Ras-related GTP-binding proteins and leukocyte signal transduction.

abstract：:Gene transfer has allowed a number of biologic issues in the therapy of hematologic malignancy to be addressed. In autologous bone marrow transplantation, gene marking studies have shown that infused marrow contributes to relapse in acute myeloid leukemia, neuroblastoma, and chronic myeloid leukemia. In addition, doub...

journal_title：Current opinion in hematology

authors： Heslop HE,Roskrow M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The transmembrane protein tissue factor (TF), the initiator of the extrinsic coagulation cascade and a risk factor for thrombotic disease, largely resides on the cell surface in an inactive, encrypted conformation. Whereas TF procoagulant activation, or decryption, is closely associated with the expos...

journal_title：Current opinion in hematology

authors： Versteeg HH,Ruf W

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the rationale, efficacy, and toxicity of a variety of immune approaches being evaluated in the therapy of acute myeloid leukemia (AML) including naked and conjugated monoclonal antibodies, bispecific T-cell engager antibodies, and immune checkpoint blockade via antibodies targeti...

journal_title：Current opinion in hematology

authors： Assi R,Kantarjian H,Ravandi F,Daver N

更新日期：2018-03-01 00:00:00

abstract：:Leukocytes use an array of antimicrobial peptides and proteins to help them destroy invading microorganisms. These endogenous antibiotic molecules are remarkable for their structural variety, rapid evolutionary divergence, intraspecies variation, and complex yet subtle interactions with their targets. This arsenal has...

journal_title：Current opinion in hematology

authors： Ganz T,Lehrer RI

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to the crucial role of vascular endothelial growth factor (VEGF)A in vessel development, it has become apparent that the VEGF signaling pathway (VSP) plays an important role during adulthood in the maintenance of tissue homeostasis in normal physiological processes, as well as in pathologi...

journal_title：Current opinion in hematology

authors： Sung HK,Michael IP,Nagy A

更新日期：2010-05-01 00:00:00

abstract：:Hairy cell leukemia is an indolent, chronic B-cell lymphoproliferative disorder comprising approximately 2 to 3% of all adult leukemias in the United States. Hairy cells are clonal expansions of mature, activated B-cells. They co-express CD11c, CD19, CD20, CD22, CD25, and CD103. Hairy cells possess clonal immunoglobul...

journal_title：Current opinion in hematology

authors： Goodman GR,Bethel KJ,Saven A

更新日期：2003-07-01 00:00:00

abstract：:Contrast venography remains the gold standard for the diagnosis of deep-vein thrombosis (DVT). However, an ongoing interest exists in developing safe diagnostic strategies that are less invasive, less expensive, widely and readily available, and more acceptable to patients than venography. For patients with symptoms s...

journal_title：Current opinion in hematology

authors： Birdwell B

更新日期：1999-09-01 00:00:00

abstract：:Recent studies have improved our understanding of the cytogenesis, biology, and therapy of chronic lymphocytic leukemia (CLL). This review highlights this recent progress reported over the past year. We have improved our understanding of the cytogenetic abnormalities in CLL and soon may see identification of new tumor...

journal_title：Current opinion in hematology

authors： Kipps TJ

更新日期：1998-07-01 00:00:00

abstract：:A variety of agents are available to improve hemostasis and reduce blood loss in multiple clinical settings. These agents are most commonly used to reduce bleeding when an underlying hemostatic defect is present. Some new agents offer the potential to decrease blood loss even in the absence of an obvious underlying he...

journal_title：Current opinion in hematology

authors： Chiu J,Ketchum LH,Reid TJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Barth syndrome (BTHS) is a mitochondrial disorder characterized by neutropenia, among other defects. As yet, the correlation between the mitochondrial defect in BTHS and the neutropenia observed in these patients is unclear. In this review, we hope to shed some light upon the correlation between the m...

journal_title：Current opinion in hematology

authors： van Raam BJ,Kuijpers TW

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize the recent experimental and clinical literature on the pathogenesis of transfusion-related acute lung injury (TRALI). RECENT FINDINGS:In both experimental and clinical TRALI, an immune priming step is generally necessary to produce lung injury. Experimental ...

journal_title：Current opinion in hematology

authors： Looney MR,Gilliss BM,Matthay MA

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To outline the rationale, limitations, and execution of bloodless medical and surgical programs, highlighting characteristics that contribute to successful outcomes. RECENT FINDINGS:Clinical experiences with patients who refuse blood transfusions for religious reasons have provided valuable lessons a...

journal_title：Current opinion in hematology

authors： Shander A,Goodnough LT

更新日期：2006-11-01 00:00:00

abstract：:Endothelial cell invasion is an essential event during angiogenesis (the formation of new blood vessels). This process involves the degradation of the extracellular matrix, the basement membrane, and interstitial stroma, and is governed by the activation of matrix metalloproteinases. However, the contribution of matri...

journal_title：Current opinion in hematology

authors： Heissig B,Hattori K,Friedrich M,Rafii S,Werb Z

更新日期：2003-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT), despite improvements in our understanding of its pathophysiology as well as the generation of new monoclonal antibodies, immunomodulatory chemotherapy, cellular ...

journal_title：Current opinion in hematology

authors： Paczesny S,Choi SW,Ferrara JL

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Therapy-related myelodysplastic syndromes and acute myelogenous leukemia (t-MDS/AML) comprise an increasingly common, poor-risk disease cohort without standard treatment options. This review describes available treatments and recent advances that may influence the clinical management of t-MDS/AML. RE...

