Abstract:
INTRODUCTION:Direct quantification of atherosclerotic plaque volume by three-dimensional vascular ultrasound (3DVUS) is more reproducible than 2DUS-based three-dimensional (2D/3D) techniques that generate pseudo-3D volumes from summed 2D plaque areas; however, its accuracy has not been reported. We aimed to determine 3DVUS accuracy for plaque volume measurement with special emphasis on small plaques (a hallmark of early atherosclerosis). METHODS:The in vitro study consisted of nine phantoms of different volumes (small and medium-large) embedded at variable distances from the surface (superficial vs. >5 cm-depth) and comparison of 3DVUS data generated using a novel volumetric-linear array method with the real phantom volumes. The in vivo study was undertaken in a rabbit model of atherosclerosis in which 3DVUS and 2D/3D volume measurements were correlated against gold-standard histological measurements. RESULTS:In the in vitro setting, there was a strong correlation between 3DVUS measures and real phantom volume both for small (3.0-64.5 mm(3) size) and medium-large (91.1-965.5 mm(3) size) phantoms embedded superficially, with intraclass correlation coefficients (ICC) of 0.99 and 0.98, respectively; conversely, when phantoms were placed at >5 cm, the correlation was only moderate (ICC = 0.67). In the in vivo setting there was strong correlation between 3DVUS-measured plaque volumes and the histological gold-standard (ICC = 0.99 [4.02-92.5 mm(3) size]). Conversely, the correlation between 2D/3D values and the histological gold standard (sum of plaque areas) was weaker (ICC = 0.87 [49-520 mm(2) size]), with large dispersion of the differences between measurements in Bland-Altman plots (mean error, 79.2 mm(2)). CONCLUSIONS:3DVUS using the volumetric-linear array method accurately measures plaque volumes, including those of small plaques. Measurements are more accurate for superficial arterial territories than for deep territories.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
López-Melgar B,Fernández-Friera L,Sánchez-González J,Vilchez JP,Cecconi A,Mateo J,Peñalvo JL,Oliva B,García-Ruiz JM,Kauffman S,Jiménez-Borreguero LJ,Ruiz-Cabello J,Fernández-Ortiz A,Ibáñez B,Fuster Vdoi
10.1016/j.atherosclerosis.2016.03.002subject
Has Abstractpub_date
2016-05-01 00:00:00pages
230-7eissn
0021-9150issn
1879-1484pii
S0021-9150(16)30077-6journal_volume
248pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract::We have used discoidal reconstituted high density lipoproteins (rHDL) containing apolipoprotein (apo) A-I and dimyristoyl phosphatidylcholine (DMPC) as a tool to investigate the time sequence of the HDL-mediated inhibition of vascular cell adhesion molecule (VCAM)-1 and E-selectin expression in cytokine-activated huma...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(00)00659-6
更新日期:2001-07-01 00:00:00
abstract:UNLABELLED:Inflammation plays an important role in atherosclerosis and the genesis of acute coronary syndromes, i.e., atheromatous plaque disruption. Neutrophil count and C-reactive protein (CRP) levels are markers of ongoing inflammation and predictors of cardiovascular risk. We sought to assess whether these inflamma...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.03.013
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:Th1 activation and regulatory T (Treg) cell suppression have been observed in acute coronary syndrome (ACS), including unstable angina (UA) and acute myocardial infarction (AMI). However, the role of Th17 cell or IL-17A remains controversial in ACS patients, and little is known about the role of recently disc...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2011.03.043
更新日期:2011-08-01 00:00:00
abstract::Secretory non-pancreatic (group II) phospholipase A2 (sPLA2) releases precursors of important mediators of inflammation from phospholipids. Based on the inflammatory character of atherosclerosis we previously described the identification of sPLA2 in human atherosclerotic plaques. In vitro studies on lipoproteins have ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(99)00045-3
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:PPARgamma (PPARg) is a nuclear transcription factor involved in the control of lipid and glucose homeostasis. Two PPARg common polymorphisms, Pro12Ala and 161C>T, have been found to be associated with cardiovascular disease. In this study, in addition to PPARg coding region, we looked for genetic variations ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2008.11.009
更新日期:2009-07-01 00:00:00
abstract::Lipoprotein(a) (Lp(a)) is regarded as an independent risk factor for Atherosclerotic cardiovascular disease. The objectives of this study were: to determine the effects of diet and exercise on Lp(a) and to evaluate the relation of Lp(a) with the lipid profile (total serum cholesterol (TC), triglycerides (TG), low dens...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2003.09.017
更新日期:2004-01-01 00:00:00
abstract::Macrophage scavenger receptors class A (MSR) are thought to play an important role in atherogenesis by mediating the unrestricted uptake of modified lipoproteins by macrophages in the vessel wall leading to foam cell formation. To investigate the in vivo role of the MSR in this process, a transgenic mouse model expres...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(99)00204-x
更新日期:1999-12-01 00:00:00
abstract::High-density lipoprotein (HDL) cholesteryl esters (CE) are taken up by many cells without parallel uptake of HDL apolipoproteins. This selective uptake of HDL CE was investigated in human monocyte-derived macrophages (HMM). HDL3 (d = 1.125-1.21 g/ml) was labeled in its apolipoprotein A-I moiety with 125I and in its CE...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(94)90044-2
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND AIMS:We aimed to identify a blood-based gene expression score (GES) to predict the severity of coronary artery stenosis in patients with known or suspected coronary artery disease (CAD) by integrative use of gene network construction, Support Vector Machine (SVM) algorithm, and multi-cohort validation. ...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2019.10.001
更新日期:2019-12-01 00:00:00
abstract::A recent study has suggested that symptoms of chronic bronchitis predict the risk of coronary disease independently of the known major cardiovascular risk factors. High serum levels of lipoprotein(a) (Lp(a)) have also been considered as an independent risk factor for coronary heart disease. Therefore, the aim of the p...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章
doi:10.1016/s0021-9150(99)00192-6
更新日期:1999-12-01 00:00:00
abstract::The ultrastructure of the aortic intima and serum lipid levels in Fischer 344 rats were examined at the ages of 12, 18 and 24 months after feeding the animals an atherogenic diet (2% cholesterol, 0.25% sodium cholate, 5% beef fat) for 6 months. Structural changes in the intima were noticeable only at the age of 24 mon...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(89)90114-7
