Abstract:
PURPOSE OF REVIEW:Early T-cell precursor (ETP) leukaemias have been recently recognized as a form of T-cell acute lymphoblastic leukaemia (T-ALL) with a poor prognosis. The purpose of this review is to outline the most recent advances in the biology, genetics and prognostic significance of this aggressive disease. RECENT FINDINGS:Detailed immunophenotypic analyses have defined ETP T-ALLs as a distinct group of T-ALL with a poor prognosis. Transcriptionally, ETP T-ALLs and early immature T-ALLs, a broader group of tumours characterized by very early arrest in T-cell differentiation, are most related to haematopoietic stem cells and myeloid progenitors. Consistently, these leukaemias show lower frequencies of prototypical T-ALL lesions such as CDKN2A/B deletions and activating mutations in NOTCH1 and show a higher prevalence of mutations typically associated with the pathogenesis of acute myeloid leukaemias (AMLs). SUMMARY:ETP and early immature T-ALLs are characterized by a very early differentiation arrest and show unique genetic and transcriptional features that overlap both with T-ALL and with AML. Given the unique biology and poor prognosis associated with the ETP T-ALL group, there is an urgent need of new tailored therapeutic strategies for the treatment of this disease.
journal_name
Curr Opin Hematoljournal_title
Current opinion in hematologyauthors
Haydu JE,Ferrando AAdoi
10.1097/MOH.0b013e3283623c61subject
Has Abstractpub_date
2013-07-01 00:00:00pages
369-73issue
4eissn
1065-6251issn
1531-7048journal_volume
20pub_type
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journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
doi:10.1097/MOH.0b013e3282f42898
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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更新日期:2009-11-01 00:00:00
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journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00
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journal_title:Current opinion in hematology
pub_type: 杂志文章,收录出版,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
doi:10.1097/01.moh.0000208466.63861.9f
更新日期:2006-03-01 00:00:00
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journal_title:Current opinion in hematology
pub_type: 杂志文章
doi:10.1097/00062752-200111000-00012
更新日期:2001-11-01 00:00:00
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journal_title:Current opinion in hematology
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doi:10.1097/01.moh.0000143393.49202.f0
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:In addition to the crucial role of vascular endothelial growth factor (VEGF)A in vessel development, it has become apparent that the VEGF signaling pathway (VSP) plays an important role during adulthood in the maintenance of tissue homeostasis in normal physiological processes, as well as in pathologi...
journal_title:Current opinion in hematology
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更新日期:2010-05-01 00:00:00
abstract::This article presents the most recent insights into the biology, prognostic significance, and therapeutic approaches to TEL/AML1-positive leukemia. The TEL/AML1 fusion gene, also known as ETV6 /CBFA2, is the most commonly occurring gene rearrangement in pediatric acute lymphoblastic leukemia (ALL). Considerable contro...
journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
doi:10.1097/00062752-200207000-00013
更新日期:2002-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Gfi-1, originally identified as a transcriptional repressor in lymphoid cells, is now recognized to have essential, independent functions in neutrophil maturation and hematopoietic stem cell biology. Here we review recent studies pertaining to Gfi-1 and its cell context specific functions in hematopoi...
journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
doi:10.1097/01.moh.0000190111.85284.8f
更新日期:2006-01-01 00:00:00
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journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
doi:
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abstract:PURPOSE OF REVIEW:Adoptive T-cell therapy has become one of the most exciting fields of cancer therapy in the past few years. In this article, we describe a method which combines adoptive T-cell therapy with antibody therapy by arming T cells from cord blood, normal patients, and cancer patients with bispecific antibod...
journal_title:Current opinion in hematology
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doi:10.1097/MOH.0000000000000176
更新日期:2015-11-01 00:00:00
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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更新日期:2009-09-01 00:00:00
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journal_title:Current opinion in hematology
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更新日期:2007-01-01 00:00:00
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journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
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更新日期:2000-11-01 00:00:00