当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > The late Na current as a therapeutic target: where are we?

The late Na current as a therapeutic target: where are we?

Abstract：

:In this article we review the late Na current which functionally can be measured using patch-clamp electrophysiology (INa,late). This current is largely enhanced under pathological myocardial conditions such as ischemia and heart failure. In addition, INa,late can cause systolic and diastolic contractile dysfunction via a Na-dependent Ca-overload of the myocyte. Moreover, INa,late plays a crucial role as ventricular and atrial proarrhythmic substrate in myocardial pathology by changing cellular electrophysiology. We summarize recent experimental and clinical studies that investigate therapeutic inhibition of this current and discuss the significance of the available data and try to answer not only the question, where we currently are but also where we may go in the near future. This article is part of a Special Issue entitled "Na(+) Regulation in Cardiac Myocytes".

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Maier LS,Sossalla S

doi

10.1016/j.yjmcc.2013.03.001

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

44-50

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(13)00082-5

journal_volume

61

pub_type

杂志文章,评审

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • Organization and function of sarcolemmal phospholipids in control and ischemic/reperfused cardiomyocytes.

    abstract：:The topic of this review is the lipidic part of the sarcolemma, the plasma membrane of the myocardial cell, and its role in (dis)function of the cardiomyocyte. First the isolation of the sarcolemma and its lipid composition are discussed. These phospholipids are not randomly distributed over the two monolayers of the ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0022-2828(95)90080-2

    authors： Post JA,Verkleij AJ,Langer GA

    更新日期：1995-02-01 00:00:00

  • Cardioprotective signaling to mitochondria.

    abstract：:Mitochondria are central players in the pathophysiology of ischemia-reperfusion. Activation of plasma membrane G-coupled receptors or the Na,K-ATPase triggers cytosolic signaling pathways that result in cardioprotection. Our working hypothesis is that the occupied receptors migrate to caveolae, where signaling enzymes...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2008.11.019

    authors： Garlid KD,Costa AD,Quinlan CL,Pierre SV,Dos Santos P

    更新日期：2009-06-01 00:00:00

  • Inhibition of sodium influx and improved preservation of rat hearts during hypothermic ischemia by furosemide and bumetanide: a 23Na- and 31P-NMR study.

    abstract：:The importance of the Na+/K+/Cl- co-transport system of the rat myocardial sarcolemma was studied under hypothermic ischemia by investigating the effect of the co-transport blockers furosemide and bumetanide on the sodium influx into the myocardium. The intracellular Na+ accumulation during hypothermic ischemia was fo...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1993.1157

    authors： Rubin Y,Navon G

    更新日期：1993-12-01 00:00:00

  • 31P-NMR analysis of congestive heart failure in the SHHF/Mcc-facp rat heart.

    abstract：:31P-NMR was used to monitor myocardial bioenergetics in compensated and failing SHHF/MCC-fa(cp) (SHF) rat hearts. The SHHF/Mcc-fa(cp) (spontaneous hypertension and heart failure) rat is a relatively new genetic model in which all individuals spontaneously develop congestive heart failure, most during the second year o...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0587

    authors： Michael O'Donnell J,Narayan P,Bailey MQ,Abduljalil AM,Altschuld RA,McCune SA,Robitaille PM

    更新日期：1998-02-01 00:00:00

  • Energy metabolism in the perfused, arrested rabbit heart.

    abstract：:Energy metabolism of quiescent cardiac muscle was studied in the isolated rabbit heart preparation perfused at constant pressure by the Langendorff technique. Oxygen consumption (MVo2), coronary flow rate (CFR) and the steady state concentrations of high energy phosphate compounds were determined in hearts rendered as...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(89)90863-8

    authors： Kotsanas G,Gibbs CL,Wendt IR

    更新日期：1989-02-01 00:00:00

  • Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210.

    abstract：:It has been reported that the Frank-Starling mechanism is coordinately regulated in cardiac muscle via thin filament "on-off" equilibrium and titin-based lattice spacing changes. In the present study, we tested the hypothesis that the deletion mutation ΔK210 in the cardiac troponin T gene shifts the equilibrium toward...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2013.07.001

    authors： Inoue T,Kobirumaki-Shimozawa F,Kagemoto T,Fujii T,Terui T,Kusakari Y,Hongo K,Morimoto S,Ohtsuki I,Hashimoto K,Fukuda N

