当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Differential expression of heat shock proteins in normal and failing human hearts.

Differential expression of heat shock proteins in normal and failing human hearts.

Abstract：

BACKGROUND:Heat shock proteins (hsp) constitute an endogenous stress response that protects cells from injury. Most work on these important proteins has focused on the immediate response to acute stress in cell culture systems and mammalian models of heart disease. Little is known about the expression of the hsps in human hearts. We were interested in whether there was increased expression of the hsps in heart failure, a setting of chronic, sustained stress. Five different hsps were examined: hsp27, hsp60, hsp72, hsc70 and hsp90. METHODS AND RESULTS:Three groups of explanted hearts were studied: dilated cardiomyopathy (DCM), ischemic cardiomyopathy (IHD), and normal controls. Western-blotting with a standard curve of purified protein on each blot was used to quantify the expression of the hsps. Hsp27 was increased almost two-fold in DCM compared to normal hearts, and was significantly greater than in IHD hearts. Levels of hsp60 were doubled in both DCM and IHD hearts (P < 0.05). Hsp72, hsc70 and hsp90 were not significantly changed. CONCLUSIONS:This study shows for the first time that differential changes in hsp levels occur in end-stage heart failure. Since hsps can render cells resistant to apoptosis, and are associated with the mitochondria and the cytoskeleton, which are known to be abnormal in heart failure, these studies may lead to new insights into the pathogenesis of cardiac decompensation.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Knowlton AA,Kapadia S,Torre-Amione G,Durand JB,Bies R,Young J,Mann DL

doi

10.1006/jmcc.1998.0646

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

811-8

issue

4

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(98)90646-0

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • Skeletal muscle metabolism in experimental heart failure.

    abstract：:We studied peripheral skeletal muscle metabolism in monocrotaline-treated rats. Two distinct groups emerged: a percentage of the animals developed ventricular hypertrophy, with no signs of heart failure (compensated group), whilst others, besides ventricular hypertrophy, developed the syndrome of congestive heart fail...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0219

    authors： Bernocchi P,Ceconi C,Pedersini P,Pasini E,Curello S,Ferrari R

    更新日期：1996-11-01 00:00:00

  • Captopril treatment improves the sarcoplasmic reticular Ca(2+) transport in heart failure due to myocardial infarction.

    abstract：:Although captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been shown to exert a beneficial effect on cardiac function in heart failure, its effect on the status of sarcoplasmic reticulum (SR) Ca(2+) transport in the failing heart has not been examined previously. In order to determine whether captopril...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.1000

    authors： Shao Q,Ren B,Zarain-Herzberg A,Ganguly PK,Dhalla NS

    更新日期：1999-09-01 00:00:00

  • Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel.

    abstract：:Activation of adenosine A(3) receptor (A(3)AR) protects against ischemia/reperfusion injury in the heart. However, the downstream signaling mechanisms leading to its delayed anti-ischemic effects remain unclear. We hypothesized that A(3)AR stimulation protects the heart via activation of nuclear transcription factor k...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2001.1510

    authors： Zhao TC,Kukreja RC

    更新日期：2002-03-01 00:00:00

  • Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.

    abstract：:We have previously proposed that the heterogeneous collapse of mitochondrial inner membrane potential (DeltaPsi(m)) during ischemia and reperfusion contributes to arrhythmogenesis through the formation of metabolic sinks in the myocardium, wherein clusters of myocytes with uncoupled mitochondria and high K(ATP) curren...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2009.11.011

    authors： Brown DA,Aon MA,Frasier CR,Sloan RC,Maloney AH,Anderson EJ,O'Rourke B

    更新日期：2010-04-01 00:00:00

  • Protection of cardiomyocyte function by propofol during simulated ischemia is associated with a direct action to reduce pro-oxidant activity.

    abstract：:To demonstrate a direct protective effect of propofol on myocardial contractile performance during an ischemic episode and investigate underlying mechanisms, isolated adult rat ventricular cardiomyocytes were subjected for 2 h to (i) ischemic medium containing 2-deoxyglucose (20 mM), gassed with 100% N(2) at pH 6.4, (...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.12.002

    authors： McDermott BJ,McWilliams S,Smyth K,Kelso EJ,Spiers JP,Zhao Y,Bell D,Mirakhur RK

    更新日期：2007-03-01 00:00:00

  • Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction.

