Abstract：
:Often in drug trials only the objective, or the subjective responses of the subjects are investigated, depending on the kind of drug. It is, however, desirable to check both the objective and the subjective responses in every drug trial. The investigation of the objective symptoms which is especially necessary in psycho-pharmacological trials, presents great difficulties. When a bodily function is found which reflects the emotional reactions which it is desired to investigate, it is necessary to plan the trial in a way that allows the results to be seen as proof of the effects of the drugs. Proposals for such a therapeutic trial are made. In the checking of the subjective responses the questionnaire is reckoned to be the best method. Problems of how the questionnaires are made and how they are used in the trials are discussed. By checking the subjective reactions, not only the side effects of the drug are demonstrated, but also their therapeutic effects. The author does not agree with the opinion that the double blind test is better than the single blind test in every case. Appropriate investigations should be made to clarify these questions.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
von Eiff AWsubject
Has Abstractpub_date
1963-01-01 00:00:00pages
26-9issue
1eissn
0026-1270issn
2511-705Xpii
63010026journal_volume
2pub_type
杂志文章abstract：OBJECTIVES:To design, implement in Java, and evaluate a method and means for the automated localization of artificial landmarks in optical images for tuned-aperture computed tomography (TACT) that allows the replacement of radiographic with optical landmarks. METHODS:Circular, colored, optical landmarks were designed ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:To provide a comprehensive bottom-up categorization of model-based segmentation techniques that allows to select, implement, and apply well-suited active contour models for segmentation of medical images, where major challenges are the high variability in shape and appearance of objects, noise, artifacts, pa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to develop a solution to preserve security and privacy in a healthcare environment where health-sensitive information will be accessed by many parties and stored in various distributed databases. The solution should maintain anonymous medical records and it should be able to lin...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/me9116
更新日期：2008-01-01 00:00:00
abstract：:A Bayesian decision support system was developed for the diagnosis of rheumatic disorders. Knowledge in this system is represented as evidential weights of findings. Simple weights were calculated as the logarithm of likelihood ratios on the basis of 1,000 consecutive patients from a rheumatological clinic. The effect...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：OBJECTIVES:To assess the impact of a CPOE system on medication-related communication of nurses and physicians. METHODS:In six internal medicine wards of an academic medical center, two questionnaires were used to evaluate nurses' attitudes toward the impact of a paper-based medication system and then a CPOE system on ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0572
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:Record linkage of patient data originating from various data sources and record linkage for checking uniqueness of patient registration are common tasks for every cancer registry. In Austria, there is no unique person identifier in use in the medical system. Hence, it was necessary and the goal of this work t...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Delayed patient recruitment is a common problem in clinical trials. According to the literature, only about a third of medical research studies recruit their planned number of patients within the time originally specified. OBJECTIVES:To provide a method to estimate patient accrual rates in clinical trials b...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0582
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:To contribute a new perspective on recent investigations into the scientific foundations of medical informatics (MI) and bioinformatics (BI). To support efforts that could generate synergies and new research directions. METHODS:MI and BI are compared and contrasted from a philosophy of science perspective. ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:A low rate of newly developed pressure ulcers is considered as an important quality indicator in nursing. However, the result of a hospital depends not only on the quality of care but on the risk profile of its patients as well. Therefore, based on multiple logistic regression models we describe a method for...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME10-01-0019
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:The traditional techniques of data analysis are often not sufficient to characterize the complex dynamics of respiration. In this study the respiratory pattern variability was analyzed using symbolic dynamics. METHODS:A group of 20 patients on weaning trials from mechanical ventilation were studied at two d...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:Hospital information systems (HIS) are the hospital's nervous system. The HIS are mostly grown over several years, dedicated to specific needs and comprise individual workarounds. Changes to such complex systems may cause a variety of differ-ent negative side-effects. In order to understand the nature of inc...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9220
更新日期：2009-01-01 00:00:00
abstract：:There are three grand challenges for medical informatics policy: (1) What is it? (2) What should it be? (3) How can we influence its development? To address these challenges requires: (1) an historical analysis of medical informatics policies in a representative sample of countries. This should include an account of m...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVES:To assess the effects of a CPOE system on inter-professional workflow in the medication process. METHODS:Twenty-three semi-structured interviews with physicians, nurses, and pharmacists were conducted in a Dutch academic hospital. In addition, the handwritten and system-generated documents used daily were c...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0631