journal_title：Current opinion in hematology

authors： Klimek VM

更新日期：2013-03-01 00:00:00

abstract：:Hematopoietic stem cells are the cells primarily responsible for short term and long term hematological reconstitution when a graft is infused into a myeloablated host. The number and quality of hematopoietic stem cells within a graft are the major determinants of the time to and durability of hematological reconstitu...

journal_title：Current opinion in hematology

authors： Hoffman R

更新日期：1999-05-01 00:00:00

abstract：:Over a decade has passed since the first cases of AIDS were reported in hemophiliacs and transfusion recipients. Studies published over the past year offer an increasingly clear understanding of the extent of the early transfusion-associated AIDS epidemic, and of the effectiveness of progressive donor screening measur...

journal_title：Current opinion in hematology

authors： Busch MP

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Lymphocyte trafficking is regulated by adhesion molecules mediating the initial shear-resistant binding of circulating cells to target tissue endothelium (Step 1). This review focuses on the current and emerging perspectives of the biology of these 'homing receptors.' RECENT FINDINGS:The conventional...

journal_title：Current opinion in hematology

authors： Sackstein R

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF. RECENT FINDINGS:Levels of circulating active VWF are increased in von Willebrand disease type 2B, HELLP syndrome, ma...

journal_title：Current opinion in hematology

authors： Groot E,de Groot PG,Fijnheer R,Lenting PJ

更新日期：2007-05-01 00:00:00

abstract：:Platelet production is primarily regulated by the thrombopoietic cytokine thrombopoietin (TPO). In most cases thrombopoietin serum levels are determined by the rate of c-mpl receptor-mediated degradation after TPO uptake into platelets and megakaryocytes. The contribution of increased TPO protein synthesis by a transl...

journal_title：Current opinion in hematology

authors： Verbeek W,Faulhaber M,Griesinger F,Brittinger G

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review elucidates the potentials of recombinant blood group proteins (BGPs) for red blood cell (RBC) antibody detection and identification in pretransfusion testing and the achievements in this field so far. RECENT FINDINGS:Many BGPs have been eukaryotically and prokaryotically expressed ...

journal_title：Current opinion in hematology

authors： Seltsam A,Blasczyk R

更新日期：2009-11-01 00:00:00

abstract：:The Epstein-Barr virus is a ubiquitous human herpesvirus that is associated with an increasing number of human malignancies. Among these are Epstein-Barr virus-associated lymphoproliferative diseases in immunocompromised patients, a spectrum of mainly B-cell diseases that range from polyclonal lymphoproliferative dise...

journal_title：Current opinion in hematology

authors： Mosier DE

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Graft-versus-host disease is one of the commonest complications of allogeneic bone marrow or peripheral blood stem cell transplantation. This review will cover advances in the pathophysiology of graft-versus-host disease and new agents under investigation for the treatment of this disorder. Patients d...

journal_title：Current opinion in hematology

authors： Bolaños-Meade J,Vogelsang GB

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of JAK2V617F and other JAK-STAT-activating mutations in BCR-ABL1-negative myeloproliferative neoplasms (MPN) has led to the development of small-molecule ATP-mimetics that inhibit wild-type and mutant JAK. Here, we review the current experience with JAK inhibitors used for the treatment ...

journal_title：Current opinion in hematology

authors： Pardanani A,Tefferi A

更新日期：2011-03-01 00:00:00

abstract：:The advent of better diagnostic tools, molecular techniques, and cytokine therapies have come together at the end of the 20th century to provide an improved outlook for patients with autoimmune neutropenia. Severe chronic neutropenia is no longer idiopathic in most cases, and growth factor therapy can be safely offere...

journal_title：Current opinion in hematology

authors： Smith MA,Smith JG

更新日期：2001-05-01 00:00:00

abstract：:Considerable data now support the hypothesis that platelets actively regulate the propagation of coagulation by (1) expressing specific, high-affinity receptors for coagulation proteases, zymogens, and cofactors; (2) protecting the bound coagulation enzymes from inactivation/inhibition; (3) restricting coagulant activ...

journal_title：Current opinion in hematology

authors： Bouchard BA,Tracy PB

更新日期：2001-09-01 00:00:00

abstract：:FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. FLT3 mutations occur in a broad spectrum of FAB subtypes in adult and pediatric AML...

journal_title：Current opinion in hematology

authors： Gilliland DG,Griffin JD

更新日期：2002-07-01 00:00:00

abstract：:Platelet aggregation, a process mediated by GP IIb-IIIa, is responsible for the occlusive events in thrombosis: indeed, GP IIb-IIIa antagonists are effective in blocking arterial thrombosis. Recent studies have suggested that activated platelets and platelet thrombi can contribute significantly to the initiation and p...

journal_title：Current opinion in hematology

authors： Prasad KS,Andre P,Yan Y,Phillips DR

更新日期：2003-09-01 00:00:00

abstract：:The risk of transmission of viruses and other pathogenic organisms by blood can be reduced but not eliminated through donor selection and screening methodologies. The safety of blood derivatives prepared from plasma pools from thousands of donors requires virus inactivation, without which transmission rates approach c...

journal_title：Current opinion in hematology

authors： Horowitz B,Ben-Hur E

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Re...

journal_title：Current opinion in hematology

authors： Harris ES,Weyrich AS,Zimmerman GA

更新日期：2013-01-01 00:00:00