Perspectives in adjuvant chemotherapy in NSCLC.

abstract：INTRODUCTION:Cystic fibrosis-related diabetes (CFRD) is the end-point of a spectrum of glucose abnormalities in cystic fibrosis that begins with early insulin deficiency and ultimately results in accelerated nutritional decline and loss of lung function. Current diagnostic and management regimens are unable to entirely...

journal_title：Expert review of respiratory medicine

authors： Prentice B,Hameed S,Verge CF,Ooi CY,Jaffe A,Widger J

更新日期：2016-07-01 00:00:00

abstract：:Introduction: Detection and characterization of pulmonary nodules is an important issue, because the process is the first step in the management of lung cancers.Areas covered: Literature review was performed on May 15 2019 by using the PubMed, US National Library of Medicine National Institutes of Health, and the Nati...

journal_title：Expert review of respiratory medicine

authors： Kim TJ,Kim CH,Lee HY,Chung MJ,Shin SH,Lee KJ,Lee KS

更新日期：2020-02-01 00:00:00

abstract：:Innovations in surgery have significantly increased the number of procedures performed every year. While more individuals benefit from better surgical techniques and technology, a larger group of patients previously deemed ineligible for surgery now undergo high-complexity surgical procedures. Despite continuous impro...

journal_title：Expert review of respiratory medicine

authors： Restrepo RD,Braverman J

更新日期：2015-02-01 00:00:00

abstract：:Refractory breathlessness is one of the most common and devastating symptoms of advanced cardiorespiratory disease, both malignant and nonmalignant. In spite of increased interest in research in the last 20 years, there have been few significant advances in the palliation of this distressing condition. The most succes...

journal_title：Expert review of respiratory medicine

authors： Booth S,Bausewein C,Higginson I,Moosavi SH

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:A growing number of immunocompromised (IC) patients with acute hypoxemic respiratory failure (ARF) is admitted to the intensive care unit (ICU) worldwide. Areas covered: This review provides an overview of the current knowledge of the ways to prevent intubation in IC patients with ARF. Expert commentary: S...

journal_title：Expert review of respiratory medicine

authors： De Jong A,Calvet L,Lemiale V,Demoule A,Mokart D,Darmon M,Jaber S,Azoulay E

更新日期：2018-10-01 00:00:00

abstract：:Introduction: Knowledge of the pathophysiology of cough has continued to advance over recent decades. Establishing anatomic-diagnostic protocols, based on the anatomy and distribution of vagus nerve pathways regulating the cough reflex, was the first breakthrough in modern clinical medicine for chronic cough. The unme...

journal_title：Expert review of respiratory medicine

authors： Song WJ,Chung KF

更新日期：2020-03-01 00:00:00

abstract：:Introduction: Neuromotor control of diaphragm muscle and the recovery of diaphragm activity following spinal cord injury have been narrowly focused on ventilation. By contrast, the understanding of neuromotor control for non-ventilatory expulsive/straining maneuvers (including coughing, defecation, and parturition) is...

journal_title：Expert review of respiratory medicine

authors： Fogarty MJ,Sieck GC

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Interstitial lung diseases (ILD) include a broad range of diffuse parenchymal lung disorders of known and unknown etiologies. Patients with ILD can experience acute exacerbations (AE) which are associated with extremely high morbidity and mortality. Little is known about the etiology of AEs, and whether in...

journal_title：Expert review of respiratory medicine

authors： Azadeh N,Moua T,Baqir M,Ryu JH

更新日期：2018-04-01 00:00:00

abstract：:Aspergillus species are commonly isolated from lower respiratory tract samples of patients with cystic fibrosis (CF) and markers of immunological sensation to Aspergillus are frequently encountered in this group of patients; however, the contribution of Aspergillus to CF lung disease outside of the typical complicatio...

journal_title：Expert review of respiratory medicine

authors： Jones AM,Horsley A,Denning DW

更新日期：2014-08-01 00:00:00

abstract：:Allergic airway disease is a major global health burden, and novel treatment options are urgently needed. Numerous epidemiological and experimental studies suggest that certain helminths and bacteria protect against respiratory allergies. These microorganisms are strong regulators of the immune system, and various pot...

