Abstract：
OBJECTIVES:To contribute a new perspective on recent investigations into the scientific foundations of medical informatics (MI) and bioinformatics (BI). To support efforts that could generate synergies and new research directions. METHODS:MI and BI are compared and contrasted from a philosophy of science perspective. Historical examples from MI and BI are analyzed based on contrasting viewpoints about the evolution of scientific disciplines. RESULTS:Our analysis suggests that the scientific approaches of MI and BI involve different assumptions and foundations, which, together with largely non-overlapping communities of researchers for the two disciplines, have led to different courses of development. We indicate how their respective application domains, medicine, and biology may have contributed to these differences in development. CONCLUSIONS:An analysis from the point of view of the philosophy of science is characteristic of established scientific disciplines. From a Kuhnian perspective, both disciplines may be entering a period of scientific crisis, where their foundations are questioned and where new ideas (or paradigm shifts) and a progressive research programme are needed to advance them scientifically. We discuss research directions and trends both supporting and challenging integration of the subdisciplines of MI and BI into a unified field of biomedical informatics (BMI), centered around the evolution of information cybernetics.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Maojo V,Kulikowski Csubject
Has Abstractpub_date
2006-01-01 00:00:00pages
474-82issue
5eissn
0026-1270issn
2511-705Xpii
06050474journal_volume
45pub_type
杂志文章abstract：BACKGROUND:Delayed patient recruitment is a common problem in clinical trials. According to the literature, only about a third of medical research studies recruit their planned number of patients within the time originally specified. OBJECTIVES:To provide a method to estimate patient accrual rates in clinical trials b...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0582
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To intensify the collaboration between WHO, the World Health Organization, and IMIA, the International Medical Informatics Association. METHODS:Identifying key areas of collaboration and publishing a joint communiqué during Medinfo 2007 in Brisbane, Australia. RESULTS AND CONCLUSIONS:WHO and IMIA have ident...
journal_title：Methods of information in medicine
pub_type： 社论
doi：10.1160/me5006
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:Several researchers have proposed the use of logical ontologies as 'reference terminologies'. However, there are a number of unresolved issues. This article describes the development of a logical ontology for nursing interventions and presents the results of evaluation. METHODS:Initially this study involved...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:This article describes a system for the optimization of the prehospital assessment of emergency, in cases involving thoraco-abdominal complaints and consciousness problems. This assessment is performed by nurses on the basis of a telephone interview at ambulance dispatch centers. The system has a body of biomedical an...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND:Unsupervised home exercise is a major component of physical therapy (PT). This study proposes an inexpensive, inertial measurement unit-based wearable device to capture kinematic data to facilitate exercise. However, conveying and interpreting kinematic data to non-experts poses a challenge due to the comple...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1055/s-0040-1710380
更新日期：2020-02-01 00:00:00
abstract：:Human event-related potentials reflect cognitive processing, and are normally elicited by external events, such as acoustic sounds or visual stimuli. As such they provide an opportunity to study normal and abnormal brain function noninvasively, at sub-second resolution. Advances in multimedia technology permit special...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:The UMLS assigns semantic types to all its integrated concepts. The semantic types are widely used in various natural language processing tasks in the biomedical domain, such as named entity recognition, semantic disambiguation, and semantic annotation. Due to the size of the UMLS, erroneous semantic type as...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME17-01-0120
更新日期：2018-02-01 00:00:00
abstract：:Version 3 of the Read Codes was designed in response to a new set of requirements generated by three new terming initiatives in the UK, the Clinical Terms Project, the Professions Allied to Medicine Terms Project and the Nursing Terms Project. The challenge was to cope with the detail required by clinical specialists ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVES:The traditional techniques of data analysis are often not sufficient to characterize the complex dynamics of respiration. In this study the respiratory pattern variability was analyzed using symbolic dynamics. METHODS:A group of 20 patients on weaning trials from mechanical ventilation were studied at two d...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Diagnosis and management of dementia is a complex process and primary care physicians are under-equipped to deal with uncertainties in the provision of optimal care for the patient. OBJECTIVE:To develop a computer decision support system (CDSS) which could assist physicians with diagnosis and management and...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The medical information systems of the future will probably include the entire medical record as well as a knowledge base, providing decision support for the physician during patient care. Data dictionaries will play an important role in integrating the medical knowledge bases with the clinical databases. This article...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems". OBJECTIVES:The aim of this study is to assess the reliability of the estimated Nocturnal Heart Rate (HR), recorded through a be...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0053
更新日期：2014-01-01 00:00:00
