Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1.

abstract：:NF-kappaB plays a central role in mediating pathogen and cytokine-stimulated gene transcription. NF-kappaB repressing factor (NRF) has been shown to interact with specific negative regulatory DNA elements (NRE) to mediate transcriptional repression by inhibition of the NF-kappaB activity at certain promoters. mRNA abl...

journal_title：Journal of cell science

authors： Niedick I,Froese N,Oumard A,Mueller PP,Nourbakhsh M,Hauser H,Köster M

更新日期：2004-07-15 00:00:00

abstract：:In situ hybridization has become a powerful technique for dissecting nuclear structure. By localizing nucleic acids with high precision, it is possible to infer the native structure of chromosomes, replication factories and transcript processing complexes. To increase the value of this technique, we have established t...

journal_title：Journal of cell science

authors： Gunawardena S,Heddle E,Rykowski MC

更新日期：1995-05-01 00:00:00

abstract：:The current paradigm of noncanonical NF-κB signaling suggests that the loss of TRAF2, TRAF3 or cIAP1 and cIAP2 leads to stabilization of NF-κB-inducing kinase (NIK) to activate the noncanonical pathway. Although a crucial role of RIP1 in the TNFα-induced canonical NF-κB pathway has been well established, its involveme...

journal_title：Journal of cell science

authors： Kim JY,Morgan M,Kim DG,Lee JY,Bai L,Lin Y,Liu ZG,Kim YS

更新日期：2011-02-15 00:00:00

abstract：:Nedd1 is a new member of the gamma-tubulin ring complex (gammaTuRC) and targets the gammaTuRC to the centrosomes for microtubule nucleation and spindle assembly in mitosis. Although its role is known, its functional regulation mechanism remains unclear. Here we report that the function of Nedd1 is regulated by Cdk1 an...

journal_title：Journal of cell science

authors： Zhang X,Chen Q,Feng J,Hou J,Yang F,Liu J,Jiang Q,Zhang C

更新日期：2009-07-01 00:00:00

abstract：:Integrin-mediated cell adhesion is central to cell survival, differentiation and motility. Many cell responses induced by integrins require both receptor occupancy and receptor aggregation, and appear to be regulated by both biochemical and biophysical means. Multidomain extracellular matrix molecules may serve to fos...

journal_title：Journal of cell science

authors： Koo LY,Irvine DJ,Mayes AM,Lauffenburger DA,Griffith LG

更新日期：2002-04-01 00:00:00

abstract：:Rat small hepatocytes have been shown to proliferate in culture and to form organoids with differentiated hepatocytes in vitro. To evaluate the degree of polarized transporter differentiation of rat small hepatocytes during 9 weeks of culturing, we studied the time-dependent expression and subcellular localization of ...

journal_title：Journal of cell science

authors： Sidler Pfändler MA,Höchli M,Inderbitzin D,Meier PJ,Stieger B

更新日期：2004-08-15 00:00:00

abstract：:Protein kinases AKT and PKBR1 of Dictyostelium belong to the AGC protein kinase superfamily. AKT and PKBR1 are phosphorylated at similar sites by phosphoinositide-dependent kinase 1 (PDK1) and TORC2 kinases; however, they have different subcellular localizing domains. AKT has a phosphoinositide 3-kinase (PI3K)/phospha...

journal_title：Journal of cell science

authors： Liao XH,Buggey J,Kimmel AR

更新日期：2010-03-15 00:00:00

abstract：:We have isolated a fourth myosin gene (MYO4) in yeast (Saccharomyces cerevisiae). MYO4 encodes a approximately 170 kDa (1471 amino acid) class V myosin, using the classification devised by Cheney et al. (1993a; Cell Motil. Cytoskel. 24, 215-223); the motor domain is followed by a neck region containing six putative ca...

journal_title：Journal of cell science

authors： Haarer BK,Petzold A,Lillie SH,Brown SS

更新日期：1994-04-01 00:00:00

abstract：:NADH:ubiquinone oxidoreductases catalyse the first step within the diverse pathways of mitochondrial NADH oxidation. In addition to the energy-conserving form commonly called complex I, fungi and plants contain much simpler alternative NADH:ubiquinone oxido-reductases that catalyze the same reaction but do not translo...

journal_title：Journal of cell science

authors： Kerscher SJ,Okun JG,Brandt U

更新日期：1999-07-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) establishes life-long latent infection in hematopoietic progenitor cells and circulating monocytes in infected individuals. Myeloid differentiation coupled with immune dysregulation leads to viral reactivation, which can cause severe disease and mortality. Reactivation of latent virus requ...

