Core binding factor acute myeloid leukemia (CBF-AML): is high-dose Ara-C (HDAC) consolidation as effective as you think?

abstract：PURPOSE OF REVIEW:Barth syndrome (BTHS) is a mitochondrial disorder characterized by neutropenia, among other defects. As yet, the correlation between the mitochondrial defect in BTHS and the neutropenia observed in these patients is unclear. In this review, we hope to shed some light upon the correlation between the m...

journal_title：Current opinion in hematology

authors： van Raam BJ,Kuijpers TW

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune responses to commensal bacteria and resulting chronic inflammation are hallmarks of inflammatory bowel disease. Considerable evidence has accumulated to suggest that innate immune defense mechanisms interact with pro-inflammatory pathways and exacerbate or perhaps even initiate development of i...

journal_title：Current opinion in hematology

authors： Michelsen KS,Arditi M

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:B-cell tumors originating from the transformation of germinal center B cells frequently harbor genetic mutations, leading to constitutive activation of the nuclear factor-κB (NF-κB) signaling pathway. The present review highlights recent insights into the roles of separate NF-κB transcription factors ...

journal_title：Current opinion in hematology

authors： Klein U,Heise N

更新日期：2015-07-01 00:00:00

abstract：:Bone marrow transplantation protocols for inherited metabolic storage diseases are unique for each disorder treated. Differences depend also upon how old the patient was when onset occurred and rate of progression of disease. Treatment is directed to prevent or ameliorate the inexorable neurological deterioration that...

journal_title：Current opinion in hematology

authors： Krivit W,Aubourg P,Shapiro E,Peters C

更新日期：1999-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite parenteral artesunate therapy, the fatality rate of cerebral malaria remains high. Adjunctive therapy targeting the underlying pathophysiology of cerebral malaria may further improve the clinical outcome. Endothelial activation and dysfunction is a central process in the pathogenesis of cerebr...

journal_title：Current opinion in hematology

authors： Kim H,Higgins S,Liles WC,Kain KC

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Clonal heterogeneity is a significant obstacle to successful treatment of patients with acute myeloid leukemia (AML). Here, we review new advances in the understanding of genetic heterogeneity in AML using single-cell DNA-sequencing technology. RECENT FINDINGS:New genomics and immunologic discovery t...

journal_title：Current opinion in hematology

authors： Romer-Seibert JS,Meyer SE

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The treatment of patients with refractory or relapsed acute myeloid leukemia remains challenging. Management of these patients must take into account patient and leukemia-related factors in order to organize a comprehensive approach to treatment. Many new therapies are under study. RECENT FINDINGS:Ne...

journal_title：Current opinion in hematology

authors： Litzow MR

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From the moment of HSC embryonic specification from hemogenic endothelium, endothelial cells (ECs) act as a critical cellular-hub that regulates a ...

journal_title：Current opinion in hematology

authors： Ramalingam P,Poulos MG,Butler JM

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Inconsistent results regarding the clinical efficacy of granulocyte transfusions for the treatment or prophylaxis of life-threatening infections in neutropenic patients have been attributed to insufficient number of transfused neutrophils. Since the introduction of granulocyte colony-stimulating facto...

journal_title：Current opinion in hematology

authors： Yoshihara S,Ikemoto J,Fujimori Y

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review elucidates the potentials of recombinant blood group proteins (BGPs) for red blood cell (RBC) antibody detection and identification in pretransfusion testing and the achievements in this field so far. RECENT FINDINGS:Many BGPs have been eukaryotically and prokaryotically expressed ...

journal_title：Current opinion in hematology

authors： Seltsam A,Blasczyk R

更新日期：2009-11-01 00:00:00

abstract：:In 1994 four biotechnology research groups reported the isolation and cloning of the ligand for the cytokine receptor c-Mpl and showed it to be the long-sought regulator of platelet production, thrombopoietin. Thrombopoietin is a hematopoietic growth factor of 332 amino acids composed of an amino terminal domain homol...

journal_title：Current opinion in hematology

authors： Eaton DL,de Sauvage FJ

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is designed to help readers understand seasonal blood shortages and provide solutions through the use of technology that can increase the number of red blood cell units collected and the use of recruitment and marketing initiatives that appeal to the increasingly diverse donor base. RECEN...

journal_title：Current opinion in hematology

authors： Gilcher RO,McCombs S

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Re...

journal_title：Current opinion in hematology

authors： Harris ES,Weyrich AS,Zimmerman GA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The transmembrane protein tissue factor (TF), the initiator of the extrinsic coagulation cascade and a risk factor for thrombotic disease, largely resides on the cell surface in an inactive, encrypted conformation. Whereas TF procoagulant activation, or decryption, is closely associated with the expos...

journal_title：Current opinion in hematology

authors： Versteeg HH,Ruf W

更新日期：2011-09-01 00:00:00

abstract：:Considerable data now support the hypothesis that platelets actively regulate the propagation of coagulation by (1) expressing specific, high-affinity receptors for coagulation proteases, zymogens, and cofactors; (2) protecting the bound coagulation enzymes from inactivation/inhibition; (3) restricting coagulant activ...

journal_title：Current opinion in hematology

authors： Bouchard BA,Tracy PB

更新日期：2001-09-01 00:00:00

abstract：:FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. FLT3 mutations occur in a broad spectrum of FAB subtypes in adult and pediatric AML...

