Update on thrombopoietin in preclinical and clinical trials.

abstract：PURPOSE OF REVIEW:In the postnatal life, hematopoietic stem cell (HSC) niches are specialized microenvironments in the bone marrow that are essential for the maintenance and function of HSCs. The purpose of this review is to discuss the concept of HSC niche in light of recent studies that broaden its complexity and bet...

journal_title：Current opinion in hematology

authors： Carlesso N,Cardoso AA

更新日期：2010-07-01 00:00:00

abstract：:This article presents new insights into potential roles that three erythrocyte cytoskeletal proteins, protein 4.1, ankyrin, and spectrin, may play in nonerythroid nucleated cells. Each of these proteins is encoded by several closely related genes characterized by complex alternative splicing of their pre-mRNA, thus re...

journal_title：Current opinion in hematology

authors： Gascard P,Mohandas N

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF. RECENT FINDINGS:Levels of circulating active VWF are increased in von Willebrand disease type 2B, HELLP syndrome, ma...

journal_title：Current opinion in hematology

authors： Groot E,de Groot PG,Fijnheer R,Lenting PJ

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The polycomb group gene BMI1 fulfills essential roles in both normal and leukemic stem cells. The underlying molecular mechanisms are beginning to become unraveled and an overview of the current knowledge on BMI1 signaling in normal and leukemic stem cells will be presented here. RECENT FINDINGS:In a...

journal_title：Current opinion in hematology

authors： Schuringa JJ,Vellenga E

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes recent insights into the pathophysiology of immune thrombocytopenic purpura, a disorder in which autoantibodies against cell-specific glycoproteins (GPIIb-IIIa, GPIb-IX and others) accelerate platelet destruction. RECENT FINDINGS:Autoantibodies are produced by a limited number...

journal_title：Current opinion in hematology

authors： Cines DB,McMillan R

更新日期：2007-09-01 00:00:00

abstract：:Genetic defects of the blood platelet membrane glycoproteins, GPIIb-IIIa (alpha IIb/beta 3; CD41/CD61) and GPIb-V-IX (CD42) are the origin of several rare bleeding disorders, the best known of which are Glanzmann's thrombasthenia, Bernard-Soulier syndrome, and platelet-type von Willebrand's disease. In Glanzmann's thr...

journal_title：Current opinion in hematology

authors： Clemetson KJ,Clemetson JM

更新日期：1994-09-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Monitoring for residual leukemic burden is an integral part of ongoing evaluation in chronic myeloid leukemia. With high rates of complete cytogenetic response induced by imatinib and other tyrosine kinase inhibitors, exploring refinements in current methods of minimal residual disease monitoring ...

journal_title：Current opinion in hematology

authors： Sahay T,Schiffer CA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The 'mobilization' of hematopoietic stem cells (HSCs) out of the bone marrow and into the peripheral blood is used clinically to obtain HSCs for transplantation. Although generally successful, mobilization protocols remain imperfect and the mechanisms involved are not fully understood. This review dis...

journal_title：Current opinion in hematology

authors： Bendall LJ,Basnett J

更新日期：2013-07-01 00:00:00

abstract：:Modern molecular technology helped identify more than 10 protein tyrosine kinases related to myeloid malignancies, which allowed the development of small molecule inhibitors targeting deregulated protein tyrosine kinase activity. Protein tyrosine kinase deregulation can occur as a consequence of fusion gene formation ...

journal_title：Current opinion in hematology

authors： Anastasiadou E,Schwaller J

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune responses to commensal bacteria and resulting chronic inflammation are hallmarks of inflammatory bowel disease. Considerable evidence has accumulated to suggest that innate immune defense mechanisms interact with pro-inflammatory pathways and exacerbate or perhaps even initiate development of i...

journal_title：Current opinion in hematology

authors： Michelsen KS,Arditi M

更新日期：2007-01-01 00:00:00

abstract：:Allogeneic barriers to transfusion are caused by differences between those portions of the donor and recipient genomes that define the antigenicity and immune response to the transfused cells. Historically, a blood group antigen was identified when an immune response (alloantibody) was detected by hemagglutination in ...

journal_title：Current opinion in hematology

authors： Reid ME,Lomas-Francis C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence and current trends in the use of haematopoietic stem cell transplantation (HSCT) for autoimmune diseases. RECENT FINDINGS:Updates of published trials and data from the registries indicate a long-lasting, immunosuppression-free condition in about 50% of the patients who un...

journal_title：Current opinion in hematology

authors： Saccardi R,Di Gioia M,Bosi A

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the last years, long non-coding RNAs (lncRNAs) have emerged as putative regulators of malignant hematopoietic development. Here, we review recent literature on the involvement of lncRNAs in leukemia, including their role in driving or sustaining disease and their potential impact on diagnosis, cl...

journal_title：Current opinion in hematology

authors： Lammens T,Durinck K,Wallaert A,Speleman F,Van Vlierberghe P

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduction would be inefficient at preventing transmission of the disease by blood transfusion. Nevertheless, approximately 14 years ago, a significant proportion of European countries decided to implement l...

journal_title：Current opinion in hematology

authors： Douet JY,Bujdoso R,Andréoletti O

更新日期：2015-01-01 00:00:00

abstract：:Platelet aggregation, a process mediated by GP IIb-IIIa, is responsible for the occlusive events in thrombosis: indeed, GP IIb-IIIa antagonists are effective in blocking arterial thrombosis. Recent studies have suggested that activated platelets and platelet thrombi can contribute significantly to the initiation and p...

