Abstract:
OBJECTIVE:Suboptimal treatment of chemotherapy-induced nausea and vomiting and unsatisfactory response to antiemetic drugs cause impairment of cancer patient's daily functioning. This study was aimed to investigate the association of selected germline polymorphisms with ondansetron and metoclopramide response in Indonesian cancer patients treated with highly emetogenic chemotherapy. METHODS:We enrolled 202 chemotherapy naïve patients treated with cisplatin at a dosage of ≥50 mg/m(2) as monotherapy or as combined chemotherapy. Ondansetron 8 mg and dexamethasone 8 mg intravenously were the standard antiemetic therapy for prevention of acute chemotherapy-induced nausea and vomiting. Metoclopramide 10 mg orally, three times per day as fixed prescription, was given until 5 days after chemotherapy to prevent delayed chemotherapy-induced nausea and vomiting. Primary and secondary outcomes were the occurrence of chemotherapy-induced nausea and vomiting in the acute and delayed phase. The following single-nucleotide polymorphisms were determined in ABCB1: rs1045642, rs2032582 and rs1128503; in 5-HT3B-R: rs45460698, rs4938058 and rs7943062; and in CYP2D6: rs16947 (CYP2D6 2), rs3892097 (CYP2D6 4) and rs1065852 (CYP2D6 10) using Taqman assays. RESULTS:During the acute phase, 21.8 and 30.2% patients experienced Grade 3 and 4 nausea and vomiting, respectively, whereas 38.6% patients experienced nausea and/or vomiting in the delayed phase. Carriers of the CTG haplotype of the ABCB1 gene experienced Grade 3 and 4 chemotherapy-induced nausea and vomiting more often than other haplotypes in the delayed phase (P< 0.05). No associations were found with the 5-HT3B receptor haplotypes and CYP2D6-predicted phenotypes. CONCLUSIONS:Our study shows that in Indonesian cancer patients treated with highly cytostatic emetogenic, carriership of the CTG haplotype of the ABCB1 gene is related to an increased risk of delayed chemotherapy-induced nausea and vomiting.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Perwitasari DA,Wessels JA,van der Straaten RJ,Baak-Pablo RF,Mustofa M,Hakimi M,Nortier JW,Gelderblom H,Guchelaar HJdoi
10.1093/jjco/hyr117subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1168-76issue
10eissn
0368-2811issn
1465-3621pii
hyr117journal_volume
41pub_type
杂志文章abstract::Immunoperoxidase staining for human keratin proteins was performed cytologically on samples from 90 patients with malignant tumors, and histologically on samples from 164 patients with malignant tumors. At the cytological level, almost all tumor cells not only in squamous cell carcinoma but also in nonsquamous cell ca...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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abstract:OBJECTIVE:Transcatheter arterial embolization (TAE) with gelatin sponge particles and iodized oil often yields poor results when used to treat unresectable multifocal hepatocellular carcinoma (HCC). The present study retrospectively investigated the utility of a novel combination chemotherapy regimen for treating multi...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:1993-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,meta分析
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更新日期:2005-09-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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更新日期:1983-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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