Beyond Philadelphia: 'Ph-like' B cell precursor acute lymphoblastic leukemias - diagnostic challenges and therapeutic promises.

abstract：:Commitment of hematopoietic cells to the erythroid lineage involves the actions of several transcription factors, including TAL1, LMO2, and GATA-2. The differentiation of committed erythroid progenitor cells involves other transcription factors, including NF-E2 and EKLF. Upon binding erythropoietin, the principal regu...

journal_title：Current opinion in hematology

authors： Koury MJ,Sawyer ST,Brandt SJ

更新日期：2002-03-01 00:00:00

abstract：:: Hematopoietic stem cells (HSCs) are a unique population of cells with the remarkable ability to replenish themselves through self-renewal and to give rise to differentiated cell lineages. Though having been discovered more than 50 years ago, and having been widely used in bone marrow transplantation to treat blood d...

journal_title：Current opinion in hematology

authors： Li Z,He XC,Li L

更新日期：2019-07-01 00:00:00

abstract：:Therapy with unconjugated monoclonal antibodies (mAbs) and radiolabeled mAbs has shown activity in patients with B-cell non-Hodgkin's lymphoma and leukemia. Drug-conjugated mAbs are active in relapsed leukemia. Using these new agents with and after chemotherapy induces a high rate of remission, but this needs to be co...

journal_title：Current opinion in hematology

authors： Maloney DG

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity has become a worldwide epidemic that is driving increased morbidity and mortality from thrombotic disorders such as myocardial infarction, stroke, and venous thromboembolism. Effective prevention and treatment of thrombosis in obese patients is limited by an incomplete understanding of the und...

journal_title：Current opinion in hematology

authors： Blokhin IO,Lentz SR

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Glycogen storage disease Ib (GSD Ib) is characterized by hepatomegaly, hypoglycemia, neutropenia, enterocolitis and recurrent bacterial infections. It is attributable to mutations in G6PT1, the gene for the glucose-6-phosphate transporter responsible for transport of glucose into the endoplasmic retic...

journal_title：Current opinion in hematology

authors： Dale DC,Bolyard AA,Marrero T,Kelley ML,Makaryan V,Tran E,Leung J,Boxer LA,Kishnani PS,Austin S,Wanner C,Ferrecchia IA,Khalaf D,Maze D,Kurtzberg J,Zeidler C,Welte K,Weinstein DA

更新日期：2019-01-01 00:00:00

abstract：:Fibrinogen abnormalities can be classified as congenital or acquired. Each class manifests quantitative or qualitative alterations; the latter are known as dysfibrinogenemias. In dysfibrinogenemias, structural defects cause alterations in the conversion of fibrinogen to fibrin. Approximately 300 abnormal fibrinogens h...

journal_title：Current opinion in hematology

authors： Martinez J

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the rationale, efficacy, and toxicity of a variety of immune approaches being evaluated in the therapy of acute myeloid leukemia (AML) including naked and conjugated monoclonal antibodies, bispecific T-cell engager antibodies, and immune checkpoint blockade via antibodies targeti...

journal_title：Current opinion in hematology

authors： Assi R,Kantarjian H,Ravandi F,Daver N

更新日期：2018-03-01 00:00:00

abstract：:Recent advances in our understanding of hypereosinophilia have related particularly to the definition of criteria for distinguishing between eosinophilic leukemia and the 'idiopathic' hypereosinophilic syndromes. In this article, leukemogenic mechanisms have been identified in a number of subtypes of eosinophilic leuk...

journal_title：Current opinion in hematology

authors： Bain BJ

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on advances in the area of iron chelation therapy, including new indications and uses of currently available agents, and preliminary data on potential new agents in development. RECENT FINDINGS:Two new oral agents, deferasirox and deferiprone, have become available in t...

journal_title：Current opinion in hematology

authors： Sheth S

更新日期：2014-05-01 00:00:00

abstract：:The reconstitution of T-cell populations is a critical component of immune recovery after allogeneic stem cell transplantation. Recent studies have used new techniques to focus on the interplay of thymopoiesis and peripheral expansion that defines T-cell repopulation. Peripheral expansion, driven by host cytokines and...

journal_title：Current opinion in hematology

authors： Hakim FT,Gress RE

更新日期：2002-11-01 00:00:00

abstract：:Following on the heels of multiple failed clinical trials of adjunctive therapeutic agents in sepsis, the positive outcome of a recent phase III study using activated protein C (APC) has led to a renewed optimism in targeted biotherapies for this syndrome. A growing body of data (both preclinical and clinical) suggest...

journal_title：Current opinion in hematology

authors： Key NS,Ely EW

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Gfi-1, originally identified as a transcriptional repressor in lymphoid cells, is now recognized to have essential, independent functions in neutrophil maturation and hematopoietic stem cell biology. Here we review recent studies pertaining to Gfi-1 and its cell context specific functions in hematopoi...

journal_title：Current opinion in hematology

authors： Hock H,Orkin SH

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Barth syndrome (BTHS) is a mitochondrial disorder characterized by neutropenia, among other defects. As yet, the correlation between the mitochondrial defect in BTHS and the neutropenia observed in these patients is unclear. In this review, we hope to shed some light upon the correlation between the m...

journal_title：Current opinion in hematology

authors： van Raam BJ,Kuijpers TW

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this article, we summarize the recent advances in treating primary immune deficiency (PID) disorders by stem cell transplantation (SCT); we have focused on articles published in the past 2 years since the last major review of SCT for PID. RECENT FINDINGS:Analyses of the outcomes of SCT for PID by ...

journal_title：Current opinion in hematology

authors： Worth AJ,Booth C,Veys P

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent advances in the use of immune-based therapy to treat patients with refractory and relapsing acquired thrombotic thrombocytopenic purpura. RECENT FINDINGS:Advances in understanding of the pathophysiology of idiopathic thrombotic thrombocytopenic purpura have provided the ...

