Neutrophilic dermatosis: disease mechanism and treatment.

abstract：:Considerable data now support the hypothesis that platelets actively regulate the propagation of coagulation by (1) expressing specific, high-affinity receptors for coagulation proteases, zymogens, and cofactors; (2) protecting the bound coagulation enzymes from inactivation/inhibition; (3) restricting coagulant activ...

journal_title：Current opinion in hematology

authors： Bouchard BA,Tracy PB

更新日期：2001-09-01 00:00:00

abstract：:Neutropenia is often attributed to immunologically mediated injury to mature neutrophils or their precursors. Clinically it is useful to classify immune mediated neutropenias as isoimmune, autoimmune (including some drug-associated neutropenias), and idiopathic (cases possibly with an immune mechanism). Isoimmune neut...

journal_title：Current opinion in hematology

authors： Dale DC

更新日期：1998-01-01 00:00:00

abstract：:Chronic myelogenous leukemia is a clonal hematopoietic malignancy characterized by a balanced translocation between chromosomes 9 and 22 that results in the generation of an abnormal bcr/abl fusion protein with increased tyrosine kinase activity. This abnormal fusion protein has transforming activity for hematopoietic...

journal_title：Current opinion in hematology

authors： Enright H,McGlave PB

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To outline the rationale, limitations, and execution of bloodless medical and surgical programs, highlighting characteristics that contribute to successful outcomes. RECENT FINDINGS:Clinical experiences with patients who refuse blood transfusions for religious reasons have provided valuable lessons a...

journal_title：Current opinion in hematology

authors： Shander A,Goodnough LT

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The presence of the Philadelphia chromosome causing the fusion between BCR to ABL1 in B cell precursor acute lymphoblastic leukemias (ALLs) was associated with a particularly bad prognosis, which has been markedly improved with the addition of imatinib to chemotherapy. Recent genomic studies have lead...

journal_title：Current opinion in hematology

authors： Izraeli S

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity has become a worldwide epidemic that is driving increased morbidity and mortality from thrombotic disorders such as myocardial infarction, stroke, and venous thromboembolism. Effective prevention and treatment of thrombosis in obese patients is limited by an incomplete understanding of the und...

journal_title：Current opinion in hematology

authors： Blokhin IO,Lentz SR

更新日期：2013-09-01 00:00:00

abstract：:Endothelial cell invasion is an essential event during angiogenesis (the formation of new blood vessels). This process involves the degradation of the extracellular matrix, the basement membrane, and interstitial stroma, and is governed by the activation of matrix metalloproteinases. However, the contribution of matri...

journal_title：Current opinion in hematology

authors： Heissig B,Hattori K,Friedrich M,Rafii S,Werb Z

更新日期：2003-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic stem cells (HSCs) possess two fundamental characteristics, the capacity for self-renewal and the sustained production of all blood cell lineages. The fine balance between HSC expansion and lineage specification is dynamically regulated by the interplay between external and internal stimu...

journal_title：Current opinion in hematology

authors： Pouzolles M,Oburoglu L,Taylor N,Zimmermann VS

更新日期：2016-07-01 00:00:00

abstract：:The bulk of antigens that are presented by major histocompatibility complex (MHC) class I molecules are processed in the cytosol. Therefore, the cellular protein degradation machinery is thought to play a major role in antigen processing. For example, there is clear evidence that the ubiquitin-proteasome pathway, the ...

journal_title：Current opinion in hematology

authors： Androlewicz MJ

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this article, we summarize the recent advances in treating primary immune deficiency (PID) disorders by stem cell transplantation (SCT); we have focused on articles published in the past 2 years since the last major review of SCT for PID. RECENT FINDINGS:Analyses of the outcomes of SCT for PID by ...

journal_title：Current opinion in hematology

authors： Worth AJ,Booth C,Veys P

更新日期：2013-11-01 00:00:00

abstract：:Hematopoietic stem cells are the cells primarily responsible for short term and long term hematological reconstitution when a graft is infused into a myeloablated host. The number and quality of hematopoietic stem cells within a graft are the major determinants of the time to and durability of hematological reconstitu...

journal_title：Current opinion in hematology

authors： Hoffman R

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Bone marrow transplantation is the only curative treatment for severe thalassemia. Since its successful first report in 1981, more than 4000 patients with this disease worldwide underwent bone marrow transplantation. The purpose of this review is to update the most recent reports of matched sibling do...

journal_title：Current opinion in hematology

authors： Issaragrisil S,Kunacheewa C

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduction would be inefficient at preventing transmission of the disease by blood transfusion. Nevertheless, approximately 14 years ago, a significant proportion of European countries decided to implement l...

journal_title：Current opinion in hematology

authors： Douet JY,Bujdoso R,Andréoletti O

更新日期：2015-01-01 00:00:00

abstract：:In 1994 four biotechnology research groups reported the isolation and cloning of the ligand for the cytokine receptor c-Mpl and showed it to be the long-sought regulator of platelet production, thrombopoietin. Thrombopoietin is a hematopoietic growth factor of 332 amino acids composed of an amino terminal domain homol...

journal_title：Current opinion in hematology

authors： Eaton DL,de Sauvage FJ

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic stem cell (HSC) transplantation is the most powerful treatment modality for a variety of hematological disorders. Successful hematopoietic recovery after transplantation depends on optimal homing of HSCs to the bone marrow and subsequent lodging in the HSC niche. The molecular mechanisms...

