Abstract：
:The objective of this report was to analyse a potential role for FGF6 in muscle resistance to mechanical stress. Normal or regenerating muscles of FGF6 (-/-) mice versus wild-type mice were submitted to different protocols of damaging eccentric contractions (eccentric electrostimulation and intermittent downhill exercise). Then muscular structural properties were analysed by histological and immunochemistry techniques to evaluate the post-injury muscle recovery; their muscle contractile parameters (maximal tetanic force, kinetics properties and fatigue resistance) were assessed. The absence of FGF6 causes (1) a fast-to-slow myofibre type switch in adult control and regenerating Tibialis anterior (TA) muscle; (2) muscle weakness in regenerating muscles in animals submitted to eccentric exercise protocols due to aberrant extensive necrotic zones. These observations point out a crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Laziz I,Ferry A,Armand AS,Gallien CL,Gaspera BD,Charbonnier F,Chanoine Cdoi
10.1007/s00421-010-1784-0subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1507-15issue
7eissn
1439-6319issn
1439-6327journal_volume
111pub_type
杂志文章abstract：:We have previously shown that Achilles tendon length is related to walking economy on the flat, presumably because of increased stretch-shortening cycle elastic energy savings. In addition, greater walking economy in African American (AA) women compared to European American (EA) women is explained by longer Achilles t...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-010-1816-9
更新日期：2011-08-01 00:00:00
abstract：:The SenseWear Armband (SWA) has been shown to be a valid and practical tool to assess energy expenditure during habitual physical activity. However, previous studies have focused on low-to-moderate intensity activities. The purpose of this study was to assess the validity of the SWA during high intensity exercise. Twe...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1695-0
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the effect of exhaustive exercise on technique preference and the accompanying physiological response during classic skiing at constant workload, but with varying incline-speed combinations. METHODS:Seven male competitive cross-country skiers performed four tests, each ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-018-3965-1
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:Neural drive and contractile properties are well-defined physiological determinants of explosive strength, the influence of muscle architecture and related morphology on explosive strength is poorly understood. The aim of this study was to examine the relationships between Quadriceps muscle architecture (pennat...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04585-1
更新日期：2021-01-17 00:00:00
abstract：:The purpose of this study was to compare the effects of active vs. passive recovery on the time to exhaustion for intermittent runs (15 s) at supramaximal velocity (120% of maximal aerobic speed). Twelve male subjects performed a graded test, an intermittent run to exhaustion with active recovery (50% of maximal aerob...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-003-0834-2
更新日期：2003-08-01 00:00:00
abstract：PURPOSE:To determine whether mechanomyographic (MMG) determined contractile properties of the biceps brachii change during exercise-induced hypertrophy and subsequent disuse atrophy. METHODS:Healthy subjects (mean ± SD, 23.7 ± 2.6 years, BMI 21.8 ± 2.4, n = 19) performed unilateral biceps curls (9 sets × 12 repetition...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-016-3469-9
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:The purpose of this research is to determine the pacing and nutrition strategies which minimize completion time and carbohydrate intake for athletes competing in ultramarathon races. METHODS:We present the formulation of a two-phase optimization model. The first-phase mixed-integer nonlinear program (MINLP) de...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-017-3741-7
更新日期：2017-12-01 00:00:00
abstract：:In this study, the effect of a simulated dive on rat brain was investigated using several magnetic resonance imaging (MRI)-methods and immunohistochemistry. Rats were randomly assigned to a dive- or a control group. The dive group was exposed to a simulated air dive to 600 kPa for 45 min. Pulmonary artery was monitore...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2565-8
更新日期：2013-06-01 00:00:00
abstract：:In 1976, Paolo Cerretelli published an article entitled "Limiting factors to oxygen transport on Mount Everest" in the Journal of Applied Physiology. The paper demonstrated the role of cardiovascular oxygen transport in limiting maximal oxygen consumption (VO2max). In agreement with the predominant view of VO2max limi...
journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-003-0923-2
更新日期：2003-10-01 00:00:00
abstract：:Body tilt angle affects the fatigue of human calf muscle at a high contractile force (i.e. 70 %MVC); but the range of forces across which this effect occurs is not known and we sought to determine this in the present study. Fourteen men performed intermittent calf muscle contractions at either 30, 40, 50 and 60 %MVC (...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-006-0308-4
更新日期：2007-01-01 00:00:00
abstract：:The purpose of this study was to assess the effect of a soccer match on the cardiac autonomic control of heart rate (HR) in soccer referees. Sixteen Spanish regional and third division referees (11 males: 26 ± 7 years, 74.4 ± 4.1 kg, 178 ± 3 cm, Yo-Yo IR1 ~600-1,560 m; 5 females: 22 ± 3 years, 59.3 ± 4.8 kg, 158 ± 8 c...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2202-y
更新日期：2012-06-01 00:00:00
abstract：:One of the possible risks incurred while diving is inert gas narcosis (IGN), yet its mechanism of action remains a matter of controversy. Although providing insights in the basic mechanisms of IGN, research has been primarily limited to animal studies. A human study, in real diving conditions, was needed. Twenty volun...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2391-z
更新日期：2012-12-01 00:00:00
abstract：:The aim of this study was to quantify the influence of head-up-tilt (HUT) on the isocapnic hypoxic ventilatory response (HVR) in man, and to investigate the effect of orthostatic blood shifts separately from other gravitational effects by the application of lower-body negative pressure (LBNP) with subjects in a horizo...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210050070
更新日期：2000-04-01 00:00:00
abstract：:The aim of the present study was to investigate the relationship between physical fitness, heart rate variability (HRV) and cognitive function in 37 male sailors from the Royal Norwegian Navy. All subjects participated in an 8-week training program, after which the subjects completed the initial cognitive testing (pre...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-004-1208-0
更新日期：2004-12-01 00:00:00
abstract：:Future activities in space will require greater periods of time in extreme environments in which the body periphery will be vulnerable to chilling. Maintaining the hands and fingers in comfortable conditions enhances finger flexibility and dexterity, and thus effects better work performance. We have evaluated the effi...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210050658
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate whether different types of visual feedback influence the control of standing balance. METHODS:Twenty-six subjects performed three tasks on a force platform: (1) standing with eyes open; (2) maintaining the own center of pressure (COP) displacement (internal feedback) on a ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-016-3434-7
更新日期：2016-09-01 00:00:00
abstract：:Exercise-induced muscle damage (EIMD) is a common occurrence following activities with a high eccentric component. Alterations to the torque-velocity relationship following EIMD would appear to have serious implications for athletic performance, particularly as they relate to impairment of maximal intensity exercise. ...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-005-1357-9
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:Standing workstations have recently been promoted as a healthy alternative to sitting. However, it is unknown how prolonged standing affects arterial stiffness, a prognostic indicator of cardiovascular health. The purpose of this study was twofold: to observe changes in arterial stiffness, as assessed by pulse ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-018-3956-2
更新日期：2018-10-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. ...
journal_title：European journal of applied physiology
pub_type： 已发布勘误
doi：10.1007/s00421-020-04497-0
更新日期：2020-12-01 00:00:00
abstract：:When muscle is artificially activated, as with electromyostimulation (EMS), action potentials are evoked in both intramuscular nerve branches and cutaneous receptors, therefore activating spinal motoneurons reflexively. Maximal soleus and gastrocnemii H- and T-reflex and the respective mechanical output were thus quan...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-003-0914-3
更新日期：2003-11-01 00:00:00
abstract：:Advancing age is associated with changes in fat and carbohydrate (CHO) metabolism, which is considered a risk factor for cardiovascular disease and diabetes. The effects of exercise intensity and duration on fat and CHO metabolism in elderly male subjects were investigated in the present study. Seven trained (63.7+/-4...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0523-7
更新日期：2007-11-01 00:00:00
abstract：:Isometric maximum voluntary force (MVF) of the adductor pollicis and first dorsal interosseous muscles was measured in 11 pre- and 11 post-menopausal (Pre-M and Post-M) human subjects. The temperature of the hand varied in the range 18°-38°C by water immersion and skin temperature was recorded. MVF at each temperature...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-011-2061-6
更新日期：2012-03-01 00:00:00
abstract：:This study aimed to determine metabolic and respiratory adaptations during intense exercise and improvement of long-sprint performance following six sessions of long-sprint training. Nine subjects performed before and after training (1) a 300-m test, (2) an incremental exercise up to exhaustion to determine the veloci...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2018-9
更新日期：2012-02-01 00:00:00
abstract：:The aim of this study was to analyze the pedaling rate (PR) adopted by professional cyclists in different mountain passes. PR, heart rate (HR), velocity and power to overcome gravity were monitored during special (HM), 1st (M1), 2nd (M2) and 3rd (M3) category mountain passes. HM and M1 within high-mountain stages were...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0745-3
更新日期：2008-07-01 00:00:00
abstract：:Early effects of a resistance training program include neural adaptations at multiple levels of the neuraxis, but direct evidence of central changes is lacking. Plasticity exhibited by multiple supraspinal centers following training may alter slow negative electroencephalographic activity, referred to as movement-rela...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1432-8
更新日期：2010-07-01 00:00:00
abstract：: ...
journal_title：European journal of applied physiology
pub_type： 评论,信件
doi：10.1007/s00421-018-3990-0
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:This study aimed at identifying the short-term effect of creep deformation on the trunk repositioning sense. METHODS:Twenty healthy participants performed two different trunk-repositioning tasks (20° and 30° trunk extension) before and after a prolonged static full trunk flexion of 20 min in order to induce sp...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-017-3754-2
更新日期：2018-01-01 00:00:00
abstract：:The fatality of deep hypothermia in non-hibernating mammals follows the cessation of respiration and heart beat, and a massive influx of calcium (Ca(++)) into cells. This review presents evidence relating to restoration of key physiological functions during hypothermia in several animal preparations. For example, in a...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0875-7
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:The purpose of the present study was to evaluate the effects of superimposed electromyostimulation (E) during cycling on the acute hormonal and metabolic response, as E might be a useful tool to intensify endurance training without performing high external workloads. METHODS:Thirteen subjects participated in t...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-014-2952-4
更新日期：2014-11-01 00:00:00
abstract：:Adaptations to chronic hypoxia involve changes in membrane transport proteins. The underlying mechanism of this response may be related to concomitant occurring changes in erythropoietin (Epo) levels. We therefore tested the direct effects of recombinant human erythropoietin (rHuEpo) treatment on the expression of mus...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0567-8
更新日期：2007-12-01 00:00:00
