Abstract:
:Improving endurance capacity leads to increased athletic performance and active lifestyles. The aim of this study was to investigate the effect of the intake of red grape leaf extract (RGLE), used as a traditional herbal medicine in the Mediterranean area, on endurance capacity in mice. Male BALB/c mice were divided into three experimental groups with similar swimming times and body weights; control group, 0.2% (w/w) and 0.5% RGLE group. Swimming times were measured for evaluation of endurance capacity once a week during the 10-week experimental period. Blood and tissues were collected from anesthetized mice immediately after 30 min of swimming exercise, and analyzed blood component and fatty acid oxidation enzyme activity, and gene expression in soleus muscle and mesenteric adipose tissue. Endurance capacity was improved by RGLE in a dose-related manner, and was significantly longer in the 0.5% RGLE group than in the control group at week 10. Plasma lactate levels after exercise in the 0.5% RGLE group were significantly lower than that in the control group. RGLE induced the upregulation of hormone-sensitive lipase mRNA in mesenteric adipose tissue, increased the plasma free fatty acid concentration after exercise, and enhanced fatty acid oxidation enzyme activity in the soleus muscle. Furthermore, peroxisome proliferator-activated receptor-gamma coactivator 1α (Pgc1α) and its downstream target genes were also significantly upregulated in the soleus muscle in the 0.5% RGLE group. Intake of RGLE upregulated Pgc1α expression and facilitated fatty acid oxidation in skeletal muscle, and these effects contributed, in part, to improve endurance capacity.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Minegishi Y,Haramizu S,Hase T,Murase Tdoi
10.1007/s00421-011-1826-2subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1983-9issue
9eissn
1439-6319issn
1439-6327journal_volume
111pub_type
杂志文章abstract::The purpose of this study was to evaluate the effects of various modes of training on the time-course of changes in lipoprotein-lipid profiles in the blood, cardiovascular fitness, and body composition after 16 weeks of training and 6 weeks of detraining in young women. A group of 48 sedentary but healthy women [mean ...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s004210000234
更新日期:2000-08-01 00:00:00
abstract::Regular physical activity is recognized as a non-pharmacological treatment of genetic obesity and type-II diabetes, and based on the "anti-inflammatory" effects of exercise, it has been also proposed for improving the "chronic low-grade inflammation" in metabolic syndrome (MS). The aim of the present work was to evalu...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1140-4
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine the effects of high-intensity aerobic interval training (AIT) on exercise hemodynamics in metabolic syndrome (MetS) volunteers. METHODS:Thirty-eight, MetS participants were randomly assigned to a training (TRAIN) or to a non-training control (CONT) group. TRAIN consisted ...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-017-3697-7
更新日期:2017-10-01 00:00:00
abstract::To test whether adding insulation to the arms would improve cold water swimming performance by delaying swimming failure (SF). Novice (n = 7) and expert (n = 8) swimmers, clothed and equipped with a personal flotation device, each performed two trials in a swimming flume filled with 10 degrees C water. During free swi...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0690-1
更新日期:2008-09-01 00:00:00
abstract::The impact of resistance training has not been thoroughly examined in overweight older adults undergoing weight loss. Subjects (n = 27) were overweight and obese (BMI 31.7 +/- 3.6 kg/m(2)) older (age 67 +/- 4 years) adults and were randomized into either a 10-week Dietary Approaches to Stop Hypertension for weight los...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-010-1387-9
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:Walking is a complex locomotor process that involves both spinal cord reflexes and cortical integration of peripheral nerve input. Maintaining an upright body position requires not only neuromuscular activity but also cardiovascular regulation. We postulated that plantar mechanical stimulation might modulate au...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-016-3479-7
更新日期:2016-12-01 00:00:00
abstract::The compound muscle action potential (M wave) has been commonly used to assess the peripheral properties of the neuromuscular system. More specifically, changes in the M-wave features are used to examine alterations in neuromuscular propagation that can occur during fatiguing contractions. The utility of the M wave is...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-017-3788-5
更新日期:2018-03-01 00:00:00
