Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases.

abstract：INTRODUCTION:Cystic fibrosis (CF) is an autosomal dominant chloride channelopathy caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results clinically in a multisystem disorder. The major source of morbidity and mortality in CF is lung disease, which is characterized by recurrent cycles...

journal_title：Expert review of respiratory medicine

authors： McElvaney OJ,Gunaratnam C,McElvaney OF,Bagwe I,Reeves EP,McElvaney NG

更新日期：2018-10-01 00:00:00

abstract：:Treprostinil is a prostacyclin derivative approved for the treatment of pulmonary arterial hypertension by intravenous, subcutaneous and inhalational administration. Unlike its precursor epoprostenol, treprostinil is chemically stable at room temperature and neutral pH, and its plasma half-life is longer. In addition ...

journal_title：Expert review of respiratory medicine

authors： LeVarge BL,Channick RN

更新日期：2012-06-01 00:00:00

abstract：:For the last 100 years, the tuberculin skin test (TST) has been the only diagnostic tool available for latent TB infection (LTBI) and no biomarker per se is available to diagnose the presence of LTBI. With the introduction of M. tuberculosis-specific IFN-gamma release assays (IGRAs), a new area of in vitro immunodiagn...

journal_title：Expert review of respiratory medicine

authors： Ruhwald M,Ravn P

更新日期：2009-08-01 00:00:00

abstract：:Background: Few studies have provided real-world evidence of mepolizumab efficacy and safety. We aimed to evaluate mepolizumab for severe eosinophilic asthma in daily clinical practice.Research design and methods: Patients included in the RINOVA (Interdisciplinary Network for the management of severe asthma in Veneto ...

journal_title：Expert review of respiratory medicine

authors： Caminati M,Cegolon L,Vianello A,Chieco Bianchi F,Festi G,Marchi MR,Micheletto C,Mazza F,Tognella S,Senna G

更新日期：2019-12-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become one of the leading etiologies of nosocomial pneumonia as a result of an increase in staphylococcal infections caused by methicillin-resistant strains paired with extended ventilatory support of critically, and often, chronically ill patients. The prevalence...

journal_title：Expert review of respiratory medicine

authors： Woods C,Colice G

更新日期：2014-10-01 00:00:00

abstract：:Budesonide/formoterol is a combination of an inhaled corticosteroid plus a long-acting beta(2)-agonist available as a dry-powder inhaler for the indication of asthma and chronic obstructive pulmonary disease in various countries outside of the USA and as a pressurized metered-dose inhaler in the USA for the indication...

journal_title：Expert review of respiratory medicine

authors： Lee C,Corren J

更新日期：2008-10-01 00:00:00

abstract：:Introduction: Knowledge of the pathophysiology of cough has continued to advance over recent decades. Establishing anatomic-diagnostic protocols, based on the anatomy and distribution of vagus nerve pathways regulating the cough reflex, was the first breakthrough in modern clinical medicine for chronic cough. The unme...

journal_title：Expert review of respiratory medicine

authors： Song WJ,Chung KF

更新日期：2020-03-01 00:00:00

abstract：:Conducting clinical trials on pulmonary hypertension in the US and Western Europe has become increasingly difficult and costly because of many challenges. These include a limited patient population that makes recruitment difficult. Recruiting internationally has helped, but can add variability. The choice of end point...

journal_title：Expert review of respiratory medicine

authors： Hill NS,Roberts K,Preston I

更新日期：2015-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by persistent airflow limitation. It is the third leading cause of death worldwide, and there are currently no curative strategies for this disease. Many factors contribute to COPD susceptibility, progression and exacerbations. These...

journal_title：Expert review of respiratory medicine

authors： Goh F,Shaw JG,Savarimuthu Francis SM,Vaughan A,Morrison L,Relan V,Marshall HM,Dent AG,O'Hare PE,Hsiao A,Bowman RV,Fong KM,Yang IA

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:The use of beta-blockers in chronic obstructive pulmonary disease (COPD) is controversial, primarily due to concerns that they may worsen lung function and attenuate bronchodilator response. Areas covered: This review summarizes the reasons for and against the use of beta-blockers in COPD by evaluating the...

