当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > DNA binding site of the growth factor-inducible protein Zif268.

DNA binding site of the growth factor-inducible protein Zif268.

Abstract：

:Zif268, a zinc finger protein whose mRNA is rapidly activated in cells exposed to growth factors or other signaling agents, is thought to play a role in regulating the genetic program induced by extracellular ligands. We report that Zif268 has one of the characteristics of a transcriptional regulator, namely, sequence-specific binding to DNA. Zif268 synthesized in Escherichia coli bound to two sites upstream of the zif268 gene and to sites in the promoter regions of other genes. The nucleotide sequences responsible for binding were defined by DNase I footprinting, by methylation interference experiments, and by use of synthetic oligonucleotides. From these results we derived the following consensus sequence for a Zif268 high-affinity binding site: GCGTGGGGCG.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Christy B,Nathans D

doi

10.1073/pnas.86.22.8737

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

8737-41

issue

22

eissn

0027-8424

issn

1091-6490

journal_volume

86

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Calcium-dependent increase in adenosine 3',5'-monophosphate and induction of the acrosome reaction in guinea pig spermatozoa.

    abstract：:Experiments were designed to determine the interrelationship between cyclic AMP and Ca(2+) during the processes of sperm capacitation and the acrosome reaction. In minimal culture media containing pyruvate and lactate as substrates, guinea pig spermatozoa required a minimum of 1.0-1.5 hr to capacitate in the presence ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.76.11.5699

    authors： Hyne RV,Garbers DL

    更新日期：1979-11-01 00:00:00

  • Transcriptomic analysis of growth heterosis in larval Pacific oysters (Crassostrea gigas).

    abstract：:Compared with understanding of biological shape and form, knowledge is sparse regarding what regulates growth and body size of a species. For example, the genetic and physiological causes of heterosis (hybrid vigor) have remained elusive for nearly a century. Here, we investigate gene-expression patterns underlying gr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0610880104

    authors： Hedgecock D,Lin JZ,DeCola S,Haudenschild CD,Meyer E,Manahan DT,Bowen B

    更新日期：2007-02-13 00:00:00

  • Delivery of foreign antigens by engineered outer membrane vesicle vaccines.

    abstract：:As new disease threats arise and existing pathogens grow resistant to conventional interventions, attention increasingly focuses on the development of vaccines to induce protective immune responses. Given their admirable safety records, protein subunit vaccines are attractive for widespread immunization, but their dis...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0805532107

    authors： Chen DJ,Osterrieder N,Metzger SM,Buckles E,Doody AM,DeLisa MP,Putnam D

    更新日期：2010-02-16 00:00:00

  • Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore.

    abstract：:The flux of solvent water coupled to the transit of ions through protein pores is considerable. The effect of this electroosmotic solvent flow on the binding of a neutral molecule [beta-cyclodextrin (betaCD)] to sites within the staphylococcal alpha-hemolysin pore was investigated. Mutant alpha-hemolysin pores were us...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2531778100

    authors： Gu LQ,Cheley S,Bayley H

    更新日期：2003-12-23 00:00:00

  • Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.

    abstract：:The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A-retinol-binding protein complex. Mutations with...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1121005109

    authors： Bulawa CE,Connelly S,Devit M,Wang L,Weigel C,Fleming JA,Packman J,Powers ET,Wiseman RL,Foss TR,Wilson IA,Kelly JW,Labaudinière R

    更新日期：2012-06-12 00:00:00

  • Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.

    abstract：:A central problem in understanding enzyme regulation is to define the conformational states that account for allosteric changes in catalytic activity. For Escherichia coli aspartate transcarbamoylase (ATCase; EC) the active, relaxed (R state) holoenzyme is generally assumed to be represented by the crystal structure o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.090087197

    authors： Endrizzi JA,Beernink PT,Alber T,Schachman HK

    更新日期：2000-05-09 00:00:00

  • Advancing a clinically relevant perspective of the clonal nature of cancer.

