Abstract：
OBJECTIVE:Joint data analysis is a key requirement in medical research networks. Data are available in heterogeneous formats at each network partner and their harmonization is often rather complex. The objective of our paper is to provide a generic approach for the harmonization process in research networks. We applied the process when harmonizing data from three sites for the Lung Cancer Phenotype Database within the German Center for Lung Research. METHODS:We developed a spreadsheet-based solution as tool to support the harmonization process for lung cancer data and a data integration procedure based on Talend Open Studio. RESULTS:The harmonization process consists of eight steps describing a systematic approach for defining and reviewing source data elements and standardizing common data elements. The steps for defining common data elements and harmonizing them with local data definitions are repeated until consensus is reached. Application of this process for building the phenotype database led to a common basic data set on lung cancer with 285 structured parameters. The Lung Cancer Phenotype Database was realized as an i2b2 research data warehouse. CONCLUSION:Data harmonization is a challenging task requiring informatics skills as well as domain knowledge. Our approach facilitates data harmonization by providing guidance through a uniform process that can be applied in a wide range of projects.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Firnkorn D,Ganzinger M,Muley T,Thomas M,Knaup Pdoi
10.3414/ME14-02-0030subject
Has Abstractpub_date
2015-01-01 00:00:00pages
455-60issue
5eissn
0026-1270issn
2511-705Xpii
14-02-0030journal_volume
54pub_type
杂志文章abstract：INTRODUCTION:This article is part of the Focus Theme of METHODs of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND:SALUS project aims at building an interoperability platform and a dedicated toolkit to enable secondary use of electronic health records (EHR) data for ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0025
更新日期：2015-01-01 00:00:00
abstract：:A tree-based method for estimating time-varying effects of baseline patient characteristics on survival is introduced. A Cox-type model for censored survival data is used in which the time-varying relative risks are modelled as piecewise constants. The tree method consists of three steps: 1. Growing the tree, in which...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:We conducted a pilot randomised trial of computerised templates for the management of asthma and diabetes in general practice in six general practices in North London. Uptake of the guidelines by general practitioners and practice nurses was assessed using qualitative (semi-structured interviews designed to assess the...
journal_title：Methods of information in medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-09-01 00:00:00
abstract：:The increased use of computers is a response to the considerable growth in information in all fields of activities. Related to this, in the field of medicine a new component appeared about 40 years ago: Medical Informatics. Its goals are to assist health care professionals in the choice of data to manage and in the ch...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVES:Due to the high complexity of structures and processes in health care, thorough systems analyses in health care run the risk of becoming very complex and difficult to handle. Therefore, we aimed to support systematic systems analysis in health care by developing a comprehensive framework that presents and de...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:This paper describes a methodology for the monitoring of the fetal cardiac health status during pregnancy, through the effective and non-invasive monitoring of the abdominal ECG signals (abdECG) of the mother. METHODS:For this purpose, a three-stage methodology has been developed. In the first stage, the fe...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-01-0041
更新日期：2010-01-01 00:00:00
abstract：:BRAINDEX (Brain-Death Expert System) is an interactive, knowledge-based expert system offering support to physicians in decision making concerning brain death. The physician is given the possibility of communicating in almost natural language and, therefore, in terms with which he is familiar. This updated version of ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：OBJECTIVES:The aging of the population creates pressure on the healthcare systems in various ways. A massive increase of chronic disease conditions and age-related illness are predicted as the dominant forces driving the future health care. The objective of this paper is to present future research demands in pervasive ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-02-0044
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:This paper aims to present an activity-theoretical method for studying the effects of user participation in IS development. METHODS:This method is developed through a case study of the process of designing a diabetes database. RESULTS AND CONCLUSIONS:The method consists of a historical analysis of the desi...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Requirements and approaches of Software Engineering education in the field of Medical Informatics are described with respect to the impact of (1) experiences characterizing the "software misery", (2) status and tendencies in software methodology, and (3) educational status and needs in computer science education influ...