abstract::Stressful exercise results in temporary immune depression. However, the impact of exercise on the immune responses via toll-like receptor (TLR) 7, which recognizes the common viral genomic feature, single-stranded RNA, remains unclear. To clarify the effect of stressful exercise on immune function in response to viral...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-010-1560-1
更新日期:2010-11-01 00:00:00
abstract::An inverse relationship has been shown between running and cycling exercise economy and maximum oxygen uptake (VO2max). The purposes were: 1) determine the relationship between walking economy and VO2max; and 2) determine the relationship between muscle metabolic economy and muscle oxidative capacity and fiber type. S...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-005-1370-z
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:This study examined whether lower-volume exercise-induced muscle damage (EIMD) performed 2 weeks before high-volume muscle-damaging exercise protects against its detrimental effect on running performance. METHODS:Sixteen male participants were randomly assigned to a lower-volume (five sets of ten squats, n = 8...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-015-3131-y
更新日期:2015-07-01 00:00:00
abstract::An objective of a warm-up prior to an athletic event is to optimize performance. Warm-ups are typically composed of a submaximal aerobic activity, stretching and a sport-specific activity. The stretching portion traditionally incorporated static stretching. However, there are a myriad of studies demonstrating static s...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-011-1879-2
更新日期:2011-11-01 00:00:00
abstract::Maximal exercise elicits systemic acidosis where venous pH can drop to 6.74 and here we assessed how much lower the intracellular value (pH(i)) might be. The wrist flexor muscles are intensively involved in rowing and (31)P-magnetic resonance spectroscopy allows for calculation of forearm pH(i) and energy metabolites ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-010-1451-5
更新日期:2010-08-01 00:00:00
abstract::A model that describes the blood lactate concentration (BLC) dynamics [BLC(t)] of a Wingate Anaerobic Test (WAnT) as a function of (a) BLC at the start of exercise (BLC(0)), (b) extra-vascular increase in lactate (A), (c) two corresponding velocity constants of appearance (k (1)) and disappearance (k (2)) of lactate i...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-010-1481-z
更新日期:2010-09-01 00:00:00
abstract::We examined changes in muscle buffer capacity (beta m(in vitro)), VO2peak and the lactate threshold (LT) after 5 weeks of high-intensity interval training (INT) above the LT or moderate-intensity continuous training (CON) just below the LT. Prior to and immediately after training, 16 female subjects performed a graded...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-005-0068-6
更新日期:2006-01-01 00:00:00
abstract::Stretch-shortening cycle (SSC)-type fatigue is associated with acute and delayed functional defects, and appears to be a useful model to reveal the flexibility of both central and reflex adjustments to the contractile failure. SSC fatigue was induced in an experimental (EXP) group (n=6) on a sledge ergometer with an e...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-004-1221-3
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Isometric resistance training has repeatedly shown to be an effective exercise modality in lowering resting blood pressure (BP), yet associated mechanisms and sex differences in the response to training remain unclear. Exploration into potential sex differences in the response to isometric resistance train...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-016-3366-2
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To examine acute responses and recovery of force and serum hormones to combined endurance and strength loadings utilizing different orders of exercises before and after training. METHODS:Physically active men were matched to an order sequence of endurance followed by strength (E + S, n = 12) or strength follow...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-013-2813-6
更新日期:2014-04-01 00:00:00
abstract::Limited research documents if new and existing interactive computer gaming "exergaming" increase energy expenditure and cardio-respiratory costs comparable to common exercise modalities. To address this, healthy male volunteers (n = 15) completed six by 12-min test elements: PlayStation2 (PS2(hand)), Nintendo Wii boxi...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-010-1773-3
更新日期:2011-07-01 00:00:00
abstract::This study is aimed to evaluate whether circulating adiponectin concentration is associated with physical activity (PA) level in healthy older females. To date, daily PA in older adults (> or = 65 years) has primarily relied on self-report. This study used accelerometry, which objectively measured minute-by-minute mov...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-010-1423-9
