Olodaterol + tiotropium bromide for the treatment of COPD.

abstract：INTRODUCTION:There is an ongoing need for additional interventions in idiopathic pulmonary fibrosis (IPF) as antifibrotic drugs currently available only inhibit and do not stall disease progression. Vitamin K is a co-factor for the activation of coagulation factors. However, it is also required to activate proteins wit...

journal_title：Expert review of respiratory medicine

authors： De Brouwer B,Piscaer I,Von Der Thusen JH,Grutters JC,Schutgens RE,Wouters EF,Janssen R

更新日期：2018-03-01 00:00:00

abstract：:Techniques to promote clearance of sputum from the airways (airway clearance techniques; ACTs) have existed in clinical practice for more than a century. This review examines current evidence and clinical recommendations regarding ACTs for individuals with chronic obstructive pulmonary disease. Comparisons between thi...

journal_title：Expert review of respiratory medicine

authors： Osadnik CR,McDonald CF,Holland AE

更新日期：2013-12-01 00:00:00

abstract：:Despite marginal improvements in survival gained from multimodality treatment, long-term survival rates remain low for lung cancer, which remains the leading cause of cancer-related mortality in North America. BLP25 liposomal (L-BLP25) vaccine (Stimuvax) is a promising liposomal vaccine designed to generate an immune ...

journal_title：Expert review of respiratory medicine

authors： Powell E,Chow LQ

更新日期：2008-02-01 00:00:00

abstract：:Sarcoidosis is a multisystem disease for which diagnosis relies on the integration of clinical, radiologic, laboratory, and pathologic information. Assessment of clinical features is an important part of the disease evaluation. Computer Tomography provides information not available on routine chest roentgenogram which...

journal_title：Expert review of respiratory medicine

authors： Zhou Y,Lower EE,Li H,Baughman RP

更新日期：2016-01-01 00:00:00

abstract：:Introduction: Idiopathic pulmonary fibrosis (IPF), the most common of the idiopathic interstitial pneumonias, is a disease with a poor prognosis, and a highly heterogeneous and unpredictable clinical course. While most patients experience a relatively slow clinical, functional and radiological deterioration, a signifi...

journal_title：Expert review of respiratory medicine

authors： Biondini D,Balestro E,Sverzellati N,Cocconcelli E,Bernardinello N,Ryerson CJ,Spagnolo P

更新日期：2020-04-01 00:00:00

abstract：:Long-term oxygen therapy (LTOT) has been shown to reduce pulmonary hypertension and improve survival in patients with chronic obstructive pulmonary disease and resting hypoxemia (reduced arterial partial pressure of oxygen ≤55 mmHg). However, the benefit of its use for chronic pulmonary diseases other than chronic obs...

journal_title：Expert review of respiratory medicine

authors： Jindal SK,Agarwal R

更新日期：2012-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease is an inflammatory disorder characterized by airflow limitation. Its cardinal symptom is dyspnea, which develops gradually with even low levels of exercise. Bronchodilators (BDs) are the most effective drugs for relieving dyspnea. Two main types of BD are currently available, β-mi...

journal_title：Expert review of respiratory medicine

authors： Baloira A

更新日期：2013-04-01 00:00:00

abstract：:Although mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory distress syndrome (ARDS), it can aggravate or cause lung injury, known as ventilator-induced lung injury (VILI). The biophysical characteristics of heterogeneously injured ARDS lungs increase the parenchymal stress a...

journal_title：Expert review of respiratory medicine

authors： Plataki M,Hubmayr RD

更新日期：2010-06-01 00:00:00

abstract：:During the last decade, there have been major advances in knowledge of the effects of oxygen therapy in patients with acute exacerbations of chronic obstructive pulmonary disease. This includes a randomised controlled trial of oxygen therapy in the pre-hospital setting, which showed that high concentration oxygen ther...

journal_title：Expert review of respiratory medicine

authors： Pilcher J,Weatherall M,Perrin K,Beasley R

更新日期：2015-06-01 00:00:00

abstract：:In 2007 the long-term outcome of lung cancer is still disappointing, with a 5-year survival rate not exceeding 15%. However, small but significant improvements in survival times have been achieved in the last decade. This progress has been achieved through the improvement of surgical techniques and following the intro...

