May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for?

abstract：:Heat shock protein 70 (HSP70) has been shown to play a fundamental role in the induction of thermotolerance in many biological systems. Elevated synthesis of HSP70 in response to diverse stresses such as heat, anoxia, ischaemia, ethanol and heavy metals has been correlated with protection against subsequent more sever...

journal_title：Journal of molecular and cellular cardiology

authors： Heads RJ,Latchman DS,Yellon DM

更新日期：1994-06-01 00:00:00

abstract：:The metabolism of pantothenic acid (Pa) by cardiac muscle was studied in normal and diabetic rats. Tissue levels of Coenzyme A (CoA) are elevated in the heart during early (6 to 12 h) diabetes, remains at a high level for several days, and then returns to normal or below normal levels. The increase in total tissue CoA...

journal_title：Journal of molecular and cellular cardiology

authors： Beinlich CJ,Robishaw JD,Neely JR

更新日期：1989-07-01 00:00:00

abstract：:Cardiac myocytes have a high affinity. Mg(2+)-dependent, electrogenic, Na-inositol co-transporter on the plasma or sarcolemma (SL) membrane (Rubin and Hale, 1993). The ion specificity and stoichiometry of this transport process is unknown. Using bovine cardiac SL vesicles, we have determined that transmembrane movemen...

journal_title：Journal of molecular and cellular cardiology

authors： Hale CC,Rubin LJ

更新日期：1995-05-01 00:00:00

abstract：:Free radicals and lipid peroxides have recently been identified by us [1, 2, 3] as metabolic intermediates during acute myocardial ischemia. The mechanisms by which evolving myocardial ischemia initiates free radical production are not clear. Based on studies in vitro, it is feasible to consider the following possibil...

journal_title：Journal of molecular and cellular cardiology

authors： Rao PS,Cohen MV,Mueller HS

更新日期：1983-10-01 00:00:00

abstract：:Following diazoxide (DZ) induced hypoinsulinemia, cardiac luminal lipoprotein lipase (LPL) increases [Cardiovasc. Res. 3 (2003) 788]. To identify circulating mediators that maintain high LPL in vivo, DZ hearts were perfused for 1 h in the presence or absence of glucose, triglyceride (TG), palmitic acid or palmitoyl ly...

journal_title：Journal of molecular and cellular cardiology

authors： Pulinilkunnil T,An D,Yip P,Chan N,Qi D,Ghosh S,Abrahani A,Rodrigues B

更新日期：2004-11-01 00:00:00

abstract：:Hypertrophic cardiomyopathy occurs in two variants, either as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. Different genes coding sarcomeric proteins of the heart have been identified as causing hypertrophic cardiomyopathy. Missense mutations in the cardiac beta-myosin...

journal_title：Journal of molecular and cellular cardiology

authors： Greber-Platzer S,Marx M,Fleischmann C,Suppan C,Dobner M,Wimmer M

更新日期：2001-01-01 00:00:00

abstract：:To test a prediction that trans-sarcolemmal lactate movement is carrier mediated, 14C-labelled lactate or pyruvate and 3H-mannitol were transiently infused (2 min) into aerobically perfused rat hearts that had been depleted of intracellular monocarboxylates by a 30 min pre-perfusion in the absence of substrates. Uptak...

journal_title：Journal of molecular and cellular cardiology

authors： Dennis SC,Kohn MC,Anderson GJ,Garfinkel D

更新日期：1985-10-01 00:00:00

abstract：:The aim of this study was to examine whether short- and long-term gene transfer of Ca(2+) handling proteins restore left ventricular (LV) mechanoenergetics in aortic banding-induced failing hearts. Aortic-banded rats received recombinant adenoviruses carrying sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) (Banding+SER...

journal_title：Journal of molecular and cellular cardiology

authors： Sakata S,Lebeche D,Sakata N,Sakata Y,Chemaly ER,Liang LF,Tsuji T,Takewa Y,del Monte F,Peluso R,Zsebo K,Jeong D,Park WJ,Kawase Y,Hajjar RJ

更新日期：2007-04-01 00:00:00

abstract：:The adult newt cardiac ventricular myocyte has been successfully placed in cell culture and has been shown to undergo in vitro DNA synthesis. Although several growth factors have been reported to increase DNA synthesis in cardiac myocytes in vitro, PDGF has not been reported to do so, but has been shown to be active i...

journal_title：Journal of molecular and cellular cardiology

authors： Soonpaa MH,Oberpriller JO,Oberpriller JC

更新日期：1992-09-01 00:00:00

abstract：:With electrophysiological methods, mechanisms of the restorative action of coenzyme Q10 (CoQ10) in 2,4-dinitrophenol-depressed electrical and mechanical activities of isolated guinea-pig hearts were studied. Isoproterenol (3 X 10(-8) M)-induced action potential and contraction of the heart in 27 mM KCl Tyrode solution...

