Mesenchymal stem cells for repair of the airway epithelium in asthma.

abstract：INTRODUCTION:Cystic fibrosis (CF) is an autosomal dominant chloride channelopathy caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results clinically in a multisystem disorder. The major source of morbidity and mortality in CF is lung disease, which is characterized by recurrent cycles...

journal_title：Expert review of respiratory medicine

authors： McElvaney OJ,Gunaratnam C,McElvaney OF,Bagwe I,Reeves EP,McElvaney NG

更新日期：2018-10-01 00:00:00

abstract：:Smoke inhalation injury continues to increase morbidity and mortality in burn patients in both the third world and industrialized countries. The lack of uniform criteria for the diagnosis and definition of smoke inhalation injury contributes to the fact that, despite extensive research, mortality rates have changed li...

journal_title：Expert review of respiratory medicine

authors： Rehberg S,Maybauer MO,Enkhbaatar P,Maybauer DM,Yamamoto Y,Traber DL

更新日期：2009-06-01 00:00:00

abstract：:There have been many advances in the field of diagnostic and therapeutic pulmonary medicine in the past several years, with major progress in the field of imaging. Optical coherence tomography (OCT) is a high-resolution (micron level) imaging modality currently being advanced with the potential to image airway wall st...

journal_title：Expert review of respiratory medicine

authors： Hou R,Le T,Murgu SD,Chen Z,Brenner M

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Pulmonary mold infections are caused by ubiquitous organisms found in soil, water, and decaying vegetation, including Aspergillus spp., the Mucormycetes, hyaline molds, and dematiaceous (black) molds. Areas covered: These infections are often a challenge to diagnose and even more difficult to treat. Recent...

journal_title：Expert review of respiratory medicine

authors： McCarthy MW,Petraitis V,Walsh TJ

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure, and ultimately to death. It is characterized by marked heterogeneity regarding its clinical course. Despite significant progress in the understanding of its pathogenesis, the course of the ...

journal_title：Expert review of respiratory medicine

authors： Inchingolo R,Varone F,Sgalla G,Richeldi L

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Optimal management of malignant pleural effusion (MPE) is important in the care of patients with advanced cancer. Surgical (especially video-assisted thoracoscopic surgery (VATS)) and non-surgical strategies are available. Clinicians should be aware of the evidence supporting the use of different modalitie...

journal_title：Expert review of respiratory medicine

authors： Fitzgerald DB,Koegelenberg CFN,Yasufuku K,Lee YCG

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Positive airway pressure (PAP) devices are generally considered to be the first-line treatment of choice for most adults with obstructive sleep apnea (OSA). However, there are several alternatives. It is important for patients and their sleep providers to be aware of the most up-to-date information regardi...

journal_title：Expert review of respiratory medicine

authors： Camacho M,Chang ET,Neighbors CLP,Noller MW,Mack D,Capasso R,Kushida CA

更新日期：2018-11-01 00:00:00

abstract：:Although wheezing illness is at its most prevalent in infancy and early childhood, its self-limiting nature in the majority poses considerable challenges in offering a long-term prognosis and in initiating long-term prophylaxis. Many of the established treatments in adults have not been adequately assessed in children...

journal_title：Expert review of respiratory medicine

authors： Helms PJ

更新日期：2009-04-01 00:00:00

abstract：:Premature infants are at substantial risk for a spectrum of morbidities that are gestational age dependent. Respiratory syncytial virus (RSV) infection is most common in the first two years of life with the highest burden in children aged <6 months. Preterm infants ≤35 weeks' gestation are handicapped by incomplete im...

journal_title：Expert review of respiratory medicine

authors： Abraha HY,Lanctôt KL,Paes B

更新日期：2015-01-01 00:00:00

abstract：:Patients suffering from COPD not controlled by a single bronchodilator should be given two bronchodilators with different mechanisms of action. Addition of a LABA to a LAMA induces a larger bronchodilation than that obtained with the LAMA as monotherapy and also improves many patient-reported outcomes. Since the clini...

journal_title：Expert review of respiratory medicine

authors： Calzetta L,Ciaprini C,Puxeddu E,Cazzola M

更新日期：2016-04-01 00:00:00

abstract：:Introduction: Idiopathic pulmonary fibrosis (IPF), the most common of the idiopathic interstitial pneumonias, is a disease with a poor prognosis, and a highly heterogeneous and unpredictable clinical course. While most patients experience a relatively slow clinical, functional and radiological deterioration, a signifi...

