Histochemical alterations of acute and chronic doxorubicin cardiotoxicity.

abstract：:Recent data indicates that DJ-1 plays a role in the cellular response to stress. Here, we aimed to examine the underlying molecular mechanisms mediating the actions of DJ-1 in the heart following myocardial ischemia-reperfusion (I/R) injury. In response to I/R injury, DJ-1 KO mice displayed increased areas of infarcti...

journal_title：Journal of molecular and cellular cardiology

authors： Shimizu Y,Lambert JP,Nicholson CK,Kim JJ,Wolfson DW,Cho HC,Husain A,Naqvi N,Chin LS,Li L,Calvert JW

更新日期：2016-08-01 00:00:00

abstract：:This study describes the effect of oxygen radicals on the ultrastructure of the isolated Langendorff-perfused rat heart. Oxygen radicals were enzymatically generated by xanthine oxidase (0.025 U/ml) and hypoxanthine (0.96 mM). Hearts were perfusion-fixed for electron microscopy and stereological technique was performe...

journal_title：Journal of molecular and cellular cardiology

authors： Ytrehus K,Myklebust R,Olsen R,Mjøs OD

更新日期：1987-04-01 00:00:00

abstract：:The possible involvement of protein kinase C in modulating membrane currents was investigated in isolated guinea-pig ventricular cells. In a Na(+)-and K(+)-free external solution, the delayed rectifier K+ current (IK) was increased by the activator of protein kinase C (PKC), 12-O-tetradecanoylphorbol-13-acetate (TPA)....

journal_title：Journal of molecular and cellular cardiology

authors： Tohse N,Kameyama M,Sekiguchi K,Shearman MS,Kanno M

更新日期：1990-06-01 00:00:00

abstract：:Application of ultrasound-mediated destruction of microbubbles (US + Bubble) to skeletal muscle creates capillary ruptures leading to leakage of the cell components. We studied whether US + Bubble combined with bone-marrow-derived mononuclear cells (BM-MNCs) infusion enables the targeted delivery of endothelial-lineag...

journal_title：Journal of molecular and cellular cardiology

authors： Zen K,Okigaki M,Hosokawa Y,Adachi Y,Nozawa Y,Takamiya M,Tatsumi T,Urao N,Tateishi K,Takahashi T,Matsubara H

更新日期：2006-06-01 00:00:00

abstract：:With electrophysiological methods, mechanisms of the restorative action of coenzyme Q10 (CoQ10) in 2,4-dinitrophenol-depressed electrical and mechanical activities of isolated guinea-pig hearts were studied. Isoproterenol (3 X 10(-8) M)-induced action potential and contraction of the heart in 27 mM KCl Tyrode solution...

journal_title：Journal of molecular and cellular cardiology

authors： Furukawa K,Yamasaki Y,Kizu A,Furukawa K,Katsume H,Ijichi H,Kitamura K

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Dilated cardiomyopathy (DCM) could be caused by mutations in more than 40 different genes. However, the pathogenic impact of specific mutations is in most cases unknown complicating the genetic counseling of affected families. Therefore, functional studies could contribute to distinguish pathogenic mutations...

journal_title：Journal of molecular and cellular cardiology

authors： Brodehl A,Dieding M,Biere N,Unger A,Klauke B,Walhorn V,Gummert J,Schulz U,Linke WA,Gerull B,Vorgert M,Anselmetti D,Milting H

更新日期：2016-02-01 00:00:00

abstract：:In single guinea pig ventricular cells, genistein, a potent inhibitor of protein tyrosine kinase (PTK), was found to suppress the delayed-rectifier K (IK) current. The present study was carried out to examine the underlying mechanism. Ventricular myocytes were voltage-clamped in the conventional whole-cell mode (36 de...

journal_title：Journal of molecular and cellular cardiology

authors： Washizuka T,Horie M,Obayashi K,Sasayama S

更新日期：1998-12-01 00:00:00

abstract：:The volume of blood in the left ventricular wall increases as coronary perfusion pressure or coronary blood flow increase, but it is unclear whether such an increase in volume can acutely alter the diastolic pressure-dimension relationship of the intact, working left ventricle. In 19 dogs, we measured left ventricular...

journal_title：Journal of molecular and cellular cardiology

authors： Verrier ED,Bristow JD,Hoffman JI

更新日期：1986-06-01 00:00:00

abstract：:Elevation of intracellular cAMP concentration has numerous vascular protective effects that are in part mediated via actin cytoskeleton-remodelling and subsequent regulation of gene expression. However, the mechanisms are incompletely understood. Here we investigated whether cAMP-induced actin-cytoskeleton remodelling...

journal_title：Journal of molecular and cellular cardiology

authors： Duggirala A,Kimura TE,Sala-Newby GB,Johnson JL,Wu YJ,Newby AC,Bond M

更新日期：2015-02-01 00:00:00

abstract：:We made novel measurements of the influence of rest intervals and stimulation frequency on twitch contractions and on sarcoplasmic reticulum (SR) Ca(2+)-content (using rapid cooling contractures, RCCs) in isolated ventricular muscle strips from rat and rabbit hearts at a physiological temperature of 37 degrees C. In a...