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Defects in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a highly atherogenic condition. The effect of different LDLR mutations on coronary heart disease (CHD) risk is insufficiently defined. We assessed carotid intima-media thickness (IMT), a surro...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2009.07.058
更新日期:2010-02-01 00:00:00
abstract::Interleukin-8 is a cytokine produced by mononuclear cells that is involved in polymorphonuclear neutrophil leukocyte (PMN) recruitment and activation. Several studies have previously demonstrated a leukocyte activation during hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(99)00160-4
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Carotid intima-media thickness (cIMT) is associated with CV events in adults. Thicker cIMT is found in youth with CV risk factors including obesity. Which risk factors have the most effect upon cIMT in youth and whether obesity has direct or indirect effects is not known. We used structural equation modeling...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.11.033
更新日期:2016-03-01 00:00:00
abstract::The effect of low dose (600 mg/day) alpha-tocopheryl nicotinate on serum lipoprotein(a) (Lp(a] concentration was studied in 28 hyperlipidaemic patients. Serum lipids, lipoproteins and apolipoproteins, except for Lp(a), tended to increase after treatment. In particular, the changes in HDL-cholesterol and apo C-II level...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章
doi:10.1016/0021-9150(90)90093-x
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:Subjects with metabolic syndrome (MetS) and individuals with type 2 diabetes are at high risk for vascular complications. Hormones acting on vascular endothelium may be involved in the atherogenic process associated with metabolic disorders. The objective of this study was to determine the correlation of pro-...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.07.047
更新日期:2013-10-01 00:00:00
abstract::We have previously reported that mouse peritoneal macrophages have three types of modified low density lipoprotein (LDL) receptors. One is specific for acetylated LDL (Ac-LDL), the second is for oxidized LDL (Ox-LDL), and the third recognizes both (Arai, H. et al. (1989) Biochem. Biophys. Res. Commun. 159, 1375-1382)....
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(93)90098-f
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here, we addressed wh...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.04.020
更新日期:2014-07-01 00:00:00
abstract::Gross dissection of the coronary arteries of 566 subjects aged 0--45 years from an unselected population sample of Bucharest revealed the presence of a similar anatomical branching pattern in 58% of cases. Starting from this common type of distribution of coronary arteries, some minor deviations were detected coexisti...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(81)90141-6
更新日期:1981-11-01 00:00:00
abstract::Low density lipoproteins (LDL) isolated by ultracentrifugation induce cytotoxic changes in cultured human endothelial cells (EC) and fibroblasts if the ratio between LDL cholesterol and the final protein concentration of the culture medium exceeds 0.10-0.12 mmol/g protein. In order to investigate if reactive oxygen sp...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(83)90004-7
更新日期:1983-10-01 00:00:00
abstract::The aims of this study were to determine whether non-invasive measurement of endothelial function in conduit arteries reflects that of subcutaneous resistance arteries measured in vitro and to examine whether there is an endothelial dysfunction also in resistance arteries in patients with a previous myocardial infarct...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.03.025
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort. BACKGROUND:Brachial flow-mediated dilation (FMD) is a physiologic measure and carotid IMT is an anatomic structural measure of...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2007.07.032
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Perivascular fat through the secretion of paracrine and pro-inflammatory mediators may play a role in obesity-mediated vascular disease. We sought to examine associations between adipose tissue depots immediately surrounding the thoracic aorta, metabolic risk factors, and vascular calcification. METHODS:In p...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2010.01.007
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Calcific aortic valve disease is an active and progressive condition. Data indicate that aortic valve calcification (AVC) is associated with endothelial dysfunction and accepted as a manifestation of atherosclerosis. Coronary flow reserve (CFR) determined by transthoracic echocardiography has been introduced...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.07.036
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). METHODS:We compared 28 mg/kg crystalline IR niacin, equimolar doses of crystalline IR ST0702 and control on low densit...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.01.016
更新日期:2012-04-01 00:00:00
abstract::Platelet phospholipid composition was analyzed before and after extracorporeal removal of low density lipoproteins (LDL) by LDL apheresis in six patients with familial hypercholesterolemia. Elevated levels of total plasma cholesterol and the portion of plasma cholesterol carried by LDL were reduced by 56 and 66% after...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)06087-5
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:The objective of this article is to review the current literature on Wnt5a and its signaling mechanism, along with its role in atherosclerosis. In addition, the significance of Wnt5a as a diagnostic marker and a potential therapeutic target is reviewed. Wnt5a, a secreted glycoprotein, belongs to a family of h...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2014.08.027
更新日期:2014-11-01 00:00:00
abstract::The concentrations of cholesterol (C) and phospholipid (PL) levels in the high density lipoprotein (HDL) fraction and the HDL2 and HDL3 subfractions were determined in 74 men with incapacitating angina pectoris and coronary artery disease (CAD) verified by angiography. An equal number of randomly sampled healthy men m...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(86)90041-9
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress. ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.04.041
更新日期:2018-07-01 00:00:00
abstract::Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various li...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.10.046
更新日期:2005-09-01 00:00:00