Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.

abstract：:Schizosaccharomyces pombe cells were transformed with an S. pombe expression vector containing a full-length cDNA of the Chlorella hexose transporter. The transformed cells accumulated 3-O-methylglucose up to 10-fold, whereas wild-type S. pombe and control transformants could only equilibrate this sugar analogue. In a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauer N,Caspari T,Klebl F,Tanner W

更新日期：1990-10-01 00:00:00

abstract：:Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a Q precursor. While many bacteria are capable of Q de novo synthesis, salvag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuan Y,Zallot R,Grove TL,Payan DJ,Martin-Verstraete I,Šepić S,Balamkundu S,Neelakandan R,Gadi VK,Liu CF,Swairjo MA,Dedon PC,Almo SC,Gerlt JA,de Crécy-Lagard V

更新日期：2019-09-17 00:00:00

abstract：:We demonstrate how a conventional confocal spinning-disk (CSD) microscope can be converted into a doubly resolving image scanning microscopy (ISM) system without changing any part of its optical or mechanical elements. Making use of the intrinsic properties of a CSD microscope, we illuminate stroboscopically, generati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz O,Pieper C,Clever M,Pfaff J,Ruhlandt A,Kehlenbach RH,Wouters FS,Großhans J,Bunt G,Enderlein J

更新日期：2013-12-24 00:00:00

abstract：:The transmission of complexity during DNA replication has been investigated to clarify the significance of this molecular property in a deterministic process. Complexity was equated with the amount of randomness within an ordered molecular structure and measured by the entropy of a posteriori probabilities for discret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis BK

更新日期：1979-05-01 00:00:00

abstract：:Replication-competent viruses, such as Vaccinia virus (VACV), are powerful tools for the development of oncolytic viral therapies and elicit superior immune responses when used as vaccine and immunotherapeutic vectors. However, severe complications from uncontrolled viral replication can occur, particularly in immunoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grigg P,Titong A,Jones LA,Yilma TD,Verardi PH

更新日期：2013-09-17 00:00:00

abstract：:Recently, a 29-residue cyclic peptide was synthesized (TrPepz) that was reported to possess nearly the same catalytic activity and specificity as the pancreatic serine protease, trypsin, for hydrolysis of a small ester substrate, N-tosyl-L-arginine methyl ester (TAME), and small and large peptides [Atassi, M. Z. & Man...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wells JA,Fairbrother WJ,Otlewski J,Laskowski M Jr,Burnier J

更新日期：1994-05-10 00:00:00

abstract：:The spatial organization of complex natural microbiomes is critical to understanding the interactions of the individual taxa that comprise a community. Although the revolution in DNA sequencing has provided an abundance of genomic-level information, the biogeography of microbiomes is almost entirely uncharted at the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mark Welch JL,Rossetti BJ,Rieken CW,Dewhirst FE,Borisy GG

更新日期：2016-02-09 00:00:00

abstract：:The nod (no distributive disjunction) and the ncd (non-claret disjunctional) mutations are both female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of nondisjunction at meiosis I and both have been shown to encode kinesin-like proteins. Unlike the nc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles BA,Hawley RS

更新日期：1991-08-15 00:00:00

abstract：:How did human cooperation evolve? Recent evidence shows that many people are willing to engage in altruistic punishment, voluntarily paying a cost to punish noncooperators. Although this behavior helps to explain how cooperation can persist, it creates an important puzzle. If altruistic punishment provides benefits to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH

更新日期：2005-05-10 00:00:00

abstract：:The image that best expresses Darwin's thinking is the tree of life. However, Darwin's human evolutionary tree lacked almost everything because only the Neanderthals were known at the time and they were considered one extreme expression of our own species. Darwin believed that the root of the human tree was very deep ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL

更新日期：2010-05-11 00:00:00

abstract：:The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhao D,Horie T,Chen G,Bao H,Chen S,Liu W,Horie R,Liang T,Dong B,Feng Q,Tao Q,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and apoptosis has been identified as a central mechanism responsible for oocyte elimination. A few recent reports suggest that uncontrolled inflammation may adversely affect ovarian reserve. We tested the possible role of the proi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uri-Belapolsky S,Shaish A,Eliyahu E,Grossman H,Levi M,Chuderland D,Ninio-Many L,Hasky N,Shashar D,Almog T,Kandel-Kfir M,Harats D,Shalgi R,Kamari Y

更新日期：2014-08-26 00:00:00

abstract：:One of the factors required for the antiviral activity of the synthetic nucleoside, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is the ability of the molecule to adopt the substrate conformation specified by the enzyme for which it is a competitive inhibitor, inosine 5'-phosphate dehydrogenase (IM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DL,Miles DW,Redington P,Eyring H

更新日期：1976-12-01 00:00:00

abstract：:We report measurements of the geometrical structure and temporal evolution of metastable helical intermediates in the pathway for cholesterol crystallization in native and model biles. We find that the lecithin component in the bile can dramatically affect the kinetics along this pathway. We also present a theoretical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung DS,Benedek GB,Konikoff FM,Donovan JM

更新日期：1993-12-01 00:00:00

abstract：:Estimates of 21st Century global-mean surface temperature increase have generally been based on scenarios that do not include climate policies. Newly developed multigas mitigation scenarios, based on a wide range of modeling approaches and socioeconomic assumptions, now allow the assessment of possible impacts of clim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Vuuren DP,Meinshausen M,Plattner GK,Joos F,Strassmann KM,Smith SJ,Wigley TM,Raper SC,Riahi K,de la Chesnaye F,den Elzen MG,Fujino J,Jiang K,Nakicenovic N,Paltsev S,Reilly JM