abstract：:The graduates and students of the School of Health Information Science (HIS) at the University of Victoria (UVic) have pioneered the Canadian sphere in health informatics since 1982. After six years of growth this co-operative education program has matured and establishment of a research base and graduate school has b...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:Many clinics are interested to use software packages in daily practice, but lack of integration of such packages seriously limits their scope. In practice this often entails switching between programs and interrupting the run of an individual program. A multi-task approach would not solve this problem as it would not ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVES:As millions of consumers perform health information retrieval online, the mismatch between their terminology and the terminologies of the information sources could become a major barrier to successful retrievals. To address this problem, we studied the characteristics of consumer terminology for health infor...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:EEG scalp potential distributions recorded in humans are affected by low spatial resolution and by the dependence on the electrical reference used. High resolution EEG technologies are available to drastically increase the spatial resolution of the raw EEG. Such technologies include the computation of surfac...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：UNLABELLED:The HL7 Clinical Document Architecture (CDA) is an important XML-based standard for the representation of clinical documents. OBJECTIVES:The use of Markup Languages could satisfy the demands of involved healthcare staff as well as the needs of patients, to receive an overview of the patient's treatment duri...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Often in drug trials only the objective, or the subjective responses of the subjects are investigated, depending on the kind of drug. It is, however, desirable to check both the objective and the subjective responses in every drug trial. The investigation of the objective symptoms which is especially necessary in psyc...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：OBJECTIVES:The filtered backprojection is not able to cope with metal-induced inconsistencies in the Radon space which leads to artifacts in reconstructed CT images. A new algorithm is presented that reduces the drawbacks of existing artifact reduction strategies. METHODS:Inconsistent projection data are bridged by di...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1160/ME9041
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:ICD is used for coding medical diagnoses across the world, but there is no globally accepted coding system for health care procedures. The need for the introduction of a common international medical procedure classification has been addressed by the Australian NCCH, which proposed the International Classific...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-01-0007
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To draw a parallel between the challenges by which a research department in biomedical informatics is confronted and those of a symphony orchestra; in both areas different disciplines and various groups of instruments can be discerned. METHOD:Retrospective, personal review of how to conduct biomedical resear...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Acute appendicitis is the most common cause of acute abdomen requiring surgical intervention. The clinical diagnosis of acute appendicitis is not always easy due to variable symptomatology, particularly at the onset. The contributions of history-taking and physical examination in the diagnosis of acute appendicitis wa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVES:The main objective of this study is to learn more on the image use and search requirements of radiologists. These requirements will then be taken into account to develop a new search system for images and associated meta data search in the Khresmoi project. METHODS:Observations of the radiology workflow, ca...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME11-02-0025
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVES:Biomedical ontologies exist to serve integration of clinical and experimental data, and it is critical to their success that they be put to widespread use in the annotation of data. How, then, can ontologies achieve the sort of user-friendliness, reliability, cost-effectiveness, and breadth of coverage that ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9302
更新日期：2010-01-01 00:00:00
abstract：:To examine inter-observer variation in the monitoring of patients with chronic disease, four nephrologists independently assessed 62 patients on maintenance hemodialysis. Deviation from normal was determined for adequacy of dialysis, protein intake, and metabolic state. The kappa-index, which allows to adjust for chan...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:The use of computers in the field of medical education is common. Our purpose is to present a Computer-Assisted Instruction system which has been developed over ten years at the University of Compiègne and the University of Rennes Medical School. This system can be used to help the student to solve clinical cases by a...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：OBJECTIVES:To discuss the advantages and disadvantages of an interfaced approach to clinical information systems architecture. METHODS:After many years of internally building almost all components of a hospital clinical information system (HELP) at Intermountain Health Care, we changed our architectural approach as we...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Differential Interference Contrast (DIC) microscopy is a powerful visualization tool used to study live biological cells. Its use, however, has been limited to qualitative observations. The inherent non-linear relation between the object properties and the image intensity makes quantitative analysis difficult. As a fi...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND:Data sharing and integration between the clinical research data management system and the electronic health record system remains a challenging issue. T...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0019
更新日期：2015-01-01 00:00:00
abstract：:Continuous recording of intraluminal pressures for extended periods of time is currently regarded as a valuable method for detection of esophageal motor abnormalities. A subsequent automatic analysis of the resulting motility data relies on strict mathematical criteria for recognition of pressure events. Due to great ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
