Role of FLT3 in leukemia.

abstract：:Disorders of the erythrocyte membrane, such as hereditary spherocytosis, hereditary elliptocytosis, and hereditary pyropoikilocytosis, are characterized by heterogeneity in their clinical and laboratory manifestations. Recent work has shown that these disorders also exhibit marked genetic heterogeneity. Multiple genet...

journal_title：Current opinion in hematology

authors： Gallagher PG,Ferriera JD

更新日期：1997-03-01 00:00:00

abstract：:Recent advances in our understanding of hypereosinophilia have related particularly to the definition of criteria for distinguishing between eosinophilic leukemia and the 'idiopathic' hypereosinophilic syndromes. In this article, leukemogenic mechanisms have been identified in a number of subtypes of eosinophilic leuk...

journal_title：Current opinion in hematology

authors： Bain BJ

更新日期：2000-01-01 00:00:00

abstract：:Gene transfer has allowed a number of biologic issues in the therapy of hematologic malignancy to be addressed. In autologous bone marrow transplantation, gene marking studies have shown that infused marrow contributes to relapse in acute myeloid leukemia, neuroblastoma, and chronic myeloid leukemia. In addition, doub...

journal_title：Current opinion in hematology

authors： Heslop HE,Roskrow M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this short study is to review recently published data bearing on how to resuscitate massive uncontrolled hemorrhage. RECENT FINDINGS:New data inform our understanding of the mechanisms of the acute coagulopathy of trauma, the median time to death of trauma patients with uncontrolled hemorr...

journal_title：Current opinion in hematology

authors： Murphy CH,Hess JR

更新日期：2015-11-01 00:00:00

abstract：:Anemia is a common disorder in patients with cancer and can be caused by the disease itself or by cancer-related therapy. The cardinal symptom of anemia, fatigue, is the most commonly reported symptom in patients with cancer and has profound effects on patient well-being and quality of life. Until recently, blood tran...

journal_title：Current opinion in hematology

authors： Yount S,Lai JS,Cella D

更新日期：2002-05-01 00:00:00

abstract：:Neutropenia is often attributed to immunologically mediated injury to mature neutrophils or their precursors. Clinically it is useful to classify immune mediated neutropenias as isoimmune, autoimmune (including some drug-associated neutropenias), and idiopathic (cases possibly with an immune mechanism). Isoimmune neut...

journal_title：Current opinion in hematology

authors： Dale DC

更新日期：1998-01-01 00:00:00

abstract：:When a new product with huge clinical potential explodes on the scene, the hope is that the benefits far outweigh the risks in long-term administration. After 10 years of clinical use, granulocyte colony-stimulating factor (G-CSF) has lived up to that promise so far. In the context of severe chronic neutropenia, more ...

journal_title：Current opinion in hematology

authors： Freedman MH

更新日期：1997-05-01 00:00:00

abstract：:The ability to move is one of the most basic and critical functions of the neutrophil. The neutrophil changes its shape from round to highly polar and glides along the surface, pausing every 45 to 60 seconds to reestablish its direction. Iterations of this sequence of small-scale motion, or shape change, sum to form t...

journal_title：Current opinion in hematology

authors： Coates TD

更新日期：1996-01-01 00:00:00

abstract：:Many aspects of leukocyte function are regulated by both heterotrimeric and Ras-related GTP-binding proteins, but there is little definite information about their roles in the specialized processes utilized by leukocytes for cell killing. Recent progress in understanding the regulation of the phagocyte NADPH oxidase b...

journal_title：Current opinion in hematology

authors： Bokoch GM,Knaus UG

更新日期：1994-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The treatment of patients with refractory or relapsed acute myeloid leukemia remains challenging. Management of these patients must take into account patient and leukemia-related factors in order to organize a comprehensive approach to treatment. Many new therapies are under study. RECENT FINDINGS:Ne...

journal_title：Current opinion in hematology

authors： Litzow MR

更新日期：2007-03-01 00:00:00

abstract：:Several methods to model human Ph+ leukemia in laboratory mice are available, including propagation of BCR/ABL-expressing cells in mice, xenotransplantation of primary Ph+ leukemia cells into immunodeficient mice, BCR/ABL transgenic mice, and BCR/ABL retroviral bone marrow transduction and transplantation. Recent stud...

journal_title：Current opinion in hematology

authors： Van Etten RA

更新日期：2001-07-01 00:00:00

abstract：:Platelet production is primarily regulated by the thrombopoietic cytokine thrombopoietin (TPO). In most cases thrombopoietin serum levels are determined by the rate of c-mpl receptor-mediated degradation after TPO uptake into platelets and megakaryocytes. The contribution of increased TPO protein synthesis by a transl...

journal_title：Current opinion in hematology

authors： Verbeek W,Faulhaber M,Griesinger F,Brittinger G

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis and/or obstetrical morbidity in the presence of persistently positive antiphospholipid antibodies. Recent insights into the pathogenesis of APS have begun to elucidate pathophysiology and led to...

journal_title：Current opinion in hematology

authors： Chaturvedi S,McCrae KR

更新日期：2014-09-01 00:00:00

abstract：:Acute chest syndrome (ACS) is the presence of a new pulmonary infiltrate in combination with fever or respiratory symptoms in a patient with sickle cell disease. ACS is the leading cause of death in sickle cell disease, and many patients suffer from multiple, severe episodes. Age has a striking effect on the clinical ...

journal_title：Current opinion in hematology

authors： Golden C,Styles L,Vichinsky E

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduction would be inefficient at preventing transmission of the disease by blood transfusion. Nevertheless, approximately 14 years ago, a significant proportion of European countries decided to implement l...