journal_title：Expert review of respiratory medicine

authors： Leitao Filho FS,Alotaibi NM,Yamasaki K,Ngan DA,Sin DD

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:The independent and central role of the patient with a complex chronic respiratory disease in targeted, personalized disease management strategies is becoming increasingly important. Patients are the ones living with the disease and are finally responsible for their lives underlining their role as essentia...

journal_title：Expert review of respiratory medicine

authors： Houben-Wilke S,Augustin IM,Wouters BB,Stevens RA,Janssen DJ,Spruit MA,Vanfleteren LE,Franssen FM,Wouters EF

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Approximately 14% of UK hospital in-patients receive supplemental oxygen therapy, only 57% have valid prescriptions. Oxygen must be optimally prescribed to ensure maximal therapeutic response whilst minimizing adverse outcomes (including fatality). This study investigates prescription compliance. METHODS:Al...

journal_title：Expert review of respiratory medicine

authors： Barrett R,Catangui E,Scott R

更新日期：2020-10-14 00:00:00

abstract：:Since chronic obstructive pulmonary disease (COPD) has a progressive and major impact on health management, many aspects of this disorder, including development of effective and reliable biomarkers to monitor disease progression, are under intensive investigation. A huge amount of data, accumulated over the years, hav...

journal_title：Expert review of respiratory medicine

authors： Iadarola P,Luisetti M

更新日期：2013-04-01 00:00:00

abstract：:Introduction: Cystic fibrosis (CF) is a complex, multi-system, genetic disease affecting over 70,000 people worldwide. The underlying defect is a mutation in the CFTR gene. Dysfunctional CFTR protein results in abnormal anion movement across epithelial membranes in affected organs. There has been a paradigm shift in C...

journal_title：Expert review of respiratory medicine

authors： Paterson SL,Barry PJ,Horsley AR

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Anemia is often seen in chronic obstructive pulmonary disease (COPD) patients. However, the implications of anemia on the outcomes of patients with COPD is not clearly known. Therefore, we conducted a systematic review and meta-analysis to evaluate the effects of anemia on the morbidity and mortality of pati...

journal_title：Expert review of respiratory medicine

authors： Xu Y,Hu T,Ding H,Chen R

更新日期：2020-12-01 00:00:00

abstract：:Introduction. Optimizing nutrition remains the cornerstone of therapy for patients with cystic fibrosis (CF) since it is associated with better pulmonary function and survival. However, a significant proportion of patients still fail to achieve normal growth and nutritional status. Areas covered. This review describes...

journal_title：Expert review of respiratory medicine

authors： Colombo C,Nobili RM,Alicandro G

更新日期：2019-06-01 00:00:00

abstract：:Asthma is perceived as a heterogeneous disease with several clinical phenotypes and triggering factors. In general, cytokines from T-helper 2 cells are believed to be critical contributors of asthma. In recent years, IL-17, another T-helper lymphocyte-associated cytokine, has been put forward as another potentially im...

journal_title：Expert review of respiratory medicine

authors： Silverpil E,Lindén A

更新日期：2012-04-01 00:00:00

abstract：:With advances in CT technology and the popularity of low-dose CT as a device for lung cancer screening, the detection rate of sub-solid pulmonary nodules as well as solid nodules has been increased. Distinguishing solid from sub-solid features is an essential step in the CT evaluation of solitary pulmonary nodules (SP...

journal_title：Expert review of respiratory medicine

authors： Cha MJ,Lee KS,Kim HS,Lee SW,Jeong CJ,Kim EY,Lee HY

更新日期：2016-01-01 00:00:00

abstract：:Although mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory distress syndrome (ARDS), it can aggravate or cause lung injury, known as ventilator-induced lung injury (VILI). The biophysical characteristics of heterogeneously injured ARDS lungs increase the parenchymal stress a...

journal_title：Expert review of respiratory medicine

authors： Plataki M,Hubmayr RD

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure, and ultimately to death. It is characterized by marked heterogeneity regarding its clinical course. Despite significant progress in the understanding of its pathogenesis, the course of the ...