journal_title：Expert review of respiratory medicine

authors： Selvaggi G,Scagliotti GV

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:Positive airway pressure (PAP) devices are generally considered to be the first-line treatment of choice for most adults with obstructive sleep apnea (OSA). However, there are several alternatives. It is important for patients and their sleep providers to be aware of the most up-to-date information regardi...

journal_title：Expert review of respiratory medicine

authors： Camacho M,Chang ET,Neighbors CLP,Noller MW,Mack D,Capasso R,Kushida CA

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:The use of beta-blockers in chronic obstructive pulmonary disease (COPD) is controversial, primarily due to concerns that they may worsen lung function and attenuate bronchodilator response. Areas covered: This review summarizes the reasons for and against the use of beta-blockers in COPD by evaluating the...

journal_title：Expert review of respiratory medicine

authors： Leitao Filho FS,Alotaibi NM,Yamasaki K,Ngan DA,Sin DD

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Approximately 14% of UK hospital in-patients receive supplemental oxygen therapy, only 57% have valid prescriptions. Oxygen must be optimally prescribed to ensure maximal therapeutic response whilst minimizing adverse outcomes (including fatality). This study investigates prescription compliance. METHODS:Al...

journal_title：Expert review of respiratory medicine

authors： Barrett R,Catangui E,Scott R

更新日期：2020-10-14 00:00:00

abstract：:Although wheezing illness is at its most prevalent in infancy and early childhood, its self-limiting nature in the majority poses considerable challenges in offering a long-term prognosis and in initiating long-term prophylaxis. Many of the established treatments in adults have not been adequately assessed in children...

journal_title：Expert review of respiratory medicine

authors： Helms PJ

更新日期：2009-04-01 00:00:00

abstract：:Owing to the prevalence, the considerable risk of accidents and cardiovascular consequences, optimal treatment of obstructive sleep apnea syndrome is of crucial importance. However, many patients look for alternative conservative or surgical therapies to continuous positive airway pressure to avoid discomfort and loca...

journal_title：Expert review of respiratory medicine

authors： Randerath WJ

更新日期：2009-06-01 00:00:00

abstract：:Sepsis is a state of systemic inflammation directed at microbes or their toxins in blood or tissues. Nitric oxide (NO) is one of many vasoactive molecules released from a variety of cell types during sepsis. Almost two decades ago, NO emerged as a potential therapeutic target in sepsis. NO produced by the constitutive...

journal_title：Expert review of respiratory medicine

authors： De Cruz SJ,Kenyon NJ,Sandrock CE

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:The Global Initiative for Asthma (GINA) annual report summarizes the latest evidence for asthma management. GINA recommends stepwise pharmacological treatment, advocating inhaled corticosteroids (ICS) plus rapid, long-acting β2-agonists (LABA) delivered in a single inhaler for maintenance and relief at Ste...

journal_title：Expert review of respiratory medicine

authors： Lin J,Zhou X,Wang C,Liu C,Cai S,Huang M

更新日期：2018-03-01 00:00:00

abstract：:Lung transplantation has evolved over the past two decades as a well-recognized therapy for patients with end-stage lung diseases. However, lung transplantation has been limited, in part, due to the scarcity of donor lung organs. Previously, donor lung organs were allocated based on a potential recipient's waiting lis...

journal_title：Expert review of respiratory medicine

authors： Stern E,Bhorade SM

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:The treatment of lung cancer has radically changed over the last few years. The discovery of druggable oncogenic alterations and the introduction of immunotherapy have provided lung cancer patients with the possibility of more efficient and less toxic therapeutic alternatives than chemotherapy. In the case...

journal_title：Expert review of respiratory medicine

authors： Lazzari C,Karachaliou N,Gregorc V,Bulotta A,Gonzalez-Cao M,Verlicchi A,Altavilla G,Rosell R,Santarpia M

更新日期：2017-06-01 00:00:00

abstract：:Non-small-cell lung cancer is the most common cause of cancer-related death worldwide. Surgery remains the cornerstone of treatment for localized, resectable lung cancer, although advanced stages are associated with a high risk of developing distant metastases. Large randomized trials have demonstrated an improvement ...

