Abstract:
:The aim of this study was to quantify the influence of head-up-tilt (HUT) on the isocapnic hypoxic ventilatory response (HVR) in man, and to investigate the effect of orthostatic blood shifts separately from other gravitational effects by the application of lower-body negative pressure (LBNP) with subjects in a horizontal position. HVR was measured in 15 subjects during passive HUT from 0 degrees to 85 degrees as well as during -7 degrees head-down-tilt and while they were in a sitting position. In a subgroup of eight subjects the effect of 85 degrees HUT was compared to a corresponding LBNP of -70 mbar on HVR. Moreover, by imposing graded HUT (7 degrees, 15 degrees, 30 degrees, 50 degrees) and LBNP (-15, -30 mbar) we studied the effect of low-level orthostatic stress on HVR. Ventilation, end-tidal partial pressure of CO2, heart rate and blood pressure were recorded continuously for 1 min before, and during HVR. HVR was significantly increased by approximately equal to 50% through both 85 degrees HUT and -70 mbar LBNP as compared to 0 degrees and 0 mbar, respectively, at unchanged mean arterial pressure. Low-level HUT and LBNP had no effect on HVR. It was concluded that the orthostatic HVR increase may be attributable to caudal blood shifts (i.e., central hypovolemia). This HVR increase requires a pronounced hypovolemic stress but no decrease in arterial blood pressure. It is suggested that a central interaction of arterial and cardiopulmonary baroreceptors is underlying this response. Their separate contribution remains to be assessed.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Hildebrandt W,Ottenbacher A,Schuster M,Baisch F,Bärtsch Pdoi
10.1007/s004210050070keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
470-8issue
6eissn
1439-6319issn
1439-6327journal_volume
81pub_type
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journal_title:European journal of applied physiology
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journal_title:European journal of applied physiology
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journal_title:European journal of applied physiology
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pub_type: 杂志文章,随机对照试验
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
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