journal_title：Expert review of respiratory medicine

authors： Inchingolo R,Varone F,Sgalla G,Richeldi L

更新日期：2019-01-01 00:00:00

abstract：:Introduction: Muscle impairments are prevalent in COPD and have adverse clinical implications in terms of physical performance capacity, disease burden, quality of life and even mortality. During acute exacerbations of COPD (AECOPDs) the respiratory symptoms worsen and this might also apply to the muscle impairments. ...

journal_title：Expert review of respiratory medicine

authors： Gosker HR,Langen RC,Simons SO

更新日期：2021-01-01 00:00:00

abstract：:Chronic airway infection and inflammation are the hallmarks of cystic fibrosis (CF) lung disease. As these events occur early in life, it is critical to develop techniques for the assessment and monitoring of early-CF lung disease in infants and young children. In the last several years, there have been major advances...

journal_title：Expert review of respiratory medicine

authors： Ren CL

更新日期：2008-06-01 00:00:00

abstract：:Erdosteine is a multimechanism, mucolytic agent that decreases the sputum viscoelastic properties and bacterial adhesion to the cell membrane, endowed with bronchial anti-inflammatory activity and a scavenging effect on free oxidant radicals. Erdosteine is a prodrug and metabolite I is the active metabolite of erdoste...

journal_title：Expert review of respiratory medicine

authors： Moretti M

更新日期：2007-12-01 00:00:00

abstract：:Introduction: There is an unmet clinical need for improved diagnostic tests for active tuberculosis (TB) to provide high sensitivity for all cases, accelerate time to diagnosis and ensure timely and appropriate treatment. Whilst the measurement of M.tb-specific immune responses is widely used for detecting infection i...

journal_title：Expert review of respiratory medicine

authors： Halliday A,Masonou T,Tolosa-Wright M,Mandagere V,Lalvani A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Cardiorespiratory physiotherapy is an evidence-based practice that has evolved alongside changes in medical and surgical management, analgesia, the ageing society and increasing comorbidities of our patient populations. Continued research provides the profession with the ability to adapt to meet the changi...

journal_title：Expert review of respiratory medicine

authors： Denehy L,Granger CL,El-Ansary D,Parry SM

更新日期：2018-03-01 00:00:00

abstract：:Introduction: Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibito...

journal_title：Expert review of respiratory medicine

authors： Abad VC,Guilleminault C

更新日期：2018-12-01 00:00:00

abstract：:There have been many advances in the field of diagnostic and therapeutic pulmonary medicine in the past several years, with major progress in the field of imaging. Optical coherence tomography (OCT) is a high-resolution (micron level) imaging modality currently being advanced with the potential to image airway wall st...

journal_title：Expert review of respiratory medicine

authors： Hou R,Le T,Murgu SD,Chen Z,Brenner M

更新日期：2011-10-01 00:00:00

abstract：:Despite marginal improvements in survival gained from multimodality treatment, long-term survival rates remain low for lung cancer, which remains the leading cause of cancer-related mortality in North America. BLP25 liposomal (L-BLP25) vaccine (Stimuvax) is a promising liposomal vaccine designed to generate an immune ...

journal_title：Expert review of respiratory medicine

authors： Powell E,Chow LQ

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:N-acetyl-l-cysteine (NAC), a derivative of the naturally occurring amino acid l-cysteine, is a mucolytic agent that may also act as an antioxidant by providing cysteine intracellularly for increased production of glutathione. It is also used for the treatment of acetaminophen overdose. Areas covered: The r...

journal_title：Expert review of respiratory medicine

authors： Calzetta L,Matera MG,Rogliani P,Cazzola M

更新日期：2018-08-01 00:00:00

abstract：:Endobronchial ultrasound (EBUS) is an evolving diagnostic tool in respiratory medicine that allows the bronchoscopist to see beyond the airway. The radial probe EBUS was first introduced to evaluate the central airway structure. With advances in technology, the small radial probes can now visualize and assist transbro...

journal_title：Expert review of respiratory medicine

authors： Yasufuku K

更新日期：2010-08-01 00:00:00