifactorial and a thrombotic event is the result of a combination of genetic and circumstantial risk factors. Until recently, genetic defects could only be identified in a minority of thrombosis ...

journal_title：Current opinion in hematology

authors： Zöller B,Dahlbäck B

更新日期：1995-09-01 00:00:00

abstract：:Bone marrow transplantation protocols for inherited metabolic storage diseases are unique for each disorder treated. Differences depend also upon how old the patient was when onset occurred and rate of progression of disease. Treatment is directed to prevent or ameliorate the inexorable neurological deterioration that...

journal_title：Current opinion in hematology

authors： Krivit W,Aubourg P,Shapiro E,Peters C

更新日期：1999-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Early T-cell precursor (ETP) leukaemias have been recently recognized as a form of T-cell acute lymphoblastic leukaemia (T-ALL) with a poor prognosis. The purpose of this review is to outline the most recent advances in the biology, genetics and prognostic significance of this aggressive disease. REC...

journal_title：Current opinion in hematology

authors： Haydu JE,Ferrando AA

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of bone morphogenetic proteins (BMPs) in vasculogenesis is still not well understood, despite many recent developments in this area of research. In this review, we discuss the most recent studies that identify new critical mechanisms through which BMP signaling acts with a focus on angiogenes...

journal_title：Current opinion in hematology

authors： Moreno-Miralles I,Schisler JC,Patterson C

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize the recent experimental and clinical literature on the pathogenesis of transfusion-related acute lung injury (TRALI). RECENT FINDINGS:In both experimental and clinical TRALI, an immune priming step is generally necessary to produce lung injury. Experimental ...

journal_title：Current opinion in hematology

authors： Looney MR,Gilliss BM,Matthay MA

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial cells dysfunctions are crucial determinants of several human diseases. We review here the most recent reports on endothelial cell defects in cerebral cavernous malformations (CCMs), particularly focusing on adherens junctions. CCM is a vascular disease that affects specifically the venous ...

journal_title：Current opinion in hematology

authors： Lampugnani MG,Malinverno M,Dejana E,Rudini N

更新日期：2017-05-01 00:00:00

abstract：:A variety of agents are available to improve hemostasis and reduce blood loss in multiple clinical settings. These agents are most commonly used to reduce bleeding when an underlying hemostatic defect is present. Some new agents offer the potential to decrease blood loss even in the absence of an obvious underlying he...

journal_title：Current opinion in hematology

authors： Chiu J,Ketchum LH,Reid TJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent advances in the use of immune-based therapy to treat patients with refractory and relapsing acquired thrombotic thrombocytopenic purpura. RECENT FINDINGS:Advances in understanding of the pathophysiology of idiopathic thrombotic thrombocytopenic purpura have provided the ...

journal_title：Current opinion in hematology

authors： Cataland SR,Wu HM

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the application of minimal residual disease (MRD) testing in childhood acute lymphoblastic leukemia (ALL). RECENT FINDINGS:Polymerase chain reaction amplification of antigen receptor genes, one of the two main methods to study MRD in ALL, could be made more r...

journal_title：Current opinion in hematology

authors： Campana D

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Angioimmunoblastic T cell lymphoma is a complex lymphoproliferative disorder. While recent evidence suggests that the Epstein-Barr virus and B cell disregulation are implicated in the disease's pathogenesis, their mechanistic roles remain largely unknown. The prognosis with traditional chemotherapy ha...

journal_title：Current opinion in hematology

authors： Dunleavy K,Wilson WH,Jaffe ES

更新日期：2007-07-01 00:00:00

abstract：:The search for, and discovery of, a physiologic model in which the developmentally regulated switch from fetal to adult globin gene expression could be prevented has resulted in the development of a new class of therapeutic agents, consisting of simple fatty acids, such as butyric acid, for the treatment of the beta-h...

journal_title：Current opinion in hematology

authors： Faller DV,Perrine SP

更新日期：1995-03-01 00:00:00

abstract：:Much of our understanding of the organization of the cells that comprise the hematopoietic system and the cellular and molecular mechanisms that regulate their development is derived from mouse models. However, knowledge of the human hematopoietic system and identification of human stem cells have, until recently, bee...

