Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells.

abstract：:APOBEC3 (A3) genes are members of the AID/APOBEC gene family that are found exclusively in mammals. A3 genes encode antiviral proteins that restrict the replication of retroviruses by inducing G-to-A mutations in their genomes and have undergone extensive amplification and diversification during mammalian evolution. E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito J,Gifford RJ,Sato K

更新日期：2020-01-07 00:00:00

abstract：:Human brain functional networks are embedded in anatomical space and have topological properties--small-worldness, modularity, fat-tailed degree distributions--that are comparable to many other complex networks. Although a sophisticated set of measures is available to describe the topology of brain networks, the selec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vértes PE,Alexander-Bloch AF,Gogtay N,Giedd JN,Rapoport JL,Bullmore ET

更新日期：2012-04-10 00:00:00

abstract：:In this study, we used functional MRI (fMRI) at high field (3T) to track the time course of activation in the entire basal ganglia circuitry, as well as other motor-related structures, during the explicit learning of a sequence of finger movements over a month of training. Fourteen right-handed healthy volunteers had ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehéricy S,Benali H,Van de Moortele PF,Pélégrini-Issac M,Waechter T,Ugurbil K,Doyon J

更新日期：2005-08-30 00:00:00

abstract：:Previous studies have shown that the effect of language on categorical perception of color is stronger when stimuli are presented in the right visual field than in the left. To examine whether this lateralized effect occurs preattentively at an early stage of processing, we monitored the visual mismatch negativity, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mo L,Xu G,Kay P,Tan LH

更新日期：2011-08-23 00:00:00

abstract：:To evaluate [3H]phencyclidine ([3H]PCP)as a probe for the ionic channel of the nicotinic receptor, the characteristics of its binding to electric organ membranes od Torpedo ocellata and its effects on frog sartorius muscle were studied. Similar to PCP, [3H]PCP depressed the peak amplitude of endplate current, caused n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eldefrawi ME,Eldefrawi AT,Aronstam RS,Maleque MA,Warnick JE,Albuquerque EX

更新日期：1980-12-01 00:00:00

abstract：:Vertebrates can modulate the sound levels entering their inner ears in the face of intense external sound or during their own vocalizations. Middle ear muscle contractions restrain the motion of the middle ear ossicles, attenuating the transmission of low-frequency sound and thereby protecting the hair cells in the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gridi-Papp M,Feng AS,Shen JX,Yu ZL,Rosowski JJ,Narins PM

更新日期：2008-08-05 00:00:00

abstract：:The bottom-up design of protein-based signaling networks is a key goal of synthetic biology; yet, it remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Here, we report a generic approach for the construction of protein-base...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein V,Alexandrov K

更新日期：2014-11-11 00:00:00

abstract：:We studied the abundance and structure of globin mRNAs present in K562 cells both before and after induction of hemoglobin synthesis by hemin. In vitro translation of poly(A)+ RNA from K562 cells generated protein products corresponding to alpha, A gamma-, G gamma-, epsilon-, and zeta-globin mRNAs. Individual globin m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dean A,Ley TJ,Humphries RK,Fordis M,Schechter AN

更新日期：1983-09-01 00:00:00

abstract：:In cultures of spleen cells from normal mice, recombinant human granulocyte colony-stimulating factor (G-CSF) supported the formation of multipotential blast cell colonies. Serial replating of the blast cell colonies in the presence of G-CSF, however, failed to demonstrate any direct effect of G-CSF on murine multipot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikebuchi K,Clark SC,Ihle JN,Souza LM,Ogawa M

更新日期：1988-05-01 00:00:00

abstract：:Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced glucocorticoid-dependent social dominance ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tada H,Miyazaki T,Takemoto K,Takase K,Jitsuki S,Nakajima W,Koide M,Yamamoto N,Komiya K,Suyama K,Sano A,Taguchi A,Takahashi T