journal_title：Expert review of respiratory medicine

authors： Obieglo K,van Wijck Y,de Kleijn S,Smits HH,Taube C

更新日期：2014-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by persistent airflow limitation. It is the third leading cause of death worldwide, and there are currently no curative strategies for this disease. Many factors contribute to COPD susceptibility, progression and exacerbations. These...

journal_title：Expert review of respiratory medicine

authors： Goh F,Shaw JG,Savarimuthu Francis SM,Vaughan A,Morrison L,Relan V,Marshall HM,Dent AG,O'Hare PE,Hsiao A,Bowman RV,Fong KM,Yang IA

更新日期：2013-12-01 00:00:00

abstract：:Studies on cough have come a long way but many shortfalls still exist. These shortfalls can be attributed to: the lack of randomized controlled studies with a focus on cough; studies not using robust cough outcome measures, poor definition of target groups in studies and guidelines, the lack of safe and efficacious tr...

journal_title：Expert review of respiratory medicine

authors： Chang AB

更新日期：2011-08-01 00:00:00

abstract：:Techniques to promote clearance of sputum from the airways (airway clearance techniques; ACTs) have existed in clinical practice for more than a century. This review examines current evidence and clinical recommendations regarding ACTs for individuals with chronic obstructive pulmonary disease. Comparisons between thi...

journal_title：Expert review of respiratory medicine

authors： Osadnik CR,McDonald CF,Holland AE

更新日期：2013-12-01 00:00:00

abstract：:The hallmarks of allergic bronchial asthma arise from chronic airway inflammation. Thus, elucidating the mechanisms regulating the maintenance of this chronic inflammatory response is key to understanding asthma pathogenesis. To date, it is not clear whether a predominance of proinflammatory factors or a reduced capac...

journal_title：Expert review of respiratory medicine

authors： Lunding L,Schröder A,Wegmann M

更新日期：2015-01-01 00:00:00

abstract：:Treprostinil is a prostacyclin derivative approved for the treatment of pulmonary arterial hypertension by intravenous, subcutaneous and inhalational administration. Unlike its precursor epoprostenol, treprostinil is chemically stable at room temperature and neutral pH, and its plasma half-life is longer. In addition ...

journal_title：Expert review of respiratory medicine

authors： LeVarge BL,Channick RN

更新日期：2012-06-01 00:00:00

abstract：:Research on asthma pathophysiology over the past decade has expanded the complex repertoire involved in the pathophysiology of asthma to include inflammatory, immune and structural cells, as well as a wide range of mediators. Studies have identified a role for connective and other mesenchymal tissues involved in airwa...

journal_title：Expert review of respiratory medicine

authors： Orihara K,Dil N,Anaparti V,Moqbel R

更新日期：2010-10-01 00:00:00

abstract：:Introduction: Cystic fibrosis (CF) is a complex, multi-system, genetic disease affecting over 70,000 people worldwide. The underlying defect is a mutation in the CFTR gene. Dysfunctional CFTR protein results in abnormal anion movement across epithelial membranes in affected organs. There has been a paradigm shift in C...

journal_title：Expert review of respiratory medicine

authors： Paterson SL,Barry PJ,Horsley AR

更新日期：2020-01-01 00:00:00

abstract：:Budesonide/formoterol is a combination of an inhaled corticosteroid plus a long-acting beta(2)-agonist available as a dry-powder inhaler for the indication of asthma and chronic obstructive pulmonary disease in various countries outside of the USA and as a pressurized metered-dose inhaler in the USA for the indication...

journal_title：Expert review of respiratory medicine

authors： Lee C,Corren J

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:The treatment of lung cancer has radically changed over the last few years. The discovery of druggable oncogenic alterations and the introduction of immunotherapy have provided lung cancer patients with the possibility of more efficient and less toxic therapeutic alternatives than chemotherapy. In the case...

journal_title：Expert review of respiratory medicine

authors： Lazzari C,Karachaliou N,Gregorc V,Bulotta A,Gonzalez-Cao M,Verlicchi A,Altavilla G,Rosell R,Santarpia M

更新日期：2017-06-01 00:00:00

abstract：:Long-term oxygen therapy (LTOT) has been shown to reduce pulmonary hypertension and improve survival in patients with chronic obstructive pulmonary disease and resting hypoxemia (reduced arterial partial pressure of oxygen ≤55 mmHg). However, the benefit of its use for chronic pulmonary diseases other than chronic obs...