journal_title：Current opinion in hematology

authors： Cataland SR,Wu HM

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence and current trends in the use of haematopoietic stem cell transplantation (HSCT) for autoimmune diseases. RECENT FINDINGS:Updates of published trials and data from the registries indicate a long-lasting, immunosuppression-free condition in about 50% of the patients who un...

journal_title：Current opinion in hematology

authors： Saccardi R,Di Gioia M,Bosi A

更新日期：2008-11-01 00:00:00

abstract：:D-dimer, a breakdown product of cross-linked fibrin has been extensively evaluated as a diagnostic test for acute venous thromboembolism. Rapid, highly sensitive D-dimer assays are now available that are suitable for testing in the emergency setting. Preliminary studies suggest that when using a highly sensitive D-dim...

journal_title：Current opinion in hematology

authors： Anderson DR,Wells PS

更新日期：2000-09-01 00:00:00

abstract：:A variety of agents are available to improve hemostasis and reduce blood loss in multiple clinical settings. These agents are most commonly used to reduce bleeding when an underlying hemostatic defect is present. Some new agents offer the potential to decrease blood loss even in the absence of an obvious underlying he...

journal_title：Current opinion in hematology

authors： Chiu J,Ketchum LH,Reid TJ

更新日期：2002-11-01 00:00:00

abstract：:Human parvovirus B19 shows remarkable tropism for human erythroid progenitor cells. The pathogenesis of disease resulting from infection is a dynamic between the viral suppression of erythropoiesis and the host's ability to mount an effective immune response. Understanding this process has led to strategies for treati...

journal_title：Current opinion in hematology

authors： Carper E,Kurtzman GJ

更新日期：1996-03-01 00:00:00

abstract：:Recent studies have improved our understanding of the cytogenesis, biology, and therapy of chronic lymphocytic leukemia (CLL). This review highlights this recent progress reported over the past year. We have improved our understanding of the cytogenetic abnormalities in CLL and soon may see identification of new tumor...

journal_title：Current opinion in hematology

authors： Kipps TJ

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Development of a technique prospectively to isolate hematopoietic stem cells (HSCs) to near homogeneity has enabled clonal analysis and thus converted our understanding of HSCs from conceptual and qualitative to realistic and quantitative. Recent studies have revealed that despite their high prolifera...

journal_title：Current opinion in hematology

authors： Yamazaki S,Nakauchi H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of bone morphogenetic proteins (BMPs) in vasculogenesis is still not well understood, despite many recent developments in this area of research. In this review, we discuss the most recent studies that identify new critical mechanisms through which BMP signaling acts with a focus on angiogenes...

journal_title：Current opinion in hematology

authors： Moreno-Miralles I,Schisler JC,Patterson C

更新日期：2009-05-01 00:00:00

abstract：:Neutropenia is often attributed to immunologically mediated injury to mature neutrophils or their precursors. Clinically it is useful to classify immune mediated neutropenias as isoimmune, autoimmune (including some drug-associated neutropenias), and idiopathic (cases possibly with an immune mechanism). Isoimmune neut...

journal_title：Current opinion in hematology

authors： Dale DC

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In response to agonists produced at vascular lesions, platelets release a host of components from their three granules: dense core, alpha, and lysosome. This releasate activates other platelets, promotes wound repair, and initiates inflammatory responses. Although widely accepted, the specific mechani...

journal_title：Current opinion in hematology

authors： Ren Q,Ye S,Whiteheart SW

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent publications that bear on the evidential basis for therapeutic apheresis in diseases in which hemolytic anemia is a prominent feature. RECENT FINDINGS:Therapeutic plasma exchange continues to be reported sporadically in severe autoimmune hemolytic anemia, with inconsistent...

journal_title：Current opinion in hematology

authors： McLeod BC

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Platelet microparticles were identified more than 40 years ago and are the most abundant circulating microparticle subtype. Yet fundamental questions about their formation and role in human disease are just beginning to be understood at the cellular and molecular level. This review will address mechan...

journal_title：Current opinion in hematology

authors： Italiano JE Jr,Mairuhu AT,Flaumenhaft R

更新日期：2010-11-01 00:00:00

abstract：:Leukocytes use an array of antimicrobial peptides and proteins to help them destroy invading microorganisms. These endogenous antibiotic molecules are remarkable for their structural variety, rapid evolutionary divergence, intraspecies variation, and complex yet subtle interactions with their targets. This arsenal has...

journal_title：Current opinion in hematology

authors： Ganz T,Lehrer RI

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Graft-versus-host disease is one of the commonest complications of allogeneic bone marrow or peripheral blood stem cell transplantation. This review will cover advances in the pathophysiology of graft-versus-host disease and new agents under investigation for the treatment of this disorder. Patients d...

journal_title：Current opinion in hematology

authors： Bolaños-Meade J,Vogelsang GB

更新日期：2005-01-01 00:00:00

abstract：:Stem cell factor is an early-acting hematopoietic cytokine that probably functions constitutively to support the proliferation and survival of pluripotent progenitor cells and to increase their receptivity to lineage commitment and differentiation in response to lineage-specific cytokines. Stem cell factor also can in...

journal_title：Current opinion in hematology

authors： Glaspy J

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Intravenous immunoglobulin (IVIg) is an effective treatment for an increasing number of autoimmune and inflammatory conditions. However, IVIg continues to be limited by problems of potential shortages and cost. A number of mechanisms have been described for IVIg, which have been captured in newly emer...

journal_title：Current opinion in hematology

authors： Norris PAA,Kaur G,Lazarus AH

更新日期：2020-11-01 00:00:00