journal_title：Expert review of respiratory medicine

authors： Biondini D,Balestro E,Sverzellati N,Cocconcelli E,Bernardinello N,Ryerson CJ,Spagnolo P

更新日期：2020-04-01 00:00:00

abstract：:Objectives: Pleurodesis is an important management option to palliate breathlessness in patients with malignant pleural effusion (MPE). This systematic review aimed to examine available literature for studies investigating factors that predict pleurodesis outcome.Methods: The healthcare databases advanced search (HDAS...

journal_title：Expert review of respiratory medicine

authors： Hassan M,Gadallah M,Mercer RM,Harriss E,Rahman NM

更新日期：2020-06-01 00:00:00

abstract：:In many countries numbers of adults with cystic fibrosis (CF) exceed that of children, with median survival predicted to surpass 50 years. Increasing longevity is, in part, due to intensive therapies including eradication of early infection and suppressive therapies and pulmonary exacerbations. Initial infections with...

journal_title：Expert review of respiratory medicine

authors： Ramsay KA,Stockwell RE,Bell SC,Kidd TJ

更新日期：2016-01-01 00:00:00

abstract：:Lung transplantation has evolved over the past two decades as a well-recognized therapy for patients with end-stage lung diseases. However, lung transplantation has been limited, in part, due to the scarcity of donor lung organs. Previously, donor lung organs were allocated based on a potential recipient's waiting lis...

journal_title：Expert review of respiratory medicine

authors： Stern E,Bhorade SM

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:The aim of this pilot study was to determine the combined effect of vitamin D and omega-3 polyunsaturated fatty acid (PUFA) supplementation on airway function and inflammation in recreational athletes with exercise-induced bronchoconstriction (EIB). METHODS:Ten recreational athletes with EIB participated in ...

journal_title：Expert review of respiratory medicine

authors： Price OJ,Hull JH,Howatson G,Robson-Ansley P,Ansley L

更新日期：2015-06-01 00:00:00

abstract：:Chronic airway infection and inflammation are the hallmarks of cystic fibrosis (CF) lung disease. As these events occur early in life, it is critical to develop techniques for the assessment and monitoring of early-CF lung disease in infants and young children. In the last several years, there have been major advances...

journal_title：Expert review of respiratory medicine

authors： Ren CL

更新日期：2008-06-01 00:00:00

abstract：:Introduction: Knowledge of the pathophysiology of cough has continued to advance over recent decades. Establishing anatomic-diagnostic protocols, based on the anatomy and distribution of vagus nerve pathways regulating the cough reflex, was the first breakthrough in modern clinical medicine for chronic cough. The unme...

journal_title：Expert review of respiratory medicine

authors： Song WJ,Chung KF

更新日期：2020-03-01 00:00:00

abstract：:Innovations in surgery have significantly increased the number of procedures performed every year. While more individuals benefit from better surgical techniques and technology, a larger group of patients previously deemed ineligible for surgery now undergo high-complexity surgical procedures. Despite continuous impro...

journal_title：Expert review of respiratory medicine

authors： Restrepo RD,Braverman J

更新日期：2015-02-01 00:00:00

abstract：:Despite marginal improvements in survival gained from multimodality treatment, long-term survival rates remain low for lung cancer, which remains the leading cause of cancer-related mortality in North America. BLP25 liposomal (L-BLP25) vaccine (Stimuvax) is a promising liposomal vaccine designed to generate an immune ...

journal_title：Expert review of respiratory medicine

authors： Powell E,Chow LQ

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Survival after lung transplantation lags behind outcomes of other solid organ transplants, and complications from lung transplant are the second most common cause of death in cystic fibrosis. Evolving surgical techniques, therapeutics, and perioperative management have improved short-term survival after lu...

journal_title：Expert review of respiratory medicine

authors： Li SS,Tumin D,Krone KA,Boyer D,Kirkby SE,Mansour HM,Hayes D Jr

更新日期：2018-11-01 00:00:00

abstract：:Sepsis is a state of systemic inflammation directed at microbes or their toxins in blood or tissues. Nitric oxide (NO) is one of many vasoactive molecules released from a variety of cell types during sepsis. Almost two decades ago, NO emerged as a potential therapeutic target in sepsis. NO produced by the constitutive...