journal_title：Expert review of respiratory medicine

authors： Jindal SK,Agarwal R

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Lung Clearance Index, measured using the multiple breath washout (MBW) technique, may be a useful test in infants with Cystic Fibrosis (CF). However, the requirement for specialised equipment and a number of important technical and methodological considerations relevant to testing in infants have complicat...

journal_title：Expert review of respiratory medicine

authors： Davies G,Aurora P

更新日期：2017-01-01 00:00:00

abstract：:Introduction: There is an unmet clinical need for improved diagnostic tests for active tuberculosis (TB) to provide high sensitivity for all cases, accelerate time to diagnosis and ensure timely and appropriate treatment. Whilst the measurement of M.tb-specific immune responses is widely used for detecting infection i...

journal_title：Expert review of respiratory medicine

authors： Halliday A,Masonou T,Tolosa-Wright M,Mandagere V,Lalvani A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:N-acetyl-l-cysteine (NAC), a derivative of the naturally occurring amino acid l-cysteine, is a mucolytic agent that may also act as an antioxidant by providing cysteine intracellularly for increased production of glutathione. It is also used for the treatment of acetaminophen overdose. Areas covered: The r...

journal_title：Expert review of respiratory medicine

authors： Calzetta L,Matera MG,Rogliani P,Cazzola M

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:The independent and central role of the patient with a complex chronic respiratory disease in targeted, personalized disease management strategies is becoming increasingly important. Patients are the ones living with the disease and are finally responsible for their lives underlining their role as essentia...

journal_title：Expert review of respiratory medicine

authors： Houben-Wilke S,Augustin IM,Wouters BB,Stevens RA,Janssen DJ,Spruit MA,Vanfleteren LE,Franssen FM,Wouters EF

更新日期：2017-12-01 00:00:00

abstract：:Asthma is often associated with various comorbidities. The most frequently reported asthma comorbid conditions include rhinitis, sinusitis, gastroesophageal reflux disease, obstructive sleep apnea, hormonal disorders and psychopathologies. These conditions may, first: share a common pathophysiological mechanism with a...

journal_title：Expert review of respiratory medicine

authors： Boulet LP,Boulay MÈ

更新日期：2011-06-01 00:00:00

abstract：:Patients suffering from COPD not controlled by a single bronchodilator should be given two bronchodilators with different mechanisms of action. Addition of a LABA to a LAMA induces a larger bronchodilation than that obtained with the LAMA as monotherapy and also improves many patient-reported outcomes. Since the clini...

journal_title：Expert review of respiratory medicine

authors： Calzetta L,Ciaprini C,Puxeddu E,Cazzola M

更新日期：2016-04-01 00:00:00

abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized in 2012 and since then has resulted in cases in 23 countries in four continents. The majority of these cases were reported from the Kingdom of Saudi Arabia. The disease caused a spectrum of illness, from asymptomatic to severe and possibly fa...

journal_title：Expert review of respiratory medicine

authors： Al-Tawfiq JA,Memish ZA

更新日期：2015-06-01 00:00:00

abstract：:Caveolin-1 (Cav-1) is the major protein present in invaginations of the plasma membrane of cells known as caveolae. Cav-1 is expressed in numerous resident and inflammatory cells implicated in the pathogenesis of asthma and chronic inflammatory respiratory diseases including chronic obstructive pulmonary disease. A re...

journal_title：Expert review of respiratory medicine

authors： Royce SG,Le Saux CJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Approximately 14% of UK hospital in-patients receive supplemental oxygen therapy, only 57% have valid prescriptions. Oxygen must be optimally prescribed to ensure maximal therapeutic response whilst minimizing adverse outcomes (including fatality). This study investigates prescription compliance. METHODS:Al...

journal_title：Expert review of respiratory medicine

authors： Barrett R,Catangui E,Scott R

更新日期：2020-10-14 00:00:00

abstract：:Introduction: Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibito...

journal_title：Expert review of respiratory medicine

authors： Abad VC,Guilleminault C

更新日期：2018-12-01 00:00:00