Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay.

Abstract:

:The zebrafish (Danio rerio) has emerged as a promising model organism for affective or cognitive neuroscience research, and may be useful to study the interplay between memory and anxiety-related states. To assess the effects of acute psychological stress on spatial and cued memory, adult zebrafish were trained in an aquatic plus-maze for 14 days using food bait as a reward. Two ecologically relevant stressors (alarm pheromone or Indian leaf fish exposure) were applied to acutely stress zebrafish immediately prior to the final (testing) trial. Overall, acute single inescapable stress markedly impaired spatial and cued memory in zebrafish plus-maze test, reducing the number of correct arm entries and time spent in the target arm. This observation parallels rodent and clinical literature on memory-impairing effects of acute stress, strongly supporting the utility of zebrafish in neurobehavioral research.

journal_name

Behav Processes

journal_title

Behavioural processes

authors

Gaikwad S,Stewart A,Hart P,Wong K,Piet V,Cachat J,Kalueff AV

doi

10.1016/j.beproc.2011.04.004

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

224-30

issue

2

eissn

0376-6357

issn

1872-8308

pii

S0376-6357(11)00080-5

journal_volume

87

pub_type

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