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Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function.

Abstract：

:The post-translational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAc) is emerging as an important mechanism for the regulation of numerous biological processes critical for normal cell function. Active synthesis of O-GlcNAc is essential for cell viability and acute activation of pathways resulting in increased protein O-GlcNAc levels improves the tolerance of cells to a wide range of stress stimuli. Conversely sustained increases in O-GlcNAc levels have been implicated in numerous chronic disease states, especially as a pathogenic contributor to diabetic complications. There has been increasing interest in the role of O-GlcNAc in the heart and vascular system and acute activation of O-GlcNAc levels have been shown to reduce ischemia/reperfusion injury, attenuate vascular injury responses as well mediate some of the detrimental effects of diabetes and hypertension on cardiac and vascular function. Here we provide an overview of our current understanding of pathways regulating protein O-GlcNAcylation, summarize the different methodologies for identifying and characterizing O-GlcNAcylated proteins and subsequently focus on two emerging areas: 1) the role of O-GlcNAc as a potential regulator of cardiac metabolism and 2) the cross talk between O-GlcNAc and reactive oxygen species. This article is part of a Special Section entitled "Post-translational Modification."

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Darley-Usmar VM,Ball LE,Chatham JC

doi

10.1016/j.yjmcc.2011.08.009

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

538-49

issue

3

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(11)00329-4

journal_volume

52

pub_type

杂志文章,评审

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