journal_title：Expert review of respiratory medicine

authors： Kueng MM,Betticher DC

更新日期：2008-10-01 00:00:00

abstract：:Introduction: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury common in critically ill patients and characterized by significant morbidity and mortality. It frequently manifests long-lasting effects beyond hospitalization, from cognitive impairment to physical weakness.Areas covered: S...

journal_title：Expert review of respiratory medicine

authors： Mart MF,Ware LB

更新日期：2020-06-01 00:00:00

abstract：:Asthma is perceived as a heterogeneous disease with several clinical phenotypes and triggering factors. In general, cytokines from T-helper 2 cells are believed to be critical contributors of asthma. In recent years, IL-17, another T-helper lymphocyte-associated cytokine, has been put forward as another potentially im...

journal_title：Expert review of respiratory medicine

authors： Silverpil E,Lindén A

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Cystic fibrosis (CF) outcomes and survival have improved over the last century primarily due to advancements in antibiotics, nutritional, and pulmonary therapies. Reviewed here are the significant unmet needs that exist for individuals with CF. Areas covered: With the recent development of medications that...

journal_title：Expert review of respiratory medicine

authors： West NE,Flume PA

更新日期：2018-07-01 00:00:00

abstract：:Objectives: Pleurodesis is an important management option to palliate breathlessness in patients with malignant pleural effusion (MPE). This systematic review aimed to examine available literature for studies investigating factors that predict pleurodesis outcome.Methods: The healthcare databases advanced search (HDAS...

journal_title：Expert review of respiratory medicine

authors： Hassan M,Gadallah M,Mercer RM,Harriss E,Rahman NM

更新日期：2020-06-01 00:00:00

abstract：:Introduction: Muscle impairments are prevalent in COPD and have adverse clinical implications in terms of physical performance capacity, disease burden, quality of life and even mortality. During acute exacerbations of COPD (AECOPDs) the respiratory symptoms worsen and this might also apply to the muscle impairments. ...

journal_title：Expert review of respiratory medicine

authors： Gosker HR,Langen RC,Simons SO

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Malignant pleural effusion (MPE) is a feature of metastatic cancer associated with significant morbidity and cost. The typical management of MPE is systemic chemotherapy and mechanical intervention. Vascular endothelial growth factor (VEGF), an inducer of vascular permeability, has been shown to mediate fl...

journal_title：Expert review of respiratory medicine

authors： Sabang RL,Gandhiraj D,Fanucchi M,Epelbaum O

更新日期：2018-02-01 00:00:00

abstract：:Inhaled antibiotic therapy, targeting Pseudomonas aeruginosa, is a fundamental component of cystic fibrosis (CF) management. Tobramycin inhalation solution (TIS) was approved in the United States (US) in 1998. Subsequent research efforts focused on developing products with a reduced treatment time burden. Aztreonam fo...

journal_title：Expert review of respiratory medicine

authors： Fiel SB

更新日期：2014-06-01 00:00:00

abstract：:Caveolin-1 (Cav-1) is the major protein present in invaginations of the plasma membrane of cells known as caveolae. Cav-1 is expressed in numerous resident and inflammatory cells implicated in the pathogenesis of asthma and chronic inflammatory respiratory diseases including chronic obstructive pulmonary disease. A re...

journal_title：Expert review of respiratory medicine

authors： Royce SG,Le Saux CJ

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Lung Clearance Index, measured using the multiple breath washout (MBW) technique, may be a useful test in infants with Cystic Fibrosis (CF). However, the requirement for specialised equipment and a number of important technical and methodological considerations relevant to testing in infants have complicat...

journal_title：Expert review of respiratory medicine

authors： Davies G,Aurora P

更新日期：2017-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by persistent airflow limitation. It is the third leading cause of death worldwide, and there are currently no curative strategies for this disease. Many factors contribute to COPD susceptibility, progression and exacerbations. These...

journal_title：Expert review of respiratory medicine

authors： Goh F,Shaw JG,Savarimuthu Francis SM,Vaughan A,Morrison L,Relan V,Marshall HM,Dent AG,O'Hare PE,Hsiao A,Bowman RV,Fong KM,Yang IA

更新日期：2013-12-01 00:00:00