A time contraction effect of acute tail-pinch stress on the associative learning of rats.

Abstract:

:The effect of tail-pinch stress interpolated between the saccharin conditioned stimulus (CS) and the illness-inducing unconditioned stimulus (US) during long-trace taste-aversion conditioning was examined in young- and old adult rats with a two-cylinder (saccharin versus water) test. A 2 x 2 x 4 factorial ANOVA was performed on percent-preference-for-saccharin data, with age (young, old), stress condition (stressed, non-stressed), and CS-US interval (22.5-, 45-, 90-, and 180-min) being the factors under consideration. The ANOVA yielded only significant main effects of stress condition and CS-US interval. These findings indicate that stress weakens the CS-US association as evidenced by a higher percent preference for saccharin in the stressed rats than in non-stressed rats at all CS-US intervals. A comparison of the stressed and non-stressed conditioned rats with pseudo-conditioned controls showed that the non-stressed rats formed strong aversions up to the 45-min CS-US interval whereas the stressed rats showed no conditioning beyond the 22.5 min CS-US interval, indicating that stress decreases the effective CS-US interval. Results were interpreted in terms of time-contraction and an internal biological countdown timer hypothesized to govern processes involved in associative learning over long delays.

journal_name

Behav Processes

journal_title

Behavioural processes

authors

Misanin JR,Kaufhold SE,Paul RL,Hinderliter CF,Anderson MJ

doi

10.1016/j.beproc.2005.09.001

keywords:

subject

Has Abstract

pub_date

2006-01-10 00:00:00

pages

16-20

issue

1

eissn

0376-6357

issn

1872-8308

pii

S0376-6357(05)00188-9

journal_volume

71

pub_type

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