Seasonal blood shortages can be eliminated.

abstract：:This article presents the most recent insights into the biology, prognostic significance, and therapeutic approaches to TEL/AML1-positive leukemia. The TEL/AML1 fusion gene, also known as ETV6 /CBFA2, is the most commonly occurring gene rearrangement in pediatric acute lymphoblastic leukemia (ALL). Considerable contro...

journal_title：Current opinion in hematology

authors： Loh ML,Rubnitz JE

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Core binding factor acute myeloid leukemia (CBF-AML) corresponds to two distinct subtypes of AML characterized by recurrent favorable chromosome translocations, namely t(8;21) and inv(16)/t(16;16). Given the relatively good outcome of patients with CBF-AML, when treated with intensive chemotherapy inc...

journal_title：Current opinion in hematology

authors： Dombret H,Preudhomme C,Boissel N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Deficiency of antithrombin, protein C, and protein S increases the risk of a first venous thromboembolism (VTE) by at least 10-fold and is rare (i.e., <0.5% of population), whereas factor V Leiden and the prothrombin G20210A gene increase this risk by 2-5-fold and are common (2-5% of whites). Antiphos...

journal_title：Current opinion in hematology

authors： Kearon C

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Neutrophils priming has been long studied in vitro. Recent studies describe it in vivo. In pathophysiological conditions, complex, heterogeneous characteristics of priming are described in the last few years. RECENT FINDINGS:Priming can occur systemically when insults such as sepsis or trauma result ...

journal_title：Current opinion in hematology

authors： Vogt KL,Summers C,Condliffe AM

更新日期：2019-01-01 00:00:00

abstract：:A variety of agents are available to improve hemostasis and reduce blood loss in multiple clinical settings. These agents are most commonly used to reduce bleeding when an underlying hemostatic defect is present. Some new agents offer the potential to decrease blood loss even in the absence of an obvious underlying he...

journal_title：Current opinion in hematology

authors： Chiu J,Ketchum LH,Reid TJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The review describes recent advances in our understanding of mechanisms leading to development of neutralizing antibodies following factor VIII (FVIII) replacement therapy for hemophilia A. Novel interventions with translational potential to lessen the incidence of these deleterious immune responses a...

journal_title：Current opinion in hematology

authors： Pratt KP

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss how mechanical cues and Rho signaling contribute to control of vascular development and hematopoiesis. RECENT FINDINGS:Rho guanine trinucleotide phosphatases are ubiquitious regulators of cytoskeletal structure and tension generation. Recent work shows that Rho-dependent mechanical interac...

journal_title：Current opinion in hematology

authors： Mammoto A,Mammoto T,Ingber DE

更新日期：2008-05-01 00:00:00

abstract：:When a new product with huge clinical potential explodes on the scene, the hope is that the benefits far outweigh the risks in long-term administration. After 10 years of clinical use, granulocyte colony-stimulating factor (G-CSF) has lived up to that promise so far. In the context of severe chronic neutropenia, more ...

journal_title：Current opinion in hematology

authors： Freedman MH

更新日期：1997-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Infantile hemangioma is a common vascular tumor with a unique lifecycle: rapid growth in infancy, followed by a period of involution, leading to complete regression. This review summarizes recent studies of molecular mechanisms of hemangioma formation and places new findings and hypotheses in the cont...

journal_title：Current opinion in hematology

authors： Boye E,Olsen BR

更新日期：2009-05-01 00:00:00

abstract：:Hematopoietic stem cells, defined as cells with extensive self-renewal and pluripotent differentiation potential, represent a minor population of adult bone marrow (< 1 in 10(4) to 10(5) nucleated marrow cells). Recent advances in cell surface phenotype analysis and separation technology have permitted enrichment of h...

journal_title：Current opinion in hematology

authors： Moore MA,Shapiro F

更新日期：1994-05-01 00:00:00

abstract：:The ability to move is one of the most basic and critical functions of the neutrophil. The neutrophil changes its shape from round to highly polar and glides along the surface, pausing every 45 to 60 seconds to reestablish its direction. Iterations of this sequence of small-scale motion, or shape change, sum to form t...

journal_title：Current opinion in hematology

authors： Coates TD

更新日期：1996-01-01 00:00:00

abstract：:Stem cell factor is an early-acting hematopoietic cytokine that probably functions constitutively to support the proliferation and survival of pluripotent progenitor cells and to increase their receptivity to lineage commitment and differentiation in response to lineage-specific cytokines. Stem cell factor also can in...

journal_title：Current opinion in hematology

authors： Glaspy J

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of JAK2V617F and other JAK-STAT-activating mutations in BCR-ABL1-negative myeloproliferative neoplasms (MPN) has led to the development of small-molecule ATP-mimetics that inhibit wild-type and mutant JAK. Here, we review the current experience with JAK inhibitors used for the treatment ...

journal_title：Current opinion in hematology

authors： Pardanani A,Tefferi A

更新日期：2011-03-01 00:00:00

abstract：:Following on the heels of multiple failed clinical trials of adjunctive therapeutic agents in sepsis, the positive outcome of a recent phase III study using activated protein C (APC) has led to a renewed optimism in targeted biotherapies for this syndrome. A growing body of data (both preclinical and clinical) suggest...

journal_title：Current opinion in hematology

authors： Key NS,Ely EW

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic idiopathic and severe congenital neutropenias are rare disorders for which recent discoveries have highlighted mechanisms and consequences. RECENT FINDINGS:An inflammatory bone marrow milieu has been shown to be a major contributor to the pathophysiology of chronic idiopathic neutropenia. Act...

