Abstract：
INTRODUCTION:This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems". BACKGROUND:Adaptation of the QT-interval to changes in heart rate reflects on the body-surface electrocardiogram the adaptation of action potential duration (APD) at the cellular level. The initial fast phase of APD adaptation has been shown to modulate the arrhythmia substrate. Whether the slow phase is potentially proarrhythmic remains unclear. OBJECTIVES:To analyze in-vivo human data and use computer simulations to examine effects of the slow APD adaptation phase on dispersion of repolarization and reentry in the human ventricle. METHODS:Electrograms were acquired from 10 left and 10 right ventricle (LV/RV) endocardial sites in 15 patients with normal ventricles during RV pacing. Activation-recovery intervals, as a surrogate for APD, were measured during a sustained increase in heart rate. Observed dynamics were studied using computer simulations of human tissue electrophysiology. RESULTS:Spatial heterogeneity of rate adaptation was observed in all patients. Inhomogeneity in slow APD adaptation time constants (Δτ(s)) was greater in LV than RV (Δτ(s)(LV) = 31.8 ± 13.2, Δτ(s)(RV) = 19.0 ± 12.8 s , P< 0.01). Simulations showed that altering local slow time constants of adaptation was sufficient to convert partial wavefront block to block with successful reentry. CONCLUSIONS:Using electrophysiological data acquired in-vivo in human and computer simulations, we identify heterogeneity in the slow phase of APD adaptation as an important component of arrhythmogenesis.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Bueno-Orovio A,Hanson BM,Gill JS,Taggart P,Rodriguez Bdoi
10.3414/ME13-02-0039subject
Has Abstractpub_date
2014-01-01 00:00:00pages
320-3issue
4eissn
0026-1270issn
2511-705Xpii
13-02-0039journal_volume
53pub_type
杂志文章abstract：:A rough-sets approach was applied to a data set consisting of animal study results and other compound characteristics to generate local and global (certain/possible) sets of rules for prediction of developmental toxicity in human subjects. A modified version of the rough-sets approach is proposed to allow the construc...
journal_title：Methods of information in medicine
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abstract：OBJECTIVES:This study aims to demonstrate the usability of discourse analyses as a means of evaluating medical informatics systems by examining one particular computer-based data-to-text system for delivering neonatal health care information. METHODS:Six textual summaries of clinical information, three produced by hum...
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journal_title：Methods of information in medicine
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journal_title：Methods of information in medicine
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journal_title：Methods of information in medicine
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journal_title：Methods of information in medicine
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journal_title：Methods of information in medicine
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journal_title：Methods of information in medicine
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doi：
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journal_title：Methods of information in medicine
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journal_title：Methods of information in medicine
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journal_title：Methods of information in medicine
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