journal_title：Current opinion in hematology

authors： Buitenhuis M

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Platelet microparticles were identified more than 40 years ago and are the most abundant circulating microparticle subtype. Yet fundamental questions about their formation and role in human disease are just beginning to be understood at the cellular and molecular level. This review will address mechan...

journal_title：Current opinion in hematology

authors： Italiano JE Jr,Mairuhu AT,Flaumenhaft R

更新日期：2010-11-01 00:00:00

abstract：:: Hematopoietic stem cells (HSCs) are a unique population of cells with the remarkable ability to replenish themselves through self-renewal and to give rise to differentiated cell lineages. Though having been discovered more than 50 years ago, and having been widely used in bone marrow transplantation to treat blood d...

journal_title：Current opinion in hematology

authors： Li Z,He XC,Li L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent publications that bear on the evidential basis for therapeutic apheresis in diseases in which hemolytic anemia is a prominent feature. RECENT FINDINGS:Therapeutic plasma exchange continues to be reported sporadically in severe autoimmune hemolytic anemia, with inconsistent...

journal_title：Current opinion in hematology

authors： McLeod BC

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The advent of tyrosine kinase inhibitors (TKI) has remarkably changed the treatment of chronic myeloid leukemia (CML). Patients treated in chronic phase can enjoy an expected survival similar to the general population. In the last few years we have found that some patients with an excellent therapeuti...

journal_title：Current opinion in hematology

authors： Bansal A,Radich J

更新日期：2016-03-01 00:00:00

abstract：:Following on the heels of multiple failed clinical trials of adjunctive therapeutic agents in sepsis, the positive outcome of a recent phase III study using activated protein C (APC) has led to a renewed optimism in targeted biotherapies for this syndrome. A growing body of data (both preclinical and clinical) suggest...

journal_title：Current opinion in hematology

authors： Key NS,Ely EW

更新日期：2002-09-01 00:00:00

abstract：:Hematopoietic stem cells, defined as cells with extensive self-renewal and pluripotent differentiation potential, represent a minor population of adult bone marrow (< 1 in 10(4) to 10(5) nucleated marrow cells). Recent advances in cell surface phenotype analysis and separation technology have permitted enrichment of h...

journal_title：Current opinion in hematology

authors： Moore MA,Shapiro F

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Therapy-related myelodysplastic syndromes and acute myelogenous leukemia (t-MDS/AML) comprise an increasingly common, poor-risk disease cohort without standard treatment options. This review describes available treatments and recent advances that may influence the clinical management of t-MDS/AML. RE...

journal_title：Current opinion in hematology

authors： Klimek VM

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The capacity of lithium to induce neutrophilia and increase circulating CD34(+) cells of marrow origin has long been known. Lithium has been the object of hematological investigations for many years, but no definitive use in hematology has yet emerged. RECENT FINDINGS:We review the evidence that lith...

journal_title：Current opinion in hematology

authors： Petrini M,Azzarà A

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Lymphocyte trafficking is regulated by adhesion molecules mediating the initial shear-resistant binding of circulating cells to target tissue endothelium (Step 1). This review focuses on the current and emerging perspectives of the biology of these 'homing receptors.' RECENT FINDINGS:The conventional...

journal_title：Current opinion in hematology

authors： Sackstein R

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Core binding factor acute myeloid leukemia (CBF-AML) corresponds to two distinct subtypes of AML characterized by recurrent favorable chromosome translocations, namely t(8;21) and inv(16)/t(16;16). Given the relatively good outcome of patients with CBF-AML, when treated with intensive chemotherapy inc...

journal_title：Current opinion in hematology

authors： Dombret H,Preudhomme C,Boissel N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial cells dysfunctions are crucial determinants of several human diseases. We review here the most recent reports on endothelial cell defects in cerebral cavernous malformations (CCMs), particularly focusing on adherens junctions. CCM is a vascular disease that affects specifically the venous ...

journal_title：Current opinion in hematology

authors： Lampugnani MG,Malinverno M,Dejana E,Rudini N

更新日期：2017-05-01 00:00:00

abstract：:The search for, and discovery of, a physiologic model in which the developmentally regulated switch from fetal to adult globin gene expression could be prevented has resulted in the development of a new class of therapeutic agents, consisting of simple fatty acids, such as butyric acid, for the treatment of the beta-h...

journal_title：Current opinion in hematology

authors： Faller DV,Perrine SP

更新日期：1995-03-01 00:00:00

abstract：:Anemia is a common disorder in patients with cancer and can be caused by the disease itself or by cancer-related therapy. The cardinal symptom of anemia, fatigue, is the most commonly reported symptom in patients with cancer and has profound effects on patient well-being and quality of life. Until recently, blood tran...

journal_title：Current opinion in hematology

authors： Yount S,Lai JS,Cella D

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms...

journal_title：Current opinion in hematology

authors： Zhao L,Lu W

更新日期：2014-01-01 00:00:00

abstract：:This overview concentrates on familial and congenital polycythemias in the context of other polycythemic disorders, with emphasis on those with established molecular lesions. Recent advances in the regulation of erythropoiesis, as they may relate to polycythemic states, are discussed as a background for those well-def...

journal_title：Current opinion in hematology

authors： Prchal JF,Prchal JT

更新日期：1999-03-01 00:00:00