    abstract：:Cancers frequently arise as a result of an acquired genomic instability and the subsequent clonal evolution of neoplastic cells with variable patterns of genetic aberrations. Thus, the presence and behaviors of distinct clonal populations in each patient's tumor may underlie multiple clinical phenotypes in cancers. We...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1104009108

    authors： Ruiz C,Lenkiewicz E,Evers L,Holley T,Robeson A,Kiefer J,Demeure MJ,Hollingsworth MA,Shen M,Prunkard D,Rabinovitch PS,Zellweger T,Mousses S,Trent JM,Carpten JD,Bubendorf L,Von Hoff D,Barrett MT

    更新日期：2011-07-19 00:00:00

  • Tropical forests can maintain hyperdiversity because of enemies.

    abstract：:Explaining the maintenance of tropical forest diversity under the countervailing forces of drift and competition poses a major challenge to ecological theory. Janzen-Connell effects, in which host-specific natural enemies restrict the recruitment of juveniles near conspecific adults, provide a potential mechanism. Jan...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1813211116

    authors： Levi T,Barfield M,Barrantes S,Sullivan C,Holt RD,Terborgh J

    更新日期：2019-01-08 00:00:00

  • Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4.

    abstract：:Hermansky-Pudlak syndrome (HPS) defines a group of autosomal recessive disorders characterized by deficiencies in lysosome-related organelles such as melanosomes and platelet-dense granules. Several HPS genes encode proteins of unknown function including HPS1, HPS3, and HPS4. Here we have identified and characterized ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1532040100

    authors： Nazarian R,Falcón-Pérez JM,Dell'Angelica EC

    更新日期：2003-07-22 00:00:00

  • A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.

    abstract：:As 3D culture has become central to investigation of tissue biology, mammary epithelial organoids have emerged as powerful tools for investigation of epithelial cell polarization and carcinogenesis. However, most current protocols start from single cells suspended in Matrigel, which can also restrict cell differentiat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1702372116

    authors： Florian S,Iwamoto Y,Coughlin M,Weissleder R,Mitchison TJ

    更新日期：2019-06-04 00:00:00

  • The circadian oscillator in Synechococcus elongatus controls metabolite partitioning during diurnal growth.

    abstract：:Synechococcus elongatus PCC 7942 is a genetically tractable model cyanobacterium that has been engineered to produce industrially relevant biomolecules and is the best-studied model for a prokaryotic circadian clock. However, the organism is commonly grown in continuous light in the laboratory, and data on metabolic p...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1504576112

    authors： Diamond S,Jun D,Rubin BE,Golden SS

    更新日期：2015-04-14 00:00:00

  • Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.

    abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, employs two key host proteins to gain entry and replicate within cells, angiotensin-converting enzyme 2 (ACE2) and the cell surface transmembrane protease serine 2 (TMPRSS2). TMPRSS2 was first characterized as an androgen...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2021450118

    authors： Qiao Y,Wang XM,Mannan R,Pitchiaya S,Zhang Y,Wotring JW,Xiao L,Robinson DR,Wu YM,Tien JC,Cao X,Simko SA,Apel IJ,Bawa P,Kregel S,Narayanan SP,Raskind G,Ellison SJ,Parolia A,Zelenka-Wang S,McMurry L,Su F,Wang R,

    更新日期：2020-12-11 00:00:00

  • Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation.

    abstract：:The physiological effects of nitroglycerin as a potent vasodilator have long been documented. However, the molecular mechanisms by which nitroglycerin exerts its biological functions are still a matter of intense debate. Enzymatic pathways converting nitroglycerin to vasoactive compounds have been identified, but none...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0708615105

    authors： Bonini MG,Stadler K,Silva SO,Corbett J,Dore M,Petranka J,Fernandes DC,Tanaka LY,Duma D,Laurindo FR,Mason RP

    更新日期：2008-06-24 00:00:00

  • Diurnal down-regulation of ethylene biosynthesis mediates biomass heterosis.