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:Combination of multiple testing and modeling techniques in dose-response studies. Use of hypotheses tests to assess the significance of the dose-response signal associated with a given candidate dose-response model. Estimation of target dose(s) following the previous model selection step. Illustration of the...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to investigate the effects of hybrid environments (i.e. where part of the patient record is paper-based and part of it is electronic) upon aspects of novice nurse information seeking (i.e. amount of information accessed, choice of key information sources, type of information and ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9222
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:Record linkage may create powerful datasets with which investigators can conduct comparative effectiveness studies evaluating the impact of tests or interventions on health. All linkages of health care data files to date have used protected health information (PHI) in their linkage variables. A technique to l...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-01-0093
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:The UMLS assigns semantic types to all its integrated concepts. The semantic types are widely used in various natural language processing tasks in the biomedical domain, such as named entity recognition, semantic disambiguation, and semantic annotation. Due to the size of the UMLS, erroneous semantic type as...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME17-01-0120
更新日期：2018-02-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems". BACKGROUND:Adaptation of the QT-interval to changes in heart rate reflects on the body-surface electrocardiogram the adaptation...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0039
更新日期：2014-01-01 00:00:00
abstract：:The Read Thesaurus is a comprehensive user-led clinical vocabulary developed from earlier, and structurally simpler, versions of the Read Codes, with substantial input from United Kingdom health care professionals. A constituent template table underpins a range of functions, including semantic definition of concepts u...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:Based on personal experiences, observations are offered on health information in developing countries, ways in which information systems can be strengthened, and opportunities for health-information science graduates. Although data collection consumes a significant portion of the health worker's day, information syste...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Heart rate is known to increase under the influence of increased sympathetic stimulation rates during exertion or stress. Few data are available regarding the rate response to exercise near the fatigue limit, for normal women. The effects on heart rate were studied of fatigue limiting exercise in 87 asymptomatic, norm...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:ICD is used for coding medical diagnoses across the world, but there is no globally accepted coding system for health care procedures. The need for the introduction of a common international medical procedure classification has been addressed by the Australian NCCH, which proposed the International Classific...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-01-0007
更新日期：2009-01-01 00:00:00
abstract：:In this paper the design and implementation of a decision support system for diabetes care is examined from an ethical perspective. It is noted that the system creates potential for enhancing the realization of the principle of autonomy through improved information to patients and participation by patients. However, t...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVES:Personal digital assistants (PDAs) are in widespread use by resident physicians in many countries, reaching as high as 95% in some reports. Uses are varied and include clinical decision support and support of evidence-based practice. Utilization by resident doctors in Japan has not been characterized. This s...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0607
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:This paper describes a methodology for the monitoring of the fetal cardiac health status during pregnancy, through the effective and non-invasive monitoring of the abdominal ECG signals (abdECG) of the mother. METHODS:For this purpose, a three-stage methodology has been developed. In the first stage, the fe...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-01-0041
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To intensify the collaboration between WHO, the World Health Organization, and IMIA, the International Medical Informatics Association. METHODS:Identifying key areas of collaboration and publishing a joint communiqué during Medinfo 2007 in Brisbane, Australia. RESULTS AND CONCLUSIONS:WHO and IMIA have ident...
journal_title：Methods of information in medicine
pub_type： 社论
doi：10.1160/me5006
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:The availability of large amounts of data in heterogeneous formats and the rapid progress in fields such as computer based drug design, medical imaging and medical simulations have lead to a growing demand for large computational power and easy accessibility to heterogeneous data sources. OBJECTIVES:The goa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:Information systems integration is hard, especially when semantic and business process interoperability requirements need to be met. To succeed, a unified methodology, approaching different aspects of systems architecture such as business, information, computational, engineering and technology viewpoints, has...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-02-0012
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:Compiling individual records coming from different sources is necessary for multi-center studies. Legal aspects can be satisfied by implementing anonymization procedures. When using these procedures with a different key for each study it becomes almost impossible to link records from separate data collection...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/me0546
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Joint data analysis is a key requirement in medical research networks. Data are available in heterogeneous formats at each network partner and their harmonization is often rather complex. The objective of our paper is to provide a generic approach for the harmonization process in research networks. We applied...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-02-0030
更新日期：2015-01-01 00:00:00
