Changes in thyroid state affect pHi and Nai+ homeostasis in rat ventricular myocytes.

abstract：:We tested the hypothesis that the early action potential shortening induced by hypoxia in perfused hearts is attributable to chloride currents activated or modulated by endogenous catecholamine release. Rabbit hearts perfused at 33 degrees C and paced at 2.5-2.8 Hz were used for membrane potential recordings with micr...

journal_title：Journal of molecular and cellular cardiology

authors： Ruiz Petrich E,Ponce Zumino A,Schanne OF

更新日期：1996-02-01 00:00:00

abstract：:The aim of this study was to determine if embryonic stem cell derived cardiomyocyte aggregates (ESdCs) can act as pacemakers in spontaneously active cardiomyocyte preparations when their connexin isoform expression is tuned toward a more sinus nodal phenotype. Using microelectrode array recordings (MEAs), we demonstra...

journal_title：Journal of molecular and cellular cardiology

authors： Fahrenbach JP,Ai X,Banach K

更新日期：2008-11-01 00:00:00

abstract：:In a recent issue of Journal of Molecular and Cellular Cardiology, George et al. [1] identified discoidin domain receptor 2 (DDR2) as a positive modulator of collagen production in cardiac fibroblasts stimulated with angiotensin II (Ang II). DDR2 is a tyrosine kinase collagen receptor and is associated with pathologic...

journal_title：Journal of molecular and cellular cardiology

authors： DeLeon-Pennell KY

更新日期：2016-02-01 00:00:00

abstract：:The effects of variations in serum concentrations of potassium on the occurrence and severity of ischemia- and reperfusion-induced arrhythmias have been studied in conscious rats. Serum potassium concentrations were modified by maintaining rats on diets which varied in potassium concentration, by treatment with hydroc...

journal_title：Journal of molecular and cellular cardiology

authors： Saint KM,Abraham S,MacLeod BA,McGough J,Yoshida N,Walker MJ

更新日期：1992-07-01 00:00:00

abstract：:This study addresses the role of polyamines and their rate limiting enzyme, ornithine decarboxylase in regulation of macromolecular transport of two macromolecules, fluorescein and horseradish peroxidase, across coronary capillaries. Rat hearts were isolated and retrogradely perfused through the aorta (Langendorff met...

journal_title：Journal of molecular and cellular cardiology

authors： Trout JJ,Lu CY,Goldstone AD,Iqbal Z,Koenig H

更新日期：1994-03-01 00:00:00

abstract：:Studies to test whether superoxide dismutase (SOD), with or without catalase, limits myocardial infarct size have produced conflicting results. Positive results following short periods of reperfusion vs negative results following longer periods of reperfusion could be explained if either: (1) myocytes, initially salva...

journal_title：Journal of molecular and cellular cardiology

authors： Tanaka M,Richard VJ,Murry CE,Jennings RB,Reimer KA

更新日期：1993-04-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent agonist of cell growth that also stimulates Na(+)/H(+) exchanger isoform 1 (NHE-1) activity. It was hypothesized that the increase in intracellular Na(+) ([Na(+)](i)) mediated by NHE-1 activity may induce the reverse mode of Na(+)/Ca(2+) exchanger (NCX(rev)) increasing intracellular Ca(...

journal_title：Journal of molecular and cellular cardiology

authors： Dulce RA,Hurtado C,Ennis IL,Garciarena CD,Alvarez MC,Caldiz C,Pierce GN,Portiansky EL,Chiappe de Cingolani GE,Camilión de Hurtado MC

更新日期：2006-11-01 00:00:00

abstract：:The volume of blood in the left ventricular wall increases as coronary perfusion pressure or coronary blood flow increase, but it is unclear whether such an increase in volume can acutely alter the diastolic pressure-dimension relationship of the intact, working left ventricle. In 19 dogs, we measured left ventricular...

journal_title：Journal of molecular and cellular cardiology

authors： Verrier ED,Bristow JD,Hoffman JI

更新日期：1986-06-01 00:00:00

abstract：:The E2F4-p130 transcriptional repressor complex is a cell-cycle inhibitor in mitotic cells. However, the role of E2F4/p130 in differentiated cells is largely unknown. We investigated the role of E2F4/p130 in the regulation of apoptosis in postmitotic cardiomyocytes. Here we demonstrate that E2F4 can inhibit hypoxia-in...

journal_title：Journal of molecular and cellular cardiology

authors： Dingar D,Konecny F,Zou J,Sun X,von Harsdorf R

更新日期：2012-12-01 00:00:00

abstract：:The importance of endogenous and exogenous estrogen levels to the development of cardiovascular disease in women in controversial. The purpose of our study was to examine the effect of estrogen on the development of hypertension, cardiac hypertrophy, ventricular function, and gene expression for atrial natriuretic pep...