    更新日期：2013-10-01 00:00:00

  • Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy.

    abstract：:Familial hypertrophic cardiomyopathy (HCM) is a primary cardiomyopathy with an autosomal dominant pattern of inheritance. The disease bearing genes for HCM in HCM families have been identified as beta-myosin heavy chain, alpha-tropomyosin, cardiac troponin T (cTnT) and myosin binding protein-C genes. In the present st...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0322

    authors： Nakajima-Taniguchi C,Matsui H,Fujio Y,Nagata S,Kishimoto T,Yamauchi-Takihara K

    更新日期：1997-02-01 00:00:00

  • Nitric oxide-dependent vasodilation maintains blood flow in true hibernating myocardium.

    abstract：:Patients with chronic coronary artery disease may exhibit chronically depressed regional myocardial function, which can be reversed by revascularization. This was called hibernating myocardium, since it was thought that myocardial blood flow was also chronically reduced and since animals during true hibernation are th...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(03)00174-3

    authors： Kudej RK,Vatner SF

    更新日期：2003-08-01 00:00:00

  • Autophagic dysregulation in doxorubicin cardiomyopathy.

    abstract：:Doxorubicin (DOX)-induced cardiotoxicity has been a well-known phenomenon to clinicians and scientists for decades; however, molecular mechanisms underlying DOX cardiotoxicity are still being uncovered. Although the majority of prior research have implicated nuclear and mitochondrial events to be an important etiologi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2017.01.007

    authors： Bartlett JJ,Trivedi PC,Pulinilkunnil T

    更新日期：2017-03-01 00:00:00

  • Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers.

    abstract：:Atrial tissue gene expression profiling may help to determine how differentially expressed genes in the human atrium before cardiopulmonary bypass (CPB) are related to subsequent biologic pathway activation patterns, and whether specific expression profiles are associated with an increased risk for postoperative atria...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2016.02.006

    authors： Kertai MD,Qi W,Li YJ,Lombard FW,Liu Y,Smith MP,Stafford-Smith M,Newman MF,Milano CA,Mathew JP,Podgoreanu MV,Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team.

    更新日期：2016-03-01 00:00:00

  • Piezo1 is required for outflow tract and aortic valve development.

    abstract：AIMS:During embryogenesis, the onset of circulatory blood flow generates a variety of hemodynamic forces which reciprocally induce changes in cardiovascular development and performance. It has been known for some time that these forces can be detected by as yet unknown mechanosensory systems which in turn promote cardi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2020.03.013

    authors： Faucherre A,Moha Ou Maati H,Nasr N,Pinard A,Theron A,Odelin G,Desvignes JP,Salgado D,Collod-Béroud G,Avierinos JF,Lebon G,Zaffran S,Jopling C

    更新日期：2020-06-01 00:00:00

  • Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration.

    abstract：:The effects of variations in serum concentrations of potassium on the occurrence and severity of ischemia- and reperfusion-induced arrhythmias have been studied in conscious rats. Serum potassium concentrations were modified by maintaining rats on diets which varied in potassium concentration, by treatment with hydroc...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)93384-v

    authors： Saint KM,Abraham S,MacLeod BA,McGough J,Yoshida N,Walker MJ

    更新日期：1992-07-01 00:00:00

  • Suppression of myocardial mitochondrial respiratory function in acute failing hearts made by a short-term Ca2+ free, high Ca2+ coronary perfusion.

    abstract：:We made acute cardiac failure in excised cross-circulated canine hearts by a new coronary perfusion protocol consisting of Ca2+ free Tyrode perfusion for the first 10 min, high Ca2+ (16 mmol/l) Tyrode perfusion for the next 5 min, and normal Tyrode perfusion for the last 5 min interrupting blood cross circulation. Aft...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(95)90022-5

    authors： Takaki M,Zhao DD,Zhao LY,Araki J,Mori M,Suga H

    更新日期：1995-09-01 00:00:00

  • Mitochondrial adaptations within chronically ischemic swine myocardium.