journal_title：Journal of molecular and cellular cardiology

authors： Maier LS,Bers DM,Pieske B

更新日期：2000-12-01 00:00:00

abstract：:Vascular tone is regulated by a variety of neurotransmitters, vasoactive hormones and autacoids, and vasoactive drugs. These actions are mediated, at least in part, by actions on the membrane ion channels, exerted either directly or indirectly. In this article, we described evidence that four different protein kinase ...

journal_title：Journal of molecular and cellular cardiology

authors： Xiong Z,Sperelakis N

更新日期：1995-01-01 00:00:00

abstract：:Mitochondrial adenine nucleotide translocase (ANT) is a specific target for the autoantibody response in idiopathic dilated cardiomyopathy (IDCM). We have undertaken an epitope analysis of ANT in IDCM by immunoblot with recombinant GST-ANT fusion proteins and with cellulose-bound decapeptides of human ANT1. Forty-five...

journal_title：Journal of molecular and cellular cardiology

authors： Manchado C,Orús J,Villarroya F,Roig E,Heras M,Giralt M,Iglesias R,Sanz G,Mampel T,Viñas O

更新日期：2002-05-01 00:00:00

abstract：:The question was investigated whether mild acidosis can provide energetic protection on the hypoxic myocardial cell by mechanisms other than negative inotropy. The experimental model used was quiescent ventricular cardiomyocytes isolated from the adult rat. The extracellular pH (pHe) in modified hypoxic Tyrode's solut...

journal_title：Journal of molecular and cellular cardiology

authors： Koop A,Piper HM

更新日期：1992-01-01 00:00:00

abstract：:Milrinone, a potent positive inotropic and vasodilating agent, has shown promise in the clinical treatment of congestive heart failure, but significant controversy about its mechanism of action exists. To approach these mechanistic problems in a non-innervated, non-diffusion-limited system, the effects of milrinone on...

journal_title：Journal of molecular and cellular cardiology

authors： Olson EM,Kim D,Smith TW,Marsh JD

更新日期：1987-01-01 00:00:00

abstract：:The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within ...

journal_title：Journal of molecular and cellular cardiology

authors： Moreau C,Prost AL,Dérand R,Vivaudou M

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Circulating monocytes play pivotal roles in chronic inflammatory diseases. Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, are known to have anti-inflammatory effects and are hydrolyzed by soluble epoxide hydrolase (sEH). OBJECTIVE:We aimed to investigate the effect of sEH inhibition in at...

journal_title：Journal of molecular and cellular cardiology

authors： Li D,Liu Y,Zhang X,Lv H,Pang W,Sun X,Gan LM,Hammock BD,Ai D,Zhu Y

更新日期：2016-09-01 00:00:00

abstract：:Hypertrophic cardiomyopathy occurs in two variants, either as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. Different genes coding sarcomeric proteins of the heart have been identified as causing hypertrophic cardiomyopathy. Missense mutations in the cardiac beta-myosin...

journal_title：Journal of molecular and cellular cardiology

authors： Greber-Platzer S,Marx M,Fleischmann C,Suppan C,Dobner M,Wimmer M

更新日期：2001-01-01 00:00:00

abstract：:The 23Na NMR shift-reagent complexes (Dy(PPP)2, Dy(TTHA), and Tm(DOTP)) bind stoichiometric amounts of Ca2+. Thus, in perfused rat heart systems, a supplementation of Ca2+ is required to maintain the requisite extracellular free calcium concentration ([Ca(o)]f) and to approximate a physiological level of contractile f...

journal_title：Journal of molecular and cellular cardiology

authors： Gaszner B,Simor T,Hild G,Elgavish GA

更新日期：2001-11-01 00:00:00

abstract：:To investigate the interaction of cytoskeleton with the receptor modulation of ionic currents, we studied the effect of muscarinic and beta-adrenergic stimulation in adult guinea-pig ventricular cardiac myocytes treated with paclitaxel and colchicine, two drugs that respectively stabilize or destabilize microtubules. ...

journal_title：Journal of molecular and cellular cardiology

authors： Malan D,Gallo MP,Bedendi I,Biasin C,Levi RC,Alloatti G

更新日期：2003-02-01 00:00:00

abstract：:Neural structures have been shown to be present in valve cusp tissue. We aimed to characterise the influence of neuronal stimulation on the component structures of the aortic root and cusps. Specimens of sinus, sinotubular junction (STJ), annulus and cusp tissue were dissected from porcine aortic roots and either stim...