    abstract：AIMS:One unaddressed aspect of healing after myocardial infarction (MI) is how non-myocyte cells that survived the ischemic injury, keep withstanding additional cellular damage by stress forms typically arising during the post-infarction inflammation. Here we aimed to determine if cell survival is conferred by expressi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2020.10.013

    authors： Razin T,Melamed-Book N,Argaman J,Galin I,Lowy Y,Anuka E,Naftali-Shani N,Kandel-Kfir M,Garfinkel BP,Brielle S,Granot Z,Apte RN,Conway SJ,Molkentin JD,Kamari Y,Leor J,Orly J

    更新日期：2020-10-30 00:00:00

  • Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart.

    abstract：:Short duration exposure to cellular stresses have been shown to activate p38 mitogen-activated protein kinase (MAPK) in cultured rat ventricular cardiomyocytes and isolated perfused hearts; however, effects of chronic stress on p38 MAPK are not well understood. This study determined whether alterations in the p38 MAPK...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2001.1415

    authors： Lemke LE,Bloem LJ,Fouts R,Esterman M,Sandusky G,Vlahos CJ

    更新日期：2001-08-01 00:00:00

  • Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors.

    abstract：:Autophagy is a process that removes damaged proteins and organelles and is of particular importance in terminally differentiated cells such as cardiomyocytes, where it has primarily a protective role. We investigated the involvement of inositol(1,4,5)trisphosphate (Ins(1,4,5)P(3)) and its receptors in autophagic respo...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.10.014

    authors： Wong A,Grubb DR,Cooley N,Luo J,Woodcock EA

    更新日期：2013-01-01 00:00:00

  • Distribution of the neuropeptide galanin in the cat heart and coexistence with vasoactive intestinal peptide, substance P and neuropeptide Y.

    abstract：:The neuropeptide galanin (GAL) has been detected in the peripheral and central nervous systems. However, little is known about its distribution and localization in heart, and the possible coexistence of GAL with other neuropeptides in the heart is not established. The present immunocytochemical study describes the dis...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)91157-z

    authors： Zhu W,Dey RD

    更新日期：1992-01-01 00:00:00

  • Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes.

    abstract：:K. Suzuki, S. Kostin, V. Person, A. Elsässer and J. Schaper. Time Course of the Apoptotic Cascade and Effects of Caspase Inhibitors in Adult Rat Ventricular Cardiomyocytes. Journal of Molecular and Cellular Cardiology (2001) 33, 983-994. Interpretation of the rate of apoptosis in diseased hearts is hampered by the fac...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2001.1364

    authors： Suzuki K,Kostin S,Person V,Elsässer A,Schaper J

    更新日期：2001-05-01 00:00:00

  • Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain.

    abstract：:Cardiac myosin binding protein-C (cMyBP-C) has 11 immunoglobulin or fibronectin-like domains, C0 through C10, which bind sarcomeric proteins, including titin, myosin and actin. Using bacterial expressed mouse N-terminal fragments (C0 through C3) in an in vitro motility assay of myosin-generated actin movement and the ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.09.019

    authors： Weith A,Sadayappan S,Gulick J,Previs MJ,Vanburen P,Robbins J,Warshaw DM

    更新日期：2012-01-01 00:00:00

  • The effect of linoleic and arachidonic acid derivatives on calcium transport in vesicles from cardiac sarcoplasmic reticulum.

    abstract：:The effect of linoleic and arachidonic acid derivatives on ATP-dependent calcium transport was studied in the isolated vesicles from cardiac sarcoplasmic reticulum of guinea-pigs. Oxidation products of linoleic and arachidonic acids, obtained either by autoxidation or incubation with soybean lipoxygenase, effectively ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(88)80025-7

    authors： Kim RS,LaBella FS

    更新日期：1988-02-01 00:00:00

  • Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity.

    abstract：:We measured myosin crossbridge detachment rate and the rates of MgADP release and MgATP binding in mouse and rat myocardial strips bearing one of the two cardiac myosin heavy chain (MyHC) isoforms. Mice and rats were fed an iodine-deficient, propylthiouracil diet resulting in ~100% expression of β-MyHC in the ventricl...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.10.010

    authors： Wang Y,Tanner BC,Lombardo AT,Tremble SM,Maughan DW,Vanburen P,Lewinter MM,Robbins J,Palmer BM

    更新日期：2013-01-01 00:00:00

  • Diabetes and susceptibility to reperfusion-induced ventricular arrhythmias.