更新日期：2008-10-07 00:00:00

abstract：:H2O2, in concentrations achieved in the proximity of stimulated leukocytes, induces injury and lysis of target cells. This may be an important aspect of inflammatory injury of tissues. Cell lysis in two target cells, the murine macrophage-like tumor cell line P388D1 and human peripheral lymphocytes, was found to be as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schraufstatter IU,Hyslop PA,Hinshaw DB,Spragg RG,Sklar LA,Cochrane CG

更新日期：1986-07-01 00:00:00

abstract：:A Mr 70,000 protein was isolated from cytotoxic human large granular lymphocytes and shown to have cytotoxic activity. The protein was demonstrated to be immunochemically related to the ninth component (C9) of complement and was therefore designated C9-related protein (C9RP). This finding suggests that C9RP and C9 sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalman LS,Brothers MA,Chiu FJ,Müller-Eberhard HJ

更新日期：1986-07-01 00:00:00

abstract：:Circular dichroism (CD) and magnetic circular dichroism (MCD) spectra of nitrogenase components (MoFe protein and Fe protein) from Azotobacter vinelandii (Av) and Klebsiella pneumoniae (Kp) have been obtained in the near infrared-visible-near ultraviolet spectral region. Previously, visible CD was reported to be absen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephens PJ,McKenna CE,Smith BE,Nguyen HT,McKenna MC,Thomson AJ,Devlin F,Jones JB

更新日期：1979-06-01 00:00:00

abstract：:Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient. Four electrons and protons are used for chemistry, while four more protons are pumped. Proton pumping requires that residues on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu J,Gunner MR

更新日期：2014-08-26 00:00:00

abstract：:In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation of endocardial cells and that its deletion therein results in fully penetrant, dose-dependent atria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadeau M,Georges RO,Laforest B,Yamak A,Lefebvre C,Beauregard J,Paradis P,Bruneau BG,Andelfinger G,Nemer M

更新日期：2010-11-09 00:00:00

abstract：:Transcription of the type 1 herpes simplex virus (HSV-1) genome in trigeminal ganglia of latently infected mice was studied using in situ hybridization. Probes representative of each temporal gene class were used to determine the regions of the genome that encode the transcripts present in latently infected cells. Pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deatly AM,Spivack JG,Lavi E,Fraser NW

更新日期：1987-05-01 00:00:00

abstract：:The fatty acids associated with phospholipids of cell membranes, and particularly their degree of unsaturation, contribute to the fluidity of their structure and hance determine many of their biological properties. We describe a technique for modulating membrane fluidity which consists of hydrogenating the unsaturated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chapman D,Quinn PJ

更新日期：1976-11-01 00:00:00

abstract：:We report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotem R,Paz GF,Homonnai ZT,Kalina M,Naor Z

更新日期：1990-09-01 00:00:00

abstract：:Mesp2 is a transcription factor that plays fundamental roles in somitogenesis, and its expression is strictly restricted to the anterior presomitic mesoderm just before segment border formation. The transcriptional on-off cycle is linked to the segmentation clock. In our current study, we show that a T-box transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasuhiko Y,Haraguchi S,Kitajima S,Takahashi Y,Kanno J,Saga Y

更新日期：2006-03-07 00:00:00

abstract：:State transition in photosynthesis is a short-term balancing mechanism of energy distribution between photosystem I (PSI) and photosystem II (PSII). When PSII is preferentially excited (state 2), a pool of mobile light-harvesting complex II (LHCII) antenna proteins is thought to migrate from PSII to PSI, but biochemic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi H,Iwai M,Takahashi Y,Minagawa J

更新日期：2006-01-10 00:00:00

abstract：:The Ipl (Tssc3) gene lies in an extended imprinted region of distal mouse chromosome 7, which also contains the Igf2 gene. Expression of Ipl is highest in placenta and yolk sac, where its mRNA is derived almost entirely from the maternal allele. Ipl encodes a small cytoplasmic protein with a pleckstrin-homology (PH) d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frank D,Fortino W,Clark L,Musalo R,Wang W,Saxena A,Li CM,Reik W,Ludwig T,Tycko B

更新日期：2002-05-28 00:00:00

abstract：:Diphtheria toxin ( DTx ) is an extremely potent inhibitor of protein synthesis. It is secreted as a linear polypeptide, which is cleaved to produce disulfide-linked A and B fragments. Fragment A, the inhibitor of protein synthesis, requires fragment B, the recognition subunit, for entry into intact cells. Fragment B h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalman LS,Wisnieski BJ

更新日期：1984-06-01 00:00:00

abstract：:Plant cell wall pectic polysaccharides are arguably the most complex carbohydrates in nature. Progress in understanding pectin synthesis has been slow due to its complex structure and difficulties in purifying and expressing the low-abundance, Golgi membrane-bound pectin biosynthetic enzymes. Arabidopsis galacturonosy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atmodjo MA,Sakuragi Y,Zhu X,Burrell AJ,Mohanty SS,Atwood JA 3rd,Orlando R,Scheller HV,Mohnen D

更新日期：2011-12-13 00:00:00

abstract：:The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between membranes. Previous studies showing that the proximal cause of abetalipoproteinemia is an absence of MTP indicate that MTP f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jamil H,Gordon DA,Eustice DC,Brooks CM,Dickson JK Jr,Chen Y,Ricci B,Chu CH,Harrity TW,Ciosek CP Jr,Biller SA,Gregg RE,Wetterau JR

更新日期：1996-10-15 00:00:00

abstract：:Zif268, a zinc finger protein whose mRNA is rapidly activated in cells exposed to growth factors or other signaling agents, is thought to play a role in regulating the genetic program induced by extracellular ligands. We report that Zif268 has one of the characteristics of a transcriptional regulator, namely, sequence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christy B,Nathans D

更新日期：1989-11-01 00:00:00