Second-line therapy of squamous non-small cell lung cancer: an evolving landscape.

abstract：:There have been many advances in the field of diagnostic and therapeutic pulmonary medicine in the past several years, with major progress in the field of imaging. Optical coherence tomography (OCT) is a high-resolution (micron level) imaging modality currently being advanced with the potential to image airway wall st...

journal_title：Expert review of respiratory medicine

authors： Hou R,Le T,Murgu SD,Chen Z,Brenner M

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:The Global Initiative for Asthma (GINA) annual report summarizes the latest evidence for asthma management. GINA recommends stepwise pharmacological treatment, advocating inhaled corticosteroids (ICS) plus rapid, long-acting β2-agonists (LABA) delivered in a single inhaler for maintenance and relief at Ste...

journal_title：Expert review of respiratory medicine

authors： Lin J,Zhou X,Wang C,Liu C,Cai S,Huang M

更新日期：2018-03-01 00:00:00

abstract：:In many countries numbers of adults with cystic fibrosis (CF) exceed that of children, with median survival predicted to surpass 50 years. Increasing longevity is, in part, due to intensive therapies including eradication of early infection and suppressive therapies and pulmonary exacerbations. Initial infections with...

journal_title：Expert review of respiratory medicine

authors： Ramsay KA,Stockwell RE,Bell SC,Kidd TJ

更新日期：2016-01-01 00:00:00

abstract：:Aspergillus species are commonly isolated from lower respiratory tract samples of patients with cystic fibrosis (CF) and markers of immunological sensation to Aspergillus are frequently encountered in this group of patients; however, the contribution of Aspergillus to CF lung disease outside of the typical complicatio...

journal_title：Expert review of respiratory medicine

authors： Jones AM,Horsley A,Denning DW

更新日期：2014-08-01 00:00:00

abstract：:Inhaled antibiotic therapy, targeting Pseudomonas aeruginosa, is a fundamental component of cystic fibrosis (CF) management. Tobramycin inhalation solution (TIS) was approved in the United States (US) in 1998. Subsequent research efforts focused on developing products with a reduced treatment time burden. Aztreonam fo...

journal_title：Expert review of respiratory medicine

authors： Fiel SB

更新日期：2014-06-01 00:00:00

abstract：:Chronic airway infection and inflammation are the hallmarks of cystic fibrosis (CF) lung disease. As these events occur early in life, it is critical to develop techniques for the assessment and monitoring of early-CF lung disease in infants and young children. In the last several years, there have been major advances...

journal_title：Expert review of respiratory medicine

authors： Ren CL

更新日期：2008-06-01 00:00:00

abstract：:Caveolin-1 (Cav-1) is the major protein present in invaginations of the plasma membrane of cells known as caveolae. Cav-1 is expressed in numerous resident and inflammatory cells implicated in the pathogenesis of asthma and chronic inflammatory respiratory diseases including chronic obstructive pulmonary disease. A re...

journal_title：Expert review of respiratory medicine

authors： Royce SG,Le Saux CJ

更新日期：2014-06-01 00:00:00

abstract：:Patients suffering from COPD not controlled by a single bronchodilator should be given two bronchodilators with different mechanisms of action. Addition of a LABA to a LAMA induces a larger bronchodilation than that obtained with the LAMA as monotherapy and also improves many patient-reported outcomes. Since the clini...

journal_title：Expert review of respiratory medicine

authors： Calzetta L,Ciaprini C,Puxeddu E,Cazzola M

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) patients experience the morning as the worst period of the day. Nevertheless, morning symptoms are not mentioned in COPD guidelines. Areas covered: Different topics on morning symptoms are covered in this review to underline their importance: occurrence, tools f...

journal_title：Expert review of respiratory medicine

authors： van Buul AR,Kasteleyn MJ,Chavannes NH,Taube C

更新日期：2017-04-01 00:00:00

abstract：:With advances in CT technology and the popularity of low-dose CT as a device for lung cancer screening, the detection rate of sub-solid pulmonary nodules as well as solid nodules has been increased. Distinguishing solid from sub-solid features is an essential step in the CT evaluation of solitary pulmonary nodules (SP...