更新日期：2016-11-08 00:00:00

abstract：:We have reported previously that murine bone marrow-derived dendritic cells (DC) pulsed with whole tumor lysates can mediate potent antitumor immune responses both in vitro and in vivo. Because successful therapy was dependent on host immune T cells, we have now evaluated whether the systemic administration of the T c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu K,Fields RC,Giedlin M,Mulé JJ

更新日期：1999-03-02 00:00:00

abstract：:Epithelial growth factor-like 7 (EGFL7) is a protein that is secreted by endothelial cells and plays an important role in angiogenesis. Although EGFL7 is aberrantly overexpressed in solid tumors, its role in leukemia has not been evaluated. Here, we report that levels of both EGFL7 mRNA and EGFL7 protein are increased...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papaioannou D,Shen C,Nicolet D,McNeil B,Bill M,Karunasiri M,Burke MH,Ozer HG,Yilmaz SA,Zitzer N,Behbehani GK,Oakes CC,Steiner DJ,Marcucci G,Powell BL,Kolitz JE,Carter TH,Wang ES,Mrózek K,Croce CM,Caligiuri MA,Bl

更新日期：2017-06-06 00:00:00

abstract：:In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fedoroff NV

更新日期：2012-12-11 00:00:00

abstract：:The Arctic Ocean already experiences areas of low pH and high CO2, and it is expected to be most rapidly affected by future ocean acidification (OA). Copepods comprise the dominant Arctic zooplankton; hence, their responses to OA have important implications for Arctic ecosystems, yet there is little data on their curr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis CN,Brown KA,Edwards LA,Cooper G,Findlay HS

更新日期：2013-12-17 00:00:00

abstract：:Global biological datasets generated by genomics, transcriptomics, and proteomics provide new approaches to understanding the relationship between the genome and the synapse. Combined transcriptome analysis and multielectrode recordings of neuronal network activity were used in mouse embryonic primary neuronal culture...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Valor LM,Charlesworth P,Humphreys L,Anderson CN,Grant SG

更新日期：2007-03-13 00:00:00

abstract：:Annealed metals are surprisingly difficult to cut, involving high forces and an unusually thick "chip." This anomaly has long been explained, based on ex situ observations, using a model of smooth plastic flow with uniform shear to describe material removal by chip formation. Here we show that this phenomenon is actua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeung H,Viswanathan K,Compton WD,Chandrasekar S

更新日期：2015-08-11 00:00:00

abstract：:Expansins are unusual proteins discovered by virtue of their ability to mediate cell wall extension in plants. We identified cDNA clones for two cucumber expansins on the basis of peptide sequences of proteins purified from cucumber hypocotyls. The expansin cDNAs encode related proteins with signal peptides predicted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shcherban TY,Shi J,Durachko DM,Guiltinan MJ,McQueen-Mason SJ,Shieh M,Cosgrove DJ

更新日期：1995-09-26 00:00:00

abstract：:A family of nanoscale-sized supramolecular cage compounds with a polyhedral framework is prepared by self-assembly from tritopic building blocks and rectangular corner units via noncovalent coordination interactions. These highly symmetrical cage compounds are described as face-directed, self-assembled truncated tetra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leininger S,Fan J,Schmitz M,Stang PJ

更新日期：2000-02-15 00:00:00

abstract：:Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects yet is associated with no universally recognized function. After discovery of the corazonin receptor in Drosophila, we identified its ortholog in the moth, Manduca sexta, as a prelude to physiological studies. The corazonin recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YJ,Spalovská-Valachová I,Cho KH,Zitnanova I,Park Y,Adams ME,Zitnan D

更新日期：2004-04-27 00:00:00

abstract：:Significantly above-chance detection of stimuli presented within the field defect of patients with postgeniculate lesions is termed "blindsight." It has been proposed that those with blindsight are more likely to benefit from visual rehabilitation by repeated stimulation, leading to increased visual sensitivity within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sahraie A,Trevethan CT,MacLeod MJ,Urquhart J,Weiskrantz L

