Mitochondrial reactive oxygen species production and elimination.

Abstract:

:Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one important source for ROS are mitochondria. Emission of ROS from mitochondria is the net result of ROS production at the electron transport chain (ETC) and their elimination by antioxidative enzymes. Both of these processes are highly dependent on the mitochondrial redox state, which is dynamically altered under different physiological and pathological conditions. The concept of "redox-optimized ROS balance" integrates these aspects and implies that oxidative stress occurs when the optimal equilibrium of an intermediate redox state is disturbed towards either strong oxidation or reduction. Furthermore, mitochondria integrate ROS signals from other cellular sources, presumably through a process termed "ROS-induced ROS release" that involves mitochondrial ion channels. Here, we attempt to integrate these recent advances in our understanding of the control of mitochondrial ROS emission and develop a concept of how in heart failure, defects in ion handling can lead to mitochondrial oxidative stress. This article is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".

journal_name

J Mol Cell Cardiol

authors

Nickel A,Kohlhaas M,Maack C

doi

10.1016/j.yjmcc.2014.03.011

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

26-33

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(14)00088-1

journal_volume

73

pub_type

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