Abstract：
PURPOSE:To determine if and how hypoxia combined with elevated carboxyhaemoglobin fraction (F HbCO) affects peripheral diffusing capacity and O2 extraction in animals exercising at their maximal aerobic capacity ([Formula: see text]). METHODS:Six goats ran on a treadmill at speeds eliciting [Formula: see text] while breathing inspired O2 fractions (F IO2) of 0.21 or 0.12 with F HbCO 0.02 or 0.30. We measured O2 consumption and arterial and mixed-venous blood variables to assess how hypoxia and elevated F HbCO individually, and in combination, alter O2 transport and utilisation. RESULTS:Peripheral diffusing capacity did not differ among the four gas combinations (P = 0.867), whereas O2 extraction fraction increased with hypoxia [0.920 ± 0.018 (SD)] and decreased with elevated F HbCO (0.792 ± 0.038) compared to control (0.897 ± 0.032). Oxygen extraction increases with hypoxia due to the sigmoid relationship between O2 saturation (SO2) and O2 partial pressures (PO2) affecting low (hypoxia) and high (normoxia) PO2 differently. Oxygen extraction decreases with elevated F HbCO because elevated F HbCO increases haemoglobin (Hb) affinity for O2 and raises SO2, especially at very low (mixed-venous) PO2. Pulmonary gas exchange was impaired only with combined hypoxia and elevated F HbCO due to hypoxia decreasing alveolar PO2 and O2 flux coupled with elevated F HbCO increasing Hb affinity for O2 and decreasing the rate of PO2 increase for a given rise in SO2. CONCLUSION:This study quantifies the mechanisms by which O2 delivery and peripheral diffusion interact to limit [Formula: see text] when O2 delivery is reduced due to breathing hypoxic gas with elevated F HbCO.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Crocker GH,Jones JHdoi
10.1007/s00421-013-2799-0subject
Has Abstractpub_date
2014-04-01 00:00:00pages
837-45issue
4eissn
1439-6319issn
1439-6327journal_volume
114pub_type
杂志文章abstract：:This study tested the hypothesis that, as compared to whole-body bioelectrical impedance (BI) analysis, segmental BI analysis can estimate lean body mass (LBM) more accurately in a population with a large difference in muscularity. In addition to whole-body BI, which determines impedance (Z) between the wrist and ankl...
journal_title：European journal of applied physiology
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abstract：:The compound muscle action potential (M wave) has been commonly used to assess the peripheral properties of the neuromuscular system. More specifically, changes in the M-wave features are used to examine alterations in neuromuscular propagation that can occur during fatiguing contractions. The utility of the M wave is...
journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00421-004-1045-1
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abstract：:No previous studies have investigated the effect of lower body compression garments (CG) on running performance in the heat. This study tested the hypothesis that CG would negatively affect running performance in the heat by comparing CG and non-CG conditions for running performance and physiological responses in hot ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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abstract：:Intramuscular and surface electromyographic (EMG) activities were recorded from the left and right upper trapezius muscle of eight healthy male subjects during 5-min long static contractions at 2% and 5% of the maximal voluntary contraction (MVC) force. Intramuscular signals were detected by wire electrodes while surf...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-015-3185-x
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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更新日期：2014-01-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000374
更新日期：2001-04-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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更新日期：2005-08-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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更新日期：2016-02-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-015-3253-2
更新日期：2015-12-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-005-1321-8
更新日期：2005-08-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0672-3
更新日期：2008-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-015-3131-y
更新日期：2015-07-01 00:00:00