journal_title：Current opinion in hematology

authors： Prasad KS,Andre P,Yan Y,Phillips DR

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent advances in the use of immune-based therapy to treat patients with refractory and relapsing acquired thrombotic thrombocytopenic purpura. RECENT FINDINGS:Advances in understanding of the pathophysiology of idiopathic thrombotic thrombocytopenic purpura have provided the ...

journal_title：Current opinion in hematology

authors： Cataland SR,Wu HM

更新日期：2005-09-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection remains a major cause of morbidity and mortality in recipients of an allogeneic stem cell transplant (SCT). Due to the broad application of antiviral prophylaxis and preemptive therapy, a decrease in early-onset and a subsequent increase in late-onset CMV disease has been observed. New ...

journal_title：Current opinion in hematology

authors： Hebart H,Einsele H

更新日期：1998-11-01 00:00:00

abstract：:Advances in platelet transfusion have contributed to improved outcomes in the treatment of patients with cancer and leukemia. However, the optimal strategies to avoid some of the side effects that could result from platelet transfusions remain under investigation. These side effects include the development of refracto...

journal_title：Current opinion in hematology

authors： Sarkodee-Adoo C,Schiffer CA

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Microtransplantation (MST) has been successfully used to manage patients with hematological malignancies, especially older patients with acute myeloid leukemia (AML). Recent clinical applications and mechanistic studies of MST are reviewed. RECENT FINDINGS:MST improves complete remission rates which ...

journal_title：Current opinion in hematology

authors： Cai B,Guo M,Ai H

更新日期：2018-11-01 00:00:00

abstract：:Leukocytes use an array of antimicrobial peptides and proteins to help them destroy invading microorganisms. These endogenous antibiotic molecules are remarkable for their structural variety, rapid evolutionary divergence, intraspecies variation, and complex yet subtle interactions with their targets. This arsenal has...

journal_title：Current opinion in hematology

authors： Ganz T,Lehrer RI

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial cells dysfunctions are crucial determinants of several human diseases. We review here the most recent reports on endothelial cell defects in cerebral cavernous malformations (CCMs), particularly focusing on adherens junctions. CCM is a vascular disease that affects specifically the venous ...

journal_title：Current opinion in hematology

authors： Lampugnani MG,Malinverno M,Dejana E,Rudini N

更新日期：2017-05-01 00:00:00

abstract：:Much of our understanding of the organization of the cells that comprise the hematopoietic system and the cellular and molecular mechanisms that regulate their development is derived from mouse models. However, knowledge of the human hematopoietic system and identification of human stem cells have, until recently, bee...

journal_title：Current opinion in hematology

authors： Dick JE

更新日期：1996-11-01 00:00:00

abstract：:A variety of agents are available to improve hemostasis and reduce blood loss in multiple clinical settings. These agents are most commonly used to reduce bleeding when an underlying hemostatic defect is present. Some new agents offer the potential to decrease blood loss even in the absence of an obvious underlying he...

journal_title：Current opinion in hematology

authors： Chiu J,Ketchum LH,Reid TJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to describe the physiopathological and therapeutic aspects of neutrophilic dermatosis, taking into account their most frequent associated conditions. RECENT FINDINGS:In autoinflammatory syndromes featuring neutrophilic dermatosis, the role of interleukin-1 and tumor necr...

journal_title：Current opinion in hematology

authors： Maalouf D,Battistella M,Bouaziz JD

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The treatment of patients with refractory or relapsed acute myeloid leukemia remains challenging. Management of these patients must take into account patient and leukemia-related factors in order to organize a comprehensive approach to treatment. Many new therapies are under study. RECENT FINDINGS:Ne...

journal_title：Current opinion in hematology

authors： Litzow MR

更新日期：2007-03-01 00:00:00

abstract：:Therapy with unconjugated monoclonal antibodies (mAbs) and radiolabeled mAbs has shown activity in patients with B-cell non-Hodgkin's lymphoma and leukemia. Drug-conjugated mAbs are active in relapsed leukemia. Using these new agents with and after chemotherapy induces a high rate of remission, but this needs to be co...

journal_title：Current opinion in hematology

authors： Maloney DG

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Re...

journal_title：Current opinion in hematology

authors： Harris ES,Weyrich AS,Zimmerman GA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Barth syndrome (BTHS) is a mitochondrial disorder characterized by neutropenia, among other defects. As yet, the correlation between the mitochondrial defect in BTHS and the neutropenia observed in these patients is unclear. In this review, we hope to shed some light upon the correlation between the m...

journal_title：Current opinion in hematology

authors： van Raam BJ,Kuijpers TW

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Development of a technique prospectively to isolate hematopoietic stem cells (HSCs) to near homogeneity has enabled clonal analysis and thus converted our understanding of HSCs from conceptual and qualitative to realistic and quantitative. Recent studies have revealed that despite their high prolifera...

journal_title：Current opinion in hematology

authors： Yamazaki S,Nakauchi H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Hemolytic anemias caused by premature destruction of red blood cells occur in many disorders including hemoglobinopathies, autoimmune conditions, during infection or following reaction to drugs or transfusions. Recent studies which will be reviewed here have uncovered several novel mechanisms by which...

journal_title：Current opinion in hematology

authors： Zhong H,Yazdanbakhsh K

更新日期：2018-05-01 00:00:00