journal_title：Journal of molecular and cellular cardiology

authors： Furukawa K,Yamasaki Y,Kizu A,Furukawa K,Katsume H,Ijichi H,Kitamura K

更新日期：1983-09-01 00:00:00

abstract：:Although 17beta-estradiol (E2) administration following trauma-hemorrhage (T-H) improves cardiac function in male rodents, it is not known whether the salutary effects of E2 are mediated via estrogen receptor (ER)-alpha or ER-beta, and whether cardiac heat shock proteins (Hsp) are affected by E2 administration. Male S...

journal_title：Journal of molecular and cellular cardiology

authors： Yu HP,Shimizu T,Choudhry MA,Hsieh YC,Suzuki T,Bland KI,Chaudry IH

更新日期：2006-01-01 00:00:00

abstract：:To establish new treatment for cardiovascular disease, the development of safe and highly efficient vectors is necessary. Especially, non-viral vectors are considered to be ideal for human gene therapy, since recent adverse events with retroviral or adenoviral vectors have highlighted the issue of safety. Although we ...

journal_title：Journal of molecular and cellular cardiology

authors： Tashiro H,Aoki M,Isobe M,Hashiya N,Makino H,Kaneda Y,Ogihara T,Morishita R

更新日期：2005-09-01 00:00:00

abstract：:Small antisense RNAs like miRNA and siRNA are of crucial importance in cardiac physiology, pathology and, moreover, can be applied as therapeutic agents for the treatment of cardiovascular diseases. Identification of novel strategies for miRNA/siRNA therapy requires a comprehensive understanding of the underlying mech...

journal_title：Journal of molecular and cellular cardiology

authors： Lemcke H,Peukert J,Voronina N,Skorska A,Steinhoff G,David R

更新日期：2016-09-01 00:00:00

abstract：:Selective pharmacological treatments targeting reperfusion injury produced modest protective effects and might be associated with immunosuppression. In order to identify novel and better-tolerated approaches, we focused on the neutralization of receptor activator of nuclear factor kappa-B ligand [RANKL], a cytokine re...

journal_title：Journal of molecular and cellular cardiology

authors： Carbone F,Crowe LA,Roth A,Burger F,Lenglet S,Braunersreuther V,Brandt KJ,Quercioli A,Mach F,Vallée JP,Montecucco F

更新日期：2016-05-01 00:00:00

abstract：:The heart responds to increased haemodynamic load with growth of the ventricles. The rise in ventricle mass is due to increasing mass of the myocytes and proliferation of fibroblasts and smooth muscle cells. The accompanying adaptation and remodelling of the interstitium, e.g. production and composition of the extrace...

journal_title：Journal of molecular and cellular cardiology

authors： Simm A,Nestler M,Hoppe V

更新日期：1997-01-01 00:00:00

abstract：:We studied the oxygen diffusion distance in the rabbit myocardium in untreated animals and in animals treated with thyroxine (T4) for 3 days and 16 days. The subepicardial and subendocardial regions were studied separately. Sixteen days of T4 treatment results in significant cardiac hypertrophy. After 16 days, the per...

journal_title：Journal of molecular and cellular cardiology

authors： Seiden D,Navidad P,Weiss HR

更新日期：1988-10-01 00:00:00

abstract：:Acquired cardiovascular diseases such as coronary heart disease, peripheral artery disease and related vascular problems contribute to more than one-third of worldwide morbidity and mortality. In many instances, particularly in the under developed world, cardiovascular diseases are diagnosed at a late stage limiting t...

journal_title：Journal of molecular and cellular cardiology

authors： Emeto TI,Moxon JV,Rush C,Woodward L,Golledge J

更新日期：2011-09-01 00:00:00

abstract：:Carnitine, certain of its derivatives, and the amino acid metabolite, taurine, when administered independently in prior studies have been shown to improve cardiac mechanic and/or metabolism. The purpose of these studies is to test a new compound, propionylcarnitine taurine (PCT), which potentially combines these actio...

journal_title：Journal of molecular and cellular cardiology

authors： Molaparast-Saless F,Nellis SH,Liedkte AJ

更新日期：1988-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV, lentivirus) type-1 based vectors have a number of attractive features for gene therapy, including the ability to transduce non-dividing cells and long term transgene expression. We used a three-plasmid expression system to generate pseudotyped lentivirus-based vectors by transient tr...

journal_title：Journal of molecular and cellular cardiology

authors： Sakoda T,Kasahara N,Hamamori Y,Kedes L

更新日期：1999-11-01 00:00:00

abstract：:The resting potential of "sodium-loaded' cardiac cells can transiently hyperpolarize to levels negative to the steady state resting potential [3,5,6]. Hyperpolarization is associated with the coupled efflux of Na+ and influx of K+ driven by an active transport process and may result from an increased K+ equilibrium po...