journal_title：Current opinion in hematology

authors： Gilliland DG,Griffin JD

更新日期：2002-07-01 00:00:00

abstract：:This article presents the most recent insights into the biology, prognostic significance, and therapeutic approaches to TEL/AML1-positive leukemia. The TEL/AML1 fusion gene, also known as ETV6 /CBFA2, is the most commonly occurring gene rearrangement in pediatric acute lymphoblastic leukemia (ALL). Considerable contro...

journal_title：Current opinion in hematology

authors： Loh ML,Rubnitz JE

更新日期：2002-07-01 00:00:00

abstract：:Thrombopoietin, also termed the c-Mpl ligand, is a lineage-dominant hematopoietic factor that primarily regulates megakaryopoiesis and thrombopoiesis. Treatment of normal animals with recombinant human megakaryocyte growth and development factor, a truncated molecule of the c-Mpl ligand, which is modified with polyeth...

journal_title：Current opinion in hematology

authors： Miyazaki H

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of bone morphogenetic proteins (BMPs) in vasculogenesis is still not well understood, despite many recent developments in this area of research. In this review, we discuss the most recent studies that identify new critical mechanisms through which BMP signaling acts with a focus on angiogenes...

journal_title：Current opinion in hematology

authors： Moreno-Miralles I,Schisler JC,Patterson C

更新日期：2009-05-01 00:00:00

abstract：:Anemia is a common disorder in patients with cancer and can be caused by the disease itself or by cancer-related therapy. The cardinal symptom of anemia, fatigue, is the most commonly reported symptom in patients with cancer and has profound effects on patient well-being and quality of life. Until recently, blood tran...

journal_title：Current opinion in hematology

authors： Yount S,Lai JS,Cella D

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The identification of regulatory T cells (Tregs) as regulators of immunological self-tolerance has stimulated tremendous interest in the field. Over the past 12 months, new studies have added greatly to our understanding of the role of Tregs in autoimmune disease, details of which are presented here. ...

journal_title：Current opinion in hematology

authors： Vila J,Isaacs JD,Anderson AE

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Microtransplantation (MST) has been successfully used to manage patients with hematological malignancies, especially older patients with acute myeloid leukemia (AML). Recent clinical applications and mechanistic studies of MST are reviewed. RECENT FINDINGS:MST improves complete remission rates which ...

journal_title：Current opinion in hematology

authors： Cai B,Guo M,Ai H

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the current literature regarding retrievable inferior vena cava filters and to discuss the appropriate indications for their clinical use. RECENT FINDINGS:Permanent filters have been shown to be effective, but have a number of long-term complications such as filter thrombosis or migration....

journal_title：Current opinion in hematology

authors： Imberti D,Ageno W,Carpenedo M

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The capacity of lithium to induce neutrophilia and increase circulating CD34(+) cells of marrow origin has long been known. Lithium has been the object of hematological investigations for many years, but no definitive use in hematology has yet emerged. RECENT FINDINGS:We review the evidence that lith...

journal_title：Current opinion in hematology

authors： Petrini M,Azzarà A

更新日期：2012-01-01 00:00:00

abstract：:Allogeneic barriers to transfusion are caused by differences between those portions of the donor and recipient genomes that define the antigenicity and immune response to the transfused cells. Historically, a blood group antigen was identified when an immune response (alloantibody) was detected by hemagglutination in ...

journal_title：Current opinion in hematology

authors： Reid ME,Lomas-Francis C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Development of a technique prospectively to isolate hematopoietic stem cells (HSCs) to near homogeneity has enabled clonal analysis and thus converted our understanding of HSCs from conceptual and qualitative to realistic and quantitative. Recent studies have revealed that despite their high prolifera...

journal_title：Current opinion in hematology

authors： Yamazaki S,Nakauchi H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the application of minimal residual disease (MRD) testing in childhood acute lymphoblastic leukemia (ALL). RECENT FINDINGS:Polymerase chain reaction amplification of antigen receptor genes, one of the two main methods to study MRD in ALL, could be made more r...

journal_title：Current opinion in hematology

authors： Campana D

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In addition to its essential role in baseline erythropoiesis, the hormone erythropoietin drives the erythropoietic response to hypoxic stress. A mechanistic understanding of stress erythropoiesis would benefit multiple clinical settings, and may aid in understanding leukemogenesis. RECENT FINDINGS:Th...

journal_title：Current opinion in hematology

authors： Socolovsky M

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:A major goal in repopulating hematopoietic stem cell (HSC) gene therapies is achieving high-efficacy gene transfer, while maintaining robust HSC engraftment and differentiation in vivo. Recent studies have documented that rapamycin treatment of HSC during lentiviral vector transduction enhances gene t...

journal_title：Current opinion in hematology

authors： Wang CX,Torbett BE

更新日期：2015-07-01 00:00:00

abstract：:The search for, and discovery of, a physiologic model in which the developmentally regulated switch from fetal to adult globin gene expression could be prevented has resulted in the development of a new class of therapeutic agents, consisting of simple fatty acids, such as butyric acid, for the treatment of the beta-h...

journal_title：Current opinion in hematology

authors： Faller DV,Perrine SP

更新日期：1995-03-01 00:00:00