    abstract：:Heterosis is widely applied in agriculture; however, the underlying molecular mechanisms for superior performance are not well understood. Ethylene biosynthesis and signaling genes are shown to be down-regulated in Arabidopsis interspecific hybrids. Ethylene is a plant hormone that promotes fruit ripening and maturati...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1722068115

    authors： Song Q,Ando A,Xu D,Fang L,Zhang T,Huq E,Qiao H,Deng XW,Chen ZJ

    更新日期：2018-05-22 00:00:00

  • Thermotaxis of Dictyostelium discoideum amoebae and its possible role in pseudoplasmodial thermotaxis.

    abstract：:Thermotaxis by individual amoebae of Dictyostelium discoideum on a temperature gradient is described. These amoebae show positive thermotaxis at temperatures between 14 degrees C and 28 degrees C shortly (3 hr) after food depletion. Increasing time on the gradient reduces the positive thermotactic response at the lowe...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.18.5646

    authors： Hong CB,Fontana DR,Poff KL

    更新日期：1983-09-01 00:00:00

  • Protein kinase C is present in human sperm: possible role in flagellar motility.

    abstract：:We report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.18.7305

    authors： Rotem R,Paz GF,Homonnai ZT,Kalina M,Naor Z

    更新日期：1990-09-01 00:00:00

  • Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?

    abstract：:By considering temperature effects on the mechanical unfolding rates of proteins and RNA, whose energy landscape is rugged, the question posed in the title is answered in the affirmative. Adopting a theory by Zwanzig [Zwanzig, R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029-2030], we show that, because of roughness char...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1833310100

    authors： Hyeon C,Thirumalai D

    更新日期：2003-09-02 00:00:00

  • Two DR beta allelic series defined by exon II-specific synthetic oligonucleotide genomic hybridization: a method of HLA typing?

    abstract：:Comparisons of exon II HLA-DR beta sequences have shown that nucleotide variations are principally clustered within the following three regions: V1 (amino acid 8-15), V2 (25-32), and V3 (70-77). V1, V2, and V3-derived 24-mers have been synthesized, the DR beta sequences coming from DR1, DR3, Drw6, DR4, DR5, and DRw53 ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.20.7836

    authors： Le Gall I,Millasseau P,Dausset J,Cohen D

    更新日期：1986-10-01 00:00:00

  • Rapid separation and purification of oligonucleotides by high-performance capillary gel electrophoresis.

    abstract：:Picomole amounts of oligodeoxynucleotides [polydeoxyadenylic acids, (dA)40-60] were baseline resolved and analyzed in less than 8 min by high-performance capillary electrophoresis with polyacrylamide gels. In addition, fast analysis of a crude 70-mer oligodeoxynucleotide and a slab gel-purified 99-mer oligodeoxynucleo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.24.9660

    authors： Cohen AS,Najarian DR,Paulus A,Guttman A,Smith JA,Karger BL

    更新日期：1988-12-01 00:00:00

  • Electroanatomy of a unique amacrine cell in the rabbit retina.

    abstract：:Intracellular electrophysiological recordings were obtained from a specialized class of "starburst" amacrine cells by using an isolated superperfused retina-eyecup preparation of the rabbit. These cells were injected intracellularly with horseradish peroxidase and identified with light microscopy. A computer-controlle...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.10.3069

    authors： Miller RF,Bloomfield SA

    更新日期：1983-05-01 00:00:00

  • Structure of the human villin gene.

    abstract：:We have isolated and characterized the complete human villin gene. The villin gene is located on chromosome 2q35-36 in humans and on chromosome 1 in mice. Villin belongs to a family of calcium-regulated actin-binding proteins that share structural and functional homologies. The villin gene is expressed mainly in cells...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.23.10811

    authors： Pringault E,Robine S,Louvard D

    更新日期：1991-12-01 00:00:00

  • Buffering of crucial functions by paleologous duplicated genes may contribute cyclicality to angiosperm genome duplication.

    abstract：:Genome duplication followed by massive gene loss has permanently shaped the genomes of many higher eukaryotes, particularly angiosperms. It has long been believed that a primary advantage of genome duplication is the opportunity for the evolution of genes with new functions by modification of duplicated genes. If so, ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0507782103

    authors： Chapman BA,Bowers JE,Feltus FA,Paterson AH

    更新日期：2006-02-21 00:00:00

  • Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells.