journal_title：Journal of molecular and cellular cardiology

authors： Sharkey LC,Holycross BJ,Park S,Shiry LJ,Hoepf TM,McCune SA,Radin MJ

更新日期：1999-08-01 00:00:00

abstract：:The possible ischemia-selective Class III anti-arrhythmic action (selective action potential widening in ischemia) of the IKATP blocker glibenclamide was assessed in anesthetized rabbits during ischemia induced by complete occlusion of a coronary artery. Coronary artery occlusion caused an initial prolongation in mono...

journal_title：Journal of molecular and cellular cardiology

authors： Barrett TD,Walker MJ

更新日期：1998-05-01 00:00:00

abstract：:Monoclonal and polyclonal antibodies to the major sarcoplasmic reticulum proteins of rabbit skeletal and canine cardiac muscle have been used to identify and characterize the corresponding components of human cardiac sarcoplasmic reticulum. The Ca2(+)-transporting ATPase of human cardiac sarcoplasmic reticulum was ide...

journal_title：Journal of molecular and cellular cardiology

authors： Movsesian MA,Leveille C,Krall J,Colyer J,Wang JH,Campbell KP

更新日期：1990-12-01 00:00:00

abstract：:The Raf/MAPK/ERK kinase (Mek)/extracellular signal-regulated kinases (Erk) pathway is activated in cardiac hypertrophy after a myocardial infarction. Although heat-shock protein 90 (Hsp90) may regulate the Raf/Mek/Erk signal pathway, the role of Hsp90 in pathophysiological cardiac hypertrophy remains unclear. In this ...

journal_title：Journal of molecular and cellular cardiology

authors： Tamura S,Marunouchi T,Tanonaka K

更新日期：2019-02-01 00:00:00

abstract：:In this article we review the late Na current which functionally can be measured using patch-clamp electrophysiology (INa,late). This current is largely enhanced under pathological myocardial conditions such as ischemia and heart failure. In addition, INa,late can cause systolic and diastolic contractile dysfunction v...

journal_title：Journal of molecular and cellular cardiology

authors： Maier LS,Sossalla S

更新日期：2013-08-01 00:00:00

abstract：:Diabetes is recognized as an independent risk factor for cardiovascular morbidity and mortality. This is due, in large part, to premature atherosclerosis, enhanced thrombogenicity and activation of systemic inflammatory programs with resultant vascular dysfunction. More enigmatic mechanisms underpinning diabetes-assoc...

journal_title：Journal of molecular and cellular cardiology

authors： Sack MN

更新日期：2009-06-01 00:00:00

abstract：:To test a prediction that trans-sarcolemmal lactate movement is carrier mediated, 14C-labelled lactate or pyruvate and 3H-mannitol were transiently infused (2 min) into aerobically perfused rat hearts that had been depleted of intracellular monocarboxylates by a 30 min pre-perfusion in the absence of substrates. Uptak...

journal_title：Journal of molecular and cellular cardiology

authors： Dennis SC,Kohn MC,Anderson GJ,Garfinkel D

更新日期：1985-10-01 00:00:00

abstract：:The ability of the myocardium to successfully adapt to cardiac injury ultimately determines whether the heart will decompensate and fail, or whether instead it will maintain preserved function. Despite the importance of the myocardial response to cardiac injury, very little is known with respect to the biochemical mec...

journal_title：Journal of molecular and cellular cardiology

authors： Wilson EM,Diwan A,Spinale FG,Mann DL

更新日期：2004-10-01 00:00:00

abstract：:Since angiotensin-converting enzyme (ACE) produces angiotensin II in the heart, ACE inhibitors may prevent coronary vasoconstriction and increase coronary blood flow. On the other hand, since ACE inhibitors also inhibit kininase II which results in reduced degradation of bradykinin, ACE inhibitors may increase cardiac...

journal_title：Journal of molecular and cellular cardiology

authors： Kitakaze M,Node K,Minamino T,Asanuma H,Ueda Y,Kosaka H,Kuzuya T,Hori M

更新日期：1998-11-01 00:00:00

abstract：:Basal levels of cyclic adenosine monophosphate (cAMP) were measured in embryonic chick hearts at various times during development. Basal cAMP was highest on incubation day 5 and decreased throughout the remaining incubation period. Cyclic AMP could not be stimulated above basal level by intravenous in ovo administrati...

journal_title：Journal of molecular and cellular cardiology

authors： Phillips MT,Kirby ML,Stewart DE

更新日期：1986-08-01 00:00:00

abstract：:Common cardiovascular diseases such as hypertension and myocardial infarction require that myocytes develop greater than normal force to maintain cardiac pump function. This requires increases in [Ca(2+)]. These diseases induce cardiac hypertrophy and increases in [Ca(2+)] are known to be an essential proximal signal ...

journal_title：Journal of molecular and cellular cardiology

authors： Gao H,Wang F,Wang W,Makarewich CA,Zhang H,Kubo H,Berretta RM,Barr LA,Molkentin JD,Houser SR

