Abstract:
:The present study investigated the changes occurring in interstitial metabolite concentrations and blood flow in insulin-resistant human skeletal muscle during the post-exercise recovery period following a single 2-h bout of one-legged exercise. In addition, the effect of microdialysis perfusion with insulin or the insulin-mimetic trace element vanadate was explored. Eight microdialysis catheters, four in each leg, were inserted in the quadriceps femoris muscle of nine insulin-resistant obese male subjects 2 h following exercise. Two catheters in each leg were perfused at 0.2 microl/min for metabolite determinations and two at 1.33 microl/min for the determination of blood flow. Samples were collected until 9 h after the end of exercise had passed. The interstitial glucose concentration (mean +/- SD) was significantly lower in the exercised (2.8 +/- 1.3 mM) than in the rested leg (3.7 +/- 0.9 mM), P = 0.001, a difference that lasted at least 8 h after the exercise bout. On the other hand, blood flow was not different in the two legs. Microdialysis perfusion with insulin (14 mU/ml) or sodium metavanadate (100 mM) decreased the interstitial glucose concentration (P = 0.001) in both the exercised and rested leg. With vanadate, this decrease was similar in the exercised (-69%) and the rested leg (-71%), whereas insulin had a larger effect in the exercised leg (-29 vs. -6.9%), P = 0.05. This study shows that the interstitial glucose concentration in insulin-resistant skeletal muscle is markedly decreased for several hours following a single exercise session. This is in accordance with recent findings in healthy subjects. This change is accompanied by an increased insulin effect on the interstitial glucose concentration. The effect of vanadate was not decreased in insulin-resistant human skeletal muscle and was not augmented by exercise.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Hamrin K,Henriksson Jdoi
10.1007/s00421-008-0753-3subject
Has Abstractpub_date
2008-07-01 00:00:00pages
595-603issue
5eissn
1439-6319issn
1439-6327journal_volume
103pub_type
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journal_title:European journal of applied physiology
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of applied physiology
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journal_title:European journal of applied physiology
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journal_title:European journal of applied physiology
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更新日期:2011-01-01 00:00:00
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journal_title:European journal of applied physiology
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
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