Strong ion reserve: a viewpoint on acid base equilibria and buffering.

Abstract:

:Evidence suggests that strong ions can exist reversibly bound to proteins in a pH-dependent manner and that they can be recruited into the biological solution, modulating its strong ion difference in a process that opposes the acid base disturbances imposed on the system. These recruitable strong ions represent the solution's 'strong ion reserve'. The physiologic [corrected] role of these protein-bound strong ions [corrected] in the buffering of acid base disorders is discussed.

journal_name

Eur J Appl Physiol

authors

Agrafiotis M

doi

10.1007/s00421-010-1803-1

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

1951-4

issue

8

eissn

1439-6319

issn

1439-6327

journal_volume

111

pub_type

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