Human stem cell assays in immune-deficient mice.

Abstract:

:Much of our understanding of the organization of the cells that comprise the hematopoietic system and the cellular and molecular mechanisms that regulate their development is derived from mouse models. However, knowledge of the human hematopoietic system and identification of human stem cells have, until recently, been hampered by the absence of in vivo assays that measure their repopulation capacity. The development of methods to transplant normal and leukemic human hematopoietic cells into immune-deficient SCID mice provides the foundation for human stem cell assays. This review will focus on recent evidence that normal and leukemic human stem cells can be assayed in these systems.

journal_name

Curr Opin Hematol

authors

Dick JE

doi

10.1097/00062752-199603060-00002

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

405-9

issue

6

eissn

1065-6251

issn

1531-7048

journal_volume

3

pub_type

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