更新日期:2010-07-01 00:00:00
abstract::The purpose of this article was to establish whether previously reported oxygen-to-mass ratios, used to predict flat and hill-climbing cycling performance, extend to similar power-to-mass ratios incorporating other, often quick and convenient measures of power output recorded in the laboratory [maximum aerobic power (...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-006-0189-6
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the changes in blood lactate concentration (BL) and muscle activity patterns during a 15-m speed climbing competition that consisted of ten consecutive climbing actions on a standardized artificial wall in trained rock climbers. METHODS:Twelve trained rock climbers ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-018-04070-w
更新日期:2019-03-01 00:00:00
abstract::The purpose of this review is to explore existing research on the physiological aspects of difficult rock climbing. Findings will be categorized into the areas of an athlete profile and an activity model. An objective here is to describe high-level climbing performance; thus the focus will primarily be on studies that...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-003-1036-7
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:This study examined the effects of combined cooling and lower body heat maintenance during half-time on second-half intermittent sprint performances. METHODS:In a repeated measures design, nine males completed four intermittent cycling trials (32.1 ± 0.3 °C and 55.3 ± 3.7% relative humidity), with either one o...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-019-04177-8
更新日期:2019-08-01 00:00:00
abstract::The aim of the present study was to assess the effects of acute dynamic resistance exercise on resting blood pressure (BP) and on endothelial function of vascular bed of spontaneously hypertensive rats. Hemodynamic measurements were performed before and after acute dynamic resistance exercise in conscious animals. Aft...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-010-1508-5
更新日期:2010-09-01 00:00:00
abstract::To clarify whether the resting background effects (genomic) or exercise-related action (non-genomic) of aldosterone (ALD) is primarily affected to an individual variation in the sweat Na+ concentration ([Na+]sweat), we analyzed the cross-sectional relationship between [Na+]sweat and the plasma ALD concentration during...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-006-0295-5
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:We examined the effect of ischemic preconditioning (IPC) on changes in muscle force, activation, and the spinal reflex pathway during and after repeated sprint cycling. METHODS:Eight recreationally active men (high-intensity cardiorespiratory training > 3 times per week, > 6 months) completed two exercise sess...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-020-04359-9
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:The purpose of the present study was to evaluate the effects of superimposed electromyostimulation (E) during cycling on the acute hormonal and metabolic response, as E might be a useful tool to intensify endurance training without performing high external workloads. METHODS:Thirteen subjects participated in t...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-014-2952-4
更新日期:2014-11-01 00:00:00
abstract::Over the years, techniques for the study of human movement have ranged in complexity and precision from direct observation of the subject through activity diaries, questionnaires, and recordings of body movement, to the measurement of physiological responses, studies of metabolism and indirect and direct calorimetry. ...
journal_title:European journal of applied physiology
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00421-011-2268-6
更新日期:2012-08-01 00:00:00
abstract::A number of mechanisms have been proposed to explain the elevation in oxygen consumption following exercise. Biochemical processes that return muscle to its pre-exercise state do not account for all of the extra oxygen consumed after exercise (excess post-exercise oxygen consumption, EPOC). Muscle at rest after aerobi...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0578-5
更新日期:2007-12-01 00:00:00
abstract::A hypoxic model was used to investigate changes in localized cerebral and muscle haemodynamics during knee extension (KE) in healthy individuals. Thirty-one young healthy volunteers performed one set of KE until failure under hypoxia (14 % O(2)) or normoxia (21 % O(2)) at 50, 75 or 100 % of 1 repetition maximum, in ra...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-012-2408-7
更新日期:2013-01-01 00:00:00