Bacterial responses to neutrophil phagocytosis.

abstract：PURPOSE OF REVIEW:This article summarizes recent insights into the pathophysiology of immune thrombocytopenic purpura, a disorder in which autoantibodies against cell-specific glycoproteins (GPIIb-IIIa, GPIb-IX and others) accelerate platelet destruction. RECENT FINDINGS:Autoantibodies are produced by a limited number...

journal_title：Current opinion in hematology

authors： Cines DB,McMillan R

更新日期：2007-09-01 00:00:00

abstract：:During embryogenesis, a pool of pluripotential, self-renewing hematopoietic stem cells is specified from undifferentiated ventral mesoderm. These cells proliferate and differentiate to yield all the peripheral blood lineages. Although the mechanisms involved in the commitment and differentiation of multipotential prog...

journal_title：Current opinion in hematology

authors： Mead PE,Zon LI

更新日期：1998-03-01 00:00:00

abstract：:The search for, and discovery of, a physiologic model in which the developmentally regulated switch from fetal to adult globin gene expression could be prevented has resulted in the development of a new class of therapeutic agents, consisting of simple fatty acids, such as butyric acid, for the treatment of the beta-h...

journal_title：Current opinion in hematology

authors： Faller DV,Perrine SP

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic stem cells are functionally heterogeneous even when isolated as phenotypically homogenous populations. How this heterogeneity is generated is incompletely understood. Several models have been formulated to explain the generation of diversity. All of these assume the existence of a single...

journal_title：Current opinion in hematology

authors： Muller-Sieburg CE,Sieburg HB

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Platelet microparticles were identified more than 40 years ago and are the most abundant circulating microparticle subtype. Yet fundamental questions about their formation and role in human disease are just beginning to be understood at the cellular and molecular level. This review will address mechan...

journal_title：Current opinion in hematology

authors： Italiano JE Jr,Mairuhu AT,Flaumenhaft R

更新日期：2010-11-01 00:00:00

abstract：:Disorders of the erythrocyte membrane, such as hereditary spherocytosis, hereditary elliptocytosis, and hereditary pyropoikilocytosis, are characterized by heterogeneity in their clinical and laboratory manifestations. Recent work has shown that these disorders also exhibit marked genetic heterogeneity. Multiple genet...

journal_title：Current opinion in hematology

authors： Gallagher PG,Ferriera JD

更新日期：1997-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Since the first discovery of microRNAs (miRNAs) in 1993, the involvement of miRNAs in different aspects of vascular disease has emerged as an important research field. In this review, we summarize the fundamental roles of miRNAs in controlling endothelial cell functions and their implication with seve...

journal_title：Current opinion in hematology

authors： Fernández-Hernando C,Suárez Y

更新日期：2018-05-01 00:00:00

abstract：:The molecular analysis of genetic alterations in acute lymphoblastic leukemia has led to the development of molecular diagnostic techniques that have improved the biologic characterization of newly diagnosed patients. Modern treatment protocols rely on this information to tailor the intensity of therapy to the risk of...

journal_title：Current opinion in hematology

authors： Rubnitz JE,Pui CH

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Monitoring for residual leukemic burden is an integral part of ongoing evaluation in chronic myeloid leukemia. With high rates of complete cytogenetic response induced by imatinib and other tyrosine kinase inhibitors, exploring refinements in current methods of minimal residual disease monitoring ...

journal_title：Current opinion in hematology

authors： Sahay T,Schiffer CA

更新日期：2008-03-01 00:00:00

abstract：:Whereas there are general guidelines for acceptable transfusion therapy, optimal transfusion therapy has not been determined for most clinical settings. Recent research has focused on controlled studies of red cell transfusion in specific clinical settings. Better determinations of oxygen delivery and consumption are ...

journal_title：Current opinion in hematology

authors： Clark P,Mintz PD

更新日期：2001-11-01 00:00:00

abstract：:Endothelial cell invasion is an essential event during angiogenesis (the formation of new blood vessels). This process involves the degradation of the extracellular matrix, the basement membrane, and interstitial stroma, and is governed by the activation of matrix metalloproteinases. However, the contribution of matri...

journal_title：Current opinion in hematology

authors： Heissig B,Hattori K,Friedrich M,Rafii S,Werb Z

更新日期：2003-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Intravenous immunoglobulin (IVIg) is an effective treatment for an increasing number of autoimmune and inflammatory conditions. However, IVIg continues to be limited by problems of potential shortages and cost. A number of mechanisms have been described for IVIg, which have been captured in newly emer...

journal_title：Current opinion in hematology

authors： Norris PAA,Kaur G,Lazarus AH

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Microtransplantation (MST) has been successfully used to manage patients with hematological malignancies, especially older patients with acute myeloid leukemia (AML). Recent clinical applications and mechanistic studies of MST are reviewed. RECENT FINDINGS:MST improves complete remission rates which ...

journal_title：Current opinion in hematology

authors： Cai B,Guo M,Ai H

更新日期：2018-11-01 00:00:00

abstract：:Thrombopoietin, also termed the c-Mpl ligand, is a lineage-dominant hematopoietic factor that primarily regulates megakaryopoiesis and thrombopoiesis. Treatment of normal animals with recombinant human megakaryocyte growth and development factor, a truncated molecule of the c-Mpl ligand, which is modified with polyeth...

journal_title：Current opinion in hematology

authors： Miyazaki H

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The transmembrane protein tissue factor (TF), the initiator of the extrinsic coagulation cascade and a risk factor for thrombotic disease, largely resides on the cell surface in an inactive, encrypted conformation. Whereas TF procoagulant activation, or decryption, is closely associated with the expos...