    abstract：:A PCR strategy is described for global amplification of DNA from a single eukaryotic cell that enables the comprehensive analysis of the whole genome. By comparative genomic hybridization, not only gross DNA copy number variations, such as monosomic X and trisomic 21 in single male cells and cells from Down's syndrome...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.8.4494

    authors： Klein CA,Schmidt-Kittler O,Schardt JA,Pantel K,Speicher MR,Riethmüller G

    更新日期：1999-04-13 00:00:00

  • Noninvasive functional optical spectroscopy of human breast tissue.

    abstract：:Near infrared diffuse optical spectroscopy and diffuse optical imaging are promising methods that eventually may enhance or replace existing technologies for breast cancer screening and diagnosis. These techniques are based on highly sensitive, quantitative measurements of optical and functional contrast between healt...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.071511098

    authors： Shah N,Cerussi A,Eker C,Espinoza J,Butler J,Fishkin J,Hornung R,Tromberg B

    更新日期：2001-04-10 00:00:00

  • Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.

    abstract：:Little is known about the large ectodomain of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor (HGF/SF). Here, we establish by deletion mutagenesis that the HGF/SF and heparin-binding sites of MET are contained within a large N-terminal domain spanning the alpha-chai...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2034936100

    authors： Gherardi E,Youles ME,Miguel RN,Blundell TL,Iamele L,Gough J,Bandyopadhyay A,Hartmann G,Butler PJ

    更新日期：2003-10-14 00:00:00

  • Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.

    abstract：:Studies of the accelerated aging disorder Hutchinson-Gilford progeria syndrome (HGPS) can potentially reveal cellular defects associated with physiological aging. HGPS results from expression and abnormal nuclear envelope association of a farnesylated, truncated variant of prelamin A called "progerin." We surveyed the...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1809683116

    authors： Chang W,Wang Y,Luxton GWG,Östlund C,Worman HJ,Gundersen GG

    更新日期：2019-02-26 00:00:00

  • Measurement of the membrane curvature preference of phospholipids reveals only weak coupling between lipid shape and leaflet curvature.

    abstract：:In biological processes, such as fission, fusion and trafficking, it has been shown that lipids of different shapes are sorted into regions with different membrane curvatures. This lipid sorting has been hypothesized to be due to the coupling between the membrane curvature and the lipid's spontaneous curvature, which ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0907354106

    authors： Kamal MM,Mills D,Grzybek M,Howard J

    更新日期：2009-12-29 00:00:00

  • Mitochondrial DNA sequence evolution in the Arctoidea.

    abstract：:Some taxa in the superfamily Arctoidea, such as the giant panda and the lesser panda, have presented puzzles to taxonomists. In the present study, approximately 397 bases of the cytochrome b gene, 364 bases of the 12S rRNA gene, and 74 bases of the tRNA(Thr) and tRNA(Pro) genes from the giant panda, lesser panda, kink...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.20.9557

    authors： Zhang YP,Ryder OA

    更新日期：1993-10-15 00:00:00

  • Promotion of lipolysis in rat adipocytes by pertussis toxin: reversal of endogenous inhibition.

    abstract：:Pertussis toxin (PT), a protein produced by Bordetella pertussis, was studied for its effect on lipolysis in isolated rat epididymal adipocytes. Exposure of adipocytes to pertussis toxin resulted in a significant increase in cyclic AMP levels and lipolysis after a lag of 1-2 hr. Both the maximal rate of lipolysis and ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.21.6547

    authors： Olansky L,Myers GA,Pohl SL,Hewlett EL

    更新日期：1983-11-01 00:00:00

  • Direct interaction of the major light-harvesting complex II and PsbS in nonphotochemical quenching.

    abstract：:The photosystem II (PSII) subunit S (PsbS) plays a key role in nonphotochemical quenching, a photoprotective mechanism for dissipation of excess excitation energy in plants. The precise function of PsbS in nonphotochemical quenching is unknown. By reconstituting PsbS together with the major light-harvesting complex of...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1205561110

    authors： Wilk L,Grunwald M,Liao PN,Walla PJ,Kühlbrandt W

    更新日期：2013-04-02 00:00:00