journal_title：Current opinion in hematology

authors： Douet JY,Bujdoso R,Andréoletti O

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence has accumulated to suggest that innate immune defense mechanisms might interact with proinflammatory pathways and exacerbate or perhaps even initiate development of arterial plaques. Unti...

journal_title：Current opinion in hematology

authors： Michelsen KS,Arditi M

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Adoptive T-cell therapy has become one of the most exciting fields of cancer therapy in the past few years. In this article, we describe a method which combines adoptive T-cell therapy with antibody therapy by arming T cells from cord blood, normal patients, and cancer patients with bispecific antibod...

journal_title：Current opinion in hematology

authors： Bhutani D,Lum LG

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:While the risks of transfusion-transmitted human immunodeficiency virus, hepatitis C virus, and human T-cell leukemia virus I/II continue to decrease, additional threats to transfusion safety are posed by emerging "new" infectious diseases. RECENT FINDINGS:Following the introduction of nucleic acid t...

journal_title：Current opinion in hematology

authors： Pomper GJ,Wu Y,Snyder EL

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent publications that bear on the evidential basis for therapeutic apheresis in diseases in which hemolytic anemia is a prominent feature. RECENT FINDINGS:Therapeutic plasma exchange continues to be reported sporadically in severe autoimmune hemolytic anemia, with inconsistent...

journal_title：Current opinion in hematology

authors： McLeod BC

更新日期：2007-11-01 00:00:00

abstract：:Within the past year substantial progress has been made in understanding the molecular changes underlying the development of acute leukemia. Development of molecular probes allowed substantial improvements in the detection of minimal residual disease. Pilot studies underlined the correlation between the expression of ...

journal_title：Current opinion in hematology

authors： Ganser A,Hoelzer D

更新日期：1994-07-01 00:00:00

abstract：:The Epstein-Barr virus is a ubiquitous human herpesvirus that is associated with an increasing number of human malignancies. Among these are Epstein-Barr virus-associated lymphoproliferative diseases in immunocompromised patients, a spectrum of mainly B-cell diseases that range from polyclonal lymphoproliferative dise...

journal_title：Current opinion in hematology

authors： Mosier DE

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Graft-versus-host disease is one of the commonest complications of allogeneic bone marrow or peripheral blood stem cell transplantation. This review will cover advances in the pathophysiology of graft-versus-host disease and new agents under investigation for the treatment of this disorder. Patients d...

journal_title：Current opinion in hematology

authors： Bolaños-Meade J,Vogelsang GB

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To outline the rationale, limitations, and execution of bloodless medical and surgical programs, highlighting characteristics that contribute to successful outcomes. RECENT FINDINGS:Clinical experiences with patients who refuse blood transfusions for religious reasons have provided valuable lessons a...

journal_title：Current opinion in hematology

authors： Shander A,Goodnough LT

更新日期：2006-11-01 00:00:00

abstract：:Therapy with unconjugated monoclonal antibodies (mAbs) and radiolabeled mAbs has shown activity in patients with B-cell non-Hodgkin's lymphoma and leukemia. Drug-conjugated mAbs are active in relapsed leukemia. Using these new agents with and after chemotherapy induces a high rate of remission, but this needs to be co...

journal_title：Current opinion in hematology

authors： Maloney DG

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial cells dysfunctions are crucial determinants of several human diseases. We review here the most recent reports on endothelial cell defects in cerebral cavernous malformations (CCMs), particularly focusing on adherens junctions. CCM is a vascular disease that affects specifically the venous ...

journal_title：Current opinion in hematology

authors： Lampugnani MG,Malinverno M,Dejana E,Rudini N

更新日期：2017-05-01 00:00:00

abstract：:Hematopoietic stem cells, defined as cells with extensive self-renewal and pluripotent differentiation potential, represent a minor population of adult bone marrow (< 1 in 10(4) to 10(5) nucleated marrow cells). Recent advances in cell surface phenotype analysis and separation technology have permitted enrichment of h...

journal_title：Current opinion in hematology

authors： Moore MA,Shapiro F

更新日期：1994-05-01 00:00:00

abstract：:Genetic defects of the blood platelet membrane glycoproteins, GPIIb-IIIa (alpha IIb/beta 3; CD41/CD61) and GPIb-V-IX (CD42) are the origin of several rare bleeding disorders, the best known of which are Glanzmann's thrombasthenia, Bernard-Soulier syndrome, and platelet-type von Willebrand's disease. In Glanzmann's thr...

journal_title：Current opinion in hematology

authors： Clemetson KJ,Clemetson JM

更新日期：1994-09-01 00:00:00

abstract：:The bulk of antigens that are presented by major histocompatibility complex (MHC) class I molecules are processed in the cytosol. Therefore, the cellular protein degradation machinery is thought to play a major role in antigen processing. For example, there is clear evidence that the ubiquitin-proteasome pathway, the ...

journal_title：Current opinion in hematology

authors： Androlewicz MJ

更新日期：2001-01-01 00:00:00

abstract：:: Hematopoietic stem cells (HSCs) are a unique population of cells with the remarkable ability to replenish themselves through self-renewal and to give rise to differentiated cell lineages. Though having been discovered more than 50 years ago, and having been widely used in bone marrow transplantation to treat blood d...

journal_title：Current opinion in hematology

authors： Li Z,He XC,Li L

更新日期：2019-07-01 00:00:00

abstract：:Myeloablative therapy followed by autologous bone marrow or peripheral blood stem cell rescue is an alternative therapeutic option for patients who are not candidates for allogeneic transplantation due to the lack of an appropriate HLA-matched donor or to advanced age. It allows therapy to be administered that is of c...

journal_title：Current opinion in hematology

authors： Hammert LC,Ball ED

更新日期：1997-11-01 00:00:00