更新日期：2013-11-05 00:00:00

abstract：:With the collapse of fisheries in many parts of the world causing widespread economic harm, attention is focused on a possible cause and remedy of fishery collapse. Economic theory for managing a renewable resource, such as a fishery, leads to an ecologically unstable equilibrium as difficult to maintain as balancing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roughgarden J,Smith F

更新日期：1996-05-14 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adheren...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang WJ,Wei H,Hagen T,Frei B

更新日期：2007-03-06 00:00:00

abstract：:A short interspersed nuclear element, Mg-SINE, was isolated and characterized from the genome of the rice blast fungus, Magnaporthe grisea. Mg-SINE was isolated as an insertion element within Pot2, an inverted-repeat transposon from M. grisea and shows typical features of a mammalian SINE. Mg-SINE is present as a 0.47...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kachroo P,Leong SA,Chattoo BB

更新日期：1995-11-21 00:00:00

abstract：:Isolated developing plastids from greening cucumber cotyledons or from photoperiodically grown pea seedlings incorporated (14)C-labeled 5-aminolevulinic acid (ALA) into chlorophyll (Chl). Incorporation was light dependent, enhanced by S-adenosylmethionine, and linear for 1 hr. The in vitro rate of Chl synthesis from A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhaya D,Castelfranco PA

更新日期：1985-08-01 00:00:00

abstract：:Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He Y,Lin F,Chipman PR,Bator CM,Baker TS,Shoham M,Kuhn RJ,Medof ME,Rossmann MG

更新日期：2002-08-06 00:00:00

abstract：:Development of the vertebrate eye has been found to require the activity of several genes encoding homeodomain proteins (Freund, C., Horsford, D. J. & McInnes, R. R. (1996) Hum. Mol. Genet. 5, 1471-1488). Some of these genes, or portions thereof, are highly conserved across phyla. In this paper, we report the identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furukawa T,Kozak CA,Cepko CL

更新日期：1997-04-01 00:00:00

abstract：:The infectivity of cloned hepatitis B viral DNA (HBV) has been tested in chimpanzees to identify a fully functional HBV genome and to assess the risk associated with its handling. Only one of two HBV DNA sequence variants tested was shown to be infectious. "Clone purified" virus of predicted nucleotide sequence was pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will H,Cattaneo R,Darai G,Deinhardt F,Schellekens H,Schaller H

更新日期：1985-02-01 00:00:00

abstract：:The recombinant plasmid p102 based on pBR322 carrying approximately equal to 50% of the replicator proximal early region of simian virus 40 (SV40) DNA, including the viral origin of replication, has been constructed. It lacks a major part of the large tumor (T) antigen 3'-coding region, the T-antigen termination codon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horst J,Weckler C,Jacob E,Aulehla-Scholz C,Deppert W

更新日期：1982-08-01 00:00:00

abstract：:Infant acute lymphoblastic leukemia (ALL) with MLL gene rearrangements is characterized by early pre-B phenotype (CD10(-)/CD19(+)) and poor treatment outcome. The t(4;11), creating MLL-AF4 chimeric transcripts, is the predominant 11q23 chromosome translocation in infant ALL and is associated with extremely poor progno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taki T,Kano H,Taniwaki M,Sako M,Yanagisawa M,Hayashi Y

更新日期：1999-12-07 00:00:00

abstract：:Retroviruses evolved from long terminal repeat (LTR) retrotransposons by acquisition of envelope functions, and subsequently reinvaded host genomes. Together, endogenous retroviruses and LTR retrotransposons represent major components of animal, plant, and fungal genomes. Sequences from these elements have been exapte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodonova SO,Prinz S,Bilanchone V,Sandmeyer S,Briggs JAG

更新日期：2019-05-14 00:00:00