    abstract：:Studies using chemically-induced models of diabetes have shown the diabetic myocardium to exhibit abnormalities in cellular ion transport, which may affect susceptibility to reperfusion-induced arrhythmias. We studied the incidence of reperfusion-induced ventricular tachycardia (VT) and fibrillation (VF) in isolated h...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)93195-p

    authors： Kusama Y,Hearse DJ,Avkiran M

    更新日期：1992-04-01 00:00:00

  • Structural vs. contractile protein remodeling and myocardial stiffness in hypertrophied rat left ventricle.

    abstract：:Left ventricular pressure overload will result in the hypertrophic growth of the myocardium and in the rat may include a remodeling of both the structural and contractile proteins. As a result, an adaptive rise in active stiffness, or the force generating capacity of the myocardium, may occur. The relative importance ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(88)90597-4

    authors： Jalil JE,Doering CW,Janicki JS,Pick R,Clark WA,Abrahams C,Weber KT

    更新日期：1988-12-01 00:00:00

  • Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension.

    abstract：:Titin is a very large alternatively spliced protein that performs multiple functions in heart and skeletal muscles. A rat strain is described with an autosomal dominant mutation that alters the isoform expression of titin. While wild type animals go through a developmental program where the 3.0 MDa N2B becomes the maj...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2008.02.272

    authors： Greaser ML,Warren CM,Esbona K,Guo W,Duan Y,Parrish AM,Krzesinski PR,Norman HS,Dunning S,Fitzsimons DP,Moss RL

    更新日期：2008-06-01 00:00:00

  • Phenylephrine preconditioning involves modulation of cardiac sarcolemmal K(ATP) current by PKC delta, AMPK and p38 MAPK.

    abstract：:Preconditioning of hearts with the α(1)-adrenoceptor agonist phenylephrine decreases infarct size and increases the functional recovery of the heart following ischaemia-reperfusion. However, the cellular mechanisms responsible for this protection are not known. We investigated the role of protein kinase C ε and δ (PKC...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.06.015

    authors： Turrell HE,Rodrigo GC,Norman RI,Dickens M,Standen NB

    更新日期：2011-09-01 00:00:00

  • Skeletal muscle stem cells propagated as myospheres display electrophysiological properties modulated by culture conditions.

    abstract：:In cardiac regenerative therapy, transplantation of stem cells to form new myocardium is limited by their inability to integrate into host myocardium and conduct cardiac electrical activity. It is now hypothesized that refining cell sorting could upgrade the therapeutic result. Here we characterized a subpopulation of...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2010.10.011

    authors： Poulet C,Wettwer E,Christ T,Ravens U

    更新日期：2011-02-01 00:00:00

  • Increased sympathoadrenomedullary activity and left ventricular hypertrophy in young patients with borderline hypertension.

    abstract：:Echocardiographic dimensions and endocrinological examination were performed in 71 young patients with borderline hypertension (BHT) and 31 age-matched normotensive subjects (NT). Patients with BHT had significantly higher relative wall thickness (RWT) and left ventricular mass index than NT, although all BHT patients...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(89)90769-4

    authors： Fujita T,Noda H,Ito Y,Isaka M,Sato Y,Ogata E

    更新日期：1989-12-01 00:00:00

  • Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.

    abstract：:Rapamycin (Sirolimus®) is used to prevent rejection of transplanted organs and coronary restenosis. We reported that rapamycin induced cardioprotection against ischemia-reperfusion (I/R) injury through opening of mitochondrial K(ATP) channels. However, signaling mechanisms in rapamycin-induced cardioprotection are cur...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.09.007

    authors： Das A,Salloum FN,Durrant D,Ockaili R,Kukreja RC

    更新日期：2012-12-01 00:00:00

  • Gene therapy for ischemic heart disease.

    abstract：:Current pharmacologic therapy for ischemic heart disease suffers multiple limitations such as compliance issues and side effects of medications. Revascularization procedures often end with need for repeat procedures. Patients remain symptomatic despite maximal medical therapy. Gene therapy offers an attractive alterna...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2010.06.007

    authors： Lavu M,Gundewar S,Lefer DJ

    更新日期：2011-05-01 00:00:00

  • LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy.

    abstract：AIMS:LCZ696, a novel angiotensin receptor neprilysin inhibitor, is effective in treating heart failure patients. Doxorubicin (DOX) is an effective antitumor medication but the cardiotoxicity limited its clinical use. In this study, we aimed to determine the effect of LCZ696 on DOX-induced cardiomyopathy in mice and in ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2017.06.003

    authors： Xia Y,Chen Z,Chen A,Fu M,Dong Z,Hu K,Yang X,Zou Y,Sun A,Qian J,Ge J

    更新日期：2017-07-01 00:00:00

  • Two potentially arrhythmogenic mechanisms of adrenaline action in cardiac muscle.