    abstract：:Experimental evidence has emerged that myocardial ischemic preconditioning can prime the mitochondria into a "stress-resistant state", so that cell death is reduced following prolonged severe ischemia and reperfusion. Using a swine model of chronically ischemic myocardium, we tested the hypothesis that mitochondria wi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.07.008

    authors： McFalls EO,Sluiter W,Schoonderwoerd K,Manintveld OC,Lamers JM,Bezstarosti K,van Beusekom HM,Sikora J,Ward HB,Merkus D,Duncker DJ

    更新日期：2006-12-01 00:00:00

  • Early remodeling of repolarizing K+ currents in the αMHC403/+ mouse model of familial hypertrophic cardiomyopathy.

    abstract：:Familial hypertrophic cardiomyopathy (HCM), linked to mutations in myosin, myosin-binding proteins and other sarcolemmal proteins, is associated with increased risk of life threatening ventricular arrhythmias, and a number of animal models have been developed to facilitate analysis of disease progression and mechanism...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2017.01.006

    authors： Hueneke R,Adenwala A,Mellor RL,Seidman JG,Seidman CE,Nerbonne JM

    更新日期：2017-02-01 00:00:00

  • Sulfhydryl modulation of K+ channels in rat ventricular myocytes.

    abstract：:Oxidative stress markedly alters protein function through redox modification of sulfhydryl groups present in cysteine residues. To explore the role of redox state in modulating cardiac K+ channels, this study examined the effects of sulfhydryl modifiers on the repolarizing transient outward current (Ito) in voltage-cl...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2002.2112

    authors： Rozanski GJ,Xu Z

    更新日期：2002-12-01 00:00:00

  • A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia.

    abstract：:Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative condition with a heterogeneous cardiac phenotype caused primarily by an expanded GAA trinucleotide repeat in the frataxin gene (FXN). FXN is important in mitochondrial iron efflux, sensitivity to oxidative stress, and cell death. The number of GAA re...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.07.001

    authors： Kelly M,Bagnall RD,Peverill RE,Donelan L,Corben L,Delatycki MB,Semsarian C

    更新日期：2011-11-01 00:00:00

  • Reduction of prostacyclin synthesis as a possible cause of transient flow reduction in a partially constricted canine coronary artery.

    abstract：:Coronary blood flow decreases cyclically in a partially occluded coronary artery of anesthetized dogs. Spontaneous aggregation and deaggregation of platelet plugs in the constricted artery have been indicated to be responsible for this phenomenon. A current hypothesis is that platelet aggregation may be determined by ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(84)80040-1

    authors： Tada M,Esumi K,Yamagishi M,Kuzuya T,Matsuda H,Abe H,Uchida Y,Murao S

    更新日期：1984-12-01 00:00:00

  • Effects of ACE-inhibition on redox status and expression of P-selectin of endothelial cells subjected to oxidative stress.

    abstract：:Redox stress during post-ischemic reperfusion may be the prime signal for processes leading to myocardial remodelling and hypertrophy. Nitric oxide (NO) is antioxidative, antiadhesive for neutrophils (PMN) and antiproliferative. Thus, enhancing endothelial production of NO, e.g. by inhibiting breakdown of endogenous b...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0530

    authors： Zahler S,Kupatt C,Möbert J,Becker BF,Gerlach E

    更新日期：1997-11-01 00:00:00

  • Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.

    abstract：:Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently identified as a general heart failure (HF) hallmark. However, whether TT per se or the overall sarcolemma is altered during HF process is still unknown. In this study, we directly examined sarcolemmal surface topography and physica...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2014.05.006

    authors： Dague E,Genet G,Lachaize V,Guilbeau-Frugier C,Fauconnier J,Mias C,Payré B,Chopinet L,Alsteens D,Kasas S,Severac C,Thireau J,Heymes C,Honton B,Lacampagne A,Pathak A,Sénard JM,Galés C

    更新日期：2014-09-01 00:00:00

  • Neural/Bayes network predictor for inheritable cardiac disease pathogenicity and phenotype.

    abstract：:The cardiac muscle sarcomere contains multiple proteins contributing to contraction energy transduction and its regulation during a heartbeat. Inheritable heart disease mutants affect most of them but none more frequently than the ventricular myosin motor and cardiac myosin binding protein c (mybpc3). These co-localiz...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2018.04.006

    authors： Burghardt TP,Ajtai K

    更新日期：2018-06-01 00:00:00

  • Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes.