journal_title：Journal of cell science

authors： Krishna BA,Wass AB,Dooley AL,O'Connor CM

更新日期：2021-01-25 00:00:00

abstract：:Hybrid cell lines between normal rat embryo fibroblasts and TA3B mouse tumour cells, or between TA3B and BI hamster sarcoma cells, have been examined for the expression of the cell surface large external-transformation-sensitive (LETS) protein and the organization of microfilament bundles. LETS protein was detected by...

journal_title：Journal of cell science

authors： Marshall CJ,Humphryes KC,Pollack RE

更新日期：1978-10-01 00:00:00

abstract：:Mammalian cytochrome P-450s in the CYP1A gene family catalyse the oxidation of a wide range of drugs and foreign compounds resulting in their excretion. These enzymes are highly inducible by a range of compounds, including polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (3-MC) and dioxins. Analysis of th...

journal_title：Journal of cell science

authors： Campbell SJ,Carlotti F,Hall PA,Clark AJ,Wolf CR

更新日期：1996-11-01 00:00:00

abstract：:Mitosis involves considerable membrane remodelling and vesicular trafficking to generate two independent cells. Consequently, endocytosis and endocytic proteins are required for efficient mitotic progression and completion. Several endocytic proteins also participate in mitosis in an endocytosis-independent manner. He...

journal_title：Journal of cell science

authors： Ma MP,Chircop M

更新日期：2012-09-15 00:00:00

abstract：:Polyethylene glycol (PEG) was used to fuse trout sperm with Chinese hamster fibroblasts (CHW-1102). As judged by light microscopy, PEG significantly increased the number of associations between the two cell types. Electron microscopy revealed that the sperm nuclei were in the cytoplasm of CHW-1102 in cultures that had...

journal_title：Journal of cell science

authors： Yip JH,Bols NC

更新日期：1982-02-01 00:00:00

abstract：:During mouse meiosis, the early prophase RAD51/DMC1 recombination protein sites, which are associated with the chromosome cores and which serve as markers for ongoing DNA-DNA interactions, are in ten-fold excess of the eventual reciprocal recombinant events. Most, if not all, of these early interactions are eliminated...

journal_title：Journal of cell science

authors： Moens PB,Kolas NK,Tarsounas M,Marcon E,Cohen PE,Spyropoulos B

更新日期：2002-04-15 00:00:00

abstract：:Diploid yeast, like most eukaryotes, can undergo meiotic differentiation to form haploid gametes. Meiotic differentiation and cell growth (proliferation) are mutually exclusive programs, and in yeast the switch between growth and meiosis is controlled by nutritional signals. The signaling pathways that mediate nutriti...

journal_title：Journal of cell science

authors： Honigberg SM,Purnapatre K

更新日期：2003-06-01 00:00:00

abstract：:The binding of GFP-tagged tetracycline repressor (TetR) molecules to chromosomally integrated tetracycline operator (tetO) sequence repeats has been used as a system to study chromosome behaviour microscopically in vivo. We found that these integrated transgenes influence the architecture of yeast interphase nuclei, a...

journal_title：Journal of cell science

authors： Fuchs J,Lorenz A,Loidl J

更新日期：2002-03-15 00:00:00

abstract：:Microinjection of a bacterially expressed, TRITC labelled fragment of the centrosome-associated protein CP190 of Drosophila melanogaster, into syncytial Drosophila embryos, shows it to associate with the centrosomes during mitosis, and to relocate to chromatin during interphase. Indirect immunofluorescence staining of...

journal_title：Journal of cell science

authors： Whitfield WG,Chaplin MA,Oegema K,Parry H,Glover DM

更新日期：1995-11-01 00:00:00

abstract：:Intercellular propagation of signals through connexin32-containing gap junctions is of major importance in physiological processes like nerve activity-dependent glucose mobilization in liver parenchymal cells and enzyme secretion from pancreatic acinar cells. In these cells, as in other organs, more than one type of c...

journal_title：Journal of cell science

authors： Niessen H,Harz H,Bedner P,Krämer K,Willecke K

更新日期：2000-04-01 00:00:00

abstract：:Previous studies have shown that unactivated lymphocytes bind to CS1 peptide and that the adhesion of these cells to high endothelium is inhibited by CS1 peptide. These results suggest that lymphocyte binding occurs via recognition of the CS1-containing splice variant of fibronectin expressed on the high endothelial s...