journal_title：Expert review of respiratory medicine

authors： Cha MJ,Lee KS,Kim HS,Lee SW,Jeong CJ,Kim EY,Lee HY

更新日期：2016-01-01 00:00:00

abstract：:For the last 100 years, the tuberculin skin test (TST) has been the only diagnostic tool available for latent TB infection (LTBI) and no biomarker per se is available to diagnose the presence of LTBI. With the introduction of M. tuberculosis-specific IFN-gamma release assays (IGRAs), a new area of in vitro immunodiagn...

journal_title：Expert review of respiratory medicine

authors： Ruhwald M,Ravn P

更新日期：2009-08-01 00:00:00

abstract：:Long-term oxygen therapy (LTOT) has been shown to reduce pulmonary hypertension and improve survival in patients with chronic obstructive pulmonary disease and resting hypoxemia (reduced arterial partial pressure of oxygen ≤55 mmHg). However, the benefit of its use for chronic pulmonary diseases other than chronic obs...

journal_title：Expert review of respiratory medicine

authors： Jindal SK,Agarwal R

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:A growing number of immunocompromised (IC) patients with acute hypoxemic respiratory failure (ARF) is admitted to the intensive care unit (ICU) worldwide. Areas covered: This review provides an overview of the current knowledge of the ways to prevent intubation in IC patients with ARF. Expert commentary: S...

journal_title：Expert review of respiratory medicine

authors： De Jong A,Calvet L,Lemiale V,Demoule A,Mokart D,Darmon M,Jaber S,Azoulay E

更新日期：2018-10-01 00:00:00

abstract：:Lung transplantation has evolved over the past two decades as a well-recognized therapy for patients with end-stage lung diseases. However, lung transplantation has been limited, in part, due to the scarcity of donor lung organs. Previously, donor lung organs were allocated based on a potential recipient's waiting lis...

journal_title：Expert review of respiratory medicine

authors： Stern E,Bhorade SM

更新日期：2008-08-01 00:00:00

abstract：:The hallmarks of allergic bronchial asthma arise from chronic airway inflammation. Thus, elucidating the mechanisms regulating the maintenance of this chronic inflammatory response is key to understanding asthma pathogenesis. To date, it is not clear whether a predominance of proinflammatory factors or a reduced capac...

journal_title：Expert review of respiratory medicine

authors： Lunding L,Schröder A,Wegmann M

更新日期：2015-01-01 00:00:00

abstract：:Although wheezing illness is at its most prevalent in infancy and early childhood, its self-limiting nature in the majority poses considerable challenges in offering a long-term prognosis and in initiating long-term prophylaxis. Many of the established treatments in adults have not been adequately assessed in children...

journal_title：Expert review of respiratory medicine

authors： Helms PJ

更新日期：2009-04-01 00:00:00

abstract：:Introduction: Amongst allergic asthmatics, high allergen exposure increases asthma severity. However, there is no consensus on the role of mite allergen avoidance in the management of asthma, and various guidelines differ in their recommendations. Areas covered: Several systematic reviews/meta-analyses on mite avoidan...

journal_title：Expert review of respiratory medicine

authors： Custovic A,Murray CS,Simpson A

更新日期：2019-10-01 00:00:00

abstract：:Budesonide/formoterol is a combination of an inhaled corticosteroid plus a long-acting beta(2)-agonist available as a dry-powder inhaler for the indication of asthma and chronic obstructive pulmonary disease in various countries outside of the USA and as a pressurized metered-dose inhaler in the USA for the indication...

journal_title：Expert review of respiratory medicine

authors： Lee C,Corren J

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Lymphangioleiomyomatosis (LAM) is a destructive lung disease affecting primarily women. LAM is caused by inactivating mutations in the tuberous sclerosis complex (TSC) genes, resulting in hyperactivation of mechanistic/mammalian target of rapamycin complex 1 (mTORC1). Over the past five years, there have b...

journal_title：Expert review of respiratory medicine

authors： Nijmeh J,El-Chemaly S,Henske EP

更新日期：2018-02-01 00:00:00

abstract：:Introduction: Knowledge of the pathophysiology of cough has continued to advance over recent decades. Establishing anatomic-diagnostic protocols, based on the anatomy and distribution of vagus nerve pathways regulating the cough reflex, was the first breakthrough in modern clinical medicine for chronic cough. The unme...