journal_title：Methods of information in medicine
pub_type： 杂志文章,评审
doi：
更新日期：1989-11-01 00:00:00
abstract：:A problem of identifying the phase response curve of the myocardial pacemaker was investigated using a simple dynamic system model of cardiac arrhythmia. A hybrid optimization method of a genetic algorithm and a local optimization technique was employed to obtain a solution of the model fitting. The method was applied...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVES:To identify factors associated with hospital length of stay (LOS) and to model variations in LOS within Diagnosis Related Groups (DRGs). METHODS:A proportional hazards frailty modelling approach is proposed that accounts for patient transfers and the inherent correlation of patients clustered within hospita...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Studying workflow is a critical step in designing, implementing and evaluating informatics interventions in complex sociotechnical settings, such as hospital emergency departments (EDs). Known approaches to studying workflow in clinical settings attend to the activities of individual clinicians, thus being i...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME12-01-0079
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:The traditional techniques of data analysis are often not sufficient to characterize the complex dynamics of respiration. In this study the respiratory pattern variability was analyzed using symbolic dynamics. METHODS:A group of 20 patients on weaning trials from mechanical ventilation were studied at two d...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to explore suitable spatial filters for inverse estimation of cortical potentials from the scalp electroencephalogram. The effect of incorporating noise covariance into inverse procedures was examined by computer simulations and tested in human experiment. METHODS:The paramet...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:A rough-sets approach was applied to a data set consisting of animal study results and other compound characteristics to generate local and global (certain/possible) sets of rules for prediction of developmental toxicity in human subjects. A modified version of the rough-sets approach is proposed to allow the construc...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVES:In our department, we have been using an Anesthesia Information Management System (AIMS) for five years. In this study, we tested to what extent data extracted from the AIMS could be suitable for the supervision and time-management of operating rooms. METHODS:From 1995 to 1999, all relevant data from 103,26...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:To design, implement in Java, and evaluate a method and means for the automated localization of artificial landmarks in optical images for tuned-aperture computed tomography (TACT) that allows the replacement of radiographic with optical landmarks. METHODS:Circular, colored, optical landmarks were designed ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:In this paper we describe LIED (Liver: Information, Education and Diagnosis), a diagnostic expert system devoted to medical education in the field of hepatology. LIED combines the facilities of a traditional expert system for clinical diagnosis with several modules designed for educational purposes. The goal of such m...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Main requirements for an Anesthesia Information Management System (AIMS) are the supply of additional information for the anesthesiologist at his workstation and complete documentation of the anesthetic procedure. With the implementation of an AIMS (NarkoData) and effective user support, the quality of documentation a...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVES:The filtered backprojection is not able to cope with metal-induced inconsistencies in the Radon space which leads to artifacts in reconstructed CT images. A new algorithm is presented that reduces the drawbacks of existing artifact reduction strategies. METHODS:Inconsistent projection data are bridged by di...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1160/ME9041
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:We examine the potential of archetype patterns for upper-level ontology development in health information systems (HISs). METHODS:Archetype patterns, based on the integration of archetype concepts and design patterns, are conceptualized and developed for ontology in the HIS domain. The UML provides the unde...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0519
更新日期：2011-01-01 00:00:00
abstract：:Acute appendicitis is the most common cause of acute abdomen requiring surgical intervention. The clinical diagnosis of acute appendicitis is not always easy due to variable symptomatology, particularly at the onset. The contributions of history-taking and physical examination in the diagnosis of acute appendicitis wa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVES:To contribute a new perspective on recent investigations into the scientific foundations of medical informatics (MI) and bioinformatics (BI). To support efforts that could generate synergies and new research directions. METHODS:MI and BI are compared and contrasted from a philosophy of science perspective. ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:In this study, we evaluated the internal validity of EPICON, an application for grouping ICPC-coded diagnoses from electronic medical records into episodes of care. These episodes are used to estimate morbidity rates in general practice. METHODS:Morbidity rates based on EPICON were compared to a gold standa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:The main objective of the research is an application of the clustering and cluster validity methods to estimate the number of clusters in cancer tumor datasets. A weighed voting technique is going to be used to improve the prediction of the number of clusters based on different data mining techniques. These ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:The healthcare sector is facing an enormous acceleration due to the emergence of new knowledge, drugs, devices and diseases. Professional competence, continuing education, service excellence and patient benefits can be facilitated by the developments in information and computer technology--computer literacy ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to investigate the effects of hybrid environments (i.e. where part of the patient record is paper-based and part of it is electronic) upon aspects of novice nurse information seeking (i.e. amount of information accessed, choice of key information sources, type of information and ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9222
更新日期：2009-01-01 00:00:00
abstract：:For use in system development, a method based on both qualitative and quantitative data was employed to study the difficulties--the dilemmas--a general practitioner (GP) faces during daily consultations. Video recordings were used for stimulated recall of the consultation. From 46 consultations, 262 dilemmas were iden...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A one-hundred percent documentation rate of diagnoses and patient data is unfeasible and should not be pursued. Therefore, a "lean documentation" of diagnoses and basic patient data was introduced. Coding is done by a clinic-specific list of diagnoses (thesaurus) with a minimum of diagnostic codes, combined with optio...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
