Abstract：
:The objective of the present study was to determine the optimum composition for sustained-release of tamsulosin hydrochloride from microparticles intended for orally disintegrating tablets. Microparticles were prepared from an aqueous ethylcellulose dispersion (Aquacoa®), and an aqueous copolymer based on ethyl acrylate and methyl methacrylate dispersion (Eudragit®) NE30D), with microcrystalline cellulose as core particles with a fluidized bed coating process. Prepared microparticles were about 200 μm diameter and spherical. The microparticles were evaluated for in vitro drug release and in vivo absorption to assess bioequivalence in a commercial product, Harnal® pellets. The optimum ratio of Aquacoat® and Eudragit® NE30D in the matrix was 9:1. We observed similar drug release profiles in microparticles and Harnal® pellets. Higuchi model analysis of the in vitro drug release from microparticles was linear up to 80% release, typical of Fickian diffusion sustained-release profile. The in vivo absorption properties from microparticles were comparable to Harnal® pellets, and there was a linear relationship between in vitro drug release and in vivo drug release. In conclusion, this development produces microparticles in single-step coating, that provided a sustained-release of tamsulosin hydrochloride comparable to Harnal® pellets.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Maeda A,Shinoda T,Ito N,Baba K,Oku N,Mizumoto Tdoi
10.1016/j.ijpharm.2011.01.053subject
Has Abstractpub_date
2011-04-15 00:00:00pages
84-90issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(11)00084-6journal_volume
408pub_type
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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abstract：:Liposomes modified using cationic and hydrophilic nonionic polymers are 2 popular carriers for improving oral drug absorption. Cationic polymer-modified liposomes can adhere to the intestinal wall mucus (mucoadhesive type), while liposomes modified using hydrophilic nonionic polymers can penetrate across the mucus bar...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2013.04.002
更新日期：2013-06-05 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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更新日期：2001-05-07 00:00:00
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journal_title：International journal of pharmaceutics
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pub_type： 杂志文章
doi：10.1016/j.ijpharm.2008.11.019
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journal_title：International journal of pharmaceutics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2020-08-30 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2016-09-25 00:00:00