journal_title：Journal of molecular and cellular cardiology

authors： Chester AH,Kershaw JD,Sarathchandra P,Yacoub MH

更新日期：2008-06-01 00:00:00

abstract：:We recently showed that angiotensin (ANG) II as well as mechanical stretch stimulated production of tumor necrosis factor (TNF) in cardiac fibroblasts. Presently, we examined the molecular mechanisms by which ANGII and lipopolysaccharide (LPS) upregulate TNF-alpha gene expression. In neonatal rat cardiac fibroblasts, ...

journal_title：Journal of molecular and cellular cardiology

authors： Sato H,Watanabe A,Tanaka T,Koitabashi N,Arai M,Kurabayashi M,Yokoyama T

更新日期：2003-10-01 00:00:00

abstract：:This study was undertaken to evaluate the direct cardioprotective effect of trimetazidine (TMZ), an anti-anginal drug devoid of haemodynamic action, on isolated myocytes. Cultured rat ventricular myocytes were treated with the drug 16 h and 1 h before the experiments. The drug-treated cells and control cells were plac...

journal_title：Journal of molecular and cellular cardiology

authors： Fantini E,Demaison L,Sentex E,Grynberg A,Athias P

更新日期：1994-08-01 00:00:00

abstract：:The Ca(2+)-independent, voltage-gated transient outward current (I(to)) displays a marked increase during development of cardiomyocytes. However, the molecular mechanism remained unclear. In rat adult ventricular myocytes, I(to) can be divided into a fast (I(to,f)) and a slow (I(to,s)) component by recovery process fr...

journal_title：Journal of molecular and cellular cardiology

authors： Kobayashi T,Yamada Y,Nagashima M,Seki S,Tsutsuura M,Ito Y,Sakuma I,Hamada H,Abe T,Tohse N

更新日期：2003-09-01 00:00:00

abstract：:Local signaling domains and numerous interacting molecular pathways and substrates contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS). We aimed to elucidate the quantitative contribution of substrates and their local signaling environments during βARS to the canine epicardial vent...

journal_title：Journal of molecular and cellular cardiology

authors： Heijman J,Volders PG,Westra RL,Rudy Y

更新日期：2011-05-01 00:00:00

abstract：:Human hearts with idiopathic dilated cardiomyopathy have diminished adenylate cyclase activity and increased amounts of the alpha-subunit of the inhibitory guanine nucleotide-binding regulatory protein (alpha Gi) as measured by pertussis toxin catalyzed ADP-ribosylation. We utilized specific antisera against synthetic...

journal_title：Journal of molecular and cellular cardiology

authors： Feldman AM,Jackson DG,Bristow MR,Cates AE,Van Dop C

更新日期：1991-04-01 00:00:00

abstract：:Using the ultrastructural criteria established by Schaper et al. 1979 [27] for distinguishing between different degrees of ischemic change in dog myocardium, slight ischemic changes are observed in the pig suboendocardium as early as 1 min after occlusion of the LAD artery. Moderate change throughout the thickness of ...

journal_title：Journal of molecular and cellular cardiology

authors： Taylor IM,Shaikh NA,Downar E

更新日期：1984-01-01 00:00:00

abstract：:Inflammatory mediators have been implicated as a cause of reversible myocardial depression in septic shock. We previously reported that the release of lysozyme-c (Lmz-S) from leukocytes from the spleen or other organs contributes to myocardial dysfunction in Escherichia coli septic shock in dogs by binding to a cardia...

journal_title：Journal of molecular and cellular cardiology

authors： Mink SN,Bose R,Roberts DE,Jacobs H,Duke K,Bose D,Cheng ZQ,Light RB

更新日期：2005-10-01 00:00:00

abstract：:Lack of endothelial nitric oxide synthase (eNOS) may affect the sensitivity of cyclic GMP signaling through soluble guanylyl cyclase (sGC). We hypothesized that in eNOS knockout (eNOS-/-) mice, stimulation of guanylyl cyclase would have enhanced effects inhibiting cardiac contraction. We measured cell shortening and c...

journal_title：Journal of molecular and cellular cardiology

authors： Su J,Tse J,Scholz PM,Weiss HR

更新日期：2005-12-01 00:00:00

abstract：:We measured mitochondrial NADH autofluorescence or Ca(2+) using Rhod-2, simultaneously with cell shortening in isolated guinea-pig ventricular myocytes. When both frequency and amplitude of twitch shortening (work intensity) were increased by raising stimulus frequency in incremental steps from 0.1 to 3.3 Hz, the stea...

journal_title：Journal of molecular and cellular cardiology

authors： Jo H,Noma A,Matsuoka S

更新日期：2006-03-01 00:00:00

abstract：:Stress-induced regulation of the 72 kD heat shock protein (HSP 72), the major stress inducible protein in mammalian cells, is mediated by the activation and binding of a heat shock transcription factor (HSF) to a specific sequence in the 5' region of the promoter termed the heat shock element (HSE). In agreement with ...

journal_title：Journal of molecular and cellular cardiology

authors： Locke M,Tanguay RM,Ianuzzo CD

更新日期：1996-03-01 00:00:00