journal_title：Expert review of respiratory medicine

authors： De Cruz SJ,Kenyon NJ,Sandrock CE

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Approximately 14% of UK hospital in-patients receive supplemental oxygen therapy, only 57% have valid prescriptions. Oxygen must be optimally prescribed to ensure maximal therapeutic response whilst minimizing adverse outcomes (including fatality). This study investigates prescription compliance. METHODS:Al...

journal_title：Expert review of respiratory medicine

authors： Barrett R,Catangui E,Scott R

更新日期：2020-10-14 00:00:00

abstract：:Caveolin-1 (Cav-1) is the major protein present in invaginations of the plasma membrane of cells known as caveolae. Cav-1 is expressed in numerous resident and inflammatory cells implicated in the pathogenesis of asthma and chronic inflammatory respiratory diseases including chronic obstructive pulmonary disease. A re...

journal_title：Expert review of respiratory medicine

authors： Royce SG,Le Saux CJ

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Cardiorespiratory physiotherapy is an evidence-based practice that has evolved alongside changes in medical and surgical management, analgesia, the ageing society and increasing comorbidities of our patient populations. Continued research provides the profession with the ability to adapt to meet the changi...

journal_title：Expert review of respiratory medicine

authors： Denehy L,Granger CL,El-Ansary D,Parry SM

更新日期：2018-03-01 00:00:00

abstract：:Introduction: There is an unmet clinical need for improved diagnostic tests for active tuberculosis (TB) to provide high sensitivity for all cases, accelerate time to diagnosis and ensure timely and appropriate treatment. Whilst the measurement of M.tb-specific immune responses is widely used for detecting infection i...

journal_title：Expert review of respiratory medicine

authors： Halliday A,Masonou T,Tolosa-Wright M,Mandagere V,Lalvani A

更新日期：2019-06-01 00:00:00

abstract：:Aspergillus species are commonly isolated from lower respiratory tract samples of patients with cystic fibrosis (CF) and markers of immunological sensation to Aspergillus are frequently encountered in this group of patients; however, the contribution of Aspergillus to CF lung disease outside of the typical complicatio...

journal_title：Expert review of respiratory medicine

authors： Jones AM,Horsley A,Denning DW

更新日期：2014-08-01 00:00:00

abstract：:Some basic scientific data suggest that (S)-enantiomers of beta(2)-agonists have different and sometimes opposing effects to (R)-enantiomers. These data may explain the paradoxical response of the airways to the repeated, chronic administration of racemic beta(2)-agonists. Therefore, it is possible that the use of (R)...

journal_title：Expert review of respiratory medicine

authors： Cazzola M,Hanania NA,Matera MG

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Physical functional capacity is impaired in idiopathic pulmonary fibrosis (IPF). There is no tool to measure this key clinical outcome. The continuous-scale physical function performance (CS-PFP) test is one that assesses activities of daily living, but it has never been used in IPF. METHODS:We determined i...

journal_title：Expert review of respiratory medicine

authors： Olson AL,Swigris JJ,Belkin A,Hannen L,Yagihashi K,Schenkman M,Brown KK

更新日期：2015-06-01 00:00:00

abstract：:Introduction. Optimizing nutrition remains the cornerstone of therapy for patients with cystic fibrosis (CF) since it is associated with better pulmonary function and survival. However, a significant proportion of patients still fail to achieve normal growth and nutritional status. Areas covered. This review describes...

journal_title：Expert review of respiratory medicine

authors： Colombo C,Nobili RM,Alicandro G

更新日期：2019-06-01 00:00:00

abstract：:Introduction: Detection and characterization of pulmonary nodules is an important issue, because the process is the first step in the management of lung cancers.Areas covered: Literature review was performed on May 15 2019 by using the PubMed, US National Library of Medicine National Institutes of Health, and the Nati...

journal_title：Expert review of respiratory medicine

authors： Kim TJ,Kim CH,Lee HY,Chung MJ,Shin SH,Lee KJ,Lee KS

更新日期：2020-02-01 00:00:00