Abstract:
:Smoke inhalation injury continues to increase morbidity and mortality in burn patients in both the third world and industrialized countries. The lack of uniform criteria for the diagnosis and definition of smoke inhalation injury contributes to the fact that, despite extensive research, mortality rates have changed little in recent decades. The formation of reactive oxygen and nitrogen species, as well as the procoagulant and antifibrinolytic imbalance of alveolar homeostasis, all play a central role in the pathogenesis of smoke inhalation injury. Further hallmarks include massive airway obstruction owing to cast formation, bronchospasm, the increase in bronchial circulation and transvascular fluid flux. Therefore, anticoagulants, antioxidants and bronchodilators, especially when administered as an aerosol, represent the most promising treatment strategies. The purpose of this review article is to provide an overview of the pathophysiological changes, management and treatment options of smoke inhalation injury based on the current literature.
journal_name
Expert Rev Respir Medjournal_title
Expert review of respiratory medicineauthors
Rehberg S,Maybauer MO,Enkhbaatar P,Maybauer DM,Yamamoto Y,Traber DLdoi
10.1586/ERS.09.21subject
Has Abstractpub_date
2009-06-01 00:00:00pages
283-297issue
3eissn
1747-6348issn
1747-6356journal_volume
3pub_type
杂志文章abstract::The need for novel and more effective approaches to tobacco control is unquestionable. The electronic cigarette is a battery-powered electronic nicotine delivery system that looks very similar to a conventional cigarette and is capable of emulating smoking, but without the combustion products accountable for smoking's...
journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
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