journal_title：Journal of cell science

authors： May MJ,Entwistle G,Humphries MJ,Ager A

更新日期：1993-09-01 00:00:00

abstract：:Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation and differentiation. Its importance is reflected in the dramatic effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kin...

journal_title：Journal of cell science

authors： Fernandez-Martinez J,Vela EM,Tora-Ponsioen M,Ocaña OH,Nieto MA,Galceran J

更新日期：2009-05-15 00:00:00

abstract：:How signaling domains form is an important, yet largely unexplored question. Here, we show that ciliary proteins help establish two contiguous, yet distinct cyclic GMP (cGMP) signaling compartments in Caenorhabditis elegans thermosensory AFD neurons. One compartment, a bona fide cilium, is delineated by proteins assoc...

journal_title：Journal of cell science

authors： Nguyen PA,Liou W,Hall DH,Leroux MR

更新日期：2014-12-15 00:00:00

abstract：:Cofilin has emerged as a key regulator of actin dynamics at the leading edge of motile cells. Through its actin-severing activity, it creates new actin barbed ends for polymerization and also depolymerizes old actin filaments. Its function is tightly regulated in the cell. Spatially, its activity is restricted by othe...

journal_title：Journal of cell science

authors： DesMarais V,Ghosh M,Eddy R,Condeelis J

更新日期：2005-01-01 00:00:00

abstract：:Human procathepsin D carries two N-linked glycosylation sites at asparagine residues 70 and 199, widely separated on the surface of the folded protein. We created monoglycosylated procathepsin D molecules by site-directed mutagenesis in vitro of the individual glycosylation sites. With only two exceptions, all 12 muta...

journal_title：Journal of cell science

authors： Fortenberry SC,Schorey JS,Chirgwin JM

更新日期：1995-05-01 00:00:00

abstract：:During angiogenesis, anastomosing capillary sprouts align to form complex three-dimensional networks of new blood vessels. Using an endothelial cell spheroid model that was developed to study endothelial cell differentiation processes, we have devised a novel collagen gel-based three-dimensional in vitro angiogenesis ...

journal_title：Journal of cell science

authors： Korff T,Augustin HG

更新日期：1999-10-01 00:00:00

abstract：:Cardiac fibrosis is linked to fibroblast-to-myofibroblast phenoconversion and proliferation but the mechanisms underlying this are poorly understood. Ski is a negative regulator of TGF-β-Smad signaling in myofibroblasts, and might redirect the myofibroblast phenotype back to fibroblasts. Meox2 could alter TGF-β-mediat...

journal_title：Journal of cell science

authors： Cunnington RH,Northcott JM,Ghavami S,Filomeno KL,Jahan F,Kavosh MS,Davies JJ,Wigle JT,Dixon IM

更新日期：2014-01-01 00:00:00

abstract：:The detergent-insoluble T. brucei cytoskeleton consists of several morphologically distinct regions and organelles, many of which are detectable only by electron microscopy. We have produced a set of monoclonal antibodies that define each structural component of this highly ordered cytoskeleton. The monoclonal antibod...

journal_title：Journal of cell science

authors： Woods A,Sherwin T,Sasse R,MacRae TH,Baines AJ,Gull K

更新日期：1989-07-01 00:00:00

abstract：:The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show that PIKfyve activi...

journal_title：Journal of cell science

authors： Bissig C,Croisé P,Heiligenstein X,Hurbain I,Lenk GM,Kaufman E,Sannerud R,Annaert W,Meisler MH,Weisman LS,Raposo G,van Niel G

更新日期：2019-02-28 00:00:00

abstract：:The COP9 signalosome (CSN) is an evolutionarily conserved macromolecular complex that interacts with cullin-RING E3 ligases (CRLs) and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage. Here we systematically ...

journal_title：Journal of cell science

authors： Olma MH,Roy M,Le Bihan T,Sumara I,Maerki S,Larsen B,Quadroni M,Peter M,Tyers M,Pintard L

更新日期：2009-04-01 00:00:00

abstract：:In response to endovascular injury, platelet-derived growth factor-BB (PDGF-BB) and basic fibroblast growth factor (bFGF) are released locally and modulate vascular smooth muscle cells (SMC) proliferation and migration within the vascular wall. The aim of the present in vitro study was to determine how rat aorta SMC r...

journal_title：Journal of cell science

authors： Facchiano A,De Marchis F,Turchetti E,Facchiano F,Guglielmi M,Denaro A,Palumbo R,Scoccianti M,Capogrossi MC

更新日期：2000-08-01 00:00:00