    abstract：:Atrial fibrillation, the most common sustained arrhythmia, is believed to be triggered by ectopic electrical activity originating in the myocardial sleeves surrounding the pulmonary veins (PVs). It has been reported that myocardial sleeves have the potential to generate automaticity in response to norepinephrine. This...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.01.007

    authors： Okamoto Y,Takano M,Ohba T,Ono K

    更新日期：2012-05-01 00:00:00

  • Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII.

    abstract：:Recovery of intracellular Ca transients and fractional shortening during late phase acidosis are suggested to be associated with CaMKII-dependent processes of which phospholamban (PLB) phosphorylation may play an important role. To test whether increased expression levels of CaMKII may further enhance recovery, we inv...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2007.09.008

    authors： Sag CM,Dybkova N,Neef S,Maier LS

    更新日期：2007-12-01 00:00:00

  • Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.

    abstract：:The intracellular fibroblast growth factors (iFGF/FHFs) bind directly to cardiac voltage gated Na+ channels, and modulate their function. Mutations that affect iFGF/FHF-Na+ channel interaction are associated with arrhythmia syndromes. Although suspected to modulate other ionic currents, such as Ca2+ channels based on ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2017.01.009

    authors： Wang X,Tang H,Wei EQ,Wang Z,Yang J,Yang R,Wang S,Zhang Y,Pitt GS,Zhang H,Wang C

    更新日期：2017-03-01 00:00:00

  • Cardiomegaly due to myocyte hyperplasia in perinatal rats exposed to 200 ppm carbon monoxide.

    abstract：:Exposure to carbon monoxide (CO) during the fetal and neonatal period was used to evaluate cardiac ventricular regional weight and myocyte growth response to an increased hemodynamic load. Date-mated Sprague-Dawley rats inhaled 200 ppm CO from day 7 of pregnancy until parturition; another group of pregnant rats inhale...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80913-0

    authors： Clubb FJ Jr,Penney DG,Baylerian MS,Bishop SP

    更新日期：1986-05-01 00:00:00

  • A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy.

    abstract：:Angiotensin II (Ang II) induces cardiac hypertrophy and fibrosis in part by stimulating endothelin (ET-1) transcription. The involvement of the epigenetic machinery in this process is largely undefined. In the present study, we examined the epigenetic maneuvering underlying cardiac hypertrophy and fibrosis following E...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2015.02.010

    authors： Weng X,Yu L,Liang P,Li L,Dai X,Zhou B,Wu X,Xu H,Fang M,Chen Q,Xu Y

    更新日期：2015-05-01 00:00:00

  • Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats.

    abstract：:Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induced oxidative stress ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2014.10.009

    authors： Escobales N,Nuñez RE,Jang S,Parodi-Rullan R,Ayala-Peña S,Sacher JR,Skoda EM,Wipf P,Frontera W,Javadov S

    更新日期：2014-12-01 00:00:00

  • Effect of isoproterenol on myocardial mechanical function and cyclic AMP content in the fetal rabbit.

    abstract：:The effect of isoproterenol on mechanical function was studied in the isolated arterially perfused heart of the fetal (21st and 28th day of gestation) and newborn rabbits. The inotropic effect of isoproterenol in the fetus was less than in the newborn. In contrast, myocardial cyclic AMP levels after isoproterenol infu...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(87)80557-6

    authors： Okuda H,Nakanishi T,Nakazawa M,Takao A

    更新日期：1987-02-01 00:00:00

  • Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes.

    abstract：:During systole, Ca2+ is released from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyRs) while, simultaneously, other ions (specifically K+, Mg2+, and Cl-) provide counter-ion flux. These ions move back into the SR during diastole through the SERCA pump and SR K+ and Cl- channels. In homeostasis, all i...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2016.10.018

    authors： Berti C,Zsolnay V,Shannon TR,Fill M,Gillespie D

    更新日期：2017-02-01 00:00:00

  • Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes.

    abstract：:Intracellular Na(+)accumulation and K(+)loss play important roles in the pathogenesis of arrhythmias and injury in the ischemic heart. We investigated the role of metabolically sensitive connexin hemichannels as a potential route for Na(+)influx and K(+)efflux during ischemia, using dye uptake and electrophysiological...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2000.1220

    authors： Kondo RP,Wang SY,John SA,Weiss JN,Goldhaber JI

    更新日期：2000-10-01 00:00:00