Abstract：
:Exercise is linked with intensity-dependent immune response. Intracellular redox status is important in programmed cell death. This study, by closely examining 18 sedentary men who exercised moderately and severely (ie. 60% and 80% VO2max, respectively) for 40 min, investigated how exercise intensities influence intracellular redox status and oxidative stress-induced apoptosis in lymphocyte. Intracellular superoxide and reduced glutathione (GSH) levels, lipid peroxidation, mitochondrial transmembrane potential (MTP), active caspases contents, phosphotidyl serine (PS) exposure, and DNA fragmentation in lymphocytes were determined. Moreover, sublethal oxidative stress was administered by treating the lymphocyte with H2O2, to closely approximate in vivo pro-oxidative conditions. Immediately or 24 h after severe exercise, (1) lymphocyte GSH level and MTP had diminished while active caspase-8, -9, and -3 contents and DNA fragmentation had risen; and (2) H2O2 induced- lymphocyte PS exposure and DNA fragmentation were enhanced. In contrast, lymphocyte MTP, caspases activation, PS exposure, and DNA fragmentation were unaltered immediately following moderate exercise, whereas GSH level rose, lipid peroxidation diminished, and H2O2 induced- PS exposure and cell damage reduced 24 h after this exercise. These results suggest that heavy exercise diminishes lymphocyte GSH content and subsequently enhances the oxidative stress-induced apoptosis. However, moderate exercise attenuates lymphocyte apoptosis induced by oxidative stress, possibly by improving intracellular anti-oxidative capacity.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Wang JS,Huang YHdoi
10.1007/s00421-005-0005-8keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
290-7issue
4eissn
1439-6319issn
1439-6327journal_volume
95pub_type
杂志文章abstract：:In this study we investigated force loss and recovery after eccentric exercise, and further characterized profound losses in muscle function (n = 192 subjects--98 males, 94 females; population A). Maximal voluntary contractile force (MVC) was assessed before, immediately after, and at 36 and 132 h after eccentric exer...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000346
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journal_title：European journal of applied physiology
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abstract：:Forearm pain occurring during high +Gz exposure has been linked with vascular distension from elevated transmural pressure of hydrostatic origin and is exacerbated by positive pressure breathing (PBG). We postulated that at high vascular transmural pressure vascular autoregulation might be overcome and be associated w...
journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-019-04181-y
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journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-010-1534-3
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-006-0160-6
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2018-9
更新日期：2012-02-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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更新日期：2012-10-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0558-9
更新日期：2008-01-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00421-003-1031-z
更新日期：2004-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0892-6
更新日期：2009-01-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-009-1299-8
更新日期：2010-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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abstract：:Early effects of a resistance training program include neural adaptations at multiple levels of the neuraxis, but direct evidence of central changes is lacking. Plasticity exhibited by multiple supraspinal centers following training may alter slow negative electroencephalographic activity, referred to as movement-rela...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210050033
更新日期：2000-02-01 00:00:00
abstract：:In adults, exercise is a powerful and natural stimulator of immune cells and adhesion molecules. Far less is known about these exercise responses during childhood and whether or not exercise in real-life activities of healthy children might influence immune responses. We compared laboratory exercise (10 x 2 min period...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210100505
更新日期：2001-11-01 00:00:00
abstract：AIMS:To determine the effects of high-intensity interval training (HIIT) following cardiac resynchronization therapy (CRT) implantation in patients with chronic heart failure (CHF), on noninvasive estimates of systolic ventricular function, exercise performance, severity of symptoms and quality of life. METHODS:Cardio...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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更新日期：2019-08-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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更新日期：2010-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0690-1
更新日期：2008-09-01 00:00:00
abstract：:A routine method to determine total haemoglobin mass (tHb) in clinical practice and sports medicine is non-existent. Radioactive tracers or other dilution procedures like the common CO-rebreathing method (Proc(com)) are impractical, the latter in particular because of the relatively long time of respiration. According...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-0050-3
更新日期：2005-12-01 00:00:00
abstract：:Previous investigations show that metabolic syndrome (MetSyn) causes sympathetic hyperactivation. Symptoms of anxiety and mood disturbance (AMd) provoke sympatho-vagal imbalance. We hypothesized that AMd would alter even further the autonomic function in patients with MetSyn. Twenty-six never-treated patients with Met...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2476-8
更新日期：2013-03-01 00:00:00
abstract：:Post-exercise cardiac vagal reactivation is well-investigated; however, the effect of water intake during this period has not been well studied. Therefore, our aim was to assess the influence of water intake on the cardiac vagal reactivation after 30 min of a submaximal cycling exercise. Ten healthy subjects (eight me...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0584-7
更新日期：2008-02-01 00:00:00
abstract：:It has been well demonstrated that the principal factor responsible for oxidative damage during exercise is the increase in oxygen consumption. However, other theoretical factors (acidosis, catecholamine autoxidation, ischemia-reperfusion syndrome, etc.) that are known to induce, in vitro, oxidative damage may also be...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-002-0767-1
更新日期：2003-03-01 00:00:00
abstract：:Isometric unilateral elbow extension training was conducted for 10 weeks (3 times per week) on 12 young adult men to investigate the effects of equivolume exercise programs with different combinations of intensity and duration on the morphological and functional aspects of the triceps brachii muscle. One group of 6 su...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-002-0604-6
更新日期：2002-06-01 00:00:00
