Abstract：
:Stoppage of endurance exercise training leads to complete loss of maximal oxygen uptake ([Formula: see text]) gain but not submaximal exercise blood lactate concentrations. However, the detailed mechanisms are still unknown. Thus, we investigated the effects of exercise-training cessation at lactate threshold (LT) intensity on physiological adaptations and global mRNA expressions in human skeletal muscle. The [Formula: see text], muscle capillaries density and global gene expression were measured after 12 weeks of LT training, and after 12 weeks of detraining. Twelve weeks of detraining reversed the effect of 12 weeks LT training on [Formula: see text] and [Formula: see text] at LT intensity, although the later value was higher than the pre-training level. Moreover, the training cessation did not affect the number of capillaries around type I fiber, which was increased by training. The training modulated 243 characterized transcripts, in which 77% showed a significant reversible effect by detraining. However, the transcripts most-induced by the training were still elevated after the same period of detraining. The pathway and network analysis revealed that these genes were related to oxidative phosphorylation (OxPhos), calcium signalling and tissue development. Therefore, these physiological and transcriptional changes suggest improved oxygen supply and OxPhos in the skeletal muscle, which may contribute to the incomplete loss of absolute [Formula: see text] at LT intensity after training cessation. The present study does not only demonstrate, for the first time, sustained effects of training after detraining at the transcriptional level, but also indicates the possible signalling pathways.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
St-Amand J,Yoshioka M,Nishida Y,Tobina T,Shono N,Tanaka Hdoi
10.1007/s00421-011-2036-7subject
Has Abstractpub_date
2012-03-01 00:00:00pages
853-69issue
3eissn
1439-6319issn
1439-6327journal_volume
112pub_type
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