journal_title：Current opinion in hematology

authors： Palmblad J,Papadaki HA

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Cellular to animal to human studies are shedding light on metabolic pathways that contribute to sustaining lymphomagenesis. Old players with new metabolic tricks and new metabolic players come into the scene. The purpose of this review is to discuss the recent advances made in the field of lymphoma me...

journal_title：Current opinion in hematology

authors： Calvo-Vidal MN,Cerchietti L

更新日期：2013-07-01 00:00:00

abstract：:The advent of safe and practical means to correct, enhance or protect blood cells at the genetic level offers tantalizing therapeutic perspectives. At present, gene delivery using a replication-defective retrovirus is the most efficient method to stably transduce hematopoietic cells. The successful adaptation of retro...

journal_title：Current opinion in hematology

authors： Sadelain M,Frassoni F,Rivière I

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The advent of tyrosine kinase inhibitors (TKI) has remarkably changed the treatment of chronic myeloid leukemia (CML). Patients treated in chronic phase can enjoy an expected survival similar to the general population. In the last few years we have found that some patients with an excellent therapeuti...

journal_title：Current opinion in hematology

authors： Bansal A,Radich J

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Technical possibilities to screen for inborn errors of immune function at the neonatal stage have been rapidly progressing, whereas the guidelines that apply for the evaluation of benefits and concerns on expanding screening panels have not been broadly discussed for primary immunodeficiency diseases ...

journal_title：Current opinion in hematology

authors： Borte S,von Döbeln U,Hammarström L

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Although several clinical studies have investigated the effects of different treatment periods in subjects after a VTE event, the optimal duration of oral anticoagulation is still uncertain. Our review focused on studies that evaluated different risk factors that might be useful to stratify patients i...

journal_title：Current opinion in hematology

authors： Palareti G,Cosmi B

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 von Willebrand disease (VWD) is the most common form of VWD, but has remained [corrected] the least well understood. Recent work is changing this situation. This review summarizes recent analysis of the genetic basis of the disease. RECENT FINDINGS:Linkage analysis demonstrates that dominantly...

journal_title：Current opinion in hematology

authors： Goodeve A

更新日期：2007-09-01 00:00:00

abstract：:Hairy cell leukemia is an indolent, chronic B-cell lymphoproliferative disorder comprising approximately 2 to 3% of all adult leukemias in the United States. Hairy cells are clonal expansions of mature, activated B-cells. They co-express CD11c, CD19, CD20, CD22, CD25, and CD103. Hairy cells possess clonal immunoglobul...

journal_title：Current opinion in hematology

authors： Goodman GR,Bethel KJ,Saven A

更新日期：2003-07-01 00:00:00

abstract：:: Hematopoietic stem cells (HSCs) are a unique population of cells with the remarkable ability to replenish themselves through self-renewal and to give rise to differentiated cell lineages. Though having been discovered more than 50 years ago, and having been widely used in bone marrow transplantation to treat blood d...

journal_title：Current opinion in hematology

authors： Li Z,He XC,Li L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Galectins, a family of evolutionarily conserved glycan-binding proteins, are involved in the regulation of multiple cellular processes (e.g. immunity, apoptosis, cellular signaling, development, angiogenesis and cellular growth) and diseases (e.g. chronic inflammation, autoimmunity, cancer, infection)...

journal_title：Current opinion in hematology

authors： Rabinovich GA,Vidal M

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Angioimmunoblastic T cell lymphoma is a complex lymphoproliferative disorder. While recent evidence suggests that the Epstein-Barr virus and B cell disregulation are implicated in the disease's pathogenesis, their mechanistic roles remain largely unknown. The prognosis with traditional chemotherapy ha...

journal_title：Current opinion in hematology

authors： Dunleavy K,Wilson WH,Jaffe ES

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Hematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From the moment of HSC embryonic specification from hemogenic endothelium, endothelial cells (ECs) act as a critical cellular-hub that regulates a ...

journal_title：Current opinion in hematology

authors： Ramalingam P,Poulos MG,Butler JM

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF. RECENT FINDINGS:Levels of circulating active VWF are increased in von Willebrand disease type 2B, HELLP syndrome, ma...

journal_title：Current opinion in hematology

authors： Groot E,de Groot PG,Fijnheer R,Lenting PJ

更新日期：2007-05-01 00:00:00

abstract：:Gene transfer has allowed a number of biologic issues in the therapy of hematologic malignancy to be addressed. In autologous bone marrow transplantation, gene marking studies have shown that infused marrow contributes to relapse in acute myeloid leukemia, neuroblastoma, and chronic myeloid leukemia. In addition, doub...

journal_title：Current opinion in hematology

authors： Heslop HE,Roskrow M

更新日期：1995-11-01 00:00:00

abstract：:Many aspects of leukocyte function are regulated by both heterotrimeric and Ras-related GTP-binding proteins, but there is little definite information about their roles in the specialized processes utilized by leukocytes for cell killing. Recent progress in understanding the regulation of the phagocyte NADPH oxidase b...

journal_title：Current opinion in hematology

authors： Bokoch GM,Knaus UG

更新日期：1994-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To outline the rationale, limitations, and execution of bloodless medical and surgical programs, highlighting characteristics that contribute to successful outcomes. RECENT FINDINGS:Clinical experiences with patients who refuse blood transfusions for religious reasons have provided valuable lessons a...

journal_title：Current opinion in hematology

authors： Shander A,Goodnough LT

更新日期：2006-11-01 00:00:00