Abstract:
PURPOSE OF REVIEW:Hemolytic anemias caused by premature destruction of red blood cells occur in many disorders including hemoglobinopathies, autoimmune conditions, during infection or following reaction to drugs or transfusions. Recent studies which will be reviewed here have uncovered several novel mechanisms by which hemolysis can alter immunological functions and increase the risk of severe complications in hemolytic disorders. RECENT FINDINGS:Plasma-free heme can induce the formation of neutrophil extracellular traps (NETs) through reactive oxygen species signaling. Although NETs protect the host against infections, in patients with sickle disease, they are associated with vaso-occlusive crises. Heme may increase host susceptibility to infections by inducing heme oxygenase 1 (HO-1) in immature neutrophils, thereby inhibiting oxidative burst required for clearance of engulfed bacteria. In addition, heme impairs macrophage phagocytosis and microbial clearance through inhibition of cytoskeletal remodeling. Hemolysis can also favor anti-inflammatory immune cell polarization by inhibiting dendritic cell maturation necessary for effector T-cell responses, inducing differentiation of monocytes into red pulp macrophages, important for iron recycling from senescent erythrocytes, and driving regulatory T-cell expansion through modulation of HO-1 expression in nonclassical monocytes. SUMMARY:Hemolysis breakdown products show remarkable effects on the regulation of immune cell differentiation and function.
journal_name
Curr Opin Hematoljournal_title
Current opinion in hematologyauthors
Zhong H,Yazdanbakhsh Kdoi
10.1097/MOH.0000000000000423subject
Has Abstractpub_date
2018-05-01 00:00:00pages
177-182issue
3eissn
1065-6251issn
1531-7048journal_volume
25pub_type
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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更新日期:2009-05-01 00:00:00
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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更新日期:2008-05-01 00:00:00
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journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:Current opinion in hematology
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doi:10.1097/MOH.0000000000000150
更新日期:2015-07-01 00:00:00
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journal_title:Current opinion in hematology
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doi:10.1097/00062752-199603060-00013
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abstract:PURPOSE OF REVIEW:In addition to the crucial role of vascular endothelial growth factor (VEGF)A in vessel development, it has become apparent that the VEGF signaling pathway (VSP) plays an important role during adulthood in the maintenance of tissue homeostasis in normal physiological processes, as well as in pathologi...
journal_title:Current opinion in hematology
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更新日期:2010-05-01 00:00:00
abstract::Myeloablative therapy followed by autologous bone marrow or peripheral blood stem cell rescue is an alternative therapeutic option for patients who are not candidates for allogeneic transplantation due to the lack of an appropriate HLA-matched donor or to advanced age. It allows therapy to be administered that is of c...
journal_title:Current opinion in hematology
pub_type: 杂志文章,评审
doi:10.1097/00062752-199704060-00011
更新日期:1997-11-01 00:00:00
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journal_title:Current opinion in hematology
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更新日期:1994-01-01 00:00:00
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更新日期:2006-09-01 00:00:00
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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journal_title:Current opinion in hematology
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