journal_title：Expert review of respiratory medicine

authors： Song WJ,Chung KF

更新日期：2020-03-01 00:00:00

abstract：:Endobronchial ultrasound (EBUS) is an evolving diagnostic tool in respiratory medicine that allows the bronchoscopist to see beyond the airway. The radial probe EBUS was first introduced to evaluate the central airway structure. With advances in technology, the small radial probes can now visualize and assist transbro...

journal_title：Expert review of respiratory medicine

authors： Yasufuku K

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Exercise intolerance is a common and often significant limitation in pulmonary arterial hypertension (PAH). This intolerance greatly affects the quality of life and function of the individual with PAH, irrespective of its etiology. In PAH associated with connective tissue disorders (PAH-CTD), exercise into...

journal_title：Expert review of respiratory medicine

authors： Babu AS,Morris NR,Arena R,Myers J

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:The independent and central role of the patient with a complex chronic respiratory disease in targeted, personalized disease management strategies is becoming increasingly important. Patients are the ones living with the disease and are finally responsible for their lives underlining their role as essentia...

journal_title：Expert review of respiratory medicine

authors： Houben-Wilke S,Augustin IM,Wouters BB,Stevens RA,Janssen DJ,Spruit MA,Vanfleteren LE,Franssen FM,Wouters EF

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Lung Clearance Index, measured using the multiple breath washout (MBW) technique, may be a useful test in infants with Cystic Fibrosis (CF). However, the requirement for specialised equipment and a number of important technical and methodological considerations relevant to testing in infants have complicat...

journal_title：Expert review of respiratory medicine

authors： Davies G,Aurora P

更新日期：2017-01-01 00:00:00

abstract：:Since chronic obstructive pulmonary disease (COPD) has a progressive and major impact on health management, many aspects of this disorder, including development of effective and reliable biomarkers to monitor disease progression, are under intensive investigation. A huge amount of data, accumulated over the years, hav...

journal_title：Expert review of respiratory medicine

authors： Iadarola P,Luisetti M

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Paediatric severe therapy resistant asthma (STRA) affects a very small proportion of all children with asthma, but results in significant morbidity, has a high risk of mortality and utilises approximately half of all healthcare resources for childhood asthma. children with STRA need add-on 'beyond guidelin...

journal_title：Expert review of respiratory medicine

authors： Martin Alonso A,Fainardi V,Saglani S

更新日期：2017-11-01 00:00:00

abstract：:Introduction: Muscle impairments are prevalent in COPD and have adverse clinical implications in terms of physical performance capacity, disease burden, quality of life and even mortality. During acute exacerbations of COPD (AECOPDs) the respiratory symptoms worsen and this might also apply to the muscle impairments. ...

journal_title：Expert review of respiratory medicine

authors： Gosker HR,Langen RC,Simons SO

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Cystic Fibrosis is among the first diseases to have general population genetic screening tests and one of the most common indications of prenatal and preimplantation genetic diagnosis for single gene disorders. During the past twenty years, thanks to the evolution of diagnostic techniques, our knowledge of...

journal_title：Expert review of respiratory medicine

authors： Bergougnoux A,Taulan-Cadars M,Claustres M,Raynal C

更新日期：2018-05-01 00:00:00

abstract：:Studies on cough have come a long way but many shortfalls still exist. These shortfalls can be attributed to: the lack of randomized controlled studies with a focus on cough; studies not using robust cough outcome measures, poor definition of target groups in studies and guidelines, the lack of safe and efficacious tr...

journal_title：Expert review of respiratory medicine

authors： Chang AB

更新日期：2011-08-01 00:00:00

abstract：:Bronchiolitis is an inflammatory and potentially fibrosing condition affecting mainly the intralobular conducting and transitional small airways. Secondary bronchiolitis participates in disease process of the airways and/or the surrounding lobular structures in the setting of several already defined clinical entities,...

journal_title：Expert review of respiratory medicine

authors： Papiris SA,Malagari K,Manali ED,Kolilekas L,Triantafillidou C,Baou K,Rontogianni D,Bouros D,Kagouridis K

更新日期：2013-06-01 00:00:00