journal_title：Journal of molecular and cellular cardiology

authors： Rasmussen HH,TenEick RE,McCullough JR,Singer DH

更新日期：1984-08-01 00:00:00

abstract：:Neural structures have been shown to be present in valve cusp tissue. We aimed to characterise the influence of neuronal stimulation on the component structures of the aortic root and cusps. Specimens of sinus, sinotubular junction (STJ), annulus and cusp tissue were dissected from porcine aortic roots and either stim...

journal_title：Journal of molecular and cellular cardiology

authors： Chester AH,Kershaw JD,Sarathchandra P,Yacoub MH

更新日期：2008-06-01 00:00:00

abstract：:Echocardiographic dimensions and endocrinological examination were performed in 71 young patients with borderline hypertension (BHT) and 31 age-matched normotensive subjects (NT). Patients with BHT had significantly higher relative wall thickness (RWT) and left ventricular mass index than NT, although all BHT patients...

journal_title：Journal of molecular and cellular cardiology

authors： Fujita T,Noda H,Ito Y,Isaka M,Sato Y,Ogata E

更新日期：1989-12-01 00:00:00

abstract：:Beta-adrenergic receptor kinase 1 (beta ARK1) participates in the desensitization of beta-adrenergic receptors by uncoupling the signal transduction. The present study was designed to examine whether neurohumoral increase is crucial for the activation of beta ARK1 in heart failure. Four weeks after the ligation of rat...

journal_title：Journal of molecular and cellular cardiology

authors： Ishigai Y,Mori T,Moriyama S,Shibano T

更新日期：1999-06-01 00:00:00

abstract：:Myocardial protection during open heart surgery is achieved by general cooling and cold cardioplegia. However sympathetic activation during the operation causes raised circulating catecholamine levels that might negatively influence the myocardial metabolism. Moreover, local liberation of catecholamines, in "poorly pe...

journal_title：Journal of molecular and cellular cardiology

authors： Berggren H,Ekroth R,Hjalmarson A,Holm S,William-Olsson G,Waldenström A

更新日期：1983-04-01 00:00:00

abstract：:(±)-Sodium5-bromo-2-(α-hydroxypentyl) benzoate (brand name: brozopine, BZP, 1a), derived from L-3-n-butylphthalide (L-NBP), has been reported to protect the brain from stoke and has been approved by CFDA in Phase I-II clinical trials. However, it remains to be investigated whether 1a may exhibit any cardioprotective e...

journal_title：Journal of molecular and cellular cardiology

authors： Xiao Y,Song C,Lin Q,Shi X,Yu W,Huang X,Wang H,Chen Y,Wang R,Geng X,Qin M,Hu K,Fan Y,Qiao Y,Gao E,Zhao W,Chang J

更新日期：2019-10-01 00:00:00

abstract：:Coronary blood flow is tightly adjusted to the oxygen requirements of the myocardium. The underlying control mechanisms keep coronary venous pO(2) at a rather constant level around 20mm Hg under a variety of physiological conditions. Because coronary flow may increase more than 5-fold during exercise without any signs...

journal_title：Journal of molecular and cellular cardiology

authors： Deussen A,Ohanyan V,Jannasch A,Yin L,Chilian W

更新日期：2012-04-01 00:00:00

abstract：:Apoptosis is a potentially important myocardial response to pathology including ischemia and reperfusion. Na-H exchange (NHE) represents an important mechanism for mediating such injury. The present study was done to determine if NHE inhibition can affect early apoptosis in an acute model of ischemia and reperfusion. ...

journal_title：Journal of molecular and cellular cardiology

authors： Chakrabarti S,Hoque AN,Karmazyn M

更新日期：1997-11-01 00:00:00

abstract：:To determine the regulatory role of prolyl hydroxylation in intracellular cardiac procollagen turnover, we examined the effects of prolyl 4-hydroxylase inhibitors (alpha, alpha-dipyridil, 3,4-dihydroxybenzoic acid ethyl ester, pyridine 2,4-dicarboxylic acid ethyl ester) and ascorbic acid on procollagen metabolism by c...

journal_title：Journal of molecular and cellular cardiology

authors： Eleftheriades EG,Ferguson AG,Spragia ML,Samarel AM

更新日期：1995-08-01 00:00:00

abstract：:Using the ultrastructural criteria established by Schaper et al. 1979 [27] for distinguishing between different degrees of ischemic change in dog myocardium, slight ischemic changes are observed in the pig suboendocardium as early as 1 min after occlusion of the LAD artery. Moderate change throughout the thickness of ...

journal_title：Journal of molecular and cellular cardiology

authors： Taylor IM,Shaikh NA,Downar E

更新日期：1984-01-01 00:00:00

abstract：:Frequency-dependent acceleration of relaxation (FDAR) is an important intrinsic mechanism that allows for diastolic filling of the ventricle at higher heart rates, yet its molecular mechanism is still not understood. Previous studies showed that FDAR is dependent on functional sarcoplasmic reticulum (SR) and can be ab...

journal_title：Journal of molecular and cellular cardiology

authors： Huke S,Bers DM

更新日期：2007-03-01 00:00:00