journal_title：Current opinion in hematology

authors： Versteeg HH,Ruf W

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The peptide hormone hepcidin regulates iron metabolism in response to erythropoietic demand, iron stores and inflammation. Major advances have been made in understanding the regulation of hepcidin production, and consequently the availability of iron for erythropoiesis. RECENT FINDINGS:It is becoming...

journal_title：Current opinion in hematology

authors： Nemeth E

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The increasing use of high throughput sequencing and genomic analysis has facilitated the discovery of new causes of inherited platelet disorders. Studies of these disorders and their respective mouse models have been central to understanding their biology, and also in revealing new aspects of platele...

journal_title：Current opinion in hematology

authors： Pluthero FG,Kahr WHA

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we focus on three specific concepts related to platelet transfusion in the neonatal and pediatric population: choice of transfusion threshold; use of ABO-mismatched platelets; transfusion of pathogen-reduced or inactivated platelets. RECENT FINDINGS:Recent trials support the use of lo...

journal_title：Current opinion in hematology

authors： Patel RM,Josephson C

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Technical possibilities to screen for inborn errors of immune function at the neonatal stage have been rapidly progressing, whereas the guidelines that apply for the evaluation of benefits and concerns on expanding screening panels have not been broadly discussed for primary immunodeficiency diseases ...

journal_title：Current opinion in hematology

authors： Borte S,von Döbeln U,Hammarström L

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the crucial role of vascular endothelial growth factor (VEGF)A in vessel development, it has become apparent that the VEGF signaling pathway (VSP) plays an important role during adulthood in the maintenance of tissue homeostasis in normal physiological processes, as well as in pathologi...

journal_title：Current opinion in hematology

authors： Sung HK,Michael IP,Nagy A

更新日期：2010-05-01 00:00:00

abstract：:Human parvovirus B19 shows remarkable tropism for human erythroid progenitor cells. The pathogenesis of disease resulting from infection is a dynamic between the viral suppression of erythropoiesis and the host's ability to mount an effective immune response. Understanding this process has led to strategies for treati...

journal_title：Current opinion in hematology

authors： Carper E,Kurtzman GJ

更新日期：1996-03-01 00:00:00

abstract：:This overview concentrates on familial and congenital polycythemias in the context of other polycythemic disorders, with emphasis on those with established molecular lesions. Recent advances in the regulation of erythropoiesis, as they may relate to polycythemic states, are discussed as a background for those well-def...

journal_title：Current opinion in hematology

authors： Prchal JF,Prchal JT

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence and current trends in the use of haematopoietic stem cell transplantation (HSCT) for autoimmune diseases. RECENT FINDINGS:Updates of published trials and data from the registries indicate a long-lasting, immunosuppression-free condition in about 50% of the patients who un...

journal_title：Current opinion in hematology

authors： Saccardi R,Di Gioia M,Bosi A

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From the moment of HSC embryonic specification from hemogenic endothelium, endothelial cells (ECs) act as a critical cellular-hub that regulates a ...

journal_title：Current opinion in hematology

authors： Ramalingam P,Poulos MG,Butler JM

更新日期：2017-07-01 00:00:00

abstract：:Recent advances in our understanding of hypereosinophilia have related particularly to the definition of criteria for distinguishing between eosinophilic leukemia and the 'idiopathic' hypereosinophilic syndromes. In this article, leukemogenic mechanisms have been identified in a number of subtypes of eosinophilic leuk...

journal_title：Current opinion in hematology

authors： Bain BJ

更新日期：2000-01-01 00:00:00

abstract：:D-dimer, a breakdown product of cross-linked fibrin has been extensively evaluated as a diagnostic test for acute venous thromboembolism. Rapid, highly sensitive D-dimer assays are now available that are suitable for testing in the emergency setting. Preliminary studies suggest that when using a highly sensitive D-dim...

journal_title：Current opinion in hematology

authors： Anderson DR,Wells PS

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Galectins, a family of evolutionarily conserved glycan-binding proteins, are involved in the regulation of multiple cellular processes (e.g. immunity, apoptosis, cellular signaling, development, angiogenesis and cellular growth) and diseases (e.g. chronic inflammation, autoimmunity, cancer, infection)...

journal_title：Current opinion in hematology

authors： Rabinovich GA,Vidal M

更新日期：2011-11-01 00:00:00

abstract：:: Hematopoietic stem cells (HSCs) are a unique population of cells with the remarkable ability to replenish themselves through self-renewal and to give rise to differentiated cell lineages. Though having been discovered more than 50 years ago, and having been widely used in bone marrow transplantation to treat blood d...

journal_title：Current opinion in hematology

authors： Li Z,He XC,Li L

更新日期：2019-07-01 00:00:00

abstract：:Commitment of hematopoietic cells to the erythroid lineage involves the actions of several transcription factors, including TAL1, LMO2, and GATA-2. The differentiation of committed erythroid progenitor cells involves other transcription factors, including NF-E2 and EKLF. Upon binding erythropoietin, the principal regu...

journal_title：Current opinion in hematology

authors： Koury MJ,Sawyer ST,Brandt SJ

更新日期：2002-03-01 00:00:00

abstract：:Despite the reliance on platelet transfusion support in patients receiving myeloablative therapy, controversies surround platelet transfusion practices. These include the appropriate platelet dose and the threshold at which prophylactic platelet transfusions will be most effective. These issues bear directly on patien...

journal_title：Current opinion in hematology

authors： Rinder HM,Arbini AA,Snyder EL

更新日期：1999-11-01 00:00:00