更新日期：2012-11-01 00:00:00

abstract：:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is linked to mutations in the cardiac ryanodine receptor (RyR2) or calsequestrin. We recently found that the drug flecainide inhibits RyR2 channels and prevents CPVT in mice and humans. Here we compared the effects of flecainide and tetracaine, a known RyR2 ...

journal_title：Journal of molecular and cellular cardiology

authors： Hilliard FA,Steele DS,Laver D,Yang Z,Le Marchand SJ,Chopra N,Piston DW,Huke S,Knollmann BC

更新日期：2010-02-01 00:00:00

abstract：:It has recently been proposed that the Ca(2+) uptake by the SR is inhibited by blocking Cl(-) and/or K(+) movements across this intracellular membrane. We have characterised the functional and pharmacological profile of the SR K(+) channel derived from human and sheep atrial cells. Mammalian atrial SR preparations wer...

journal_title：Journal of molecular and cellular cardiology

authors： Picard L,Côté K,Teijeira J,Greentree D,Rousseau E

更新日期：2002-09-01 00:00:00

abstract：:Ventricular trabeculae from adult and newborn ferret heart were chemically skinned by Triton X-100 which disrupts all cellular membranes. In newborn preparations, maximal Ca(2+)-activated tension was two times smaller than in adult fibres while Ca2+ sensitivity was higher. Caffeine (10 mM) and cyclopiazonic acid (100 ...

journal_title：Journal of molecular and cellular cardiology

authors： Bonnet V,Léoty C

更新日期：1996-06-01 00:00:00

abstract：:Application of ultrasound-mediated destruction of microbubbles (US + Bubble) to skeletal muscle creates capillary ruptures leading to leakage of the cell components. We studied whether US + Bubble combined with bone-marrow-derived mononuclear cells (BM-MNCs) infusion enables the targeted delivery of endothelial-lineag...

journal_title：Journal of molecular and cellular cardiology

authors： Zen K,Okigaki M,Hosokawa Y,Adachi Y,Nozawa Y,Takamiya M,Tatsumi T,Urao N,Tateishi K,Takahashi T,Matsubara H

更新日期：2006-06-01 00:00:00

abstract：:The ability of cells in anoxic-perfused hearts to withstand two types of physical stresses (stretching and swelling), in the absence of reoxygenation was determined. Isolated rat hearts were perfused for 20, 40, or 60 mins with anoxic buffer after which hearts were either reoxygenated for 20 mins or exposed for 15 s t...

journal_title：Journal of molecular and cellular cardiology

authors： Vander Heide RS,Ganote CE

更新日期：1987-11-01 00:00:00

abstract：:Aftercontractions induced by beta-adrenoceptor stimulation in human and guinea-pig cardiomyocytes may be related to changes in action potential duration (APD). We investigated the effects of altering APD during the occurrence of isoproterenol-induced aftercontractions, using the KATP channel openers cromakalim and lem...

journal_title：Journal of molecular and cellular cardiology

authors： Tweedie D,O'Gara P,Harding SE,MacLeod KT

更新日期：1997-05-01 00:00:00

abstract：:The authors have shown that stimulation of cardiac alpha 1-adrenoceptors confers immediate cardioprotection in the isolated rat heart against post-ischemic dysfunction, and have recently demonstrated that in vivo treatment of rats with norepinephrine (NE) induces cardiac heat shock protein 72 and myocardial adaptation...

journal_title：Journal of molecular and cellular cardiology

authors： Meng X,Cleveland JC Jr,Rowland RT,Mitchell MB,Brown JM,Banerjee A,Harken AH

更新日期：1996-09-01 00:00:00

abstract：:Cardiac troponin I (cTnI), the inhibitory-unit, and cardiac troponin T (cTnT), the tropomyosin-binding unit together with the Ca-binding unit (cTnC) of the hetero-trimeric troponin complex signal activation of the sarcomeres of the adult cardiac myocyte. The unique structure and heart myocyte restricted expression of ...

journal_title：Journal of molecular and cellular cardiology

authors： Solaro CR,Solaro RJ

更新日期：2020-06-01 00:00:00

abstract：:Studying the importance of genetic factors in a desired cell type or tissue necessitates the use of precise genetic tools. With the introduction of bacteriophage Cre recombinase/loxP mediated DNA editing and promoter-specific Cre expression, it is feasible to generate conditional knockout mice in which particular gene...

journal_title：Journal of molecular and cellular cardiology

authors： Pugach EK,Richmond PA,Azofeifa JG,Dowell RD,Leinwand LA

更新日期：2015-09-01 00:00:00

abstract：:Antibodies directed against the second extracellular loop of G protein-coupled receptors have been shown to exert "agonist-like" activities. In order to test the hypothesis that this is a general phenomenon, antibodies were raised in rabbits against a synthetic peptide corresponding to the second extracellular loop of...

journal_title：Journal of molecular and cellular cardiology

authors： Sallé L,Eftekhari P,Aupart M,Cosnay P,Hoebeke J,Argibay JA

更新日期：2001-03-01 00:00:00