    abstract：:The effects of rate changes and 'premature' stimulation on the slow inward current of cardiac muscle were studied in the frog atrium. The effects of adrenaline under these conditions was investigated. It was found that adrenaline markedly accelerates the repriming kinetics of the slow inward channel. Adrenaline at low...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(84)80618-5

    authors： Shimoni Y,Raz S,Gotsman MS

    更新日期：1984-05-01 00:00:00

  • Shifts in the myosin heavy chain isozymes in the mouse heart result in increased energy efficiency.

    abstract：:Cardiac-specific transgenesis in the mouse is widely used to study the basic biology and chemistry of the heart and to model human cardiovascular disease. A fundamental difference between mouse and human hearts is the background motor protein: mouse hearts contain predominantly the alphaalpha-myosin heavy chain (MyHC)...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.08.116

    authors： Hoyer K,Krenz M,Robbins J,Ingwall JS

    更新日期：2007-01-01 00:00:00

  • Intracardiac administration of neutrophil protease cathepsin G activates noncanonical inflammasome pathway and promotes inflammation and pathological remodeling in non-injured heart.

    abstract：BACKGROUND:Inflammatory serine proteases (ISPs) play an important role in cardiac repair after injury through hydrolysis of dead cells and extracellular matrix (ECM) debris. Evidence also suggests an important role of ISPs in the coordination of the inflammatory response. However, the effect of ISPs on inflammation is ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2019.06.016

    authors： Miller SA,Kolpakov MA,Guo X,Du B,Nguyen Y,Wang T,Powel P,Dell'Italia LJ,Sabri A

    更新日期：2019-09-01 00:00:00

  • Cardiac-specific overexpression of Galphaq alters excitation-contraction coupling in isolated cardiac myocytes.

    abstract：:Transgenic mice with cardiac-specific overexpression of G alpha q exhibit a biochemical and physiological phenotype of load-independent cardiac hypertrophy with contractile dysfunction. To elucidate the cellular basis for altered contractility, we measured cellular contraction, Ca(2+)transients, and l -type Ca(2+)chan...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.0966

    authors： Yatani A,Frank K,Sako H,Kranias EG,Dorn GW 2nd

    更新日期：1999-07-01 00:00:00

  • What is the mitochondrial permeability transition pore?

    abstract：:Under conditions of mitochondrial calcium overload, especially when accompanied by oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a non-specific pore, the mitochondrial permeability transition pore (MPTP), opens in the inner mitochondrial membrane. MPTP opening enables free passa...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2009.02.021

    authors： Halestrap AP

    更新日期：2009-06-01 00:00:00

  • Contractile function of cardiomyocytes from the spontaneously hypertensive rat.

    abstract：:In essential hypertension it has been hypothesized that there is a generalized derangement in cellular Ca2+ homeostasis. The aim of this study was to assess whether there is functional evidence for increased vulnerability to Ca overload in cardiomyocytes derived from age-matched (11-week) normotensive Wistar-Kyoto (WK...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0067

    authors： Delbridge LM,Connell PJ,Morgan TO,Harris PJ

    更新日期：1996-04-01 00:00:00

  • Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor.

    abstract：:Nkx2.5 and serum response factor (SRF) are critically important transcription factors in cardiac morphogenesis. They are also widely expressed in adult cardiomyocytes, but there is little data to indicate their possible role in adult cardiac cells. In this paper we demonstrate that the interaction of Nkx2.5 and SRF in...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2002.2019

    authors： Müller JG,Thompson JT,Edmonson AM,Rackley MS,Kasahara H,Izumo S,McQuinn TC,Menick DR,O'Brien TX

    更新日期：2002-07-01 00:00:00

  • Palmitoyl lysophosphatidylcholine mediated mobilization of LPL to the coronary luminal surface requires PKC activation.

    abstract：:Following diazoxide (DZ) induced hypoinsulinemia, cardiac luminal lipoprotein lipase (LPL) increases [Cardiovasc. Res. 3 (2003) 788]. To identify circulating mediators that maintain high LPL in vivo, DZ hearts were perfused for 1 h in the presence or absence of glucose, triglyceride (TG), palmitic acid or palmitoyl ly...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2004.07.003

    authors： Pulinilkunnil T,An D,Yip P,Chan N,Qi D,Ghosh S,Abrahani A,Rodrigues B

    更新日期：2004-11-01 00:00:00