journal_title：Current opinion in hematology

authors： Dick JE

更新日期：1996-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis and/or obstetrical morbidity in the presence of persistently positive antiphospholipid antibodies. Recent insights into the pathogenesis of APS have begun to elucidate pathophysiology and led to...

journal_title：Current opinion in hematology

authors： Chaturvedi S,McCrae KR

更新日期：2014-09-01 00:00:00

abstract：:Over a decade has passed since the first cases of AIDS were reported in hemophiliacs and transfusion recipients. Studies published over the past year offer an increasingly clear understanding of the extent of the early transfusion-associated AIDS epidemic, and of the effectiveness of progressive donor screening measur...

journal_title：Current opinion in hematology

authors： Busch MP

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnosis and therapy of polycythemia vera are controversial since the molecular basis of polycythemia vera remains unknown. Distinguishing between polycythemia vera and other polycythemic disorders can be very challenging. The purpose of this review is to discuss the recent progress in this area and ...

journal_title：Current opinion in hematology

authors： Prchal JT

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite improvements in the achievement of complete remission and progress in the supportive care of adults with acute lymphoblastic leukemia during the last decade, the majority of patients have eventually relapsed with overall survival in adult acute lymphoblastic leukemia of only 30-40%. However, t...

journal_title：Current opinion in hematology

authors： Larson S,Stock W

更新日期：2008-07-01 00:00:00

abstract：:During embryogenesis, a pool of pluripotential, self-renewing hematopoietic stem cells is specified from undifferentiated ventral mesoderm. These cells proliferate and differentiate to yield all the peripheral blood lineages. Although the mechanisms involved in the commitment and differentiation of multipotential prog...

journal_title：Current opinion in hematology

authors： Mead PE,Zon LI

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Therapy-related myelodysplastic syndromes and acute myelogenous leukemia (t-MDS/AML) comprise an increasingly common, poor-risk disease cohort without standard treatment options. This review describes available treatments and recent advances that may influence the clinical management of t-MDS/AML. RE...

journal_title：Current opinion in hematology

authors： Klimek VM

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the crucial role of vascular endothelial growth factor (VEGF)A in vessel development, it has become apparent that the VEGF signaling pathway (VSP) plays an important role during adulthood in the maintenance of tissue homeostasis in normal physiological processes, as well as in pathologi...

journal_title：Current opinion in hematology

authors： Sung HK,Michael IP,Nagy A

更新日期：2010-05-01 00:00:00

abstract：:Whereas there are general guidelines for acceptable transfusion therapy, optimal transfusion therapy has not been determined for most clinical settings. Recent research has focused on controlled studies of red cell transfusion in specific clinical settings. Better determinations of oxygen delivery and consumption are ...

journal_title：Current opinion in hematology

authors： Clark P,Mintz PD

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune responses to commensal bacteria and resulting chronic inflammation are hallmarks of inflammatory bowel disease. Considerable evidence has accumulated to suggest that innate immune defense mechanisms interact with pro-inflammatory pathways and exacerbate or perhaps even initiate development of i...

journal_title：Current opinion in hematology

authors： Michelsen KS,Arditi M

更新日期：2007-01-01 00:00:00

abstract：:The advent of safe and practical means to correct, enhance or protect blood cells at the genetic level offers tantalizing therapeutic perspectives. At present, gene delivery using a replication-defective retrovirus is the most efficient method to stably transduce hematopoietic cells. The successful adaptation of retro...

journal_title：Current opinion in hematology

authors： Sadelain M,Frassoni F,Rivière I

更新日期：2000-11-01 00:00:00

abstract：:Neutropenia is often attributed to immunologically mediated injury to mature neutrophils or their precursors. Clinically it is useful to classify immune mediated neutropenias as isoimmune, autoimmune (including some drug-associated neutropenias), and idiopathic (cases possibly with an immune mechanism). Isoimmune neut...

journal_title：Current opinion in hematology

authors： Dale DC

更新日期：1998-01-01 00:00:00

abstract：:: Hematopoietic stem cells (HSCs) are a unique population of cells with the remarkable ability to replenish themselves through self-renewal and to give rise to differentiated cell lineages. Though having been discovered more than 50 years ago, and having been widely used in bone marrow transplantation to treat blood d...

journal_title：Current opinion in hematology

authors： Li Z,He XC,Li L

更新日期：2019-07-01 00:00:00