Abstract:
:The effect of low dose (600 mg/day) alpha-tocopheryl nicotinate on serum lipoprotein(a) (Lp(a] concentration was studied in 28 hyperlipidaemic patients. Serum lipids, lipoproteins and apolipoproteins, except for Lp(a), tended to increase after treatment. In particular, the changes in HDL-cholesterol and apo C-II levels were statistically significant. On the other hand, serum Lp(a) levels in all patients decreased significantly after 2 months of treatment. Furthermore, no difference between before and after treatment was observed in the group with initial Lp(a) levels less than 18 mg/dl, whereas Lp(a) concentrations decreased significantly after treatment in the group with levels greater than or equal to 18 mg/dl. The effects of probucol and alpha-tocopheryl nicotinate on serum Lp(a), total cholesterol and HDL-cholesterol were entirely different. Possible mechanisms of alpha-tocopheryl nicotinate on serum Lp(a) and lipoprotein metabolism are discussed.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Noma A,Maeda S,Okuno M,Abe A,Muto Ydoi
10.1016/0021-9150(90)90093-xsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
213-7issue
2-3eissn
0021-9150issn
1879-1484pii
0021-9150(90)90093-Xjournal_volume
84pub_type
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